A mesenteric cyst presenting as a femoral hernia: a case report

Mesenteric cysts are a rare phenomenon and can be encountered in different regions of the mesentery or in the retroperitoneal region. They are usually asymptomatic but may lead to a variety of symptoms depending on their site. We report a case of a mesenteric cyst presenting as a femoral hernia, which is, to our knowledge, the second case found in the literature. Forty-eight years old female patient presented with a history of pain and swelling in her left inguinal region for six months. Although femoral hernias are rare conditions, mesenteric cysts can protrude inside the femoral canal. In a case of clinical suspicion of such a condition, appropriate imaging should be performed

Effect of Septorhinoplasty on Olfactory Function: Assessment Using the Brief Smell Identification Test

Objective:Septorhinoplasty (SRP), one of the most commonly performed rhinologic surgery procedures, can affect olfactory function; however, the findings of studies investigating smell following SRP are controversial. We used a culturally adapted modified Brief Smell Identification Test (B-SIT) to investigate the long- and short-term effects of SRP on olfactory function.Methods:We enrolled 59 patients admitted to the Ear- Nose-Throat Clinic, who were complaining of external nasal deformity and nasal obstruction. Functional SRP was performed on all cases. The B-SIT was administered prior to surgery and at 4 and 12 weeks post-surgery. The smell identification score (SIS) reflected the number of correct answers. In addition, we investigated the effects of gender and smoking on olfactory function and whether the SRP procedure changed these associations.Results:The mean preoperative, 4-week, and 12-week postoperative SISs were 10.15±1.30, 10.21±1.52, and 10.92±0.95, respectively. The difference between the preoperative and 4-week postoperative SISs was not statistically significant; however, the 12-week postoperative score was significantly different from the preoperative and 4-week postoperative scores. Furthermore, the repeated measures analysis according to gender and smoking habit revealed a significant difference between the 4- and 12-week postoperative SISs. One patient developed postoperative anosmia; however, the patient recovered in the 12-week postoperative period.Conclusion:SRP surgery is a safe procedure in terms of olfactory function. In addition, olfactory function may increase following surgery as a result of improved nasal airflow

AKUT APANDİSİTİ TAKLİT EDEN PARSİYEL ÇEKUM NEKROZU

Amaç: Travma veya tümöre bağlı olmayan izole parsiyel çekum nekrozu yaşlılarda nadir görülen bir tablodur. Apandisit gibi sağ alt kadrana lökalize ağrı ile karekterizedir ve genellikle ameliyat esnasında tanı konur. Parsiyel çekum rezeksiyonu veya sağ hemikolektomi ile tedavi edilir. Erken teşhis ve tedavi edilirse morbidite ve mortalitesi düşüktür. Olgu sunumu: 55 yaşında erkek ve 67 yaşında bayan hastaya akut apandisit ön tanısıyla laparatomi yapıldı ve çekum nekrozu tespit edildi. Erkek hastaya sağ hemikolektomi diğer hastaya ise çekum rezeksiyonu ve tüp çekostomi yapıldı. İki hastada da herhangi bir komplikasyon olmadı. Sonuç: Akut apandisit kliniği ile gelen yaşlı hastalarda parsiyel çekum nekrozu da düşünülmelidi

New chromosomal data, karyotype asymmetry and polyploid variations of some Gundelia (Asteraceae) species from Turkey

The genus Gundelia is currently represented with 18 species, of which 16 are in Turkey. In genus Gundelia, the chromosomal data were reported from 12 species. In the present study, it is aimed to eliminate the deficiencies in the knowledge about chromosomal data of Gundelia species. In Genus Gundelia, only a single chromosome number had been detected as 2n=18 so far. The chromosome numbers of four species were reported here for the first time: G. armeniaca, G. cappadocica, G. siirtica, and G. tehranica. In addition, the polyploidy in the genus was rare and G. anatolica was identified as the first polyploid species. All karyotypes except G. tehranica were symmetrical, consisting of metacentric and submetacentric chromosomes. Secondary constrictions were observed in the distal regions of the long arms of the longest metacentric and submetacentric chromosomes. Thus, the chromosomal data of all Turkish Gundelia species were completed. In conclusion, the present study presented new data into the karyological records relating the karyotype evolution and interspecific relations of genus Gundelia

Akut apandisitte toplam oksitadif durum, toplam antioksidan durumve paraoksonaz enzim aktivitesi

WOS:000351545100010PubMed ID: 25904276AMAÇ: Bu çalışmanın amacı, akut apandisit tanısı alan hastalarda toplam okstadif durum, toplam antioksidan durum değerleri ile paraoksonaz enzim aktivitesinin araştırılmasıdır.GEREÇ VE YÖNTEM: Ameliyat öncesi akut apandisit tanısıyla ameliyata alınan 73 hasta (Grup I) ile kontrol grubu olarak (Grup II) sağlıklı 30 kişi çalışmaya alındı. Patolojik inceleme sonucunda hastalar: 1) Akut fokal apandisit, 2) Akut ilerlemiş apandisit (süpüratif, flegmenöz ve gangrenöz apan-disit), 3) Akut perfore apandisit, 4) Subakut apandisit ve 5) Negatif eksplorasyon olarak sınıflandırıldı. Paraoksonaz enzim aktivitesi, toplam okstadif durum, toplam antioksidan durum değerleri için kan örnekleri ameliyat öncesinde alındı.BULGULAR: Hastaların toplam oksidatif ve antioksidatif durum düzeyleri kontrol grubuna göre yüksekti. Paraoksonaz enzim aktivitesi karşılaştırıldı-ğında grup I ile II arasında herhangi bir anlamlı fark saptanmadı. Akut perfore apandisitli hastaların toplam oksidatif ve antioksidatif durum düzeyleri hem akut fokal apandisitli hem de akut ilerlemiş apandisitli hastalardan daha yüksek bulundu.TARTIŞMA: Toplam oksidatif ve antioksidatif durum düzeylerinin akut apandisitli hastalarda enflamasyonun ilerlemesi ile artmaktadır.BACKGROUND: The aim of this study was to investigate the levels of oxidative stress including total oxidant status, total antioxidant status, and paraoxonase activity in patients with a diagnosis of acute appendicitis. METHODS: Seventy-three patients who underwent surgery with a preoperative diagnosis of acute appendicitis (Group I) were included into the study. The control group (Group II) consisted of thirty otherwise healthy subjects. After histopathologic examination, the patients were categorized as follows: 1) Acute focal appendicitis, 2) Acute advanced appendicitis including acute suppurative, phlegmonous and gangrenous appendicitis, 3) Acute perforated appendicitis, 4) Sub-acute appendicitis, and 5) Negative exploration. Blood samples for paraoxonase activities, and total oxidant and antioxidant status levels were obtained preoperatively.RESULTS: Total oxidant and antioxidant status of the patients in the acute appendicitis group were higher than those of the control group. When paraoxonase activities of Group I was compared with Group II, no significant difference was determined. Both total oxidant and antioxidant status levels of acute perforated appendicitis were higher than those of both acute focal appendicitis and acute advanced appendicitis.CONCLUSION: The increase in the oxidative status (total oxidant and antioxidant status) was related with the progression of inflammation to the perforation in acute appendiciti

Eugenol and glycyrrhizic acid inhibit azoxymethane-induced colon carcinogenesis via inducing apoptosis

*Doğru, Mustafa Selim ( Aksaray, Yazar )The high mortality of cancer is one of the crucial problems in human beings especially colorectal carcinoma (CRC) with higher morbidity (2nd grade) required new prevention approaches. The aim of this study was to investigate the potential chemopreventive effects of eugenol (EU) and glycyrrhizic acid (GA) on azoxymethane (AOM)-induced colorectal cancer in rats. In the study, 80 Sprague Dawley male rats were used. The rats were randomly divided into eight groups as follows: Control, AOM (15mg/kg bw., sc, once a week for two weeks), EU (EU 100 mg/kg bw., gavage), GA (GA 15 mg/kg bw., gavage), EU+GA, AOM+EU, AOM+GA, and AOM+EU+GA. All the rats except those in the control and AOM groups were treated with EU and GA for 16 weeks. At the end of the study, the colon tissues were examined in terms of Aberrant Crypt Foci (ACF) and histopathology. Malondialdehyde (MDA) and reduced glutathione (GSH) levels, as well as superoxide dismutase (SOD) and catalase (CAT) activities, were evaluated biochemically in colon tissue. In addition, Bax, Bel 2 and p53 protein expressions in colon samples were determined by Western blotting. In the colon tissues of rats treated with AOM, MDA levels and CAT activities were found out to increase, whereas GSH levels and SOD activities decreased. On the other hand, AOM treatment increased Bcl-2/Bax ratio but downregulated p53 and Bax expressions. In the histopathological examination, an increase was detected in ACF numbers and malignant tumoral lesions. The use of EU+GA decreased oxidative stress and ACF numbers, induced apoptosis, and upregulated p53 expression in AOM-treated rats. In conclusion, EU+GA was determined to be more effective against colorectal cancer when compared with the other treatment groups

Subclinical right ventricular dysfunction in intermittent and persistent mildly asthmatic children on tissue Doppler echocardiography and serum NT-proBNP: Observational study

kaya, adnan/0000-0002-9225-8353WOS: 000489002900007PubMed: 30179288Background Bronchial asthma may lead to pulmonary hypertension, right ventricular (RV) dysfunction, and cor pulmonale due to elevated afterload on the RV later in life. The aim of this study was to determine whether serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) might serve as a biomarker for detecting subclinical RV dysfunction using echocardiography during the early stages of bronchial asthma. Methods Sixty-eight pediatric patients with asthma (asthma group) and 69 age- and sex-matched healthy children (control group) were enrolled. The study was conducted in a tertiary woman and child diseases education and research hospital from January 2013 to December 2013. RV function (2-D and tissue-Doppler echocardiography), pulmonary function (spirometry) and serum NT-proBNP concentration were evaluated. Results Mean age was 10.5 +/- 2.8 years in the asthma group and 10.2 +/- 2.7 years in the control group (P = 0.522). RV diastolic function was significantly decreased in the asthma group (ratio of tricuspid lateral annular early diastolic peak velocity to tricuspid lateral annular late diastolic peak velocity [E '/A '], 1.29 +/- 0.68 vs 1.74 +/- 0.89, P = 0.001). RV myocardial performance index was significantly higher in the asthma group than in the control group (0.28 +/- 0.06 vs 0.24 +/- 0.07, respectively; P = 0.003). Finally, serum NT-proBNP concentration was significantly higher in the asthma group than in the control group (292.3 +/- 142.2 pg/mL vs 208.2 +/- 70.1 pg/mL, respectively; P = 0.003). Conclusion Increased serum NT-proBNP is associated with subclinical RV dysfunction in asthmatic children. RV function is significantly affected in children with bronchial asthma