Analyse de la prise en charge du nouveau-né dans le cadre de la stratégie nationale de subvention des accouchements et des soins obstétricaux et néonatals d’urgence au Centre Hospitalier Universitaire Pédiatrique Charles de Gaulle, Ouagadougou (Burkina Fa

Introduction: il s'agit d'analyser la prise en charge du nouveau-né dans le cadre de la stratégie na-tionale de subvention des accouchements etdes soins obstétricaux et néonatals d'urgence mis en place par le  gouvernement du Burkina Faso en 2006. Méthodes: nous avons menée une étude à visée descriptive et analytique comportant un volet  ré-trospectif du 01 janvier 2006 au 31 décembre 2010 portant sur les paramètres épidémiologiques, cliniques des nouveau-nés hospitalisés et un volet prospectif du 3 octobre 2011 au 29 février 2012 par une entrevue des accompagnateurs des nouveau-nés et des prestataires des services de santé. Résultats: les hospitalisations ont augmenté de 43,65% entre 2006à 2010 Le taux de mortalité néo-natale hospitalière qui était de 11,04% a connu une réduction moyenne annuelle de 3,95%. L'entrevue a porté sur 110 accompagnateurs et 76 prestataires. La majorité des prestataires (97,44%) et des ac-compagnateurs (88,18%) étaient informés de la  stratégie mais n'avait pas une connaissance exacte de sa définition. Les prestataires (94,74%) ont signalé des ruptures de médicaments,   consommables médicaux et des pannes d' appareils de laboratoire et  d'imagerie. Parmi les accompagnateurs (89%) disaient être satisfaits desservices offerts et (72,89%) trouvaient les coûts abordables mais   évoquaient les difficultés du transport. Conclusion : La subvention a amélioré la prise en charge du nou-veau-né mais son optimisation  nécessiterait une meilleur information et implication de tous les acteurs

Knowledge, practices and beliefs of students regarding health effects of shisha use in Ouagadougou, Burkina Faso: A cross‐sectional study

Background. The tobacco epidemic is one of the biggest public health threats the world has ever faced. Shisha use has recently been gaining increased popularity in many developed and developing countries. Objective. To determine the prevalence of shisha use among students in Ouagadougou, Burkina Faso, and associated knowledge, smoking practices and beliefs about health effects. Method. A total of 443 students were selected for this cross-sectional study, using a stratified sampling method. Data on shisha use, knowledge about shisha, shisha smoking practices, and factors associated with use of shisha were collected via a questionnaire. The association between the independent variables and shisha use was assessed using a χ2 test (p<0.05). Binary logistic regression analysis was used to determine variables that were independently associated with shisha smoking. Results. Of the 421 respondents, 162 (38.5%) indicated that they had smoked shisha; 14.0% were regular smokers. We found that 183 students (43.5%) had poor knowledge about the health effects of shisha. The main reasons for shisha smoking were being in the company of friends who were users (57.4%), the pleasant flavour and fragrance of shisha (25.9%), and fashion (22.2%). Ninety-nine shisha smokers (61.1%) also consumed alcohol. Factors associated with shisha smoking included age <20 years (p<0.001), gender (p=0.034), and educational level of the respondent’s father (p=0.0001) and mother (p=0.0004). Conclusion. We found a relatively high prevalence of shisha smoking among the students, and that 43.5% of them had poor knowledge about its effects on health. Developing surveillance, intervention and regulatory/policy frameworks specific to shisha has become a public health priority

Automatic Generation of Test Cases based on Bug Reports: a Feasibility Study with Large Language Models

Software testing is a core discipline in software engineering where a large array of research results has been produced, notably in the area of automatic test generation. Because existing approaches produce test cases that either can be qualified as simple (e.g. unit tests) or that require precise specifications, most testing procedures still rely on test cases written by humans to form test suites. Such test suites, however, are incomplete: they only cover parts of the project or they are produced after the bug is fixed. Yet, several research challenges, such as automatic program repair, and practitioner processes, build on the assumption that available test suites are sufficient. There is thus a need to break existing barriers in automatic test case generation. While prior work largely focused on random unit testing inputs, we propose to consider generating test cases that realistically represent complex user execution scenarios, which reveal buggy behaviour. Such scenarios are informally described in bug reports, which should therefore be considered as natural inputs for specifying bug-triggering test cases. In this work, we investigate the feasibility of performing this generation by leveraging large language models (LLMs) and using bug reports as inputs. Our experiments include the use of ChatGPT, as an online service, as well as CodeGPT, a code-related pre-trained LLM that was fine-tuned for our task. Overall, we experimentally show that bug reports associated to up to 50% of Defects4J bugs can prompt ChatGPT to generate an executable test case. We show that even new bug reports can indeed be used as input for generating executable test cases. Finally, we report experimental results which confirm that LLM-generated test cases are immediately useful in software engineering tasks such as fault localization as well as patch validation in automated program repair

Exploring Drivers of Invasiveness of the Plant Species \u3ci\u3eSenna obtusifolia\u3c/i\u3e in Rangelands to Secure Forage Production in West Africa

Rangelands in Sahelian countries are continuously over-grazed decreasing forage resources and causing rapid environmental changes. Senna obtusifolia is a less palatable plant species that becomes increasingly invasive. This research explored drivers of its invasiveness in the perspective to propose solutions to secure forage production in the pastoral reserves. Species composition and herbaceous aboveground biomass were assessed in rangelands with different levels of invasion of Senna obtusifolia along a climatic and land-use pressure gradient. A greenhouse experiment was conducted to test the competitiveness of this species. The development of Senna obtusifolia in rangelands affected significantly forage quantity. Indeed the biomass of the others herbaceous species decreased but not the species richness. The overgrazing of Sahelian rangelands combined to the floristic selection operated by livestock reduced the abundance of fodder species and fostered the expansion of S. obtusifolia. Moreover, S. obtusifolia had a good germination rate with a rapid growth that made it more competitive. Thus, in the interspecific competition experiment, the aboveground biomass of S. obtusifolia was not influenced when associated to legume, grass and perennial grass species respectively. After 3 years of full protection experiment, the abundance of S. obtusifolia decreased, hence its invasiveness in rangelands should be supported by the mixed effect of disturbance factors as grazing and drought that lead several plant species to be vulnerable and favor undesirable species expansion. The control of S. obtusifolia expansion is conditionned by the reformulation of the land management systems and the promotion of sustainable environmental policies

Residual mother-to-child transmission of HIV in Burkina Faso

Background: Burkina Faso is one of the countries in West Africa most affected by the HIV/AIDS pandemic, despite the implementation of a mother-to-child HIV transmission prevention program as a strategy to reduce the risk of vertical transmission of the disease.Objective: To assess the current risk of mother-to-child transmission of HIV in Burkina Faso.Materials and methods: A prospective study was conducted between December 2014 and July 2016, in the 13 health regions of Burkina Faso. Women who were screened HIV-positive during a prenatal consultation were followed until delivery. Their babies received dry blood spot (DBS) at birth, at week 6 and at 1year, to screen for HIV.Results: Overall, 186 pregnant women were included in the study, with a mean age of 29.17±6.13 years. Of their children, 430 DBS actually received a PCR test, giving a 91.1% PCR implementation rate. After analyses, 6 (1.3%) babies were identified as carriers of HIV1. The newborn’s serological status was associated with delivery pattern (p=0.000), the administration of antiretroviral drugs to the mother after delivery (p=0.0064), the administration of Nevirapine to the newborn at birth (p=0.022), the use of contraceptive methods after delivery (p=0.028) and the presence of breast affections/infections since delivery (p=0.013).Conclusion: The results of our study are encouraging and demonstrate the effectiveness of interventions in the mother-tochild prevention program (PMTCT) for HIV-positive pregnant women can be improved through early initiation of triple therapy in early pregnancy and improved adherence to antiretroviral (ARV) therapy.Keywords: Burkina Faso, HIV/AIDS, mother-to-child transmission, antiretroviral drugs, pregnant wome

Importance of the confirmatory assay for the detection of the HBsAg in the epidemiological studies and in the diagnosis of the viral Hepatitis B

Several epidemiological studies have reported high prevalence of HBsAg among pregnant women in Burkina Faso. They used various algorithms, as it is also done for the routine diagnostic. Knowing this antigen carriage rate in such a population or in other clinic attendees is important for the implementation of a national immunisation programme and the monitoring of patients with hepatitis B. Often, the screening tests were not confirmed in spite of the existence of known false positive and false negative results. The aim of this study was to determine a more accurate prevalence of HBsAg, among the pregnant women in Burkina Faso. From October 2006 to January 2007, blood samples were collected from 1139 pregnant women. Each sample was analyzed for HBsAg, using two assays and according to manufacturers’ instructions vis, Hepanostika®HBsAg Uniform II B9 (Bio-Mérieux; France) and HBsAg (V2) Abbott AxSYM® system (Abbott Diagnostics). All the positive samples were tested with a confirmatory neutralization assay- Hepanostika®HBsAg Uniform II B9 Confirmatory (Bio-Merieux). The mean age of the pregnant women was 24.85years [range: 15-45years] and the age range of 20-24 (37%) and 25-29 (25.4%) years were the most represented. The overall rate of HBsAg-positive pregnant women with the two screening assays was 20.9%. The HBsAg detection rate was significantly higher with Hepanostika® UniformII B9 (16.9%) than with HBsAg (V2) AxSYM system assay (12.1%), with

Efficacy of Olyset Duo, a bednet containing pyriproxyfen and permethrin, versus a permethrin-only net against clinical malaria in an area with highly pyrethroid-resistant vectors in rural Burkina Faso: a cluster-randomised controlled trial

Background Substantial reductions in malaria incidence in sub-Saharan Africa have been achieved with massive deployment of long-lasting insecticidal nets (LLINs), but pyrethroid resistance threatens control. Burkina Faso is an area with intense malaria transmission and highly pyrethroid-resistant vectors. We assessed the effectiveness of bednets containing permethrin, a pyrethroid, and pyriproxyfen, an insect growth regulator, versus permethrin-only (standard) LLINs against clinical malaria in children younger than 5 years in Banfora, Burkina Faso. Methods In this two-group, step-wedge, cluster-randomised, controlled, superiority trial, standard LLINs were incrementally replaced with LLINs treated with permethrin plus pyriproxyfen (PPF) in 40 rural clusters in Burkina Faso. In each cluster, 50 children (aged 6 months to 5 years) were followed up by passive case detection for clinical malaria. Cross-sectional surveys were done at the start and the end of the transmission seasons in 2014 and 2015. We did monthly collections from indoor light traps to estimate vector densities. Primary endpoints were the incidence of clinical malaria, measured by passive case detection, and the entomological inoculation rate. Analyses were adjusted for clustering and for month and health centre. This trial is registered as ISRCTN21853394. Findings 1980 children were enrolled in the cohort in 2014 and 2157 in 2015. At the end of the study, more than 99% of children slept under a bednet. The incidence of clinical malaria was 2·0 episodes per child-year in the standard LLIN group and 1·5 episodes per child-year in the PPF-treated LLIN group (incidence rate ratio 0·88 [95% CI 0·77–0·99; p=0·04]). The entomological inoculation rate was 85 (95% CI 63–108) infective bites per transmission season in the standard LLIN group versus 42 (32–52) infective bites per transmission season in the PPF-treated LLIN group (rate ratio 0·49, 95% CI 0·32–0·66; p<0·0001). Interpretation PPF-treated LLINs provide greater protection against clinical malaria than do standard LLINs and could be used as an alternative to standard LLINs in areas with intense transmission of Plasmodium falciparum malaria and highly pyrethroid-resistant vectors. Funding EU Seventh Framework Programme

The impacts of weather and climate information services on technical efficiency and farm productivity among smallholder farmers in the Upper West Region of Ghana

This study evaluates the impacts of a pilot project that introduced weather and climate information services (CIS) on technical efficiency (TE) and sorghum productivity (Y) using a total of 210 plotlevel data comprising of 92 users and 118 nonusers of CIS in the Upper West Region of Ghana. First, we estimate a Stochastic Frontier model to measure the level of TE using a Cobb-Douglas functional form with the assumption of an exponential distribution for the identification of TE scores. Secondly, we measure the impact of the adoption of CIS on TE and Y separately by addressing the potential bias stemming from the existence of unobserved characteristics using a Control Function estimator. Thirdly, we employ a Recursive Structural Equation System to deal with the simultaneous problems of the endogenous treatment of CIS into Y, the endogenous covariate of TE into Y, and the reverse causality between Y and TE. Overall, our findings are robust to the different methodologies with strong evidence that the pilot project through the adoption of CIS has a substantial positive effect on improving TE and Y in the study area. Our empirical results consistently estimate approximately 6% increase in TE and 35% sorghum yield improvement corresponding to 150 Kg/Ha increased productivity among CIS users. Furthermore, when we simultaneously estimate the combined effects of the adoption of CIS and the level of TE on sorghum productivity with and without the problem of reverse causation between Y and TE, the median value of the average treatment effects (ATE) is 10%. Also, improving the level of TE has a higher payoff among users than nonusers of CIS resulting in increased sorghum productivity of 5% when we compare the average treatment effects on the treated (ATET) and the average treatment effects on the untreated (ATEU). These results underscore a valuable policy insight and the importance of privileging the wide adoption of CIS and promoting the efficient use of inputs with best-recommended climate-smart agricultural practices such as crop management and increasing trainings to raise awareness in future project expansion. However, it appears that the magnitudes of the impacts of the adoption of CIS on Y using the ATE, ATET, and ATEU are sensitive to whether we address the potential reverse causality between Y and TE. These findings indicate that more caution should be considered in the evaluation of the impacts of a project that promotes agricultural innovations including information communication technologies on farm productivity and technical efficiency