A Content Model based on LOM specification Integrating Learning Disabilities: Toward an Adaptive Framework

International audienceLearning disabilities can be defined as neurologically based processing problems that interfere with basic learning skills such as understanding, reading or counting, but also with higher-level skills such as space and time coordination. Adaptive learning systems are usually not designed to take into account learning disabilities, even if the need for enhancing support of learners with disabilities is more and more important within nowadays society. We first identify the set of learning disabilities to consider in an accessible adaptive learning system; then a content model is proposed integrating the matching abilities and extending a standard to ensure interoperability with existing solutions. Finally, a case study is presented to apply the proposed model in order to identify a learning object designed to support math skills at elementary school

Análisis de uso de un ecosistema digital como apoyo a niños con problemas de aprendizaje en lectura y matemáticas básicas

International audienceHoy en día la tecnología está presente en casi cualquier actividad del ser humano, se encuentra en los procesos tecnológicos que nos ayudan con tareas de la casa, entretenimiento, trabajo, investigación, etc. y la educación no es la excepción en la aplicación de estas herramientas tecnológicas. Una problemática consiste en la gran cantidad de recursos educativos disponibles y la necesidad de organizar, administrar y evaluar dichos recursos para su mejor aprovechamiento de una forma específica para niños de comunidades de aprendizaje, optimizando tiempos para su mejor aprovechamiento, por lo cual en este trabajo se pretende acercar la tecnología con el fin de mejorar el conocimiento básico de niños con problemas de aprendizaje tanto en lectura como en matemáticas básicas a través de un modelo de ecosistema digital, el cual comprende en términos generales comunidades de aprendizaje y proveedores de recursos educativos que interactúan a través de servicios educativos para mejorar los recursos educativos a través de la retroalimentación generada por los mismos usuarios

Análisis de uso de un ecosistema digital como apoyo a niños con problemas de aprendizaje en lectura y matemáticas básicas

Today technology is present in almost any activity of the human being, is in the technological processes that help us with household chores, entertainment, work, research, etc. and education is no exception in the application of these technological tools. One problem consists of the great amount of educational resources available and the need to organize, manage and evaluate these resources for their better use in a specific way for children in learning communities, optimizing times for their best use, so that in this work the aim is to bring technology closer to improving basic knowledge of children with learning problems in both reading and basic mathematics through a digital ecosystem model which comprehends in general terms learning communities and providers of interacting educational resources through educational services to improve educational resources through the feedback generated by the same users.Hoy en día la tecnología está presente en casi cualquier actividad del ser humano, se encuentra en los procesos tecnológicos que nos ayudan con tareas de la casa, entretenimiento, trabajo, investigación, etc. y la educación no es la excepción en la aplicación de estas herramientas tecnológicas. Una problemática consiste en la gran cantidad de recursos educativos disponibles y la necesidad de organizar, administrar y evaluar dichos recursos para su mejor aprovechamiento de una forma específica para niños de comunidades de aprendizaje, optimizando tiempos para su mejor aprovechamiento, por lo cual en este trabajo se pretende acercar la tecnología con el fin de mejorar el conocimiento básico de niños con problemas de aprendizaje tanto en lectura como en matemáticas básicas a través de un modelo de ecosistema digital, el cual comprende en términos generales comunidades de aprendizaje y proveedores de recursos educativos que interactúan a través de servicios educativos para mejorar los recursos educativos a través de la retroalimentación generada por los mismos usuarios

An Eco-System Architectural Model for Delivering Educational Services to Children with Learning Problems in Basic Mathematics

International audienceA large diverse amount of educational content can dynamically contribute to the construction of basic knowledge for elementary school children. These contents can be used to develop or expand such knowledge and this becomes different when it needs to be applied to children with learning problems in basic mathematics. Then, it is necessary to manage effectively educational resources. The current work proposes the use of an architectural model in order to support teaching activities of a multidisciplinary group of specialist in inclusive education. A case study presents here some examples of teaching activities such as the specification of context and the management of educational resources according the learning problems of children at elementary school

Evolution over Time of Ventilatory Management and Outcome of Patients with Neurologic Disease∗

OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele