Nebivolol And Quinapril Reduce P-Wave Duration And Dispersion In Hypertensive Patients

We aimed to investigate the effects of nebivolol and quinapril treatments on P-wave duration and dispersion in hypertensive patients. Hypertensive patients who were in sinus rhythm were assigned to the two treatment groups and received either 20 mg quinapril/day or 5 mg nebivolol/day. P-Wave dispersion (PWD) was measured at baseline and after four weeks of treatment and defined as the difference between the maximum (Pmax) and the minimum (Pmin) P-wave duration. The study group consisted of 54 patients (Mean age: 53 ± 9 years, 46% women) with 27 patients in each group. At 4-week follow up both treatment groups showed a significant reduction (p< 0.001) in systolic (SBP) and diastolic blood pressure (DBP). Heart rate (HR) reduction was significant in patients receiving nebivolol (P=0.001). Both groups showed a similar (P=0.413 for PWD, p=0.651 for Pmax) but significant reduction in PWD (nebivolol: -16± 14, P< 0.0001 and quinapril: -13± 11, P< 0.0001) and Pmax (nebivolol: -10± 11, P=0.001 and quinapril: -9± 11, P=0.001). A 2 (Time) x 2 (Group) mixed-model repeated-measures analysis of variance revealed that the main effect of Time was significant for Pmax (P=0.002) and PWD (P=0.008) after controlling for changes in SBP, DBP and HR. However, the main effect of Group and Time x Group interaction was not significant for both variables (All p values > 0.05). In conclusion, short-term treatment with nebivolol and quinapril produces a similar but significant reduction in Pmax and PWD in hypertensive patients. This effect is independent of blood pressure and heart rate changes

A CNN-Based Novel Approach for Classification of Sacral Hiatus with GAN-Powered Tabular Data Set

Caudal epidural anaesthesia is usually the most well-known technique in obstetrics to deal with chronic back pain. Due to variations in the shape and size of the sacral hiatus (SH), its classification is a crucial and challenging task. Clinically, it is required in trauma, where surgeons must make fast and correct selections. Past studies have focused on morphometric and statistical analysis to classify it. Therefore, it is vital to automatically and accurately classify SH types through deep learning methods. To this end, we proposed the Multi-Task Process (MTP), a novel classification approach to classify the SH MTP that initially uses a small medical tabular data set obtained by manual feature extraction on computed tomography scans of the sacrums. Second, it augments the data set synthetically through a Generative Adversarial Network (GAN). In addition, it adapts a two-dimensional (2D) embedding algorithm to convert tabular features into images. Finally, it feeds images into Convolutional Neural Networks (CNNs). The application of MTP to six CNN models achieved remarkable classification success rates of approximately 90 % to 93 %. The proposed MTP approach eliminates the small medical tabular data problem that results in bone classification on deep models

Ozone Therapy and Hyperbaric Oxygen Treatment in Lung Injury in Septic Rats

Various therapeutic protocols were used for the management of sepsis including hyperbaric oxygen (HBO) therapy. It has been shown that ozone therapy (OT) reduced inflammation in several entities and exhibits some similarity with HBO in regard to mechanisms of action. We designed a study to evaluate the efficacy of OT in an experimental rat model of sepsis to compare with HBO. Male Wistar rats were divided into sham, sepsis+cefepime, sepsis+cefepime+HBO, and sepsis+cefepime+OT groups. Sepsis was induced by an intraperitoneal injection of Escherichia coli; HBO was administered twice daily; OT was set as intraperitoneal injections once a day. The treatments were continued for 5 days after the induction of sepsis. At the end of experiment, the lung tissues and blood samples were harvested for biochemical and histological analysis. Myeloperoxidase activities and oxidative stress parameters, and serum proinflammatory cytokine levels, IL-1β and TNF-α, were found to be ameliorated by the adjuvant use of HBO and OT in the lung tissue when compared with the antibiotherapy only group. Histologic evaluation of the lung tissue samples confirmed the biochemical outcome. Our data presented that both HBO and OT reduced inflammation and injury in the septic rats' lungs; a greater benefit was obtained for OT. The current study demonstrated that the administration of OT as well as HBO as adjuvant therapy may support antibiotherapy in protecting the lung against septic injury. HBO and OT reduced tissue oxidative stress, regulated the systemic inflammatory response, and abated cellular infiltration to the lung demonstrated by findings of MPO activity and histopathologic examination. These findings indicated that OT tended to be more effective than HBO, in particular regarding serum IL-1β, lung GSH-Px and histologic outcome

Prognostic and Clinical Role of Contrast Enhancement on Magnetic Resonance Imaging in Patients with Bell’s Palsy

Objective:To investigate the prognostic value of the magnetic resonance imaging in Bell’s palsy patients.Methods:Patients who were diagnosed and treated with Bell’s palsy between October 2013 and March 2016 retrospectively selected. House–Brackmann grades, pre- and post-treatment pure tone audiograms, stapedial reflexes were analyzed and magnetic resonance imaging (MRI) scans with gadolinium-based contrast agents were evaluated. Contrast-enhanced segments of the facial nerve were determined. MRI findings were compared statistically with pre- and post-treatment grade, recurrence rate of Bell’s palsy, MRI scanning timing, presence of stapes reflexes and posttreatment recovery data.Results:No significant correlation was observed between pretreatment House–Brackmann grades and enhancement (p>0.05). Similarly, there was no significant correlation between clinical recovery and enhancement (p>0.05). Also, no significant correlation was observed between MRI scanning time, the recurrence rate of Bell’s palsy and MRI findings (p>0.05). None of the MRIs showed neoplastic contrast enhancement.Conclusion:The routine use of the contrast-enhanced temporal MRI is not recommended in the diagnosis and monitoring of Bell’s palsy patients, because the contrast enhancement pattern of the facial nerve has no effect on the prognosis of Bell’s palsy. MRI should be used in cases that do not heal despite treatment, for the differential diagnosis of facial nerve tumors and in patients who are candidates for surgical decompression

A kinetic study of mercury(II) transport through a membrane assisted by new transport reagent

Background: A new organodithiophosphorus derivative, namely O-(1,3-Bispiperidino-2-propyl)-4-methoxy phenyldithiophosphonate, was synthesized and then the kinetic behavior of the transport process as a function of concentration, temperature, stirring rate and solvents was investigated.Results: The compound 1 was characterized by elemental analysis, IR, H-1 and P-31 NMR spectroscopies. The transport of mercury(II) ion by a zwitterionic dithiophosphonate 1 in the liquid membrane was studied and the kinetic behavior of the transport process as a function of concentration, temperature, stirring rate and solvents was investigated. The compound 1 is expected to serve as a model liquid membrane transport with mercury(II) ions.Conclusion: A kinetic study of mercury(II) transport through a membrane assisted by O-(1,3-Bispiperidino-2-propyl)4-methoxy phenyldithiophosphonate was performed. It can be concluded that the compound 1 can be provided a general and straightforward route to remove toxic metals ions such as mercury(II) ion from water or other solution

Conversion in Turkish : an overview

This paper presents an overview of possible cases of conversion in Turkish. I argue that apparent cases of conversion between nouns and adjectives are cases of syntactic transposition, and apparent cases of conversion between nouns/adjectives and verbs are end products of phonological changes in the history of the language, which resulted in pairs of lexemes that are formally identical synchronically, but not historically. This does not mean that no cases of morphological conversion can be traced in the language. I will present two cases of secondary word-class conversion from derived, inflected and uninflected words to toponyms which might be taken as instances of morphological conversion or derivation by zero-affixation

Karaciğer yaralanması nedeniyle cerrahi tedavi uygulanan 280 hastanın retrospektif değerlendirilmesi

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.Ege Üniversitesi Tıp Fakültesi Genel Cerrahi ünabilim Dalı1 uda..Ocak 1977- Ocak 1987 tarihleri arasında Karaciğer yaralanması nedeniyle ameliyat edilen 280 olgu incelendi. Geriye dönük olarak yapılan bu çalışmada %. 83.92' Binin er kek olduğu, % 50.35 olgunun kunt travma Bonucu yaralandığı saptandı. En sık yaralanma 21-30 yaşları arasında, yaş or talaması 30.4 olarak bulundu. En sık sağ lobda yaralanma oluştuğu gözlendi. Olguların % 80' inde karaciğer ile bir likte ek organ yaralanması mevcuttu. Tedavide yeşitli iş lemler uygulandı. Olguların % 14.28' inde (40 hastada) 51 ölümcül olmayan komplikasyon gelişti. 61 hasta yeşitli ne denlerle eksitus oldu. Hastanın haetahaneye gelişine kadar olan dönemde yapılan işlemlerin, karın idindeki kanamaya veya ekstraabdominal kanamaya bağlı gelişen preşok ve şok'- utı, karaciğer ile birlikte yaralanan organların sayı ve özelliğinin mortalite ve morbiditeyi etkilediği gözlend

On the IEEE 802.15.4 MAC Layer Attacks: GTS Attack

2nd International Conference on Sensor Technologies and Applications, SENSORCOMM 2008; Cap Esterel; France; 25 August 2008 through 31 August 2008In the last several years IEEE 802.15.4 [1] has been accepted as a major MAC layer protocol for wireless sensor networks (WSNs) and has attracted the interest of the research community involved in security issues as the increased range of application scenarios bring out new possibilities for misuse and taking improper advantage of sensor nodes and their operation. As these nodes are very resource restrained such possible attacks and their early detection must be carefully considered. This paper surveys the known attacks on wireless sensor networks, identifies and investigates a new attack, Guaranteed Time Slot (GTS) attack, taking as a basis the IEEE 802.15.4 MAC protocol for WSN. The GTS Attack is simulated with different scenarios using ns-2 and the results are evaluated both from the point of view of the attacked and the attacker