Benefit of 5S system in waste elimination: A case study in Faber Medi-Serve Sdn Bhd

5S system has been implemented in the manufacturing field to help eliminate the waste and to improve the productivity for an organization.The highlight and objectives for this paper is to show the implementation of 5S system in helping Faber Medi-Serve SDN.BHD to improve; the performance of work done, service quality and elimination of waste.This project employs qualitative methods in the data collection stage, in the form of interviews. This project has reviewed the current practices of Faber Medi-Serve SDN. BHD. and has proven that 5S system is successful in developing good practice and deliver good result for the organization performance

Hyperspectral Cubesat Constellation for Rapid Natural Hazard Response

Earth Observing 1 (E0-1) satellite has an imaging spectrometer (hyperspectral) instrument called Hyperion. The satellite is able to image any spot on Earth in the nadir looking direction every 16 days. With slewing of the satellite and allowing for up to a 23 degree view angle, any spot on the Earth can be imaged approximately every 2 to 3 days. EO-1 has been used to track many natural hazards such as wildfires, volcanoes and floods. An enhanced capability that is sought is the ability to image natural hazards in a daily time series for space based imaging spectrometers. The Hyperion can not provide this capability on EO-1 with the present polar orbit. However, a constellation of cubesats, each with the same imaging spectrometer, positioned strategically in the same orbit, can be used to provide daily coverage, cost-effectively

Hyperspectral Cubesat Constellation for Natural Hazard Response (Follow-on)

The authors on this paper are team members of the Earth Observing 1 (E0-1) mission which has flown an imaging spectrometer (hyperspectral) instrument called Hyperion for the past 15+ years. The satellite is able to image any spot on Earth in the nadir looking direction every 16 days and with slewing, of the satellite for up to a 23 degree view angle, any spot on the Earth can be imaged approximately every 2 to 3 days. EO-1 has been used to track many natural hazards such as wildfires, volcanoes and floods. An enhanced capability that has been sought is the ability to image natural hazards in a daily time series for space-based imaging spectrometers. The Hyperion cannot provide this capability on EO-1 with the present polar orbit. However, a constellation of cubesats, each with the same imaging spectrometer, positioned strategically can be used to provide daily coverage or even diurnal coverage, cost-effectively. This paper sought to design a cubesat constellation mission that would accomplish this goal and then to articulate the key tradeoffs

Global proteomics analysis of the response to starvation in <i>C. elegans</i>

Periodic starvation of animals induces large shifts in metabolism but may also influence many other cellular systems and can lead to adaption to prolonged starvation conditions. To date, there is limited understanding of how starvation affects gene expression, particularly at the protein level. Here, we have used mass-spectrometry-based quantitative proteomics to identify global changes in the Caenorhabditis elegans proteome due to acute starvation of young adult animals. Measuring changes in the abundance of over 5,000 proteins, we show that acute starvation rapidly alters the levels of hundreds of proteins, many involved in central metabolic pathways, highlighting key regulatory responses. Surprisingly, we also detect changes in the abundance of chromatin-associated proteins, including specific linker histones, histone variants, and histone posttranslational modifications associated with the epigenetic control of gene expression. To maximize community access to these data, they are presented in an online searchable database, the Encyclopedia of Proteome Dynamics (http://www.peptracker.com/epd/)

Age is a predicting factor for the association between CagA positive Helicobacter pylori (Hp) infection and serum pepsinogen I:II ratio in a high gastric cancer risk region in China

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Flacourtia rukam: biochemistry, functions and utilization

Flacourtia rukam is a species of the Flacourtiaceae. The edible, cherry-like, sweet and sour fruits of the species are not known to be commercially exploited. Phenolic compounds and flavonoids are the main constituents of the fruits, which have also been reported to have good antioxidant properties. However, the available information on the phytochemical and pharmacological aspects of F. rukam indicated it to be very much an underutilized tropical fruit tree. Nevertheless, based on the ethnomedicinal uses of the fruits and other parts of the plant, its economic potential as a health giving food crop should be further investigated and properly evaluated

A comprehensive platform for highly multiplexed mammalian functional genetic screens

<p>Abstract</p> <p>Background</p> <p>Genome-wide screening in human and mouse cells using RNA interference and open reading frame over-expression libraries is rapidly becoming a viable experimental approach for many research labs. There are a variety of gene expression modulation libraries commercially available, however, detailed and validated protocols as well as the reagents necessary for deconvolving genome-scale gene screens using these libraries are lacking. As a solution, we designed a comprehensive platform for highly multiplexed functional genetic screens in human, mouse and yeast cells using popular, commercially available gene modulation libraries. The Gene Modulation Array Platform (GMAP) is a single microarray-based detection solution for deconvolution of loss and gain-of-function pooled screens.</p> <p>Results</p> <p>Experiments with specially constructed lentiviral-based plasmid pools containing ~78,000 shRNAs demonstrated that the GMAP is capable of deconvolving genome-wide shRNA "dropout" screens. Further experiments with a larger, ~90,000 shRNA pool demonstrate that equivalent results are obtained from plasmid pools and from genomic DNA derived from lentivirus infected cells. Parallel testing of large shRNA pools using GMAP and next-generation sequencing methods revealed that the two methods provide valid and complementary approaches to deconvolution of genome-wide shRNA screens. Additional experiments demonstrated that GMAP is equivalent to similar microarray-based products when used for deconvolution of open reading frame over-expression screens.</p> <p>Conclusion</p> <p>Herein, we demonstrate four major applications for the GMAP resource, including deconvolution of pooled RNAi screens in cells with at least 90,000 distinct shRNAs. We also provide detailed methodologies for pooled shRNA screen readout using GMAP and compare next-generation sequencing to GMAP (i.e. microarray) based deconvolution methods.</p