Guanidinoacetic Acid as a Nutritional Adjuvant to Multiple Sclerosis Therapy

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Malproduction of endogenous hydrogen gas in COVID-19

The molecular footprints of COVID-19 occur everywhere, even reaching the family of biologically active gases and gasotransmitters. Besides nitric oxide and hydrogen sulfide, COVID-19 might also alter the homeostasis of dihydrogen (H2), another gaseous bioactive molecule produced endogenously by the human gut bacteria. Many studies have shown various alterations of the gut microbiota in patients with coronavirus disease 2019, including the lower abundance of hydrogen-producing bacteria that could instigate the shortage of hydrogen output. Since dihydrogen has many important bioactivities, including cytoprotective, antioxidant, anti-inflammatory, and antiapoptotic, its malproduction in COVID-19 might contribute to the disease progression and severity. On the other hand, replenishing dihydrogen by exogenous administration could be beneficial in COVID-19 for both patient- and clinical-reported outcomes. Assessing low dihydrogen along with H2 supplementation to restore normal levels could be thus combined via theranostic approaches to aid COVID-19 diagnosis and treatment

On the Environmental and Economic Impact of Utility-Scale Renewable Energy Deployment

As per the U.S Energy Information Administration’s latest inventory of electricity generators, renewable energy, most notably solar and wind, will account for roughly 70% of nearly 40 gigawatts of new electricity generating capacity to start commercial operation in 2021. The year 2021 will also set a record in the deployment of utility-scale solar capacity by adding 15.4 gigawatts of capacity to the grid, which surpasses the 12 gigawatts increase in 2020. The rapid increase of renewable energy is expected to significantly decrease emissions of greenhouse gases and change the load profile in the power grid by suppressing production from conventional generators. This paper aims to propose a framework to study the impact of utility-scale solar PV deployment on the generation resource allocation and investigate the economics and policy of electricity generation and carbon emissions. The investigation is carried on the generation resource pool of the southeast region of the U.S augmented by a substantial amount of utility-scale solar generation

The effects of six weeks of training on physical fitness and performance in teenage and mature top-level soccer players

The main aim of the present study was to investigate the effects of soccer-specific training on physical fitness components in adolescent elite soccer players and make comparisons with older counterparts. Twenty two male soccer players from the Serbian First Division team were allocated to two assigned trials according to age – young group (YG) and mature group (MG). Players in their teenage years (19 years and younger) were assigned to YG (10 subjects) and others to MG (12 subjects). Between the first and second test session, all subjects followed six weeks of soccer-specific periodized training programme. There were no differences between groups at pre- and post-training trial for body mass, vertical jump height, average anaerobic power and VO2max (P>0.05). Body fat was significantly lower in YG before and after training program as compared to MG (P<0.05). Body mass and fat dropped significantly in both groups after training program (P<0.05). Furthermore, average anaerobic power and VO2max along with vertical jump height, were significantly improved in both groups (P<0.05) at post-training performance. Finally, the magnitude of change in VO2max was significanty superior in MG as compared to YG after training program (18.3 vs. 7.8�20P<0.05). The findings of the present study indicate that the trainability indices are not highly influenced by age in top-level soccer players

Possibilities of more efficient usage of genetic potential of broilers breeders

During the last ten years, poultry production in the world and particularly, EU has been specific due to new trends, whereby special attention is focused on regulations and procedures that are adopted by European Union (EU), Food and Agriculture Organization of the United Nations (FAO), International Organization for Standardization (ISO) and the World Trade Organization. Legal regulations in EU (standards, directions) are focused on all species and categories of poultry. Based on this, breeding of broiler (meat-type line strains) and production of hatching eggs and day old chickens (incubation) as well as other issues are the focus of this review. This paper presented results of studies carried out using different technological procedures in the breeding of broiler and production of one day old chickens. These showed a full expression of genetic potential of strains, along with preservation of poultry welfare

Design of the 70 mm twin aperture superconducting quadrupole for the LHC dump insertion

The LHC dump insertion features a pair of superconducting quadrupoles located on either side of a 340 m long straight section. Two horizontally deflecting kickers, located in between the quadrupole pairs, and a septum in the centre of the insertion, vertically deflect the two counter-rotating beams past the quadrupoles on the downstream sides, and into the dump areas. Due to the layout, the optical ß function in the quadrupoles is around 640 m, the largest around the LHC at injection. The quadrupoles must therefore have enlarged aperture and specially designed cryostats to allow for the safe passage of both the circulating and ejected beams. In this paper we present the design of the twin aperture dump quadrupole based on the 70 mm four layer coil proposed for the LHC low-ß quadrupoles. In preparation for model construction, we report on improvements of the coil design and a study of the retaining structures

Correlation between Fitness and Fatness in 6-14-year Old Serbian School Children

Lack of physical activity and/or physical fitness are some reasons epidemiologists suggest for increase in childhood obesity in the last 20 years, with clear correlation between body composition and physical activity and/or physical fitness yet to be determined. The objectives of the study were to (a) investigate the prevalence of overweight and obesity among Serbian school children and (b) determine the relationship between indicators of physical activity and body fatness in Serbian school children aged 6-14 years. The study subjects included a representative sample of Serbian elementary school children (n=1, 121—754 boys and 367 girls—aged 6.2-14.1 years), all of whom were recruited in the OLIMP (Obesity and Physical Activity among Serbian School Children) study. Anthropometric and physical fitness values, including body mass index (BMI), waist-circumference, body-fat, and aerobic capacity, were measured in all the children. Significant differences were found between male and female children regarding the prevalence of obesity (6.8% vs 8.2%, p<0.05, boys and girls respectively). Boys had significantly lower body mass, BMI, waist-circumference, sum of six skinfolds, and body-fat compared to their female counterparts (p<0.05). The highest level of weight, BMI, body-fat, and waist-circumference observed in a 14-year old girl (96.3 kg, 40.5 kg/m2, 54.5%, 91.4 cm respectively) implies the existence of extreme obesity in Serbian school children. The negative relationship between body-fat and maximal oxygen (VO2max) uptake was moderately high (r=-0.76; p<0.05). The study has shown a high prevalence of adiposity among Serbian school children, with a strong negative relationship between aerobic fitness and body fatness. Data of the study emphasize the necessity to identify children with weight problems and to develop early interventions to improve physical activity in children and prevent the increase of childhood obesity