Aligning Collections With Emerging Needs in Research Informatics

Some of the North Carolina State University (NCSU) Libraries’ largest investments are in collections, digital library development, and technology‐rich collaborative spaces. The goal of the NCSU Libraries Fellows Program initiative, Aligning Collections with Emerging Needs in Research Informatics, is to ensure these areas leverage one another to the benefit of our users in support of emerging research informatics needs through licensing and acquisition of new data sources, as well as leveraging the capabilities of new high‐tech library spaces. Over its two years, this initiative seeks to address and mainstream subject specialists’ and selectors’ consideration of high‐tech research informatics needs of users. Early accomplishments of the initiative include content mining agreements, increased awareness of scholarly APIs, and an ontology to describe research informatics. Ongoing work includes an investigation of relevant collections, licensing terms, and the landscape of the current marketplace; an environmental scan of NCSU research and teaching contexts that would benefit from greater availability of content as data for computational purposes; how‐to documentation and training for more technologically sophisticated uses of existing resources; negotiations of select licenses to allow for more flexibility of content use; and revision of our website to promote the research informatics capacities of the Libraries’ collections to our users

Extended interactions with prothrombinase enforce affinity and specificity for its macromolecular substrate.

The specific action of serine proteinases on protein substrates is a hallmark of blood coagulation and numerous other physiological processes. Enzymic recognition of substrate sequences preceding the scissile bond is considered to contribute dominantly to specificity and function. We have investigated the contribution of active site docking by unique substrate residues preceding the scissile bond to the function of prothrombinase. Mutagenesis of the authentic P(1)-P(3) sequence in prethrombin 2/fragment 1.2 yielded substrate variants that could be converted to thrombin by prothrombinase. Proteolytic activation was also observed with a substrate variant containing the P(1)-P(3) sequence found in a coagulation zymogen not known to be activated by prothrombinase. Lower rates of activation of the variants derived from a decrease in maximum catalytic rate but not in substrate affinity. Replacement of the P(1) residue with Gln yielded an uncleavable derivative that retained the affinity of the wild type substrate for prothrombinase but did not engage the active site of the enzyme. Thus, active site docking of the substrate contributes to catalytic efficiency, but it is does not determine substrate affinity nor does it fully explain the specificity of prothrombinase. Therefore, extended interactions between prothrombinase and substrate regions removed from the cleavage site drive substrate affinity and enforce the substrate specificity of this enzyme complex

Building a QC Database of Meteorological Data from NASA KSC and the United States Air Force's Eastern Range

The National Aeronautics and Space Administration's (NASA) Marshall Space Flight Center (MSFC) Natural Environments Branch (EV44) provides atmospheric databases and analysis in support of space vehicle design and day-of-launch operations for NASA and commercial launch vehicle programs launching from the NASA Kennedy Space Center (KSC), co-located on the United States Air Force's Eastern Range (ER) at the Cape Canaveral Air Force Station. The ER complex is one of the most heavily instrumented sites in the United States with over 31 towers measuring various atmospheric parameters on a continuous basis. An inherent challenge with large datasets consists of ensuring erroneous data are removed from databases, and thus excluded from launch vehicle design analyses. EV44 has put forth great effort in developing quality control (QC) procedures for individual meteorological instruments, however no standard QC procedures for all databases currently exists resulting in QC databases that have inconsistencies in variables, development methodologies, and periods of record. The goal of this activity is to use the previous efforts to develop a standardized set of QC procedures from which to build meteorological databases from KSC and the ER, while maintaining open communication with end users from the launch community to develop ways to improve, adapt and grow the QC database. Details of the QC procedures will be described. As the rate of launches increases with additional launch vehicle programs, It is becoming more important that weather databases are continually updated and checked for data quality before use in launch vehicle design and certification analyses

Development of IPv6

Recent advances in collaborative theory and interactive archetypes cooperate in or- der to realize the lookaside buffer. Given the current status of cacheable epistemologies, researchers shockingly desire the understanding of redundancy. We introduce a novel application for the deployment of access points (SheldInditer), showing that the seminal psychoacoustic algorithm for the unproven unification of 64 bit architectures and symmetric encryption is recursively enumerable. Of course, this is not always the case

Gnome site decontamination and decommissioning project

In July 1977, DOE/Headquarters directed DOE/NV to design a decontamination and decommissioning plan for the Gnome site, 48 kilometers southeast of Carlsbad, New Mexico. The plan incorporated three distinct phases. During Phase I, both aerial and ground radiological surveys were conducted on the site. Radiological decontamination criteria were established, and a decontamination plan was developed based on the radiological survey results. During Phase II, site preparatory and rehabilitation work was completed. The actual land area decontamination was accomplished during Phase III with conventional earthmoving equipment. A gravity water injection system deposited 36,700 metric tons of contaminated soil and salt in the Gnome cavity. After completion of the decontamination and decommissioning operations, the Gnome site was returned to the Bureau of Land Management for unrestricted surface use

Waveguide-coupled detector in zero-change complementary metal–oxide–semiconductor

We report a waveguide-coupled photodetector realized in a standard CMOS foundry without requiring changes to the process flow (zero-change CMOS). The photodetector exploits carrier generation in the silicon-germanium normally utilized as stressor in pFETs. The measured responsivity and 3 dB bandwidth are of 0.023 A/W at a wavelength of 1180 nm and 32 GHz at −1 V bias (18 GHz at 0 V bias). The dark current is less than 10 pA and the dynamic range is larger than 60 dB.United States. Defense Advanced Research Projects Agency. Photonically Optimized Embedded Microprocessors Program (Award HR0011-11-C-0100)United States. Defense Advanced Research Projects Agency. Photonically Optimized Embedded Microprocessors Program (Contract HR0011-11-9-0009

A Lanthanide-Based Chemosensor for Bioavailable Fe3+ Using a Fluorescent Siderophore: An Assay Displacement Approach

The measurement of trace analytes in aqueous systems has become increasingly important for understanding ocean primary productivity. In oceanography, iron (Fe) is a key element in regulating ocean productivity, microplankton assemblages and has been identified as a causative element in the development of some harmful algal blooms. The chemosenor developed in this study is based on an indicator displacement approach that utilizes time-resolved fluorescence and fluorescence resonance energy transfer as the sensing mechanism to achieve detection of Fe3+ ions as low as 5 nM. This novel approach holds promise for the development of photoactive chemosensors for ocean deployment

Tolerance analysis for efficient MMI devices in silicon photonics

The proceeding at: IX Conference Silicon Photonics, took place at 2014, March, 8 in S. Francisco (USA).Silicon is considered a promising platform for photonic integrated circuits as they can be fabricated in state-of-the-art electronics foundaries with integrated CMOS electronics. While much of the existing work on CMOS photonics has used directional couplers for power splitting, multimode interference (MMI) devices may have relaxed fabrication requirements and smaller footprints, potentially energy efficient designs. They have already been used as 1x2 splitters, 2x1 combiners in Quadrature Phase Shift Keying modulators, and 3-dB couplers among others. In this work, 3-dB, butterfly and cross MMI couplers are realized on bulk CMOS technology. Footprints from around 40um2 to 200 um2 are obtained. MMI tolerances to manufacturing process and bandwidth are analyzed and tested showing the robustness of the MMI devices.This work has been sponsored by the Spanish institutions Ministerio de Economía y Competitividad under project TEC2012-37983-C03-02, and grant EEBB-1-13-07511, Ministerio de Educación under grant PRX12/00007 and Fundación Caja Madrid.Publicad