Evaluation of ultrasound by direct contact on convective drying of banana (Musa paradisiaca) slices using Principal Component Analysis and Response Surface Methodology

Conventional convective drying is one of the latest techniques used to reduce the amount of water in foods, however, due to the long times of exposure to high temperatures, these techniques can reduce the sensory quality, in addition to generating high costs associated with consumption of energy. An alternative to improve efficiency in these processes is to use innovative tools such ultrasound (US) application by using direct contact during drying to improve quality and keep nutritional content of the product with reduction in time, cost and temperatures of operation

Sustainable management of peel waste in the small-scale orange juice industries: A Colombian case study

Appropriate waste management in emerging economies like Colombia should be an asset for the overall sustainability. In the Orange Peel Waste case, incineration and Anaerobic Digestion are challenging solutions for the orange juice agro-industrial sector for avoiding the landfill, which is the conventional practice. However, these alternatives should be assessed in order to determine their feasibility. This paper aims to understand if incineration and Anaerobic Digestion are potential alternatives to landfill form a techno-economic and environmentally perspective. To this aim, a comparative Life Cycle Assessment was carried out in four scenarios. In the first scenario coal and landfill are used as source of energy and landfill disposal in the actual orange juice process. In the second scenario, the peels are incinerated to avoid landfill and reduce the need for coal. The third scenario includes the valorization of the peels by means of Anaerobic Digestion which produces biogas for the plant energy requirements. In the fourth scenario, apart from the energy from biogas, the digestate becomes a fertilizer for use in the orange crops. The results revealed that scenario III and IV are environmentally friendly options compared to Scenario I, but they incur higher costs than Scenario II. Carbon footprint found that 1.55 kg of CO2 are saving when coal substitution is reduced from 0.493 kg in SI to 0.279 kg in SII. Therefore, Scenario II is more suitable for the Colombian socioeconomic reality since Scenario II is not only techno-environmentally achievable, but also economically feasible. The methodology used in this case study could be applied to other countries or small and medium scale technologies and could also be useful for the scientific community, enterprises and policy-makers.The authors wish to acknowledge the financial support of the Fondo Regional de Tecnología Agropecuaria FONTAGRO [Contract:ATN/RF 16111RG, 2016] and of the Departamento Administrativo de Ciencia, Tecnología e Innovación, Doctorados Nacionales [Contract:727, 2015]. Also this article is the result of the work developed through the "Programa de investigación reconstrucción del tejido social en zonas de pos-conflicto en Colombia" [SIGP 57579] withthe research project "Competencias empresariales y de innovación para el desarrollo económico y la inclusión productiva de las regiones afectadas por el conflicto colombiano" [SIGP 58907]. Finally, the authors would like to express their appreciation to FLP Procesados Company for providing the data for the case study

Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: Insights from the NeoAMR network

Objective To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and middle-income country (LMIC) setting to inform the design of an observational study on the burden of unit-level antimicrobial resistance (AMR). Design A web-based survey using a REDCap database was circulated to NNUs participating in the Neonatal AMR research network. The survey included questions about NNU funding structure, size, admission rates, access to supportive therapies, empirical antimicrobial guidelines and period prevalence of neonatal blood culture isolates and their resistance patterns. Setting 39 NNUs from 12 countries. Patients Any neonate admitted to one of the participating NNUs. Interventions This was an observational cohort study. Results The number of live births per unit ranged from 513 to 27 700 over the 12-month study period, with the number of neonatal cots ranging from 12 to 110. The proportion of preterm admissions <32 weeks ranged from 0% to 19%, and the majority of units (26/39, 66%) use Essential Medicines List 'Access' antimicrobials as their first-line treatment in neonatal sepsis. Cephalosporin resistance rates in Gram-negative isolates ranged from 26% to 84%, and carbapenem resistance rates ranged from 0% to 81%. Glycopeptide resistance rates among Gram-positive isolates ranged from 0% to 45%. Conclusion AMR is already a significant issue in NNUs worldwide. The apparent burden of AMR in a given NNU in the LMIC setting can be influenced by a range of factors which will vary substantially between NNUs. These variations must be considered when designing interventions to improve neonatal mortality globally. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ

The case for simplifying and using absolute targets for viral hepatitis elimination goals

The 69th World Health Assembly endorsed the Global Health Sector Strategy for Viral Hepatitis, embracing a goal to eliminate hepatitis infection as a public health threat by 2030. This was followed by the World Health Organization's (WHO) global targets for the care and management of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. These announcements and targets were important in raising awareness and calling for action; however, tracking countries’ progress towards these elimination goals has provided insights to the limitations of these targets. The existing targets compare a country's progress relative to its 2015 values, penalizing countries who started their programmes prior to 2015, countries with a young population, or countries with a low prevalence. We recommend that (1) WHO simplify the hepatitis elimination targets, (2) change to absolute targets and (3) allow countries to achieve these disease targets with their own service coverage initiatives that will have the maximum impact. The recommended targets are as follows: reduce HCV new chronic cases to ≤5 per 100 000, reduce HBV prevalence among 1-year-olds to ≤0.1%, reduce HBV and HCV mortality to ≤5 per 100 000, and demonstrate HBV and HCV year-to-year decrease in new HCV- and HBV-related HCC cases. The objective of our recommendations is not to lower expectations or diminish the hepatitis elimination standards, but to provide clearer targets that recognize the past and current elimination efforts by countries, help measure progress towards true elimination, and motivate other countries to follow suit. © 2020 John Wiley & Sons Lt

International Nosocomial Infection Control Consortium report, data summary of 50 countries for 2010-2015: Device-associated module

•We report INICC device-associated module data of 50 countries from 2010-2015.•We collected prospective data from 861,284 patients in 703 ICUs for 3,506,562 days.•DA-HAI rates and bacterial resistance were higher in the INICC ICUs than in CDC-NHSN's.•Device utilization ratio in the INICC ICUs was similar to CDC-NHSN's. Background: We report the results of International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2010-December 2015 in 703 intensive care units (ICUs) in Latin America, Europe, Eastern Mediterranean, Southeast Asia, and Western Pacific. Methods: During the 6-year study period, using Centers for Disease Control and Prevention National Healthcare Safety Network (CDC-NHSN) definitions for device-associated health care-associated infection (DA-HAI), we collected prospective data from 861,284 patients hospitalized in INICC hospital ICUs for an aggregate of 3,506,562 days. Results: Although device use in INICC ICUs was similar to that reported from CDC-NHSN ICUs, DA-HAI rates were higher in the INICC ICUs: in the INICC medical-surgical ICUs, the pooled rate of central line-associated bloodstream infection, 4.1 per 1,000 central line-days, was nearly 5-fold higher than the 0.8 per 1,000 central line-days reported from comparable US ICUs, the overall rate of ventilator-associated pneumonia was also higher, 13.1 versus 0.9 per 1,000 ventilator-days, as was the rate of catheter-associated urinary tract infection, 5.07 versus 1.7 per 1,000 catheter-days. From blood cultures samples, frequencies of resistance of Pseudomonas isolates to amikacin (29.87% vs 10%) and to imipenem (44.3% vs 26.1%), and of Klebsiella pneumoniae isolates to ceftazidime (73.2% vs 28.8%) and to imipenem (43.27% vs 12.8%) were also higher in the INICC ICUs compared with CDC-NHSN ICUs. Conclusions: Although DA-HAIs in INICC ICU patients continue to be higher than the rates reported in CDC-NSHN ICUs representing the developed world, we have observed a significant trend toward the reduction of DA-HAI rates in INICC ICUs as shown in each international report. It is INICC's main goal to continue facilitating education, training, and basic and cost-effective tools and resources, such as standardized forms and an online platform, to tackle this problem effectively and systematically