Mentoring with Core Academy

Giving children a chance to have one person who is always rooting for them and having a positive reinforcement in their life.https://digitalscholarship.unlv.edu/educ_sys_202/1015/thumbnail.jp

Corporate Complicity In Human Rights Violations Under International Criminal Law

This paper examines the main legal elements of corporate criminal responsibility for involvement in serious human rights violations, focusing specifically on the mens rea, or mental element requirement of a crime. It analyzes in detail what it means for a business to be complicit, the degree of knowledge corporations and their officials must have to be implicated in accomplice liability, and a case study demonstrating the consequences of such liability on corporations

The Harsh Welcome of an Industrial City: Immigrant Women in Montreal, 1880–1900

Over the span 1880 to 1900, Montreal was a city of newcomers, a majority of them women, and most of them arrived before age 30 from Britain, Europe, the United States, or rural counties of Quebec and Ontario. Young people aged 15 to 29 accounted for a third of the population and half of the recorded labour force. The authors’ analyses of 1881 census data and a 5 per cent sample for 1901 uncover a wide range of factors affecting life transitions. A substantial increase in participation of young unmarried women in the waged labour force was made possible by shifts in the timing of life transitions: the ages at which girls left school, left home, entered the work force, and married. The schedule was affected by migration, and it differed among the three principal cultural communities — French-speaking Catholic, English-speaking Catholic, and Anglo-Protestant. All three groups of women increased their rates of participation in the labour force, but the distinctions based on cultural affiliation persisted in both the scheduling of life transitions and the kinds of work in which they engaged. De nombreux immigrants arrivèrent à Montréal durant les dernières décennies du XIXe siècle. Plus de la moitié d'entre eux étaient des femmes et la plupart arrivaient à un âge plutôt jeune, en provenance de la Grande-Bretagne, d’Europe, des États-Unis, ou encore des régions rurales du Québec et de l’Ontario. Les jeunes de 15 à 30 ans représentaient alors le tiers de la population totale et occupaient la moitié de tous les emplois déclarés. Tirant parti des données du recensement de 1881 et d’un échantillon de 5 p. 100 de celui de 1901, ce texte examine les facteurs susceptibles d'influencer le parcours de vie des jeunes Montréalaises à cette époque : âge auquel elles cessent d’aller à l’école, quittent le domicile familial, commencent à travailler et se marient. L'expérience migratoire affecte ces trajectoires, qui varient aussi selon la communauté culturelle d'appartenance. Les femmes des trois principaux groupes – franco-catholique, irlandais catholique et anglo-protestant - connaissent toutes une augmentation de leur taux de participation au marché du travail, mais les trajectoires empruntées et le type de travail effectué ne sont pas les mêmes dans tous les groupes

A communications canvas to improve and individualize patient engagement in healthcare systems redesign

Current healthcare systems are rife with extensive barriers to information transfer. Exacerbated by rapidly increasing volume and time constraints, these are considered a core wicked problem and key driver of healthcare system dysfunction. Thus, redesign efforts focused on collaboration and facilitating efficient, transparent, and bilateral communication are paramount to dissolving these barriers and effecting positive, sustainable system-wide transformation. It is now clear that action in two critical areas can leverage radical health information and system reform: repositioning patient needs to the center of local and extended ecosystems (patient-centered care), and enhancing patient involvement at every stage of health information transmission (patient engagement). Allowing patients and caregivers to initiate, direct, and manage information flow aligns health decisions with the individuals primarily affected. Benefits include substantial delivery cost reductions, elimination of waste, and increases in treatment efficacy. Such a shift is a profound and necessary departure from the historically passive role of the patient as a less-knowledgeable recipient of health goods and services to a highly-informed leader in disease management and prevention, and importantly, lifelong health promotion. Designing for constructive communication and relationships between diverse actors may thus be an especially potent strategy to develop infrastructure that supports and encourages this shift. To this end, we have created a communications-centered design tool (canvas) to help providers or organization managers improve patient engagement within a healthcare space, and designers, as they become increasingly more involved as agents and implementers at various levels of health systems change. The canvas is organized in a clean visual format that is flexible and approachable for diverse users and situations. Although simple in appearance, each section is inquiry-driven, requiring research, deep thinking and iteration to refocus the provider/designer on the patient’s perspective and individual needs. Drawing largely from innovation principles of user- or human-centered design, the canvas also reframes the context of health relationships by using the terms ‘health-seeker’ (Jones, 2013) and ‘health-advisor’ to diffuse assumptions of hierarchy, agency or unequal responsibility

Domain and stripe formation between hexagonal and square ordered fillings of colloidal particles on periodic pinning substrates

Using large scale numerical simulations, we examine the ordering of colloidal particles on square periodic two-dimensional muffin-tin substrates consisting of a flat surface with localized pinning sites. We show that when there are four particles per pinning site, the particles adopt a hexagonal ordering, while for five particles per pinning site, a square ordering appears. For fillings between four and five particles per pinning site, we identify a rich variety of distinct ordering regimes, including disordered grain boundaries, crystalline stripe structures, superlattice orderings, and disordered patchy arrangements. We characterize the different regimes using Voronoi analysis, energy dispersion, and ordering of the domains. We show that many of the boundary formation features we observe occur for a wide range of other fillings. Our results demonstrate that grain boundary tailoring can be achieved with muffin-tin periodic pinning substrates

Embracing Virtual Reality Technology with Black Adolescents to Redress Police Encounters

As Black youth face race-related stress from personal and vicarious experiences with police, practices advancing youth’s coping self-efficacy and agency are needed. We describe the pilot of a program supporting Black adolescents in creating virtual narratives detailing encounters and resolutions with police and offer preliminary observations of how this program could facilitate racial coping and emotional support. The program included four weeks consisting of both curriculum-based instruction and hands-on activities, four weeks solely focused on designing and developing students’ projects, and one week devoted to students’ final project presentations and peer feedback. We utilized a participatory design to co-create narratives with four high school students in Detroit, Michigan. We discuss how these processes can aid in the development of programs designed to reduce Black youth’s racial stress and improve youth’s coping self-efficacy. Our design and practical recommendations contribute to current literature investigating the utility of virtual narratives in redressing coping strategies for Black youth

Coordinated regulation of transcription by CcpA and the \u3ci\u3eStaphylococcus aureus\u3c/i\u3e twocomponent system HptRS

The success of Staphylococcus aureus as a pathogen is due in part to its ability to adapt to changing environmental conditions using signal transduction pathways, such as metaboliteresponsive regulators and two-component systems. S. aureus has a two-component system encoded by the gene pair sav0224 (hptS) and sav0223 (hptR) that regulate the hexose phosphate transport (uhpT) system in response to extracellular glucose-6-phosphate. Glycolytic intermediates such as glucose-6-phosphate are important carbon sources that also modulate the activity of the global metabolite-responsive transcriptional regulator CcpA. Because uhpT has a putative CcpA binding site in its promoter and it is regulated by HptR, it was hypothesized the regulons of CcpA and HptR might intersect. To determine if the regulatory domains of CcpA and HptRS overlap, ccpA was deleted in strains SA564 and SA564- ΔhptRS and growth, metabolic, proteomic, and transcriptional differences were assessed. As expected, CcpA represses hptS and hptR in a glucose dependent manner; however, upon CcpA derepression, the HptRS system functions as a transcriptional activator of metabolic genes within the CcpA regulon. Importantly, inactivation of ccpA and hptRS altered sensitivity to fosfomycin and ampicillin in the absence of exogenous glucose-6-phosphate, indicating that both CcpA and HptRS modulate antibiotic susceptibility

Relationship between a Weighted Multi-Gene Algorithm and Blood Pressure Control in Hypertension

Hypertension (HTN) is a complex disease with interactions among multiple organ systems, including the heart, vasculature, and kidney with a strong heritable component. Despite the multifactorial nature of HTN, no clinical guidelines utilize a multi-gene approach to guide blood pressure (BP) therapy. Non-smokers with a family history of HTN were included in the analysis (n = 384; age = 61.0 ± 0.9, 11% non-white). A total of 17 functional genotypes were weighted according to the previous effect size in the literature and entered into an algorithm. Pharmacotherapy was ranked from 1⁻4 as most to least likely to respond based on the algorithmic assessment of individual patient's genotypes. Three-years of data were assessed at six-month intervals for BP and medication history. There was no difference in BP at diagnosis between groups matching the top drug recommendation using the multi-gene weighted algorithm (n = 92) vs. those who did not match (n = 292). However, from diagnosis to nadir, patients who matched the primary recommendation had a significantly greater drop in BP when compared to patients who did not. Further, the difference between diagnosis to current 1-year average BP was lower in the group that matched the top recommendation. These data suggest an association between a weighted multi-gene algorithm on the BP response to pharmacotherapy.Geneticure Inc.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]