Influence of beta-blockers on mechanical dyssynchrony and cardiac remodeling in patients with ischemic chronic heart failure in the setting of revascularization

Diastolic dysfunction (DD) and cardiac dyssynchrony (DS) are involved in the progression of chronic heart failure (CHF). A comparative analysis was conducted of the effect of a 6-month course of nebivolol and bisoprolol on DD, DS and metalloproteinase-9 (MMP-9) level in patients with ischemic chronic heart failure with preserved ejection fraction (HFpEF) and with midrange ejection fraction (HFmrEF), as well as in patients with comorbid type 2 diabetes mellitus (T2DM) in the setting of coronary artery bypass grafting (CABG) after 6 months of therap

Narrative Polyphony in Novel “Savely’s Days” by G. Sluzhitel

The narrative structure of the novel “Savely’s Days” by G. Sluzhitel is considered. It is determined that a polyphonic system of narrative instances is expressed in the novel, and the relationship between them is established. Methods of creating a subjective versatility of the text have been studied. It is noted that the genre of memories as a whole retains constant features, which include the methods of creating a chronotope. It embodys the image of a hero, while it is the very feature of the protagonist, who is an unreliable narrator, that leads to the transformation of the classical narration of memories and to the emergence of several subject-speech plans. The relevance of the study is due to the need to study the narrative instances and the originality of their relationship in order to comprehend the narrative space of a work of art. The novelty is seen in the fact that the methods of creating the effect of polyphonic narration are determined on the basis of the material of the modern novel. The observation of the modern writer style formation is carried out. It has been proved that the polyphony of narrative images arises in the novel due to the fact that, technically, the story cannot be conducted only from the point of view of the cat-narrator, since this will significantly limit the discourse. The purpose of polyphony is to look at a modern person from different points of view, including a detached one

Choice of antihypertensive therapy in hypertensive patients with critical coronary artery stenosis

Sixty patients with stages II-III AH were studied. ABPM was performed in all the patients. DBPP was assessed by the degree of nocturnal BP lowering. Patients were randomized into groups receiving perindopril or losartan potassium. Perindopril was prescribed at a dose of 4 mg/day with subsequent rising up to 8 mg/day during 7 days. The initial dose of losartan potassium was 25 mg with subsequent rising up to 50 mg 2 times a day. The duration of observation was 8 weeks. Thus, perindopril therapy in hypertensive patients in the preoperative CABG period increased the number of people with normal BP profileyesБелгородский госуниверсите

Pharmacological correction of immune disorders in patients with chronic heart failure and ischemic heart disease

Currently, there are few data on the effect of cardiovascular drugs on the immune status of patients with heart failure (HF). This paper provides information on the impact of ß-adrenergic blocking agent (BAB), angiotensin-converting enzyme inhibitors (ACEI) on the maintenance of markers of immune inflammation in the blood, as well as on inhibition of synthesis of tumor necrosis factor-α (TNF-α) and on blocking of interaction between TNF-α and membrane receptor

Competence-oriented teaching practice bachelors in terms of networking

In article the authors considers the relevance to pedagogical practice with the changes in modern Russian education. Focuses on the specifics of networking. The author offers im-plementation and introduction of this system into the educational spaceВ статье авторами была рассмотрена актуальность организации педагогической практики с учетом изменений в современном российском образовании. Акцентируется внимание на специфике сетевого взаимодействия. Автором предложены варианты реализации и внедрения данной системы в образовательное пространств

Teaching practice of bachelors of vocational training in modern conditions

The article describes the main approaches to the preparation of bachelors in the framework of pedagogical practice. The author identifies the stages of teaching practice. The features of the organization of teaching practice in modern conditionsВ статье рассмотрены основные подходы к подготовке бакалавров в рамках педагогической практики; выделены этапы прохождения педагогической практики; отражены особенности организации педагогической практики в современных условия

Analysis of the influence of chronic heart failure type on changes in the microelement composition of myocardial tissue in patients of senile age

Aim: conduct a comparative analysis of the content and distribution of macroelements (Ca2+, K+, Mg2+, and Na+) in myocardial tissue according to autopsy data in elder patients with CHF, depending on the LV E

Application of phosphocreatine in the treatment of a patient with acute myocardial infarction on the background of auxiliary circulation

The clinical case of maintaining the patient with a sharp transmural myocardial infarction front septal areas and tops of the left ventricle, the cardiogenic shock of the II degree and alveolar hypostasis of lungs are described. In the treatment of the patient auxiliary blood circulation in the form of installation of an intra aortal balloon counterpulsation in the descending department of an aorta was applie