Multidrug-resistant Intestinal Staphylococcus aureus among Self-medicated Healthy Adults in Amassoma, South-South, Nigeria

Multiple antibiotic resistant Staphylococcus aureus is one of the common causes of severe nosocomial infections, and the gastrointestinal tract is an important source of its transmission. This study assessed the previous usage of antibiotics by healthy adults (university students and villagers) in Amassoma, Nigeria, and investigated the antimicrobial resistance patterns of their intestinal S. aureus isolates. A questionnaire was used for evaluating the previous usage of antibiotics by the volunteers. Stool samples were collected and cultured, and S. aureus isolates were confirmed using standard microbiological protocols. Their antimicrobial resistance patterns were determined using disc-diffusion and agar dilution techniques. In total, 54 (45.0%) volunteers used antibiotics on self-medications, and the practice was significantly higher (p=0.01) among the villagers than among the students. The level of judicious use of prescribed antibiotics was significantly higher (p=0.003) among the students than among the villagers. Thirty-eight (31.7%) healthy adults were colonized with intestinal S. aureus. The percentages of resistance of the isolates to some antibiotics were as follows: ampicillin–68.4%, doxycycline–60.5%, cefoxitin–34.2%, vancomycin–36.8%, erythromycin–34.2%, and gentamicin–5.3%. Twenty-five (65.8%) of the isolates were multidrug-resistant. The need for sound education on the appropriate use of antibiotics and the importance of proper personal hygiene as means of controlling the spread of bacterial antibiotic resistance are highlighted. Thus, effective strategies in these areas are strongly recommended

Multidrug-resistant Intestinal Staphylococcus aureus among Self-medicated Healthy Adults in Amassoma, South-South, Nigeria

Multiple antibiotic resistant Staphylococcus aureus is one of the common causes of severe nosocomial infections, and the gastrointestinal tract is an important source of its transmission. This study assessed the previous usage of antibiotics by healthy adults (university students and villagers) in Amassoma, Nigeria, and investigated the antimicrobial resistance patterns of their intestinal S. aureus isolates. A questionnaire was used for evaluating the previous usage of antibiotics by the volunteers. Stool samples were collected and cultured, and S. aureus isolates were confirmed using standard microbiological protocols. Their antimicrobial resistance patterns were determined using disc-diffusion and agar dilution techniques. In total, 54 (45.0%) volunteers used antibiotics on self-medications, and the practice was significantly higher (p=0.01) among the villagers than among the students. The level of judicious use of prescribed antibiotics was significantly higher (p=0.003) among the students than among the villagers. Thirty-eight (31.7%) healthy adults were colonized with intestinal S. aureus. The percentages of resistance of the isolates to some antibiotics were as follows: ampicillin-68.4%, doxycycline-60.5%, cefoxitin-34.2%, vancomycin-36.8%, erythromycin-34.2%, and gentamicin-5.3%. Twenty-five (65.8%) of the isolates were multidrug-resistant. The need for sound education on the appropriate use of antibiotics and the importance of proper personal hygiene as means of controlling the spread of bacterial antibiotic resistance are highlighted. Thus, effective strategies in these areas are strongly recommended

Physicochemical Analysis of the Aqueous Extracts of Six Nigerian Medicinal Plants

Purpose: Extracts of Picralima nitida seeds, Detarium microcarpum stem bark, Aframomum melagueta seeds, Terminalia catappa leaves, Acacia nilotica pods, and Morinda lucida stem bark, are under consideration for development into suitable dosage forms for treating diabetes mellitus, sickle cell anemia and malaria. This study aimed at evaluating the extracts for features that would influence decisions on them in the course of the project.Methods: Physicochemical determinations, including proximate analysis, were done by sensory examination, and gravimetric and electrochemical techniques. Thin layer chromatography was carried out with normal silica plates using various solvent systems. Metallic content analyses were carried out by atomic absorption spectroscopy.Results: The extracts were dry but hygroscopic, with a loss on drying range of 0.26 – 12.00 %w/w. The pH of the 5 - 10 % solutions ranged 5 - 7. No harsh sensory effects, such as lacrimation, were detected in any of the extracts. Total ash ranged from 3.79 – 20.68 %w/w, while acid insoluble ash values were below detection. The extracts yielded reproducible chromatograms on normal silica plates developed with various solvent systems. Copper, present at 0.16 - 0.58 mg/100g, was the lowest occurring microelement while calcium content was highest, at 41 - 216 mg/100g. The level of lead, a heavy metal, was 0.05 - 0.22 mg/100g.Conclusion: The results confirm that the extracts require no special handling, possess characteristics that would allow their possible development into solid dosage forms, and that their lead contentscomplied with official limits.Keywords: Aqueous extract, Picralima nitida, Detarium microcarpum, Aframomum melagueta, Terminalia catappa, Acacia nilotica, Morinda lucida

Solar quiet current response in the African sector due to a 2009 sudden stratospheric warming event

We present solar quiet (Sq) variation of the horizontal (H) magnetic field intensity deduced from Magnetic Data Acquisition System (MAGDAS) records over Africa during an unusual strong and prolonged 2009 sudden stratospheric warming (SSW) event. A reduction in the SqH magnitude that enveloped the geomagnetic latitudes between 21.13°N (Fayum FYM) in Egypt and 39.51°S (Durban DRB) in South Africa was observed, while the stratospheric polar temperature was increasing and got strengthened when the stratospheric temperature reached its maximum. Another novel feature associated with the hemispheric reduction is the reversal in the north-south asymmetry of the SqH, which is indicative of higher SqH magnitude in the Northern Hemisphere compared to the Southern Hemisphere during SSW peak phase. The reversal of the equatorial electrojet (EEJ) or the counter electrojet (CEJ) was observed after the polar stratospheric temperature reached its maximum. The effect of additional currents associated with CEJ was observed in the Southern Hemisphere at middle latitude. Similar changes were observed in the EEJ at the South America, Pacific Ocean, and Central Asia sectors. The effect of the SSW is largest in the South American sector and smallest in the Central Asian sector

Community partnerships in medical education: Narratives of medical students

While medical education has traditionally been designed, led and delivered exclusively by clinicians and academics, there has been an increasing shift towards diversifying actors involved in training future generations of health professionals. Public and patient involvement in learning increases the likelihood that learning is relevant to the communities we purport to serve. This article explores the experiences of medical students who were partnered with a community-based organisation (CBOs) as part of the intercalated Global Health BSc at Imperial College London. Students involved in this programme highlight opportunities to understand the needs of communities they were placed with, beyond what is possible to understand in clinical practice; this is essential to support them in becoming holistic, patient-centred practitioners. Students also found this opportunity helpful to gain insight into the role and value of the voluntary sector in healthcare and develop transferrable skills in project leadership and management. It is hypothesised that the benefits of this partnership extend to community-organisations; they gain experience working with students, who provide an external view of their services and may be helpful in the delivery of quality-improvement projects. Communities could also benefit from interactions with students by sharing insight into their needs and priorities, and in turn, shaping students’ priorities as future health professionals and co-designers of voluntary-sector initiatives within the community. Whilst the establishment of these partnerships does not come without its challenges, this article also highlights lessons for students and institutions undergoing similar programmes, including clarification of goals, stakeholder consultation, sustainability of interventions, voicing the community, timetable flexibility and funding

Accurate determination of 3D PSF and resist effects in grayscale laser lithography

Accurate calibration of the optical and resist parameters is invaluable for the computation of the dose distribution needed to fabricate a desired non-binary photoresist topography. This paper presents a method for precisely evaluating the 3D point spread function (PSF) and model parameters for the resist processes in laser grayscale lithography. The 3D PSF and resist model parameters were determined by fitting a detailed model of the grayscale process to experimental measurements of an array of test patterns. Measuring the entire 3D profile provides more data for process calibration, and therefore a more accurate model. The derived model parameters were applied to correctly predict the topography of sawtooth patterns

SOCIAL PROTECTION AND EMPLOYMENT IN AFRICA’S AGRICULTURAL SECTOR

Social protection is increasingly becoming a powerful tool for enhancing productivity and employment and is, therefore, important for Africa’s agricultural transformation. Thus, this study aims at examining how Africa’s agricultural sector can be transformed through social protection policies and programmes for employment. It applies the Feasible Generalised Least Squares (FGLS) econometric method on a panel of 38 African countries with the data sourced from the Country Policy and Institutional Assessment (CPIA) and World Development Indicators (WDI) for the period 2005–2017. The results from the study show that social protection has a positive impact on employment outcomes through various channels such as building human resource, equity in the use of public resources, social inclusion, among others. The study concludes by recommending that the governments of African countries should implement effective social protection programmes and policies in the agricultural sector in form of insurance, in-kind and cash support, among others to make farming attractive, thereby increasing employment and productivity

Environmental pollution, economic growth and institutional quality: exploring the nexus in Nigeria

Purpose Interaction between environmental pollution and economic growth determines the achievement of the green growth objective of developing economies. An economy turns around the inverted U-shaped environmental Kuznets curve (EKC) when pollution is effectively dampened by social, political and economic factors as such economy grows. Thus, the purpose of this paper is to examine the EKC considering the impact of institutional quality on six variables of environmental pollution (carbon dioxide (CO2), nitrous oxide (N2O), suspended particulate matters (SPM), rainfall, temperature and total greenhouse emission (TGH)) using the case of Nigeria. Design/methodology/approach The EKC model includes population density, education expenditure, foreign direct investment and gross domestic investment as control variables, and it was analysed using the autoregressive distribution lag (ARDL) econometric technique, which has not been applied in the literature on Nigeria. Findings The results, inter alia, indicate that there is EKC for CO2 and SPM. This implies that the green growth objective can be pursued in Nigeria with concerted efforts. Other environmental pollution indicators did not exert significant influence on economic growth. Practical implications Therefore, it is recommended that Nigeria’s institutional quality be strengthened to limit environmental pollution in light of economic growth. Originality/value Previous studies are yet to apply a more developed econometric method, like the ARDL, to estimate the EKC model for Nigeria. This study fills this observed knowledge gap