Перевод паровой котельной на водогрейный режим г. Кедровый Томской области

Выпускная квалификационная работа 172 страницы, 17 табл., 8 рисунков, 21 источник литературы, 8 листов графического материала. КОТЕЛЬНАЯ ПРОИЗВОДСТВЕННО - ОТОПИТЕЛЬНАЯ, КОТЕЛ ПАРОВОЙ, ВОДОГРЕЙНЫЙ РЕЖИМ, ТЕПЛОВОЙ, ГИДРАВЛИЧЕСКИЙ, АЭРОДИНАМИЧЕСКИЙ РАСЧЕТ, ЭКОНОМИЧЕСКИЙ ЭФФЕКТ. Целью работы является перевод котла ДКВр-10-13 с парового режима работы в водогрейный.Final qualifying work of 172 pages, 17 tab., 8 figures, 21 source of literature, 8 sheets of graphic material. INDUSTRIAL BOILER - Heating, steam boiler, hot-water boilers, thermal, hydraulic, aerodynamic calculations, the economic effect. The aim is to transfer the boiler DKVr-10-13 with steam mode to hot water

UvA-DARE (Digital Academic Repository) Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse Link to publication Citation for published version (APA): Class III P-Glycoproteins Mediate the Formation of Lipoprotein X in the Mouse

Abstract Cholestasis is associated with hypercholesterolemia and appearance of the abnormal lipoprotein X (LpX) in plasma. Using mice with a disrupted Mdr2 gene, we tested the hypothesis that LpX originates as a biliary lipid vesicle. Mdr2-deficient mice lack Mdr2 P-glycoprotein, the canalicular translocator for phosphatidylcholine, and secrete virtually no phospholipid and cholesterol in bile. Bile duct ligation of Mdr2 ϩ / ϩ mice induced a dramatic increase in the plasma cholesterol and phospholipid concentration. Agarose electrophoresis, density gradient ultracentrifugation, gel permeation, and electron microscopy revealed that the majority of phospholipid and cholesterol was present as LpX, a 40-100 nm vesicle with an aqueous lumen. In contrast, the plasma cholesterol and phospholipid concentration in Mdr2 Ϫ / Ϫ mice decreased upon bile duct ligation, and plasma fractionation revealed a complete absence of LpX. In mice with various expression levels of Mdr2 or MDR3 , the human homolog of Mdr2 , we observed that the plasma level of cholesterol and phospholipid during cholestasis correlated very closely with the expression level of these canalicular P-glycoproteins. These data demonstrate that during cholestasis there is a quantitative shift of lipid secretion from bile to the plasma compartment in the form of LpX. The concentration of this lipoprotein is determined by the activity of the canalicular phospholipid translocator. ( J. Clin. Invest. 1998. 102:1749-1757.