Analysis Of Online Customer Reviews

The overall satisfaction of the customer is an important issue for online retailers.  This paper analyzes online customer ratings of electronic goods in the areas of Overall Customer Satisfaction, Customer Service, Delivery, Ease of Purchase, Price, and Shipping Options.  The authors develop neural network and multiple regression models that relate Overall Customer Satisfaction evaluations to the other rating factors.  By using these models, online retail managers can determine how to best allocate their resources to improve customer service, delivery, ease of purchase, price, and/or shipping options in ways that can best improve overall customer satisfaction

Sensitization of capsaicin and icilin responses in oxaliplatin treated adult rat DRG neurons

<p>Abstract</p> <p>Background</p> <p>Oxaliplatin chemotherapy induced neuropathy is a dose related cumulative toxicity that manifests as tingling, numbness, and chronic pain, compromising the quality of life and leading to discontinued chemotherapy. Patients report marked hypersensitivity to cold stimuli at early stages of treatment, when sensory testing reveals cold and heat hyperalgesia. This study examined the morphological and functional effects of oxaliplatin treatment in cultured adult rat DRG neurons.</p> <p>Results</p> <p>48 hour exposure to oxaliplatin resulted in dose related reduction in neurite length, density, and number of neurons compared to vehicle treated controls, using Gap43 immunostaining. Neurons treated acutely with 20 μg/ml oxaliplatin showed significantly higher signal intensity for cyclic AMP immunofluorescence (160.5 ± 13 a.u., n = 3, P < 0.05), compared to controls (120.3 ± 4 a.u.). Calcium imaging showed significantly enhanced capsaicin (TRPV1 agonist), responses after acute 20 μg/ml oxaliplatin treatment where the second of paired capsaicin responses increased from 80.7 ± 0.6% without oxaliplatin, to 171.26 ± 29% with oxaliplatin, (n = 6 paired t test, P < 0.05); this was reduced to 81.42 ± 8.1% (P < 0.05), by pretretreatment with the cannabinoid CB2 receptor agonist GW 833972. Chronic oxaliplatin treatment also resulted in dose related increases in capsaicin responses. Similarly, second responses to icilin (TRPA1/TRPM8 agonist), were enhanced after acute (143.85 ± 7%, P = 0.004, unpaired t test, n = 3), and chronic (119.7 ± 11.8%, P < 0.05, n = 3) oxaliplatin treatment, compared to control (85.3 ± 1.7%). Responses to the selective TRPM8 agonist WS-12 were not affected.</p> <p>Conclusions</p> <p>Oxaliplatin treatment induces TRP sensitization mediated by increased intracellular cAMP, which may cause neuronal damage. These effects may be mitigated by co-treatment with adenylyl cyclase inhibitors, like CB2 agonists, to alleviate the neurotoxic effects of oxaliplatin.</p

Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study

Background: Ventriculitis is a complication of temporary intraventricular drains. The limited penetration of meropenem into the cerebrospinal fluid (CSF) is well known. However, ventricular CSF pharmacokinetic data in patients with ventriculitis are lacking. The aim of this study was to evaluate meropenem pharmacokinetics in the serum and CSF of neurocritical care patients with proven or suspected ventriculitis. Methods: We conducted an observational pharmacokinetic study of neurocritical care patients with proven or suspected ventriculitis receiving meropenem. Multiple blood and CSF samples were taken and were described using nonparametric pharmacokinetic modelling with Pmetrics. Results: In total, 21 patients (median age 52 years, median weight 76 kg) were included. The median (range) of peak and trough concentrations in serum were 20.16 (4.40-69.00) mg/L and 2.54 (0.00-31.40) mg/L, respectively. The corresponding peak and trough concentrations in CSF were 1.20 (0.00-6.20) mg/L and 1.28 (0.00-4.10) mg/L, respectively, with a median CSF/serum ratio (range) of 0.09 (0.03-0.16). Median creatinine clearance ranged from 60. 7 to 217.6 ml/minute (median 122.5 ml/minute). A three-compartment linear population pharmacokinetic model was most appropriate. No covariate relationships could be supported for any of the model parameters. Meropenem demonstrated poor penetration into CSF, with a median CSF/serum ratio of 9 % and high interindividual pharmacokinetic variability. Conclusions: Administration of higher-than-standard doses of meropenem and therapeutic drug monitoring in both serum and CSF should be considered to individualise meropenem dosing in neurocritical care patients with ventriculitis

Individual differences in naturalistic learning link negative emotionality to the development of anxiety

Organisms learn from prediction errors (PEs) to predict the future. Laboratory studies using small financial outcomes find that humans use PEs to update expectations and link individual differences in PE-based learning to internalizing disorders. Because of the low-stakes outcomes in most tasks, it is unclear whether PE learning emerges in naturalistic, high-stakes contexts and whether individual differences in PE learning predict psychopathology risk. Using experience sampling to assess 625 college students\u27 expected exam grades, we found evidence of PE-based learning and a general tendency to discount negative PEs, an optimism bias. However, individuals with elevated negative emotionality, a personality trait linked to the development of anxiety disorders, displayed a global pessimism and learning differences that impeded accurate expectations and predicted future anxiety symptoms. A sensitivity to PEs combined with an aversion to negative PEs may result in a pessimistic and inaccurate model of the world, leading to anxiety

Stratus 11 : Eleventh Setting of the Stratus Ocean Reference Station Cruise on board RV Moana Wave, March 31 - April 16, 2011, Arica - Arica, Chile

The Ocean Reference Station at 20°S, 85°W under the stratus clouds west of northern Chile is being maintained to provide ongoing climate-quality records of surface meteorology, air-sea fluxes of heat, freshwater, and momentum, and of upper ocean temperature, salinity, and velocity variability. The Stratus Ocean Reference Station (ORS Stratus) is supported by the National Oceanic and Atmospheric Administration’s (NOAA) Climate Observation Program. It is recovered and redeployed annually, with past cruises that have come between October and January. A NOAA vessel was not available, so this cruise was conducted on the chartered ship, Moana Wave, belonging to Stabbert Maritime. During the 2011 cruise on the Moana Wave to the ORS Stratus site, the primary activities were the recovery of the subsurface part of the Stratus 10 WHOI surface mooring, deployment of a new (Stratus 11) WHOI surface mooring, in-situ calibration of the buoy meteorological sensors by comparison with instrumentation installed on the ship by staff of the NOAA Earth System Research Laboratory (ESRL), and collection of underway and on station oceanographic data to continue to characterize the upper ocean in the stratus region. The Stratus 10 mooring had parted, and the surface buoy and upper part had been recovered earlier. Underway CTD (UCTD) profiles were collected along the track and during surveys dedicated to investigating eddy variability in the region. Surface drifters and subsurface floats were also launched along the track. The intent was also to visit a buoy for the Pacific tsunami warning system maintained by the Hydrographic and Oceanographic Service of the Chilean Navy (SHOA). This DART (Deep- Ocean Assessment and Reporting of Tsunami) buoy had been deployed in December 2010.Funding was provided by the National Oceanic and Atmospheric Administration under Grant No. NA0900AR432012

Uma visão de alunos universitários sobre a relação de seus pais como casal

En una relación de pareja, sus integrantes comparten expectativas relacionadas con lo que vivieron y aprendieron en su familia de origen, de manera que la nueva familia reflejará patrones que los hijos reproducirán en un futuro. Si los hijos perciben relaciones de pareja adecuadas, retomarán estas mismas relaciones en la formación de su nueva familia; sin embargo, cuando esta relación se ve afectada por la separación, es probable que existan diferencias importantes en la percepción de los hijos. El objetivo del presente artículo fue analizar la percepción de universitarios respecto a la relación de sus padres como pareja dentro de la dinámica familiar, tomando en cuenta si sus padres vivían juntos o separados. Se utilizó una muestra intencional compuesta por 566 alumnos universitarios, de los cuales 345 eran mujeres y 221, hombres. Se aplicó el cuestionario Dinámica de la Familia Nuclear Mexicana de Vásquez et al. (2003), aunque solo se abordó el área "Los padres. Su dinámica cómo pareja". La diferencia estadística entre grupos se obtuvo a través de la prueba U de Mann-Whitney. Los resultados mostraron diferencias estadísticamente significativas entre la percepción de los universitarios con respecto a sus padres cuando viven juntos o cuando viven separados. Se concluyó que existen diferentes factores que afectan el funcionamiento de la dinámica familiar, los cuales influyen de manera diferencial en la percepción que puede tener cada miembro de la familia.When a couple starts a new family, both members share expectations based on what they have learned from their experience in their respective families of origin, in such a way that their offspring will repeat the same patterns in the future. If children perceive a healthy appropriate relationship between their parents, chances are that they too will have a good relationship when they start their own families. However, children will have a different perception when their parents go through a separation or divorce. Based on these facts, the aim of this article was to analyze university students' perception regarding their parents' relationship as a couple within their family environment, taking into consideration whether their parents lived together or separately. A target group comprised of 566 university students of which 345 were women and 221 were men participated in the study. The instrument used was the measurement questionnaire "Dinámica de la Familia Nuclear Mexicana" [The Mexican Family Dynamics] (Vásquez, et al., 2003). In this study the only area addressed was "Parents and their relationship as a couple". The statistical difference between groups was obtained using the Mann-Whitney U test. The results showed significant statistical differences between university students' perception of their parents depending on whether they live together or separately. A conclusion was reached on the existence of different factors that affect the family environment, which has a differential influence on each family member's perception.Em uma relação de casal, seus integrantes compartilham expectativas relacionadas com o que viveram e aprenderam em sua família de origem, de forma que a nova família refletirá padrões que os filhos reproduzirão no futuro. Se os filhos percebem relações de casal adequadas, retomarão essas mesmas relações na formação da sua nova família; no entanto, quando essa relação se vê afetada pela separação, é provável que existam diferenças importantes na percepção dos filhos. O objetivo do presente artigo foi analisar a percepção de universitários com respeito à relação de seus pais como casal dentro da dinâmica familiar, levando em consideração se seus pais viviam juntos ou separados. Utilizou-se uma amostra intencional composta por 566 alunos universitários, dos quais 345 eram mulheres e 221, homens. Aplicou-se o questionário Dinâmica da Família Nuclear Mexicana, de Vásquez et al. (2003), ainda que apenas a área "Os pais - sua dinâmica como casal" tenha sido abordada. A diferença estatística entre grupos foi obtida através do Teste U de Mann-Whitney. Os resultados mostraram diferenças estatisticamente significativas entre a percepção dos universitários com respeito a seus pais quando vivem juntos ou quando vivem separados. Concluiu-se que existem diferentes fatores que afetam o funcionamento da dinâmica familiar, os quais influenciam de maneira diferencial na percepção que cada membro da família pode ter

Stratus 10 tenth setting of the Stratus Ocean Reference Station : cruise RB-10-01, January 2 - January 30, 2010 Charleston, South Carolina - Valparaiso, Chile

The Ocean Reference Station at 20°S, 85°W under the stratus clouds west of northern Chile is being maintained to provide ongoing climate-quality records of surface meteorology, air-sea fluxes of heat, freshwater, and momentum, and of upper ocean temperature, salinity, and velocity variability. The Stratus Ocean Reference Station (ORS Stratus) is supported by the National Oceanic and Atmospheric Administration’s (NOAA) Climate Observation Program. It is recovered and redeployed annually, with past cruises that have come between October and December. Due to necessary repairs on the electric motors of the ship’s propulsion system, this year the cruise was delayed until January. During the 2009/2010 cruise on the NOAA ship Ronald H. Brown to the ORS Stratus site, the primary activities were the recovery of the Stratus 9 WHOI surface mooring that had been deployed in October 2008, deployment of a new (Stratus 10) WHOI surface mooring at that site, in-situ calibration of the buoy meteorological sensors by comparison with instrumentation installed on the ship by staff of the NOAA Earth System Research Laboratory (ESRL), and collection of underway and on station oceanographic data to continue to characterize the upper ocean in the stratus region. Both underway CTD (UCTD) profiles and Vertical Microstructure Profiles (VMP) were collected along the track and during surveys dedicated to investigating eddy variability in the region. Surface drifters were also launched along the track. The intent was also to visit a buoy for the Pacific tsunami warning system maintained by the Hydrographic and Oceanographic Service of the Chilean Navy (SHOA). This DART (Deep- Ocean Assessment and Reporting of Tsunami) buoy had been equipped with IMET sensors and subsurface oceanographic instruments, and a recovery and replacement of the IMET sensors was planned. However, the DART buoy broke free from its mooring on January 3rd and was recovered by the Chilean navy; the work done at that site during this cruise was the recovery of the bottom pressure unit.Funding was provided by the National Oceanic and Atmospheric Administration under Grant No. NA17RJ1223 for the Cooperative Institute for Climate and Ocean Research (CICOR)