Damaged axons promote OPC differentiation

Oligodendrocyte progenitor cell (OPC) differentiation is an important therapeutic target to promote remyelination in multiple sclerosis (MS). We previously reported hyperphosphorylated and aggregated microtubule-associated protein tau in MS lesions, suggesting its involvement in axonal degeneration. However, the influence of pathological tau-induced axonal damage on the potential for remyelination is unknown. Therefore, we investigated OPC differentiation in human P301S tau (P301S-htau) transgenic mice, both in vitro and in vivo following focal demyelination. In 2-month-old P301S-htau mice, which show hyperphosphorylated tau in neurons, we found atrophic axons in the spinal cord in the absence of prominent axonal degeneration. These signs of early axonal damage were associated with microgliosis and an upregulation of IL-1β and TNFα. Following in vivo focal white matter demyelination we found that OPCs differentiated more efficiently in P301S-htau mice than wild type (Wt) mice. We also found an increased level of myelin basic protein within the lesions, which however did not translate into increased remyelination due to higher susceptibility of P301S-htau axons to demyelination-induced degeneration compared to Wt axons. In vitro experiments confirmed higher differentiation capacity of OPCs from P301S-htau mice compared with Wt mice-derived OPCs. Because the OPCs from P301S-htau mice do not ectopically express the transgene, and when isolated from newborn mice behave like Wt mice-derived OPCs, we infer that their enhanced differentiation capacity must have been acquired through microenvironmental priming. Our data suggest the intriguing concept that damaged axons may signal to OPCs and promote their differentiation in the attempt at rescue by remyelination. GLIA 2016;64:457-471.This project was funded by the Multiple Sclerosis Society UK via the Cambridge Centre for Myelin Repair consortium, and core support grant from the Wellcome Trust and MRC to the Wellcome Trust – Medical Research Council Cambridge Stem Cell Institute

Polarizing the Dipoles

We extend the massless dipole formalism of Catani and Seymour, as well as its massive version as developed by Catani, Dittmaier, Seymour and Trocsanyi, to arbitrary helicity eigenstates of the external partons. We modify the real radiation subtraction terms only, the primary aim being an improved efficiency of the numerical Monte Carlo integration of this contribution as part of a complete next-to-leading order calculation. In consequence, our extension is only applicable to unpolarized scattering. Upon summation over the helicities of the emitter pairs, our formulae trivially reduce to their original form. We implement our extension within the framework of Helac-Phegas, and give some examples of results pertinent to recent studies of backgrounds for the LHC. The code is publicly available. Since the integrated dipole contributions do not require any modifications, we do not discuss them, but they are implemented in the software.Comment: 20 pages, 4 figures, Integrated dipoles implemented for massless and massive case

Dynamic Critical Behavior of the Chayes-Machta Algorithm for the Random-Cluster Model. I. Two Dimensions

We study, via Monte Carlo simulation, the dynamic critical behavior of the Chayes-Machta dynamics for the Fortuin-Kasteleyn random-cluster model, which generalizes the Swendsen-Wang dynamics for the q-state Potts ferromagnet to non-integer q \ge 1. We consider spatial dimension d=2 and 1.25 \le q \le 4 in steps of 0.25, on lattices up to 1024^2, and obtain estimates for the dynamic critical exponent z_{CM}. We present evidence that when 1 \le q \lesssim 1.95 the Ossola-Sokal conjecture z_{CM} \ge \beta/\nu is violated, though we also present plausible fits compatible with this conjecture. We show that the Li-Sokal bound z_{CM} \ge \alpha/\nu is close to being sharp over the entire range 1 \le q \le 4, but is probably non-sharp by a power. As a byproduct of our work, we also obtain evidence concerning the corrections to scaling in static observables.Comment: LaTeX2e, 75 pages including 26 Postscript figure

Feynman Rules for the Rational Part of the Standard Model One-loop Amplitudes in the 't Hooft-Veltman γ5\gamma_5 Scheme

We study Feynman rules for the rational part $R$ of the Standard Model amplitudes at one-loop level in the 't Hooft-Veltman $\gamma_5$ scheme. Comparing our results for quantum chromodynamics and electroweak 1-loop amplitudes with that obtained based on the Kreimer-Korner-Schilcher (KKS) $\gamma_5$ scheme, we find the latter result can be recovered when our $\gamma_5$ scheme becomes identical (by setting $g5s=1$ in our expressions) with the KKS scheme. As an independent check, we also calculate Feynman rules obtained in the KKS scheme, finding our results in complete agreement with formulae presented in the literature. Our results, which are studied in two different $\gamma_5$ schemes, may be useful for clarifying the $\gamma_5$ problem in dimensional regularization. They are helpful to eliminate or find ambiguities arising from different dimensional regularization schemes.Comment: Version published in JHEP, presentation improved, 41 pages, 10 figure

Urban Gardens as a Space to Engender Biophilia: Evidence and Ways Forward

Cities are losing green space driving an extinction of nature experiences for urban communities. Incremental green space loss can trigger a ratcheting-down effect where individuals' expectations of nature continually decrease through time. This loss of everyday nature experiences may produce a citizenry with reduced knowledge and appreciation of biodiversity and the environment. In this review, we examine how urban gardens, as urban spaces that bring people into close contact with nature in an otherwise built environment, can combat this ratcheting-down effect by encouraging interactions and knowledge of nature. We review three ways urban gardens may engender greater biophilia: (1) the provision of natural elements to expose urban dwellers to the diversity of plants, animals, and soils that they would otherwise not encounter in their daily life; (2) fostering a greater understanding of natural processes that affect food production (e.g., climate processes, pest control, pollination) and thus the natural world; and (3) the provision of a safe space in which humans can corporeally interact with nature elements to develop greater fascination with nature. Thus, urban gardens can engender biophilia for their participants by increasing exposure, positive interactions, and knowledge of nature, potentially changing people's attitudes to nature. We present examples from a variety of urban gardens to show how these spaces can be designed using biophilic thinking to enhance people's everyday nature experiences and their drive to interact with the natural world

Dynamic critical behavior of the Chayes-Machta-Swendsen-Wang algorithm

We study the dynamic critical behavior of the Chayes-Machta dynamics for the Fortuin-Kasteleyn random-cluster model, which generalizes the Swendsen-Wang dynamics for the q-state Potts model to noninteger q, in two and three spatial dimensions, by Monte Carlo simulation. We show that the Li-Sokal bound z \ge \alpha/\nu is close to but probably not sharp in d=2, and is far from sharp in d=3, for all q. The conjecture z \ge \beta/\nu is false (for some values of q) in both d=2 and d=3.Comment: Revtex4, 4 pages including 4 figure

Analytic Structure of Three-Mass Triangle Coefficients

``Three-mass triangles'' are a class of integral functions appearing in one-loop gauge theory amplitudes. We discuss how the complex analytic properties and singularity structures of these amplitudes can be combined with generalised unitarity techniques to produce compact expressions for three-mass triangle coefficients. We present formulae for the N=1 contributions to the n-point NMHV amplitude.Comment: 22 pages; v3: NMHV n=point expression added. 7 point expression remove

Four-lepton production at hadron colliders: aMC@NLO predictions with theoretical uncertainties

We use aMC@NLO to study the production of four charged leptons at the LHC, performing parton showers with both HERWIG and Pythia6. Our underlying matrix element calculation features the full next-to-leading order $O(\alpha_S)$ result and the $O(\alpha_S^2)$ contribution of the $gg$ channel, and it includes all off-shell, spin-correlation, virtual-photon-exchange, and interference effects. We present several key distributions together with the corresponding theoretical uncertainties. These are obtained through a process-independent technique that allows aMC@NLO to compute scale and PDF uncertainties in a fully automated way and at no extra CPU-time costComment: 24 pages, 6 figure

Chinese Magic in Loop Integrals

We present an approach to higher point loop integrals using Chinese magic in the virtual loop integration variable. We show, using the five point function in the important e^+e^-\to f\bar{f}+\gamma process for ISR as a pedagogical vehicle, that we get an expression for it directly reduced to one scalar 5-point function and 4-, 3-, and 2- point integrals, thereby avoiding the computation of the usual three tensor 5-pt Passarino-Veltman reduction. We argue that this offers potential for greater numerical stability.Comment: 11 pages, 1 figure; improved figure, improved text and references;added CERN report number;extended text; corrected misprint; extended text, improved figure; improved text, fonts and style; extended text for publication in Phys. Rev. D (title changed in journal

Local and cluster critical dynamics of the 3d random-site Ising model

We present the results of Monte Carlo simulations for the critical dynamics of the three-dimensional site-diluted quenched Ising model. Three different dynamics are considered, these correspond to the local update Metropolis scheme as well as to the Swendsen-Wang and Wolff cluster algorithms. The lattice sizes of L=10-96 are analysed by a finite-size-scaling technique. The site dilution concentration p=0.85 was chosen to minimize the correction-to-scaling effects. We calculate numerical values of the dynamical critical exponents for the integrated and exponential autocorrelation times for energy and magnetization. As expected, cluster algorithms are characterized by lower values of dynamical critical exponent than the local one: also in the case of dilution critical slowing down is more pronounced for the Metropolis algorithm. However, the striking feature of our estimates is that they suggest that dilution leads to decrease of the dynamical critical exponent for the cluster algorithms. This phenomenon is quite opposite to the local dynamics, where dilution enhances critical slowing down.Comment: 24 pages, 16 figures, style file include