32,313 research outputs found

    Code Usage Analysis System (CUAS)

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    A set of computer programs is offered to aid a user in evaluating performance of an application program. The system provides reports of subroutine usage, program errors, and segment loading which occurred during the execution of an application program. It is presented in support of the development and validation of the space vehicle dynamics project

    Effect of Tryptophan Analogs on Derepression of the \u3cem\u3eEscherichia coli\u3c/em\u3e Tryptophan Operon by Indole-3-Propionic Acid

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    The abilities of 14 tryptophan analogs to repress the tryptophan (trp) operon have been studied in Escherichia coli cells derepressed by incubation with 0.25 mM indole-3-propionic acid (IPA). trp operon expression was monitored by measuring the specific activities of anthranilate synthase (EC 4.1.3.27) and the tryptophan synthase (EC 4.2.1.20) Ī² subunit. Analogs characterized by modification or removal of the Ī±-amino group or the Ī±-carboxyl group did not repress the trp operon. The only analogs among this group that appeared to interact with the trp aporepressor were IPA, which derepressed the trp operon, and d-tryptophan. Analogs with modifications of the indole ring repressed the trp operon to various degrees. 7-Methyl-tryptophan inhibited anthranilate synthase activity and consequently derepressed the trp operon. Additionally, 7-methyltryptophan prevented IPA-mediated derepression but, unlike tryptophan, did so in a non-coordinate manner, with the later enzymes of the operon being relatively more repressed than the early enzymes. The effect of 7-methyltryptophan on IPA-mediated derepression was likely not due to the interaction of IPA with the allosteric site of anthranilate synthase, even though feedback-resistant mutants of anthranilate synthase were partially resistant to derepression by IPA. The effect of 7-methyltryptophan on derepression by IPA was probably due to the effect of the analog-aporepressor complex on trp operon expression

    Literary Allusion in Jacobean Drama

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    Paper by H. J. Olive

    RascalC: A Jackknife Approach to Estimating Single and Multi-Tracer Galaxy Covariance Matrices

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    To make use of clustering statistics from large cosmological surveys, accurate and precise covariance matrices are needed. We present a new code to estimate large scale galaxy two-point correlation function (2PCF) covariances in arbitrary survey geometries that, due to new sampling techniques, runs āˆ¼104\sim 10^4 times faster than previous codes, computing finely-binned covariance matrices with negligible noise in less than 100 CPU-hours. As in previous works, non-Gaussianity is approximated via a small rescaling of shot-noise in the theoretical model, calibrated by comparing jackknife survey covariances to an associated jackknife model. The flexible code, RascalC, has been publicly released, and automatically takes care of all necessary pre- and post-processing, requiring only a single input dataset (without a prior 2PCF model). Deviations between large scale model covariances from a mock survey and those from a large suite of mocks are found to be be indistinguishable from noise. In addition, the choice of input mock are shown to be irrelevant for desired noise levels below āˆ¼105\sim 10^5 mocks. Coupled with its generalization to multi-tracer data-sets, this shows the algorithm to be an excellent tool for analysis, reducing the need for large numbers of mock simulations to be computed.Comment: 29 pages, 8 figures. Accepted by MNRAS. Code is available at http://github.com/oliverphilcox/RascalC with documentation at http://rascalc.readthedocs.io

    Clouds, photolysis and regional tropospheric ozone budgets.

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    We use a three-dimensional chemical transport model to examine the shortwave radiative effects of clouds on the tropospheric ozone budget. In addition to looking at changes in global concentrations as previous studies have done, we examine changes in ozone chemical production and loss caused by clouds and how these vary in different parts of the troposphere. On a global scale, we find that clouds have a modest effect on ozone chemistry, but on a regional scale their role is much more significant, with the size of the response dependent on the region. The largest averaged changes in chemical budgets (Ā±10ā€“14%) are found in the marine troposphere, where cloud optical depths are high. We demonstrate that cloud effects are small on average in the middle troposphere because this is a transition region between reduction and enhancement in photolysis rates. We show that increases in boundary layer ozone due to clouds are driven by large-scale changes in downward ozone transport from higher in the troposphere rather than by decreases in in-situ ozone chemical loss rates. Increases in upper tropospheric ozone are caused by higher production rates due to backscattering of radiation and consequent increases in photolysis rates, mainly J(NO2). The global radiative effect of clouds on isoprene, through decreases of OH in the lower troposphere, is stronger than on ozone. Tropospheric isoprene lifetime increases by 7% when taking clouds into account. We compare the importance of clouds in contributing to uncertainties in the global ozone budget with the role of other radiatively-important factors. The budget is most sensitive to the overhead ozone column, while surface albedo and clouds have smaller effects. However, uncertainty in representing the spatial distribution of clouds may lead to a large sensitivity of the ozone budget components on regional scales
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