Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions.

A large number of clinically used drugs and experimental pharmaceuticals possess the N,N-dimethyltryptamine (DMT) structural core. Previous reports have described the reaction of this motif with dichloromethane (DCM), a common laboratory solvent used during extraction and purification, leading to the formation of an undesired quaternary ammonium salt byproduct. However, the kinetics of this reaction under various conditions have not been thoroughly described. Here, we report a series of experiments designed to simulate the exposure of DMT to DCM that would take place during extraction from plant material, biphasic aqueous work-up, or column chromatography purification. We find that the quaternary ammonium salt byproduct forms at an exceedingly slow rate, only accumulates to a significant extent upon prolonged exposure of DMT to DCM, and is readily extracted into water. Our results suggest that DMT can be exposed to DCM under conditions where contact times are limited (<30 min) with minimal risk of degradation and that this byproduct is not observed following aqueous extraction. However, alternative solvents should be considered when the experimental conditions require longer contact times. Our work has important implications for preparing a wide-range of pharmaceuticals bearing the DMT structural motif in high yields and purities

Cook County Sheriff\u27s Reentry Council Quarterly Update (Volume 2, Issue 1: February 2010)

INSIDE THIS ISSUE: First-ever in-reach services to jail detainees Jail average daily population increases in 2009 DWJS receives grant to enhance mental-health services for women Day Reporting Center reduces recidivism, enhances transition to community By the numbers: a comparison of male and female jail detainee

Characteristics of Inmates in the Cook County Jail

Provides a detailed description of the characteristics of those admitted to and released from the Cook County Jail in 2010

Efficient synthesis of N9-alkylguanines : & evaluation of a more highly conjugated analog of guanidinium-rich molecular transporters using a pH dependent fluorescence assay

Synthesis of N9-(2-chloroethyl)guanine from 2-amino-6-chloropurine was accomplished in three steps with an overall yield of 83%. All products were purified via crystalli7.ation and no chromatography was required. Selective crystallization of the desired N9 isomer subsequent to the key alkylation step completely and efficiently removed the N7 isomer. This compound was shown to be a versatile reagent in the synthesis of various N9-substituted guanines

Population Dynamics and the Characteristics of Inmates in the Cook County Jail

An overview of the population characteristics and population dynamics in the Cook County Illinois Jail in 2011

Illinois Felony Sentencing: A Retrospective

This research bulletin provides an overview of forces that have influenced the number of felons under the supervision of Illinois\u27 justice system, including crime and arrest trends, sentencing policies and practices related to probation and prison sentences

Organizational Approaches to Drug Law Enforcement by Local Police Departments in the United States: Specialized Drug Units and Participation in Multi-Agency Drug Task Forces

This paper examines the factors associated with the decision of local police departments in the United States to operate specialized drug units or to participate in multi-jurisdictional drug task forces. Combining data from the Law Enforcement Management and Administrative Statistics (LEMAS) Survey, the 2000 Census, and the Uniform Crime Report, we use both bivariate and multivariate methods to conduct the analysis. The findings indicate that county-level agencies, those with other formalized drug control efforts, high levels of violent crime, high degrees of task specialization and formalization, and high proportions of the resident population accounted for by renters were more likely to operate drug units, participate in multi-agency drug task forces, and allocate more officers per capita to these efforts

North Dakota Crop Production Economics in 1991

Production Economics,