Formation of civil society in Ukraine in the post-soviet period

The article analyzes the main stages of formation of civil society in Ukraine since independence. Formation of the third sector, shown by the authors against the background of state policy in this area and political events in Ukraine. Based on the analysis of Ukrainian legislation, the study identifies the main stages of state policy in the field of promoting the development of civil society institutions. The analysis of statistical sources helped to establish not only the quantitative characteristics of the development of civil society institutions, but also to identify the main areas of their activities. Researchers conclude that civil society in Ukraine has developed over a long period of time against the background of sometimes contradictory state policy in this area and the lack of a broad social base for the activities of public organizations. As large masses of active, purposeful, motivated citizens who were not members of public organizations, became not only the driving force of the two revolutions to return to the ideals of freedom and equality, but also hinder the emergence of authoritarianism, and now the occupation of the country in Russian-Ukrainian war

Accounting Institute: on the Genesis and Impact of Management Revolutions

The aim of the study is to establish the presence of a causal relationship between the historical development of the accounting system (its modification) with management revolutions, identification of new characteristic features and accounting functions arising from changes in management approaches and requirements for accounting information for management purposes. Achieving the goal of the study involves identifying opportunities for further improving the accounting system based on the experience of its genesis under the influence of managerial revolutions. The methodological basis of the study is the dialectical method of cognition. The use of the historical method allowed to establish the logical dependence of the evolution of accounting on the requirements of the management system. Analytical and systematic methods were used to identify and form descriptions of the relationship of the accounting system in budgetary institutions with the processes of management system transformation and management revolutions. The impact of managerial revolutions on the accounting system in Ukraine and their consequences are established on the basis of an empirical generalization of historical archival and literary descriptions, as well as a critical analysis of the regulatory regulation of accounting, its norms and practices. The existence of a direct influence of managerial revolutions on the content, requirements, principles and methods of accounting is justified. The above result is based on the results of the analysis of the historical content of accounting, its evidence (accounting documents), as well as the assessment of the functions of the persons who carried out the accounting. The study of works on the history of accounting made it possible to assess the genesis of the introduction of the institutional approach and accounting as the basis for its transformational changes aimed at strengthening compliance with management needs. The study showed that accounting is changing under the influence of transformations in management, changes in its requests, determined by the existing needs of management.&nbsp

ECONOMIC CHALLENGES OF SUSTAINABLE DEVELOPMENT GOALS IN UKRAINE

The United Nations 2030 Agenda and its Sustainable Development Goals pose new challenges for Ukrainian businesses, which need to adapt their operations and strategies to the requirements of the SDGs. The purpose of this paper is to highlight the role of economic challenges and business opportunities of the SDGs for the Ukrainian economy. In particular, it assesses whether the SDGs can realistically be achieved after the COVID-19 pandemic and the war with the Russian Federation. Methodology. More generally, the framework allows to assess the macroeconomic coherence with the development strategies of Ukraine. The basic trends of the SDGs for Ukraine are summarized, and the estimation model of the progress in achieving the SDGs is carried out. The impact of the COVID-19 pandemic on the economy of Ukraine is studied. Results. The results show that the economic challenges after the COVID-19 pandemic and the war include ethical, social, financial, and legal aspects that meet the requirements of sustainable development, which is a very high priority for the community in Ukraine. Practical implications. A comparative analysis of the activity of Ukrainian enterprises during quarantine is made on the basis of research data and those for official statistics. Value/originality. According to this study, Ukraine will need 5-7 years to regain the potential lost during the COVID-19 pandemic and the war. The actions of the government and the National Bank of Ukraine continue to support the economic mitigation of the negative effects of the war. The research is based on the economic issues that show how the SDGs can be achieved in the country under different policy scenarios, including modernization of production, development of innovation, increasing export potential, and support from the international community, especially the EU and the US. The assessment of the progress in the implementation of the SDGs in Ukraine showed their significant indicators, such as: The share of exports of goods whose production uses technologies of high and medium-high level in the total exports of goods; Ukraine's position as assessed by the Global Innovation Index; the increase in employment; the creation of institutional and financial capacities for self-realization of the potential of the economically active population and the development of the creative economy; Development of high-quality, reliable, sustainable and accessible infrastructure based on the use of innovative technologies, including environmentally friendly means of transport; ensuring the development of sustainable food production systems that contribute to the preservation of ecosystems and the gradual improvement of the quality of land and soil, primarily through innovative technologies; doubling agricultural productivity, primarily through innovative technologies; mobilization of additional financial resources through the promotion of foreign and domestic investment. Other SDGs showed low improvement and likelihood

Дослідження впливу управлінських каналів наноекономіки на глобальні трансформаціії у світі

The problem under investigation is determined by the fact that enterprises consist of separate economic agents that play an increasingly important role in production processes and their management. The channels of such management provide the transfer of positive experience of the totality of economic agents to the global environment. Due to the permanent process of transformations in the world caused by this influence, the probability of being on the sidelines is a problem for most business entities. Their competitiveness and integration into the world economic networks depend on high-quality management and wide application of innovative technologies, including nanotechnologies. The conducted study revealed that: – nano-economy consists of baby economy, human economy, and the economy of nanotechnologies; – the human economy is the central link and the main leader of the impact of nano-economy on global markets. The main components of its management are self-management, self-marketing, and innovative management of the organization personnel; – nanotechnologies, the economics of nanotechnologies, and transfer of nano-knowledge are at the initial stage of their development; – the impact of nano-economy on the development of the global environment is carried out through the functions of nanomanagement; – the management channels of the nano-economy do not affect the entry of countries with transition economies into the global environment due to the fact that they lack the system of nano-economy. This is proved by multifactor analysis of the impact of nano-economy on exports. The obtained indicators, such as exports of USD 57 billion (by the exchange rate of 2021), 281 universities, 1,941,701 business entities, and 135 thousand scientific and technical institutions, do not correlate and determine low direct and inverse indicators of dependence. The results of the study can be used: – at separate enterprises – by using innovative personnel management, including motivating and training of personnel in self-management and self-marketing;  – at the state and regional levels – by creating favorable conditions for the development of baby economy in countries with transition economies and by promoting optimal solutions of separate economic agentsИсследуемая проблема определяется тем, что предприятия состоят из отдельных экономических агентов, которые играют все большую роль в производственных процессах и в управлении ими. Каналы такого управления обеспечивают трансфер положительного опыта совокупности экономических агентов в глобальную среду. В результате перманентного процесса трансформаций в мире, вызванного этим влиянием, вероятность оказаться на обочине является проблемой большинства предпринимательских субъектов. От качественного менеджмента и широкого применения инновационных, в том числе нанотехнологий, зависит их конкурентоспособность и интегрированность в мировые хозяйственные сети. В результате проведенного исследования было установлено, что: – наноекономика состоит из бебиэкономики, экономики человека и экономики нанотехнологий; – экономика человека является центральным звеном и главным проводником влияния наноэкономики на глобальные рынки. Основными составляющими ее менеджмента являются самоменеджмент, самомаркетинг и инновационное управление персоналом; – нанотехнологии, а соответственно и экономика нанотехнологий, находятся на начальной стадии развития; – влияние наноэкономики на развитие глобальной среды осуществляется через функции наноменеджмента; – управленческие каналы наноекономикы не влияют на вхождение стран с переходной экономикой в глобальную среду из-за отсутствия у них системы наноэкономики. Это подтверждает многофакторный анализ влияния наноекономикы на экспорт. Полученные показатели: экспорт в 57 млрд. дол. США (по курсу 2021 года), 281 университет, 1941701 субъект хозяйствования и 135 тыс. научно-технических учреждений не коррелируют и определяют низкие прямые и обратные показатели зависимости. Результаты исследования могут использоваться: – на отдельных предприятиях – путем применения инновационного управления персоналом, включая мотивацию и обучение персонала самоменеджменту и самомаркетингу; – на государственном и региональном уровнях – путем создания максимально возможных благоприятных условий развития бебиэкономики в странах с переходной экономикой и популяризации оптимальных решений отдельных экономических агентов.Проблема, що досліджується, визначається тим, що підприємства складаються з окремих економічними агентів, які відіграють все більшу роль у виробничих процесах та в управлінні ними. Канали такого управління забезпечують трансфер позитивного досвіду сукупності економічних агентів у глобальне середовище. Внаслідок перманентного процесу трансформацій у світі, викликаного цим впливом, вірогідність опинитись на узбіччі є проблемою більшості підприємницьких суб’єктів. Від якісного менеджменту та широкого застосування інноваційних, у тому числі нанотехнологій, залежить їх конкурентоспроможність та інтегрованість у світові господарські мережі. В результаті проведеного дослідження було встановлено, що: – наноекономіка складається з бебіекономіки, економіки людини та економіки нанотехнологій; – економіка людини є центральною ланкою і головвним провідником впливу наноекономіки на глобальні ринки. Основними складовими її менеджменту є самоменеджмент, самомаркетинг та інноваційне управління персоналом організації; – нанотехнології, економіка нанотехнологій й трансфер нанознань знаходяться на початковій стадії розвитку; – вплив наноекономіки на розвиток глобального середовища здійснюється через функції наноменеджменту; – управлінські канали наноекономіки не впливають на входження країн з перехідною економікою в глобальне середовище через відсутність у них системи наноекономіки. Це підтверджує багатофакторний аналіз впливу наноекономіки на експорт. Отримані показники: експорт у 57 млрд. дол. США (за курсом 2021 року), 281 університет, 1941701 суб’єкт господарювання та 135 тис. науково-технічних установ не корелюють і визначають низькі прямі та зворотні показники залежності. Результати дослідження можуть використовуватись: – на окремих підприємствах – шляхом застосування інноваційного управління персоналом, включаючи мотивування і навчання персоналу самоменеджменту й самомаркетингу; – на державному й регіональному рівнях – шляхом створення сприятливих умов розвитку бебіекономіки в країнах з перехідною економікою та популяризації оптимальних рішень окремих економічних агентів

Аналіз воєнних витрат Росії та їх структури в період 2010-2022 років (деякі аспекти впливу російсько-української війни та наслідки для України)

Мета роботи: є аналіз обсягів воєнних витрат Росії та їх структури у період 2010-2022 років з метою виявлення тенденцій підготовки РФ до війни з Україною, а також з метою розкриття воєнних втрат РФ у російсько-українській війні та формування рекомендацій щодо економічній протидії країни світу та України. Метод: основними методами досліджень є методи системного аналізу та синтезу економічних процесів, регресійного та кореляційного аналізу, методи економічної теорії та економічної логіки. Результати дослідження: розкрито структуру воєнних витрат Росії за досліджуваний період, визначені основні тенденції її зміни за роками, за обсягами воєнних витрат сформовано прогноз на наступний 2023 рік, зроблені висновки щодо дій Росії у війні та визначені практичні рекомендації щодо економічної та організаційної протидії Росії країнами світу та Україною. Теоретична цінність дослідження: основними результатами  досліджень за тематикою статті є: результати аналізу воєнних витрат Росії та їх структури за досліджуваний період, а також сформовані рекомендації щодо економічної та організаційної протидії Росії в умовах війни

Торцева фреза підвищеної надійності

Торцева фреза підвищеної надійності має корпус із отворами, циліндричні різальні вставки з напрямними плоскими лисками, які встановлені в цих отворах і закріплені за допомогою кріпильних гвинтів, останні розташовані в нарізних отворах, виконаних у корпусі, осі яких розміщені в площині осі отворів під різальні вставки та перпендикулярні їй. В корпусі фрези з боку, протилежного кріпильному гвинту, виконано отвір напроти нарізного радіального отвору різальної вставки з додатковим гвинтом. Кількість додаткових гвинтів дорівнює кількості кріпильних гвинтів. Додатковий гвинт встановлено на одній осі з відповідним кріпильним гвинтом

Торцева фреза з підвищеною надійністю закріплення різальних вставок

Торцева фреза з підвищеною надійністю закріплення різальних вставок містить корпус із отворами, циліндричні різальні вставки з напрямними плоскими лисками, які встановлені в цих отворах і закріплені за допомогою кріпильних гвинтів, останні розташовані в різьових отворах, виконаних у корпусі, осі яких розміщені в площині осі отворів під різальні вставки та перпендикулярні їй. Плоскі лиски на різальних вставках виконано у вигляді занижених ділянок-пазів, кількість яких відповідає кількості кріпильних гвинтів, і довжина кожної з цих ділянок, виміряна уздовж осі різальної вставки, є не меншою, ніж діаметр кріпильних гвинтів. Крім цього, у кожному різьовому отворі зверху кріпильного гвинта встановлено стопорний гвинт з таким же діаметром різі та контактуючий своїм робочим нижнім торцем із кріпильним гвинтом

EPMA-World Congress 2015: Bonn, Germany. 3-5 September 2015

Table of contents A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value of “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good for 1 % wealthy, not for 99 % unhealthy Russell J. Andrews A5 The role of IDO in a murine model of gingivitis: predictive and therapeutic potentials Babak Baban, Jun Yao Liu, Xu Qin, Tailing Wang, Mahmood S. Mozaffari A6 Specific diets for personalised treatment of diabetes type 2 Viktoriia V. Bati, Tamara V. Meleshko, Olga B. Levchuk, Nadiya V. Boyko A7 Towards personalized physiotherapeutic approach Joanna Bauer, Ewa Boerner, Halina Podbielska A8 Cells, animal, SHIME and in silico models for detection and verification of specific biomarkers of non-communicable chronic diseases Alojz Bomba, Viktor O. Petrov, Volodymyr G. Drobnych, Rostyslav V. Bubnov, Oksana M. Bykova, Nadiya V. Boyko A9 INTERACT-chronic care model: Self-treatment by patients with decision support e-Health solution Hans-Peter Brunner-La Rocca, Lutz Fleischhacker, Olga Golubnitschaja, Frank Heemskerk, Thomas Helms, Tiny Jaarsma, Judita Kinkorova, Jan Ramaekers, Peter Ruff, Ivana Schnur, Emilio Vanoli, Jose Verdu A10 PPPM in cardiovascular medicine in 2015 Hans-Peter Brunner-La Rocca A11 Magnetic resonance imaging of nanoparticles in mice, potential for theranostic and contrast media development – pilot results Rostyslav V. Bubnov, Sergiy A. Grabovetskyi, Olena M. Mykhalchenko, Natalia O. Tymoshok, Oleksandr B. Shcherbakov, Igor P. Semeniv, Mykola Y. Spivak A12 Ultrasound diagnosis for diabetic neuropathy - comparative study Rostyslav V. Bubnov, Tetyana V. Ostapenko A13 Ultrasound for stratification patients with diabetic foot ulcers for prevention and personalized treatment - pilot results Rostyslav V. Bubnov, Nazarii M. Kobyliak, Nadiya M. Zholobak, Mykola Ya. Spivak A14 Project ImaGenX – designing and executing a questionnaire on environment and lifestyle risk of breast cancer John Paul Cauchi A15 Genomics – a new structural brand of predictive, preventive and personalized medicine or the new driver as well? Dmitrii Cherepakhin, Marina Bakay, Artem Borovikov, Sergey Suchkov A16 Survey of questionnaires for evaluation of the quality of life in various medical fields Barbara Cieślik, Agnieszka Migasiewicz, Maria-Luiza Podbielska, Markus Pelleter, Agnieszka Giemza, Halina Podbielska A17 Personalized molecular treatment for muscular dystrophies Sebahattin Cirak A18 Secondary mutations in circulating tumour DNA for acquired drug resistance in patients with advanced ALK + NSCLC Marzia Del Re, Paola Bordi, Valentina Citi, Marta Palombi, Carmine Pinto, Marcello Tiseo, Romano Danesi A19 Recombinant species-specific FcεRI alpha proteins for diagnosis of IgE-mediated allergies in dogs, cats and horses Lukas Einhorn, Judit Fazekas, Martina Muhr, Alexandra Schoos, Lucia Panakova, Ina Herrmann, Krisztina Manzano-Szalai, Kumiko Oida, Edda Fiebiger, Josef Singer, Erika Jensen-Jarolim A20 Global methodology for developmental neurotoxicity testing in humans and animals early and chronically exposed to chemical contaminants Arpiné A. Elnar, Nadia Ouamara, Nadiya Boyko, Xavier Coumoul, Jean-Philippe Antignac, Bruno Le Bizec, Gauthier Eppe, Jenny Renaut, Torsten Bonn, Cédric Guignard, Margherita Ferrante, Maria Liusa Chiusano, Salvatore Cuzzocrea, Gerard O'Keeffe, John Cryan, Michelle Bisson, Amina Barakat, Ihsane Hmamouchi, Nasser Zawia, Anumantha Kanthasamy, Glen E. Kisby, Rui Alves, Oscar Villacañas Pérez, Kim Burgard, Peter Spencer, Norbert Bomba, Martin Haranta, Nina Zaitseva, Irina May, Stéphanie Grojean, Mathilde Body-Malapel, Florencia Harari, Raul Harari, Kristina Yeghiazaryan, Olga Golubnitschaja, Vittorio Calabrese, Christophe Nemos, Rachid Soulimani A21 Mental indicators at young people with attributes hypertension and pre-hypertension Maria E. Evsevyeva, Elena A. Mishenko, Zurida V. Kumukova, Evgeniy V. Chudnovsky, Tatyana A. Smirnova A22 On the approaches to the early diagnosis of stress-induced hypertension in young employees of State law enforcement agencies Maria E. Evsevyeva, Ludmila V. Ivanova, Michail V. Eremin, Maria V. Rostovtseva A23 Сentral aortic pressure and indexes of augmentation in young persons in view of risk factors Maria E. Evsevyeva, Michail V. Eremin, Vladimir I. Koshel, Oksana V. Sergeeva, Nadesgda M. Konovalova A24 Breast cancer prediction and prevention: Are reliable biomarkers in horizon? Shantanu Girotra, Olga Golubnitschaja A25 Flammer Syndrome and potential formation of pre-metastatic niches: A multi-centred study on phenotyping, patient stratification, prediction and potential prevention of aggressive breast cancer and metastatic disease Olga Golubnitschaja, Manuel Debald, Walther Kuhn, Kristina Yeghiazaryan, Rostyslav V. Bubnov, Vadym M. Goncharenko, Ulyana Lushchyk, Godfrey Grech, Katarzyna Konieczka A26 Innovative tools for prenatal diagnostics and monitoring: improving individual pregnancy outcomes and health-economy in EU Olga Golubnitschaja, Jan Jaap Erwich, Vincenzo Costigliola, Kristina Yeghiazaryan, Ulrich Gembruch A27 Immunohistochemical assessment of APUD cells in endometriosis Vadym M. Goncharenko, Vasyl O. Beniuk, Olga V. Kalenska, Rostyslav V. Bubnov A28 Updating personalized management algorithm of endometrial hyperplasia in pre-menopause women Vadym M. Goncharenko, Vasyl O. Beniuk, Rostyslav V. Bubnov, Olga Melnychuk A29 The personified treatment approach of polimorbid patients with periodontal inflammatory diseases Irina A. Gorbacheva, Lyudmila Y. Orekhova, Vadim V. Tachalov A30 Ukrainian experience in hybrid war – the challenge to update algorithms for personalized care and early prevention of different military injuries Olena I. Grechanyk, Rizvan Ya. Abdullaiev, Rostyslav V. Bubnov A31 Tear fluid biomarkers: a comparison of tear fluid sampling and storage protocols Suzanne Hagan, Eilidh Martin, Ian Pearce, Katherine Oliver A32 The correlation of dietary habits with gingival problems during menstruation Cenk Haytac, Fariz Salimov, Servin Yoksul, Anatoly A. Kunin, Natalia S. Moiseeva A33 Genomic medicine in a contemporary Spanish population of prostate cancer: our experience Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara, Antonia Angulo, Francisco Javier Machuca Santa-Cruz A34 Challenges, opportunities and collaborations for personalized medicine applicability in uro-oncological disease Bernardo Herrera-Imbroda, Sergio del Río-González, Maria Fernanda Lara A35 Metabolic hallmarks of cancer as targets for a personalized therapy John Ionescu A36 Influence of genetic polymorphism as a predictor of the development of periodontal disease in patients with gastric ulcer and 12 duodenal ulcer Alfiya Z. Isamulaeva, Anatoly A. Kunin, Shamil Sh. Magomedov, Aida I. Isamulaeva A37 Challenges in diabetic macular edema Tatjana Josifova A38 Overview of the EPMA strategies in laboratory medicine relevant for PPPM Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja, Vincenzo Costigliola A39 EPMA initiative for effective organization of medical travel: European concepts and criteria Vincenzo Costigliola, Marko Kapalla, Juraj Kubáň, Olga Golubnitschaja A40 Design and innovation in e-textiles: implications for PPPM Anthony Kent, Tom Fisher, Tilak Dias A41 Biobank in Pilsen as a member of national node BBMRI_CZ Judita Kinkorová, Ondřej Topolčan A42 Big data in personalized medicine: hype and hope Matthias Kohl A43 The 3P approach as the platform of the European Dentistry Department (DPPPD) Anatoly A. Kunin, Natalia S. Moiseeva A44 The endometrium cytokine patterns for predictive diagnosis of proliferation severity and cancer prevention Andrii I. Kurchenko, Vasyl A. Beniuk, Vadym M. Goncharenko, Rostyslav V. Bubnov, Nadiya V. Boyko, Andriy M. Strokan A45 A monocyte-based in-vitro system for testing individual responses to the implanted material: future for personalized implant construction Julia Kzhyshkowska, Alexandru Gudima, Ksenia S. Stankevich, Victor D. Filimonov4, Harald Klüter, Evgeniya M. Mamontova, Sergei I. Tverdokhlebov A46 Prediction and prevention of adverse health effects by meteorological factors: Biomarker patterns and creation of a device for self-monitoring and integrated care Ulyana B. Lushchyk, Viktor V. Novytskyy, Igor P. Babii, Nadiya G. Lushchyk, Lyudmyla S. Riabets, Ivanna I. Legka A47 Targeting "disease signatures" towards personalized healthcare Mira Marcus-Kalish, Alexis Mitelpunkt, Tal Galili, Neta Shachar, Yoav Benjamini A48 Influence of the skin imperfection on the personal quality of life and possible tools for objective diagnosis Agnieszka Migasiewicz, Markus Pelleter, Joanna Bauer, Ewelina Dereń, Halina Podbielska A49 The new direction in caries prevention based on the ultrastructure of dental hard tissues and filling materials Natalia S. Moiseeva, Anatoly A. Kunin, Dmitry A. Kunin A50 The use of LED radiation in prevention of dental diseases Natalia S. Moiseeva, Yury A. Ippolitov, Dmitry A. Kunin, Alexei N. Morozov, Natalia V. Chirkova, Nakhid T. Aliev A51 Status of endothelial progenitor cells in diabetic nephropathy: predictive and preventive potentials Mahmood S. Mozaffari, Jun Yao Liu, Babak Baban A52 The status of glucocorticoid-induced leucine zipper protein in salivary gland in Sjögren’s syndrome: predictive and personalized treatment potentials Mahmood S. Mozaffari, Jun Yao Liu, Rafik Abdelsayed, Xing-Ming Shi, Babak Baban A53 Maximal aerobic capacity - important quality marker of health Jaroslav Novák, Milan Štork, Václav Zeman A54 The EMPOWER project: laboratory medicine and Horizon 2020 Wytze P. Oosterhuis, Elvar Theodorsson A55 Personality profile manifestations in patient’s attitude to oral care and adherence to doctor’s prescriptions Lyudmila Y. Orekhova, Tatyana V. Kudryavtseva, Elena R. Isaeva, Vadim V. Tachalov, Ekaterina S. Loboda A56 Results of an European survey on personalized medicine addressed to directions of laboratory medicine Mario Pazzagli, Francesca Malentacchi, Irene Mancini, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc, Ron H.N. van Schaik, Gerard Siest, Elvar Theodorsson, Chiara Di Resta A57 MCI or early dementia predictive speech based diagnosis techniques Matus Pleva, Jozef Juhar A58 Personalized speech based mobile application for eHealth Matus Pleva, Jozef Juhar A59 Circulating tumor cell-free DNA as the biomarker in the management of cancer patients Jiří Polívka jr., Filip Janků, Martin Pešta, Jan Doležal, Milena Králíčková, Jiří Polívka A60 Complex stroke care – educational programme in Stroke Centre University Hospital Plzen Jiří Polívka, Alena Lukešová, Nina Müllerová, Petr Ševčík, Vladimír Rohan A61 Sleep apnea and sleep fragmentation contribute to brain aging Kneginja Richter, Lence Miloseva, Günter Niklewski A62 Personalised approach for sleep disturbances in shift workers Kneginja Richter, Jens Acker, Guenter Niklewski A63 Medical travel and innovative PPPM clusters: new concept of integration Olga Safonicheva, Vincenzo Costigliola A64 Medical travel and women health Olga Safonicheva A65 Continuity of generations in the training of specialists in the field of reconstructive microsurgery Maxim Sautin, Janna Sinelnikova, Sergey Suchkov A66 Telemonitoring of stroke patients – empirical evidence of individual risk management results from an observational study in Germany Songül Secer, Stephan von Bandemer A67 Women’s increasing breast cancer risk with n-6 fatty acid intake explained by estrogen-fatty acid interactive effect on DNA damage: implications for gender-specific nutrition within personalized medicine Niva Shapira A68 Cytobacterioscopy of the gingival crevicular fluid as a method for preventive diagnosis of periodontal diseases Aleksandr Shcherbakov, Anatoly A. Kunin, Natalia S. Moiseeva A69 Use of specially treated composites in dentistry to avoid violations of aesthetics Bogdan R. Shumilovich, Zhanna Lipkind, Yulia Vorobieva, Dmitry A. Kunin, Anastasiia V. Sudareva A70 National eHealth system – platform for preventive, predictive and personalized diabetes care Ivica Smokovski, Tatjana Milenkovic A72 The common energy levels of Prof. Szent-Györgyi, the intrinsic chemistry of melanin, and the muscle physiopathology. Implications in the context of Preventive, Predictive, and Personalized Medicine Arturo Solís-Herrera, María del Carmen Arias-Esparza, Sergey Suchkov A73 Plurality and individuality of hepatocellular carcinoma: PPPM perspectives Krishna Chander Sridhar, Olga Golubnitschaja A74 Strategic aspects of higher medical education reforms to secure newer educational platforms for getting biopharma professionals matures Maria Studneva, Sihong Song, James Creeden, Мark Мandrik, Sergey Suchkov A75 Overview of the strategies and activities of the European Federation of Clinical Chemistry and Laboratory Medicine, (EFLM) Elvar Theodorsson, EFLM A76 New spectroscopic techniques for point of care label free diagnostics Syed A. M. Tofail A77 Tumor markers for personalized medicine and oncology - the role of Laboratory Medicine Ondřej Topolčan, Judita Kinkorová, Ondřej Fiala, Marie Karlíková, Šárka Svobodová, Radek Kučera, Radka Fuchsová, Vladislav Třeška, Václav Šimánek, Ladislav Pecen, Jan Šoupal, Štěpán Svačina2 A78 Modern medical terminology (MMT) as a driver of the global educational reforms Evgeniya Tretyak, Maria Studneva, Sergey Suchkov A79 Juvenile hypertension; the relevance of novel predictive, preventive and personalized assessment of its determinants Francesca M. Trovato, G. Fabio Martines, Daniela Brischetto, Daniela Catalano, Giuseppe Musumeci, Guglielmo M. Trovato A80 Proteomarkers Biotech George Th. Tsangaris, Athanasios K. Anagnostopoulos A81 Proteomics and mass spectrometry based non-invasive prenatal testing of fetal health and pregnancy complications George Th. Tsangaris, Athanasios K. Anagnostopoulos A82 Integrated Ecosystem for an Integrated Care model for Heart Failure (HF) patients including related comorbidities (ZENITH) José Verdú, German Gutiérrez, Jordi Rovira, Marta Martinez, Lutz Fleischhacker, Donna Green, Arthur Garson, Elena Tamburini, Stefano Cuomo, Juan Martinez-Leon, Teresa Abrisqueta, Hans-Peter Brunner-La Rocca, Tiny Jaarsma, Teresa Arredondo, Cecilia Vera, Giuseppe Fico, Olga Golubnitschaja, Fernando Arribas, Martina Onderco, Isabel Vara, on behalf of ZENITH consortium A83 Predictive, preventive and personalized medicine in diabetes onset and complication (MOSAIC project) José Verdú, Francesco Sambo, Barbara Di Camillo, Claudio Cobelli, Andrea Facchinetti, Giuseppe Fico, Riccardo Bellazzi, Lucia Sacchi, Arianna Dagliati, Daniele Segnani, Valentina Tibollo, Manuel Ottaviano, Rafael Gabriel, Leif Groop, Jacqueline Postma, Antonio Martinez, Liisa Hakaste, Tiinamaija Tuomi, Konstantia Zarkogianni, on behalf of MOSAIC consortium A84 Possibilities for personalized therapy of diabetes using in vitro screening of insulin and oral hypoglycemic agents Igor Volchek, Nina Pototskaya, Andrey Petrov A85 The innovative technology for personalized therapy of human diseases based on in vitro drug screening Igor Volchek, Nadezhda Pototskaya, Andrey Petrov A86 Bone destruction and temporomandibular joint: predictive markers, pathogenetic aspects and quality of life Ülle Voog-Oras, Oksana Jagur, Edvitar Leibur, Priit Niibo, Triin Jagomägi, Minh Son Nguyen, Chris Pruunsild, Dagmar Piikov, Mare Saag A87 Sub-optimal health management – global vision for concepts in medical travel Wei Wang A88 Sub-optimal health management: synergic PPPM-TCAM approach Wei Wang A89 Innovative technologies for minimal invasive diagnostics Andreas Weinhäusel, Walter Pulverer, Matthias Wielscher, Manuela Hofner, Christa Noehammer, Regina Soldo, Peter Hettegger, Istvan Gyurjan, Ronald Kulovics, Silvia Schönthaler, Gabriel Beikircher, Albert Kriegner, Stephan Pabinger, Klemens Vierlinger A90 Rare disease diobanks for personalized medicine Ayşe Yüzbaşıoğlu, Meral Özgüç, Member of EuroBioBank - European Network of DNA, Cell and Tissue Banks for Rare Disease

Neural network and index forecasting of the strategies of development of the armed forces of Ukraine depending on their own economic opportunities and encroachments of the states of aggressors

Ukraine has a relative drawback in the economic defense capabilities, which needs to be addressed by raising the indicators of macroeconomic development, innovation, and economic potential, social health of the population of the state, and the support of the Armed Forces of Ukraine, by the state. The estimation of the defense capability of states like Ukraine, Poland, Russia and Turkey is made on the basis of the developed methodological approach to the overall representation of the health of the economies of the states and their defense capabilities using the method of constructing petal diagrams with the definition of their effective areas, which became indicators of economic status and defense capability. The article analyses the dependence of the development level of the countries’ economies and the state of development of the armed forces of these countries in the conditions of resource constraints and existing risks on the basis of macroeconomic data and indicators. This article uses the indicators for the determination of the level of defense capability and the data of petal diagrams and the scenario modeling of the development strategies of the Armed Forces of Ukraine with the aim of constructing the most optimal forecast in this area

Optimization of economic and environmental factors of the logistic system of enterprise management

The purpose of the study is to develop an economic-mathematical model of the socio-economic system, which takes into account its logistical structure and ecological viability. This allows for optimal budget planning for the new project. The methodology of the study is based on the method of J. Forster, who proposed to consider the logistics system of any enterprise as a system of reservoirs linked by material, financial and information flows. The main result of the study is as follows. The methodology is designed and developed a mathematical program that allows estimating the relative value of fixed assets of production and the number of costs for creating a retail network with the impact of the environmental components. It is shown that this ratio is determined by the value of all key parameters of the enterprise logistics system. This result was obtained through careful modeling of structural changes in the logistics system of the enterprise. All basic communications (flows) between the elements of the logistics system were also considered. Calculations were conducted for the system of the equations which have been written down in shape with discrete-time. At the same time modeling was carried out so that there were no “not physical” phenomena (such as overflow of warehouses, etc.). As a result of calculations, optimum values for all basic characteristics of the new project have been specified. The most actual has separately been considered for practice as a case of optimum planning of storage facilities. The practical importance of research consists that scientific representations about interrelation of the capacity of the enterprise with key parameters of the logistic system can form a basis for more effective planning and management budgetary and production processes at the enterprise, namely: it is more reasonable to plan scales of production and expenses on logistics creation