Slováci v Praze v době tzv. normalizace

The aim of the final thesis will be to examine the Slovak community in Prague during the socalled normalization period. The year 1968 is set as a fundamental milestone when significant events took place in the development of Czechoslovakia. In the thesis, we will be interested in the motivations behind the arrival of Slovaks in Prague, their assimilation in the new environment, and how they perceived the different cultural surroundings. An important assumption is that Slovaks came to Prague in order to improve their standard of living. At the same time, the scope of our research is limited to the 1970s, and we will attempt to analyze in more detail the experiences of Slovaks in Prague who migrated during this period.Cieľom záverečnej práce bude pozrieť sa na komunitu Slovákov v Prahe v čase tzv. normalizácie. Rok 1968 je stanovený ako základný medzník, kedy sa odohrali prelomové udalosti vo vývoji Československa. V práci nás bude zaujímať, aké boli motivácie príchodu Slovákov do Prahy, aká bola ich asimilácia v novom prostredí, respektíve ako vnímali iné kultúrne prostredie. Dôležitým predpokladom je príchod Slovákov do Prahy z dôvodu vylepšenia životnej úrovne. Zároveň je okruh nášho výskumu obmedzený na sedemdesiate roky a pokúsime sa detailnejšie rozobrať osudy pražských Slovákov, ktorí sa prisťahovali do Prahy v tomto období.Programme Oral History and Contemporary HistoryProgram Orální historie - soudobé dějinyFaculty of HumanitiesFakulta humanitních studi

Utjecaj stadija laktacije na dnevnu proizvodnju mlijeka, udjele mliječne masti i bjelančevina u ovaca pasmine cigaja i Valachian

The objective of this study was to analyse the effect of stage of lactation on daily milk yield, and milk fat and protein content in Tsigai and Improved Valachian ewes. Breed lactation curves for daily milk yield, and milk fat and protein content were modelled as a sub-model of the three-trait animal model based on repeated test-day records that were collected by the Breeding Services of the Slovak Republic between 1995 and 2010. Data included 188403 (Tsigai) and 352094 (Improved Valachian) ewe’s performance records. Pedigree file included 35484 (Tsigai) and 66994 (Improved Valachian) animals with genetic ties to ewes with milk performance data. The fixed part of the model included parity, litter size and stage of lactation. The effect of days in milk (i.e. stage of lactation) was fitted using Ali and Schaeffer lactation curve. The random part of the model included flock-test day effect, direct additive genetic effect, and permanent environmental effect of ewe nested within lactation. Due to limited number of test-day records in the first and the eighth month of lactation and related difficulties in modelling milk traits in these phases of lactation, the lactation curves were plotted between days 30 and 210. During lactation period the daily milk yield curves were decreasing, while milk fat and protein content were increasing. Because of higher changes at the beginning of lactation balanced with higher changes at the end of lactation in Tsigai and smaller changes at the beginning of lactation balanced with smaller changes at the end of lactation in Improved Valachian, 150d milk yield and average milk fat and protein content were almost the same in both breeds.Svrha ovog istraživanja bila je analizirati utjecaj stadija laktacije na dnevnu proizvodnju mlijeka, udjele mliječne masti i bjelančevina u ovaca pasmine cigaja i Valachian. Laktacijske krivulje za dnevnu proizvodnju mlijeka, mliječne masti i bjelančevina modelirane su kao pod-model životinjskog modela (za 3 svojstva) temeljenog na testnim mjerenjima koje su prikupljene od uzgojne službe Republike Slovačke između 1995. i 2010. Ukupno je analizirano 188.403 podataka (za cigaja pasminu) i 352.094 podataka (za Valachian pasminu). Podaci o karakteristikama mliječnosti uzeti su za ukupno 35.484 ovaca pasmine cigaja, i 66.994 ovaca pasmine Valachian. Fiksni dio modela uključivao je redni broj laktacije, veličinu legla i stadij laktacije. Učinak stadija laktacije utvrđen je pomoću Ali-Schaeffer laktacijske krivulje. Nasumični dio modela uključuje utjecaj testnog dana, direktni aditivni genetski efekt i trajan utjecaj okoliša na laktaciju. Zbog ograničenog broja dnevnih kontrola u prvom i osmom mjesecu laktacije i sličnih poteškoća u modeliranju osobina mliječnosti u tim fazama laktacije, laktacijske krivulje prikazane su između 30 i 210 dana. Proizvodnja mlijeka prema laktacijskim krivuljama smanjivala se prema kraju laktacije, dok su se koncentracije mliječne masti i proteina povećavale. Tijekom 150-dnevne proizvodnje mlijeka, u obje pasmine je zabilježena gotova jednaka količina mlijeka, te koncentracija mliječne masti i proteina

Study of the intersection of road I/38 with road III/40826 in Kravsko

Cieľom diplomovej práce je vypracovať štúdiu križovatky cesty I/38 s cesty III/40826 vrátane autobusových zastávok, ktoré sa na danej križovatke nachádzajú. Štúdia bude mať 3 varianty –priesečná križovatka s odbočovacím pruhom vľavo, okružná a mimoúrovňová. Dôvodom štúdie je nevyhovujúce usporiadanie stávajúceho stavu.The aim of the diploma thesis is to develop a study of the intersection od road I/38 with road III/40826, including bus stops, which are located at the intersection. The study will have 3 variants –intersection with pedestrian crossings, circular and extra-level. The reason for the study is the dangerous arrangement of the current state.

Etnické postoje a výchova k tolerancii

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The Impact of Socially - Pathological Phenomena in a Family on the School results of Children

katedra: KSS; přílohy: CD-ROM; rozsah: 74This bachelor´s work was focused on the issue of socially pathological phenomena, especially domestic violence and it´s impact on the development of the physical and mental state of a child. It´s aim was to analyse the domestic violence experience on a sample of chosen people and establish and prove it´s impact on the development of a child. This work consisted of two parts; Theoretical and practical. The theoretical part defined socially pathological phenomena with a focus on domestic violence and the results of the practical part were focused on the impact of domestic violence and help with dealing with it in the Liberec region.Tato bakalářská práce se zabývala problematikou sociálně patologických jevů, zejména domácím násilím a jeho dopadem na vývoj dítěte. Cílem bylo analyzovat na vzorku respondentů jejich zkušenosti s domácím násilím, přičemž zřetel byl kladen na dopad domácího násilí ve vývoji dítěte. Práci tvořila teoretická a praktická část. Teoretická část pomocí použitých zdrojů vymezila problematiku sociálně patologických jevů, zejména pak domácího násilí a výsledky praktické části byly zaměřeny na dopad a pomoc při tomto sociálně patologickém jevu v Libereckém regionu

Neurobiologické koreláty paměti epizodického typu

Deklaratívna pamäť je definovaná ako pamäť uvedomovaná, explicitná. Jedným zo zásadných systémov deklaratívnej pamäti je okrem sémantickej pamäti aj pamäť epizodická, ktorá nám umožňuje vybaviť si konkrétnu udalosť z minulosti. Na štúdium mechanizmov epizodickej pamäti sa často využíva zjednodušený model, tzv. pamäť epizodického typu. Podľa tohto modelu je každá spomienka uložená v určitom kontextuálnom rámci, charakterizovanom tromi základnými podmienkami: identitou udalosti (‚Čo sa stalo?'), časom (,Kedy sa to stalo?') a priestorovou zložkou (,Kde sa to stalo?'). Tento typ pamäte je testovateľný nielen u ľudí, ale aj u animálnych modelov. Cieľom diplomovej práce je študovať neurobiologický substrát jednotlivých komponent epizodickej pamäti za pomoci funkčnej magnetickej rezonancie (fMRI) u zdravých dobrovoľníkov, za využitia ekologicky validných úloh vytvorených v prostredí virtuálnej reality. Výsledky dát získaných prostredníctvom fMRI úlohy ukazujú, že okrem spoločného neuronálneho substrátu epizodickej pamäti, existujú do istej miery odlišné mozgové štruktúry zodpovedné za vybavenie jednotlivých komponent modelu pamäti epizodického typu. Behaviorálne dáta naznačujú, že náročnosť vybavenia jednotlivých komponent nie je rovnocenná. Doplňujúca analýza využívajúca parceláciu mozgu na jednotlivé...Declarative memory is characterized as a conscious, explicit memory. Declarative memory consists of two essential systems, semantic memory and episodic memory. Episodic memory enables us to recall specific past events. A simplified model, so called Episodic-like memory is often used to study episodic memory mechanisms. According to this model, all events are stored in a contextual framework consisting of three basic components: identity of the object ('what' happened), temporal information ('when' it occurred) and spatial information ('where' did it happen). This type of memory is testable not only in humans but also in animal models. Aim of this diploma thesis is to study the neuronal substrate of individual components of episodic memory in healthy volunteers by means of functional magnetic resonance imaging (fMRI) and ecologically valid tasks designed in virtual reality environment. Results obtained in the fMRI paradigm show that apart from common neuronal substrate of episodic memory, additional brain structures are responsible for recollection of individual components of the episodic-like memory. Behavioral data indicate that the demands of the recollection of individual components is not equivalent. Additional analyses with parcellation of the brain to individual structures and consecutive...Katedra fyziologieDepartment of PhysiologyFaculty of SciencePřírodovědecká fakult

Study of the intersection of road I/38 with road III/40826 in Kravsko

Cieľom diplomovej práce je vypracovať štúdiu križovatky cesty I/38 s cesty III/40826 vrátane autobusových zastávok, ktoré sa na danej križovatke nachádzajú. Štúdia bude mať 3 varianty a jednu subvariantu – mimoúrovňová, okružná, priesečná s prechodmi pre chodcov a priesečná s podchodom. Dôvodom štúdie je nebezpečné usporiadanie stávajúceho stavu.The aim of the diploma thesis is to develop a study of the intersection od road I/38 with road III/40826, including bus stops, which are located at the intersection. The study will have 3 variants and one subvariant – extra-level, circular, intersection with pedestrian crossings and intersection with an underpass. The reason for the study is the dangerous arrangement of the current state.

Transcription factors CSL and their role in the yeast Schizosaccharomyces pombe

Proteiny rodiny CSL (CBF1/RBP-Jκ/Suppressor of Hairless/LAG-1) působí v organismech říše Metazoa jako efektory signální dráhy Notch. V rámci této signalizace fungují jako represory nebo aktivátory transkripce genů a ovlivňují mnoho vývojových procesů. Metazoální proteiny CSL mohou regulovat expresi genů také nezávisle na Notch. Funkce proteinů CSL nezávislé na Notch by mohly být evolučně původní a pro buňku a organismus mohou být neméně důležité jako funkce dependentní na Notch. Přítomnost proteinů CSL byla zjištěna i u některých organismů říše Fungi, které postrádají komponenty signální dráhy Notch a většinu známých metazoálních interakčních partnerů proteinů CSL. Paralogy CSL poltivé kvasinky Schizosaccharomyces pombe, cbf11 a cbf12, jsou neesenciální geny kódující proteiny lokalizované v jádře buňky. Oba se antagonistickým způsobem zapojují do regulace procesů jako například koordinace jaderného a buněčného dělení a průchodu buněčným cyklem, udržování ploidie, adhezivity buněk a dalších. V této práci jsme prokázali, že oba paralogy CSL mají schopnost sekvenčně specificky vázat kanonický CSL-responzivní element DNA in vitro a Cbf11 také in vivo. Oba proteiny mohou aktivovat genovou expresi in vivo, a vykonávat tak funkci transkripčních faktorů. Pomocí metody ChIP-chip jsme analyzovali vazbu...Proteins of the CSL family (CBF1/RBP-Jκ/Suppressor of Hairless/LAG-1) act as effectors of the Notch signalling pathway in metazoan organisms. They function as repressors or activators of gene transcription in the framework of this pathway and influence many developmental processes. Metazoan CSL proteins can regulate gene expression Notch-independently as well. Notch-independent functions of CSL proteins might be evolutionarily ancestral and in cells and organisms may be important equally as Notch-dependent functions. Presence of CSL proteins was identified in several fungal species, organisms lacking the Notch signalling pathway components and most of known metazoan interacting partners of CSL proteins. CSL paralogs of the fission yeast Schizosaccharomyces pombe, cbf11 and cbf12, are non-essential genes encoding proteins localized in the nucleus of the cell. They exert antagonistic effects on regulation of processes like coordination of nuclear and cellular division and cell cycle progression, ploidy maintenance, cell adhesion and other. In this study, we have proved that both CSL paralogs are able to sequence-specifically bind the CSL-response element DNA in vitro and Cbf11 in vivo as well. Both proteins could activate gene expression in vivo and perform the function of transcription factors....Katedra buněčné biologieDepartment of Cell BiologyPřírodovědecká fakultaFaculty of Scienc

The effects of birth and calving seson and birth year on milk production and composition in first lactating cows

The aim of this study was to investigate the effects of birth and calving season (spring, summer, autumn, and winter (astronomical)) and birth year on milk production and composition (content of lactose, fat, protein, and total fat and protein (kg, %)) of Holstein first lactating cows. The analysed data based on milk production records of the first lactation Holstein cows (n=158 and n=246 on farm 1 and farm 2, resp.) recorded within the years of 2013 to 2017 on two farms in west part of Slovakia. The birth season of heifers had no significant effect on the milk composition and production. The significant effect of birth year was observed on all parameters evaluated, except on total fat and protein content (%). Milk yield, depending on the birth year, increased from 7793.31±1629.31 kg (in cows born in year 2013) to 9628.76±1386.45 kg (in cows born in year 2017). Similarly, the content (kg) of all components evaluated was higher in cows born in year 2017 than in cows born in year 2013. The influence of the farm was evident in all parameters evaluated, except for total fat and protein and lactose content (%). Milk production and milk composition of first-lactation cows appear to be influenced by factors other than calving and birth season. The management practices implemented on the evaluated farms could be one of the influencing factor

The effects of birth and calving seson and birth year on milk production and composition in first lactating cows

The aim of this study was to investigate the effects of birth and calving season (spring, summer, autumn, and winter (astronomical)) and birth year on milk production and composition (content of lactose, fat, protein, and total fat and protein (kg, %)) of Holstein first lactating cows. The analysed data based on milk production records of the first lactation Holstein cows (n=158 and n=246 on farm 1 and farm 2, resp.) recorded within the years of 2013 to 2017 on two farms in west part of Slovakia. The birth season of heifers had no significant effect on the milk composition and production. The significant effect of birth year was observed on all parameters evaluated, except on total fat and protein content (%). Milk yield, depending on the birth year, increased from 7793.31±1629.31 kg (in cows born in year 2013) to 9628.76±1386.45 kg (in cows born in year 2017). Similarly, the content (kg) of all components evaluated was higher in cows born in year 2017 than in cows born in year 2013. The influence of the farm was evident in all parameters evaluated, except for total fat and protein and lactose content (%). Milk production and milk composition of first-lactation cows appear to be influenced by factors other than calving and birth season. The management practices implemented on the evaluated farms could be one of the influencing factor