Mercury Levels in Sediment, Shellfish and Fish of a Water Body in the Niger Delta

The concentrations of mercury in sediment and the muscle tissues of shellfish and fish of Bonny River and creeks around Okrika were determined in order to identify possible sources and indicator species that can be used to monitor pollution of the ecosystem, as well as assess possible health risk. Sediment samples were taken from ten (10) locations including the refinery effluent discharge channel, while shellfish and fish were randomly taken within the studied area. All samples were prepared and analysed by the cold vapour technique. The mean level of detectable values (ppm) in the sediment was 0.273±0.016. Those of shellfish were: P. aurita (0.016±0.012) and G. rhizophorea (0.018±0.026), while for fish we have: P. koelreuteri (0.014±0.019), M. cephalus (0.011±0.010), S. marderensis (0.008±0.011) and T. guineensis (0.026±0.032). The sediment results reveal largely anthropogenic enrichments mainly from refinery effluent. The pattern of accumulation by both fish types was both physiologically and ecologically characterized an indication that it is only the dissolved forms of metals that are effectively available to fish for bioaccumulation. The remarkable bioaccumulation factor (130.00) was associated with T. guineensis, which appeared to be the most efficient accumulator, and therefore a good bioindicator to monitor mercury pollution of the system. Mercury levels in all sample types were however generally low and do not portend serious danger with respect to human health. Nevertheless, the continued discharge of industrial effluents without regular monitoring may have imminent detrimental effect on the flora and fauna, since the metal is detectable in all the samples at sub-lethal concentrations. KEYWORDS: concentrations, shellfish, fish, mercury, indicator species, Bonny Rive

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2•72 (95% uncertainty interval [UI] 2•66–2•79) in 2000 to 2•31 (2•17–2•46) in 2019. Global annual livebirths increased from 134•5 million (131•5–137•8) in 2000 to a peak of 139•6 million (133•0–146•9) in 2016. Global livebirths then declined to 135•3 million (127•2–144•1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2•1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27•1% (95% UI 26•4–27•8) of global livebirths. Global life expectancy at birth increased from 67•2 years (95% UI 66•8–67•6) in 2000 to 73•5 years (72•8–74•3) in 2019. The total number of deaths increased from 50•7 million (49•5–51•9) in 2000 to 56•5 million (53•7–59•2) in 2019. Under-5 deaths declined from 9•6 million (9•1–10•3) in 2000 to 5•0 million (4•3–6•0) in 2019. Global population increased by 25•7%, from 6•2 billion (6•0–6•3) in 2000 to 7•7 billion (7•5–8•0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58•6 years (56•1–60•8) in 2000 to 63•5 years (60•8–66•1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation: Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Global burden of 87 risk factors in 204 countries and territories, 1990�2019: a systematic analysis for the Global Burden of Disease Study 2019

Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods: GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk�outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk�outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk�outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. Across all six analytical steps, 30 652 distinct data sources were used in the analysis. Uncertainty in each step of the analysis was propagated into the final estimates of attributable burden. Exposure levels for dichotomous, polytomous, and continuous risk factors were summarised with use of the summary exposure value to facilitate comparisons over time, across location, and across risks. Because the entire time series from 1990 to 2019 has been re-estimated with use of consistent data and methods, these results supersede previously published GBD estimates of attributable burden. Findings: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure. Global declines also occurred for tobacco smoking and lead exposure. The largest increases in risk exposure were for ambient particulate matter pollution, drug use, high fasting plasma glucose, and high body-mass index. In 2019, the leading Level 2 risk factor globally for attributable deaths was high systolic blood pressure, which accounted for 10·8 million (95 uncertainty interval UI 9·51�12·1) deaths (19·2% 16·9�21·3 of all deaths in 2019), followed by tobacco (smoked, second-hand, and chewing), which accounted for 8·71 million (8·12�9·31) deaths (15·4% 14·6�16·2 of all deaths in 2019). The leading Level 2 risk factor for attributable DALYs globally in 2019 was child and maternal malnutrition, which largely affects health in the youngest age groups and accounted for 295 million (253�350) DALYs (11·6% 10·3�13·1 of all global DALYs that year). The risk factor burden varied considerably in 2019 between age groups and locations. Among children aged 0�9 years, the three leading detailed risk factors for attributable DALYs were all related to malnutrition. Iron deficiency was the leading risk factor for those aged 10�24 years, alcohol use for those aged 25�49 years, and high systolic blood pressure for those aged 50�74 years and 75 years and older. Interpretation: Overall, the record for reducing exposure to harmful risks over the past three decades is poor. Success with reducing smoking and lead exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens

Influence of sire on internal egg quality and linear body traits of Japanese quail raised in the humid tropical environment

A total of 270 pedigreed-hatched day old chicks of three strains of Japanese quail generated from a base population of 36 adultswere used in a randomized complete block design to estimate the influence of sire on the internal egg quality and linear body traits of the birds. Parameters measured were internal egg quality traits - albumen height, yolk height, albumen weight, yolk weight, albumen diameter, albumen length, yolk width, yolk length, yolk index, and haugh unit, and growth traits - body weight, thigh length, breast length, body length, keel length, wing length, and shank length. Results showed that linear body parameters were significant (P<0.05) except body weight at week 9. Panda white x Cinnamon brown (PWxCB) progenies out-performed the progenies of the other strains mainly at week 9. The PWxCB strain had the highest values in the following: body weight (159.30), thigh length (4.76), breast width (7.40), body length (11.94), keel length (6.77), and shank length (3.44). The haugh unit value was significantly (P< 0.05) different among the three strains mainly at week 8 with CBxCB strain having higher value of (89.07) followed by PWxCB strain (89.03). The phenotypic correlations between the linear body parameters and internal egg quality traits in Cinnamon brown x Cinnamon brown (CBxCB) strain were significant (P<0.01) in keel length and yolk weight (0.534) and between shank length and yolk weight (0.473) at week 9. For PWxCB strain, high significant (P<0.01) correlation were seen between shank lengthand albumen length (0.631) at week 8, body weight and yolk index at week 9. Silver brown x Cinnamon brown (SBxCB) strain also showed high positive significant (P<0.01) correlation between shank length and yolk weight (0.541), breast width and albumen weight (0.537) and between body length and albumen weight (0.625) at week 9. These positive correlations imply that by direct selection for any linear body trait for increased meat production, there will be a remarkable genetic improvement in the internal egg quality trait. It can be concluded that PWxCB is a strain of choice for improved growth and internal egg quality characteristics. Keywords: Japanese quail, humid tropics, linear body traits, internal egg qualit

Sire influence on reproductive, performance characteristics and growth traits in three strains of Japanese quail raised in the humid tropics

A total of 270 pedigreed-hatched day old chicks of three strains of Japanese quail generated from a base population of 45 adult Japanese quails were used to estimate the influence of sire on the hatchability and growth performance of the birds. Japanese quail strains used were Cinnamon Brown x Cinnamon Brown (CBxCB), Panda White x Cinnamon Brown (PWxCB) and Silver Brown x Cinnamon Brown (SBxCB). The experiment was a randomized complete block design. Parameters measured include: fertility and hatchability traits, growth performance traits and linear body parameters. The results showed that, average percentage range of fertility (71.64-75.76 %), hatchability (50.08-57.17%), dead in germ (55.00- 69.08%), dead in shell (11.20-18.225%) were significantly (P <0.05) better in Pander White (PW) sired progeny while number piped (13.06-20.11 %), brooding (3.00-4.6 %) and rearing (1.00-1.33 %) mortalities showed no significant difference (P>0.05) among the three sired progeny. The work also revealed that final body weight (153.79-159.78 g), daily weight gain (2.10- 2.19 g), daily feed intake (24.59-25.48 g), and feed conversion ratio (11.65-11.93) showed no significant difference (P>0.05) among the three sired progeny. The lower feed intake obtained in this experiment suggests that the feed given to these birds were able to meet up their dietary energy requirement. Panda White sired progeny gave the best feed conversion ratio. For the linear body parameters, PWxCB strain had higher thigh length (4.76 cm), breast width (7.44 cm), body length (12.09 cm), keel length (6.79 cm), and shank length (3.34 cm). The results indicate that Panda White sired progeny should be selected for better hatchability and growth performance for enhanced breeding program in the study area.Keywords: Sire, reproduction, hatchability, morphometric traits, growth performance,Japanese quail

Phenotypic correlations between body weight and morphometric traits in rabbits

This study aimed at determining the relationship between body weight and morphometric traits in rabbits. A total of 93 kittens generated from crosses of New Zealand White (NZW) x NZW, Chinchilla (CHA) x CHA, NZW x CHA and CHA x NZW genotypes of rabbits in a nested classification of a Completely Randomized Design were used for this study. Data on body weight (BW) and linear body measurements namely, body length (BL), ear length (EL), heart girth (HG), head- to- shoulder (HS), length of hind limb (LHB), length of forelimb (LFB), tail length (TL) and thigh girth (TG) in weeks 4, 8, and 12 were taken. The simple correlation procedure was used to establish the strength of relationship between growth traits. It was observed that in all the phenotypic correlations of the four (4) genotypes studied in week 4, the correlations were highly significant (P<0.01) and positive (0.70- 0.98), with the exception of CHA x NZW in which there were very low, negative and non-significant (P>0.05) correlation values (-0.11- 0.15), which implies weak association between morphometric traits and body weight. The phenotypic correlations observed in the four (4) genotypes in week 8 were highly significant and positive (0.70- 0.97), with the exception of those of NZW x NZW which had negative correlations between some of the growth traits (-0.01- -0.33), and CHA x NZW which had lower values between some of the growth traits (-0.04- 0.35). The phenotypic correlations observed in the four (4) genotypes in week 12 were non-significant (P>0.05) and low (0.02- 0.39), with the exception of NZW x CHA which had positive and very high significant values (0.70- 0.92), which implies a very strong association between morphometric traits and body weight in this genotype. It is therefore concluded that the NZW x CHA rabbits should be used for growth purposes rather than the other genotypes used for this study. Keywords: Rabbit genotypes, body weight, morphometric traits, phenotypic correlatio

Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats

From Elsevier via Jisc Publications RouterHistory: accepted 2022-03-18, epub 2022-03-25, issued 2022-03-31Article version: VoRPublication status: PublishedBackground Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. Cucumeropsis mannii seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. Methods A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. Results BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. Conclusions CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity

Hearing loss prevalence and years lived with disability, 1990-2019: findings from the Global Burden of Disease Study 2019

Background Hearing loss affects access to spoken language, which can affect cognition and development, and can negatively affect social wellbeing. We present updated estimates from the Global Burden of Disease (GBD) study on the prevalence of hearing loss in 2019, as well as the condition's associated disability. Methods We did systematic reviews of population-representative surveys on hearing loss prevalence from 1990 to 2019. We fitted nested meta-regression models for severity-specific prevalence, accounting for hearing aid coverage, cause, and the presence of tinnitus. We also forecasted the prevalence of hearing loss until 2050. Findings An estimated 1·57 billion (95% uncertainty interval 1·51–1·64) people globally had hearing loss in 2019, accounting for one in five people (20·3% [19·5–21·1]). Of these, 403·3 million (357·3–449·5) people had hearing loss that was moderate or higher in severity after adjusting for hearing aid use, and 430·4 million (381·7–479·6) without adjustment. The largest number of people with moderate-to-complete hearing loss resided in the Western Pacific region (127·1 million people [112·3–142·6]). Of all people with a hearing impairment, 62·1% (60·2–63·9) were older than 50 years. The Healthcare Access and Quality (HAQ) Index explained 65·8% of the variation in national age-standardised rates of years lived with disability, because countries with a low HAQ Index had higher rates of years lived with disability. By 2050, a projected 2·45 billion (2·35–2·56) people will have hearing loss, a 56·1% (47·3–65·2) increase from 2019, despite stable age-standardised prevalence. Interpretation As populations age, the number of people with hearing loss will increase. Interventions such as childhood screening, hearing aids, effective management of otitis media and meningitis, and cochlear implants have the potential to ameliorate this burden. Because the burden of moderate-to-complete hearing loss is concentrated in countries with low health-care quality and access, stronger health-care provision mechanisms are needed to reduce the burden of unaddressed hearing loss in these settings. Funding Bill & Melinda Gates Foundation and WHO