Development of an instrument for early detection of dementia in people with Down syndrome

The successful detection of early signs of dementia in people with Down syndrome could form a basis for useful early support and for drug treatment. This report describes the development and preliminary application of an interview and test instrument for the assessment of dementia among people with intellectual disability, as well as a framework for diagnosis that combines the findings of an interview and a test with the diagnostic criteria of ICD-10, DSM-IV and NINCDS-ADRDA. From among the number of tests and interview questions developed, those showing the most significant differences between participants in three groups of differing levels of intellectual disability and estimated dementia were kept. Reported are the assumptions for the items used, descriptions of the process and items used, and the associations of test items with predicting the presence of dementia. The authors conclude that a protocol combining testing and interview has promise and potential for detecting early signs of dementia in this population and could prove feasible for use in practice

Comparing Lung Cancer Risks in Sweden, USA, and Japan

Objective. To develop a conceptual model for lung cancer rates to describe and quantify observed differences between Sweden and USA contra Japan. Method. A two-parameter lognormal distribution was used to describe the lung cancer rates over time after a 1-year period of smoking. Based on that risk function in combination with smoking prevalence, the calculated age-standardized rates were adjusted to fit reported data from Japan, Sweden, and the USA by parameter variation. Results. The risk of lung cancer is less in Japan than in Sweden and in the USA at the same smoking prevalence and intensity. Calculated age-specific rates did also fit well to reported rates without further parameter adjustments. Conclusions. This new type of cancer model appears to have high degree of predictive value. It is recommended that data from more countries are studied to identify important life-style factors related to lung cancer

Neurotrophins and their receptors in the skin: a tribute to Rita Levi-Montalcini

The family of proteins named neurotrophins and also their receptors play an important role in differentiation and survival of specific populations of neurons, including cutaneous nerves. Recent advance in neuroscience has shown that in addition to their neurotrophic actions, neurotrophins, particularly, nerve growth factor, mediate various immune and inflammatory responses. These functions are fulfilled by alterations in cytokine and neuropeptide production, through effects on neurotrophin receptor bearing immune cells, notably, mast cells, lymphocytes, and macrophages. Within skin, different neurotrophins are synthesized and released primarily by keratinocytes, thus affecting cutaneous innervation, postinjury neural reconstruction, and nonneuronal cells, such as melanocytes, through a paracrine action. Involvement of neurotrophins and their receptors in the pathogenesis of certain skin diseases is also reviewed.Biomedical Reviews 1999; 10: 15-23

Aquatic Heterosexual Love and Wondrous Cliché Stereotypes: Amphibian Masculinity, the Beast Bridegroom Motif and ‘the Other’ in The Shape of Water

This paper addresses the representation of masculinities in the award-winning romantic fantasy film The Shape of Water (2017). The study examines how The Shape of Water communicates with other texts and myths portraying aquatic entities such as Gill Man from The Creature from the Black Lagoon (1954) and how the movie is tied to the folkloric tradition of monstrous love interest. Further, the text investigates how otherness is portrayed and constructed through the different representations in the movie. The paper concludes that the film’s diverse characters create a superficial appearance of an understanding for marginalised subjects. The Shape of Water is a classic beast bridegroom fairy tale with stagnated representations of feminine and masculine ideals that turn ‘the other’ into an instrument of self-realisation for a white subject. Moreover, the Amphibian Man is differentiated from his aquatic female counterparts through traditional masculine attributes such as a muscular body type, a reptilian appearance and being two-legged instead of having a fishtail

Effect of uniaxial strain on the site occupancy of hydrogen in vanadium from density-functional calculations

We investigate the influence of uniaxial strain on site occupancy of hydrogen vanadium, using density functional theory. The site occupancy is found to be strongly influenced by the strain state of the lattice. The results provide the conceptual framework of the atomistic description of the observed hysteresis in the alpha to beta phase transition in bulk, as well as the preferred octahedral occupancy of hydrogen in strained V layers

Multiple transcoding impact on speech quality in ideal network conditions

This paper deals with the impact of transcoding on the speech quality. We have focused mainly on the transcoding between codecs without the negative influence of the network parameters such as packet loss and delay. It has ensured objective and repeatable results from our measurement. The measurement was performed on the Transcoding Measuring System developed especially for this purpose. The system is based on the open source projects and is useful as a design tool for VoIP system administrators. The paper compares the most used codecs from the transcoding perspective. The multiple transcoding between G711, GSM and G729 codecs were performed and the speech quality of these calls was evaluated. The speech quality was measured by Perceptual Evaluation of Speech Quality method, which provides results in Mean Opinion Score used to describe the speech quality on a scale from 1 to 5. The obtained results indicate periodical speech quality degradation on every transcoding between two codecs

Apparent decreases in Swedish public health indicators after 1997-Are they due to improved diagnostics or to environmental factors?

Abstract The object of this work was to review recent trends in public health in Sweden. Data on different adverse health indicators were collected from official Swedish registries. We found that population health generally improved during the early 1990s but suddenly started to deteriorate from 1997 onwards. This quite dramatic change is not likely to be explained only by improved diagnostics but physical causes need immediately to be searched for. A connection with the increasing exposure of the population to GHz radiation from mobile phones, base stations and other communication technologies cannot be ruled out

A Simple Analysis of Harm

In this paper, we present and defend an analysis of harm that we call the Negative Influence on Well-Being Account (NIWA). We argue that NIWA has a number of significant advantages compared to its two main rivals, the Counterfactual Comparative Account (CCA) and the Causal Account (CA), and that it also helps explain why those views go wrong. In addition, we defend NIWA against a class of likely objections, and consider its implications for several questions about harm and its role in normative theorizing

The Ringloc liner compared with the Hexloc liner in total hip arthroplasty

The aim of this study was to compare the 10-year survival rate, pelvic osteolysis frequency and linear head penetration rate of the Hexloc and Ringloc liners used together with a partially threaded porous and hydroxyapatite coated cup and the Bi-Metric uncemented femoral stem. The 15-year results for the cup with the Hexloc liner are also reported. We included 332 consecutive hips (166 Hexloc and 166 Ringloc) on 281 patients in the study. Revisions of prosthesis components were recorded and pelvic osteolytic lesions were assessed using radiographs and computed tomography. The linear head penetration rate was measured using the Martell method. The 10-year survival rate of the liner with revision due to liner wear and/or osteolysis as endpoint was 88% for the Hexloc liner and 98% for the Ringloc liner. The 15-year survival rate of the Hexloc liner was 67%. Pelvic osteolysis was found in 27% of the Hexloc and 19% of the Ringloc hips. After 15 years, 53% of the Hexloc hips had developed an osteolytic lesion. The linear head penetration rate was 0.16 mm/year for the Hexloc liner and 0.12 mm/year for the Ringloc liner. This paper is the first to describe the rapidly deteriorating survival up to 15 years with the old generation gamma-in-air sterilized polyethylene used in Hexloc liners. The newer Ringloc liner with the ArCom™ polyethylene has superior clinical results but a linear wear rate and frequency of osteolytic lesions that is higher than expected