Assessment of neuroactive steroids in cerebrospinal fluid comparing acute relapse and stable disease in relapsing-remitting multiple sclerosis

Previous studies have reported an involvement of neuroactive steroids as neuroprotective and anti-inflammatory agents in neurological disorders such as multiple sclerosis (MS); an analysis of their profile during a specific clinical phase of MS is largely unknown. The pregnenolone (PREG), dehydroepiandrosterone (DHEA), and allopregnanolone (ALLO) profile was evaluated in cerebrospinal fluid (CSF) in relapsing-remitting multiple sclerosis (RR-MS) patients as well as those in patients affected by non-inflammatory neurological (control group I) and without neurological disorders (control group II). An increase of PREG and DHEA values was shown in CSF of male and female RR-MS patients compared to those observed in both control groups. The ALLO values were significantly lower in female RR-MS patients than those found in male RR-MS patients and in female without neurological disorder. During the clinical relapse, we observed female RR-MS patients showing significantly increased PREG values compared to female RR-MS patients in stable phase, while their ALLO values showed a significant decrease compared to male RR-MS patients of the same group. Male RR-MS patients with gadolinium-enhanced lesions showed PREG and DHEA values higher than those found in female RR-MS patients with gadolinium-enhanced lesions. Similary, male RR-MS patients with gadolinium-enhanced lesions showed PREG and DHEA values higher than male without gadolinium-enhanced lesions. Female RR-MS patients with gadolinium-enhanced lesions showed DHEA values higher than those found in female RR-MS patients with gadolinium-enhanced lesions. Male and female RR-MS patients with gadolinium-enhanced lesions showed ALLO values higher than those found in respective gender groups without gadolinium-enhanced lesions. ALLO values were lower in male than in female RR-MS patients without gadolinium-enhanced lesions. Considering the pharmacological properties of neuroactive steroids and the observation that neurological disorders influence their concentrations, these endogenous compounds may have an important role as prognostic factors of the disease and used as markers of MS activity such as relapses

Design of hybrid-electric aircraft with fault-tolerance considerations

The potential benefits of hybrid-electric or all-electric propulsion have led to a growing interest in this topic over the past decade. Preliminary design of propulsion systems and innovative configurations has been extensively discussed in literature, but steps towards higher levels of technological readiness, optimisation algorithms based on reliable weight estimation and simulation-based mission analysis are required. This paper focuses on the integration of a method for evaluating the lateral-directional controllability of an aircraft within a design chain that integrates aero-propulsive interactions, accurate modelling of the fuel system, and mid-fidelity estimation of the structural weight. Furthermore, the present work proposes a strategy for powerplant management in scenarios with an inoperative chain element. Benefits of hybrid-electric propulsion on the design of the vertical tail plane are evaluated involving the analysis of multiple failure scenarios and certification requirements. The proposed application concerns a commuter aircraft

Development of systemic autoimmune diseases in healthy subjects persistently positive for antiphospholipid antibodies. long-term follow-up study

We longitudinally followed a single-center cohort of anti-phospholipid (aPL) positive healthy subjects to evaluate the evolution to systemic autoimmune diseases (sAD) and to describe clinical and serological associated features. Since 2010, we have consecutively screened healthy subjects who were positive, in at least two consecutive determinations, for one or more aPL [anti-Cardiolipin (aCL) IgM/IgG, anti-Beta2Glycoprotein I (aB2GPI) IgM/IgG, Lupus Anticoagulant (LA)]. All subjects were evaluated every six months, or in accordance with the patient's clinical course, in order to record the development of clinical and laboratory features suggestive for sAD. Ninety-five subjects [M/F 20/75, median age at first determination 46 years, Interquartile Range (IQR) 19] were enrolled. Thirty-three subjects (34.7%) were positive for only one aPL [15 (15.8%) for aCL, 15 (15.8%) for LA, and 5 (5.3%) for aB2GPI]; 37 (38.9%) had double positivity [32 (33.6%) for aCL and aB2GPI; 5 (5.3%) for aCL and LA], 23 (24.2%) had triple positivity. We prospectively followed up our cohort for a median period of 72 months (IQR 84). During a total follow-up of 7692 person-months, we found an absolute risk for sAD development equal to 1.8%. Specifically, 14 (14.7%) patients developed a sAD: in four patients (4.2%), after developing a thrombotic event, an antiphospholipid syndrome was diagnosed, 7 (7.4%) patients developed an Undifferentiated Connective Tissue Disease after a median period of 76 months (IQR 75.5), and lastly, three (3.1%) patients could be classified as affected by Systemic Lupus Erythematosus according to the ACR/EULAR 2019 criteria. The presence of triple positivity status resulted in being significantly associated with the progression to sAD (p-value = 0.03). In conclusion, we observed the development of sAD in almost 15% of aPL positive subjects. Triple positivity was significantly associated with this progression, suggesting a possible role as biomarker for this condition. Thus, our results could suggest the need for periodic follow-up for such patients to assess early diagnosis and treatment

Long-term social value creation through CSR; A case study of Ferrarelle S.p.A.

In the last few years, the concept of Corporate Social Responsibility (CSR), its impact on the overall social well-being and social outcomes, has captured the interest of experts and academics. While many companies acknowledge it as an absolute strategical necessity, it is unlikely to be considered a tool to create value which goes beyond the company borders. The CSR is indeed often seen by companies simply as a way to draw positive public opinion; and even when defined by a true commitment, it fails to have a significant positive impact on society. For these reasons, CSR is seen by many as a failing attempt to turn business organizations, naturally led by the pursuit of profit, into socially oriented organizations, inconsistent with their fundamental mission. The purpose of this thesis is to develop a new concept of CSR, to work potentially as a tool to enhance companies’ business competitiveness as well as to generate “social value”. To this end, the opinions and theories of several experts were analyzed with the aim to shape a theoretical framework for CSR evolution, by stressing the crucial role of stakeholders and non-governmental organizations (NGOs). The focus is on the successful implementation of a CSR policy undertaken by the Italian company Ferrarelle S.p.A., which is active in the bottled water industry. Lastly, the data gathered were compared with the findings of the literature review in order to propose an innovative framework for sustainable and socially effective CSR.MSc in Innovation and Industrial Managemen

Bioclimatic and green building for the enhancement of rural architecture. Rehabilitate the Masseria Nicotera to Marigliano

After almost a century of investigation on the architectural value of rural buildings in all its connections with landscape, the recovery approach has not overcome the phase of ethic imperative. The effective possibilities to rehabilitation existing structures are left to the project that, through its interdisciplinarity, should specify the modalities, from the technical point of view as well as from the environmental, social, and economic advantages one. This paper aims to re-inhabit the rural buildings closer to urban centers. The methodological approach is based on a bioclimatic project integrated with green building, which had been tested in a rural house of the seventeenth century: Masseria Nicotera to Marigliano, in the province of Naples. Indeed, the bioclimatic matrix of rural architecture has been recovered and reintroduced, after being improved by the passive system and integrated by natural material. The project has been supported also by the assessment of the economic benefit and the estimation contributions that are not good for themselves but constitutes the beginning of a database available at the national level for the recovery of rural architecture

Trade liberalization and the wage gap: the role of vertical linkages and fixed costs

This paper studies the labor market impacts of trade liberalization, and specifically tariff reductions, with a focus on the wage gap between skilled and unskilled workers in presence of vertical linkages in the fixed costs of production. To that purpose, we develop and empirically test a monopolistic competition model with variable elasticity of substitution and labor differentiated by skill level, where skilled workers are the residual claimants of savings on imported inputs. Consistently with the model predictions, we find that a 10% reduction in tariffs implies on average a 3.8% increase in the wage gap. In addition, the same level of tariff reduction is expected to lower unskilled employment in domestic production by 3.3%, which is partially offset by an expansion of unskilled employment in the export segment of production. These results are obtained matching detailed international trade data with World Input–Output Tables and EU KLEMS data on country-sector wage by skill level on 17 OECD countries from 1996 to 2005

Tariff reductions, trade patterns and the wage gap

This paper studies the impact of trade liberalization on labor market outcomes. First, we find that bilateral trade liberalization does not affect exports towards third countries. To accommodate this novel result, we deviate from existing literature and rely on a three-country monopolistic competition framework with variable elasticity of substitution and vertical linkages in fixed costs. The resulting model predicts that trade liberalization is associated with an increase in the skill-driven wage gap and a reduction in unskilled employment. This prediction is empirically validated using EU-KLEMS data on country-sector wage by skill level on 17 OECD countries from 1996 to 2005

Trade liberalization and the wage gap: the role of vertical linkages and fixed costs

This paper studies the labor market impacts of trade liberalization, and specifically tariff reductions, with a focus on the wage gap between skilled and unskilled workers in presence of vertical linkages in the fixed costs of production. To that purpose, we develop and empirically test a monopolistic competition model with variable elasticity of substitution and labor differentiated by skill level, where skilled workers are the residual claimants of savings on imported inputs. Consistently with the model predictions, we find that a 10% reduction in tariffs implies on average a 3.8% increase in the wage gap. In addition, the same level of tariff reduction is expected to lower unskilled employment in domestic production by 3.3%, which is partially offset by an expansion of unskilled employment in the export segment of production. These results are obtained matching detailed international trade data with World Input–Output Tables and EU KLEMS data on country-sector wage by skill level on 17 OECD countries from 1996 to 2005.JRC.B.3-Territorial Developmen

"Like the palm of my hands": Motor imagery enhances implicit and explicit visual recognition of one's own hands

A key point in motor imagery literature is that judging hands in palm view recruits sensory-motor information to a higher extent than judging hands in back view, due to the greater biomechanical complexity implied in rotating hands depicted from palm than from back. We took advantage from this solid evidence to test the nature of a phenomenon known as self-advantage, i.e. the advantage in implicitly recognizing self vs. others' hand images. The self-advantage has been actually found when implicitly but not explicitly judging self-hands, likely due to dissociation between implicit and explicit body representations. However, such a finding might be related to the extent to which motor imagery is recruited during implicit and explicit processing of hand images. We tested this hypothesis in two behavioural experiments. In Experiment 1, right-handed participants judged laterality of either self or others' hands, whereas in Experiment 2, an explicit recognition of one's own hands was required. Crucially, in both experiments participants were randomly presented with hand images viewed from back or from palm. The main result of both experiments was the self-advantage when participants judged hands from palm view. This novel finding demonstrate that increasing the "motor imagery load" during processing of self vs. others' hands can elicit a self-advantage in explicit recognition tasks as well. Future studies testing the possible dissociation between implicit and explicit visual body representations should take into account the modulatory effect of motor imagery load on self-hand processing