20 research outputs found

    The disruption of proteostasis in neurodegenerative diseases

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    Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio

    Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

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    [This corrects the article DOI: 10.1186/s13054-016-1208-6.]

    The gene and microRNA networks of stem cells and reprogramming

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    High-mobility group box 1 is a promising diagnostic and therapeutic monitoring biomarker in Cancers: A review

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    Surface protection of Mg alloys in automotive applications: A review

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    Morphology and ultrastructure of retrovirus particles

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    Numerical techniques for electromagnetic simulation of daytime radiative cooling: A review

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    The role of melatonin in autoimmune and atopic diseases

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    Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin

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