Philosophy and Opinions

Review of Law, Pragmatism, and Democracy. By Richard A. Posner. Harvard University Press, 2003. 398 Pages. $35.00

Schwierigkeiten, den Begriff »Lebenskunst« ins Japanische zu übersetzen

Die Diskussion mit japanischen Gesprächspartnern über Fragen der Lebenskunst sieht sich mit nicht trivialen Schwierigkeiten der Übersetzung des Begriffs zur Bezeichnung des Gegenstands dieser Diskussion konfrontiert. Diese Schwierigkeiten bieten zugleich eine gute Gelegenheit für eine genuin interkulturelle philosophische Verständigung über die Sache, um die es gehen soll

Evaluating onco-geriatric scores and medication risks to improve cancer care for older patients

The cancer therapy of older patients is challenging, being more complex than the therapy of younger patients. Older cancer patients show a higher toxicity risk during therapy and drug-related problems are common. In order to individualize cancer care in this heterogeneous population, short tools combining geriatric assessment with oncologic parameters were developed for predicting toxicity during chemotherapy: the CARG (Cancer and Aging Research Group) and the CRASH (Chemotherapy Risk Assessment Scale for High Age Patients) score. The aim was to compare the scores regarding their predictive performance in a clinical routine setting. Moreover, this thesis aimed at evaluating medication-related risks in older cancer patients. In a prospective, single-center observational study, the CARG and the CRASH score were assessed for patients ≥ 70 years before the start of their systemic cancer treatment. The CARG score predicts severe overall toxicity. The CRASH score is divided into three subcategories, predicting severe overall, hematologic, and nonhematologic toxicity. Moreover, physicians’ judgments regarding the patients’ toxicity risk were documented. Grade ≥ 3 toxicity according to the Common Terminology Criteria for Adverse Events (CTCAE) was captured from medical records. The predictive performance of the scores was assessed by analyzing the proportion of patients with severe toxicity per risk category, logistic regression, and the area under the receiver operating characteristic curve (ROC-AUC). Furthermore, the prediction performance was compared with other commonly used predictors. The evaluation study of the CARG and the CRASH score comprised 120 patients (50% female, mean age 77.2 years). Severe toxicity was experienced by 81% of patients; 67% showed signs of hematologic toxicity. The predictive performances of the CARG score and the combined CRASH score were similar for overall and nonhematologic toxicity. For hematologic toxicity, the hematologic CRASH score performed better than the CARG score. Neither physicians’ judgment nor the ECOG nor age indicated adequate predictive performance for overall toxicity. Medication risks in older cancer patients were investigated regarding polymedication (defined as the use of ≥ 5 drugs), potentially inadequate medication (PIM; defined by the EU(7)-PIM list), and relevant potential drug-drug interactions (rPDDI; analyzed by the ABDA interaction database). Before the start of cancer therapy, patients took on average 5 drugs as long-term medication and 52% of patients were exposed to polymedication. More than half of patients used at least one PIM (mostly drugs for acid-related disorders). Approximately one third of patients experienced rPDDI. In conclusion, the CARG and the CRASH score exhibited similar predictive performance for overall and nonhematologic toxicity. However, the hematologic CRASH score should be preferred for predicting hematologic toxicity. Both scores performed better than clinical judgment alone and thus may be used for supporting therapy decisions in clinical routine. Medication risks were common in older cancer patients, raising the need for interdisciplinary interventions to ensure medication safety in this cohort

Rossby wave propagation into the tropical stratosphere observed by the high resolution Doppler imager

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95011/1/grl10366.pd

Tanuki Magazine- Japanese Culture Worldwide

A cultural interest magazine about Japan. Designed, written, and published by Kathryn Ortland. With accompanying thesis defense. A Thesis presented to the School of Journalism and Communication, the Department of East Asian Languages and Literature, and the Honors College of the University of Oregon in partial fulfillment of the requirements for the degree of Bachelor of Arts, June 2005.A print copy of this thesis is available through the UO Libraries under the call number: SCA Archiv Storage Ortland 2005Rich with tradition and ripe with nostalgic imagery, Japan captivates the Western mind. Japanese culture was almost unknown in the West two hundred years ago, yet its influences today permeate entertainment media worldwide. Though the popularity of Japanese music, movies, and animation is increasing cultural exposure to Japan, few resources exist to provide honest and educational information on Japanese ways of life. The unfortunate result is that the average American is far better acquainted with Hollywood stereotypes of Japan than with the real thing. TANUKI is a magazine that fills the deficit in coverage of Japanee popular and traditional culture outside of the entertainment market. It is designed as a travel-centric cultural interest magazine for readers who seek the hidden influences, new trends, and lingering traditions of Japan

Kontrastmittelinduzierte Neurotoxizität - DE_Vigilance-News-Edition_29_2022

Die Kontrastmittel-induzierte Neurotoxizität ist eine seltene, akute und meist reversible Komplikation von Kontrastmitteln in bildgebenden Verfahren, welche aufgrund ihrer Symptomatik oft einem Schlaganfall ähneln kann. Dieser Fallbericht handelt von einer 77-jährigen Patientin, bei welcher während einer Koronarangiographie mit dem Kontrastmittel Ultravist® (Iopromid) eine Aphasie und Hemiparese auftrat. Zunächst bestand der Verdacht auf einen zerebrovaskulären Insult, im Verlauf wurden die Beschwerden jedoch als eine Kontrastmittel-induzierte Enzephalopathie interpretiert