Gas Chromatograph-quadrupole Mass Spectrometric Analysis of Organic Compounds

Gas chromatography and mass spectrometry of acetonitrile, furan, pyrrole, paraffins, and other aromatic organic compounds of biological significanc

Fostering local adaptation platforms for agriculture: How context specific climate-smart villages (CSVs) can relate to local adaptation efforts.

Local adaptation platforms help empower sub-national and local government players, civil society organizations, and public-private partnerships in demonstrating the validity of agro-ecology-specific solutions to current and future climate change impacts. This brief discusses how Climate-Smart Villages, good examples of local adaptation platform, have served as centers for discovery, adaptation, learning, and sharing of climate-smart agriculture in local communities

Pathways to Attaining a Food Secure Philippines through a Competitive and Climate-Resilient Agri-Fisheries Sector

This document highlights the key messages drawn from climate adaptation efforts and events done with Philippines’ Department of Agriculture-Regional Field Offices (DA-RFOs) across the country. This brief, developed for the Climate Change Consciousness Week, offers DA a synthesis of lessons from the Adaptation and Mitigation Initiative in Agriculture (AMIA) village experience as a bankable model for establishing context specific, local adaptation platforms for developing and disseminating CRA technologies and processes. This brief also offers valuable policy insights for the Philippines’ National Adaptation Plan

Chiral transition-metal complexes as Brønsted-acid catalysts for the asymmetric Friedel-Crafts hydroxyalkylation of indoles.

The Friedel-Crafts reaction between 3,3,3-trifluoropyruvates and indoles is efficiently catalysed by the iridium complex [(η5-C 5Me5)Ir{(R)-Prophos}(H2O)][SbF 6]2 (1) with up to 84% ee. Experimental data and theoretical calculations support a mechanism involving the Brønsted-acid activation of the pyruvate carbonyl by the protons of the coordinated water molecule in 1. Water is not dissociated during the process and, therefore, the catalytic reaction occurs with no direct interaction between the substrates and the metal. This journal is © the Partner Organisations 2014.The authors acknowledge the Ministerio de Economía y Competitividad (MINECO, Grants CTQ2006-03030/BQU, CTQ2009-10303/BQU, CTQ2011-27033 and Consolider Ingenio 2010 CSD2006-003), Gobierno de Aragón (Grupo Consolidado: Catálisis Homogénea Enantioselectiva), Generalitat de Catalunya (2009SGR0259) and the ICIQ foundation for financial support. A. S. and R. R. acknowledge MINECO for predoctoral fellowships. S. D.-G. acknowledges MINECO for a “Torres Quevedo” contract.Peer Reviewe

The AMIA Experience: Supporting local actions for Climate Resilient Agriculture

The brief tackles how the Adaptation and Mitigation Initiative in Agriculture (AMIA) Program of the Philippines’ Department of Agriculture (DA) served as a platform for supporting local actions for climate resilient agriculture. The document discusses a number of key lessons emerging from the AMIA Village experience on the importance of local platforms for adaptation in the form of Climate-Smart Villages towards overall resilience building of the sector

Isotopic carbon analysis of meteoritic organic matter

Isotopic carbon analysis of meteoritic organic matte

Disciplinas de custos: uma análise nos cursos de Ciências Contábeis das IES do sistema ACAFE

A informação de custos, diante de um mercado de competitividade crescente, apresenta-se como uma base importante ao processo decisório, além de implicar novos paradigmas na gestão dos negócios. Desta forma, torna-se relevante o oferecimento de disciplinas de custos no Curso de Ciências Contábeis onde a contabilidade de custos e seu processo de ensino devem direcionar o aluno, a partir do estudo acadêmico, ao processo externo, ou seja, ao mercado tomador do profissional provido de conhecimento contábil.Considerando a relevância das disciplinas de custos no Curso de Ciências Contábeis das Instituições de Ensino Superior (IES), este artigo tem como objetivo verificar as congruências e divergências destas disciplinas ofertadas nos Cursos de Ciências Contábeis das universidades ligadas à Associação Catarinense das Fundações Educacionais (ACAFE). A metodologia da pesquisa consubstancia-se de um estudo exploratório, realizado por meio de levantamento, com abordagem predominantemente qualitativa. Utilizou-se para análise o conteúdo de ementa, a carga horária e a disposição das disciplinas de custos na grade curricular nestas instituições. A técnica estatística empregada foi análise de clusters. Diante deste estudo que teve como objetivo a verificação das congruências e divergências das disciplinas de custos ofertadas nos Cursos de Ciências Contábeis das instituições ligadas à ACAFE, conclui-se que estas instituições estabelecem um agrupamento predominante, mesmo que na análise isolada de algumas variáveis isto não ocorra. Os resultados da pesquisa evidenciam que na variável ementa, o cluster mais representativo apontou 9 instituições, representando o maior grupo com 56,25% do total de instituições pesquisadas. Na variável fase, 10 instituições apresentaram congruência, pois oferecem as disciplinas de custos em períodos semelhantes. Na variável carga horária, 10 instituições apresentam similaridade no oferecimento das disciplinas de custos e análise de custos com 120 h/a. Conclui-se que, num contexto geral, há um acentuado nível de congruência nas disciplinas de custos entre as universidades analisadas, apesar de divergências encontradas na análise isolada de algumas variáveis

c-FOS drives reversible basal to squamous cell carcinoma transition.

While squamous transdifferentiation within subpopulations of adenocarcinomas represents an important drug resistance problem, its underlying mechanism remains poorly understood. Here, using surface markers of resistant basal cell carcinomas (BCCs) and patient single-cell and bulk transcriptomic data, we uncover the dynamic roadmap of basal to squamous cell carcinoma transition (BST). Experimentally induced BST identifies activator protein 1 (AP-1) family members in regulating tumor plasticity, and we show that c-FOS plays a central role in BST by regulating the accessibility of distinct AP-1 regulatory elements. Remarkably, despite prominent changes in cell morphology and BST marker expression, we show using inducible model systems that c-FOS-mediated BST demonstrates reversibility. Blocking EGFR pathway activation after c-FOS induction partially reverts BST in vitro and prevents BST features in both mouse models and human tumors. Thus, by identifying the molecular basis of BST, our work reveals a therapeutic opportunity targeting plasticity as a mechanism of tumor resistance