Beyond the Numbers: Comprehensive Internationalization at Miami University

Marketing materials for Miami University, a public doctoral university in Oxford, Ohio, frequently reference the caliber and popularity of the university’s outbound student mobility programs. With almost sixty percent of undergraduates studying abroad or away before graduation, outbound mobility has become a core element of both the Miami student experience and the university’s vision for global engagement. This study seeks to go beyond the numbers (i.e. student mobility rates) in examining whether the success of outbound student mobility programs is indicative of successful internationalization across the university as a whole. Using the American Council on Education (ACE) Center for International and Global Engagement (CIGE) Model for Comprehensive Internationalization, this study analyzes Miami University’s internationalization progress since 2012 according to six “pillars” of internationalization: 1) articulated institutional commitment; 2) administrative leadership, structure, and staffing; 3) curriculum, co-curriculum, and learning outcomes; 4) faculty policies and practices; 5) student mobility, and 6) collaboration and partnerships. Findings revealed a clear institutional commitment to internationalization in the form of Miami 2020, the university’s most recent strategic plan, as well as the presence of international, intercultural, and multicultural elements in areas such as faculty hiring, promotion, and tenure policies; inbound and outbound student mobility opportunities; and requirements of the core curriculum. At the same time, the implementation of certain internationalization initiatives continues to present challenges, including cultural, social, and academic issues faced by international students; questions surrounding sustainable leadership in Global Initiatives, the university’s centralized internationalization hub; and the overabundance of short-term, faculty-led programs

Wind optimal flight trajectories to minimise fuel consumption within a 3 dimensional flight network

This paper assesses the potential fuel savings benefits that can be gained from wind optimal flight trajectories. This question is posed on a 3 dimensional fixed flight network consisting of discrete waypoints which is representative of the size of Europe. The optimisation implements Dijkstra's shortest path algorithm to compute the minimum fuel burn route through a network and compares this to the fuel burn for the shortest distance route. Particular effort is applied to testing the repeatability and robustness of the results. This is achieved through a sensitive analysis based on a number of identified model parameters relating to the setup of the flight network. The results of this study show fuel savings between 1.0%-10.3%, and suggest that the benefits of wind optimal flight trajectories are significant

Treshold-controlled three-stage hydraulic behaviour of a mantled shallow carbonate aquifer (Tuhala karst area, North Estonia)

As karst aquifers are often characterised by non-linear behaviour, ascertaining the turning points in their hydraulic regime may provide essential information on the functioning of the aquifer. These characteristics also apply to the Silurian-Ordovician aquifer system, composed of diverse carbonate rocks, in Estonia. The aquifer system is an important source of drinking water in northern Estonia. It also comprises the Nabala- Rakvere aquifer, a locally important groundwater resource that underlies the Tuhala karst area famous for an intermittently overflowing karst spring known as the Witch's Well. The water rich in humic substances of the Tuhala River recharges the Tuhala karst system, which is drained by two spring groups. In order to develop measures for the sustainable management of the aquifer in the future, the aim of this study was to enhance understanding of the hydraulic behaviour and hydrodynamic properties of the Tuhala karst system. From October 2014 to December 2016 an extensive field campaign was carried out comprising the observation of 22 surface- and groundwater monitoring points for water level and physico-chemical parameters and the performance of four quantitative tracer tests. The data obtained were evaluated in accordance with the input– output water level relation curves and a conceptual model of the system was set up. The results show that a strong hydraulic link exists, primarily through well-developed conduits between the recharge and discharge area of the karst system. Depending on the hydrological conditions, groundwater flow direc tions vary and maximum linear flow velocities range between ~225 and 800 m/h. A threshold-controlled throughput capacity and interaction with the adjacent aquifer cause imbalances between the input and output discharges of the karst system. Tracer tests coupled with surface and groundwater level relation curve analysis allowed the specification of flow threshold conditions for the Witch's Well spring group and the overflow threshold for the Witch's Well, among other key hydrological events. The hydraulic regime of the karst system was divided into three stages, each with differing threshold controls and hydrodynamic characteristics.Key words: karst system, shallow carbonate aquifer, monitoring, tracer test, water level relation curve, threshold, overflow. Določanje mejnih vrednosti tristopenjskega hidravljičnega obnašanja pokritega plitvega karbonatnega vodonosnika (Tuhalski kras, severna Estonija)Kraški vodonosniki se pogosto obnašajo nelinearno, zato lahko z ugotavljanjem mejnih vrednosti v hidravličnem režimu zagotovimo bistvene informacije o delovanju vodonosnika. To velja tudi za silurijsko-ordovicijski vodonosni sistem v Estoniji, ki ga sestavljajo različne karbonatne kamnine in je pomemben vir pitne vode na severu države. Vključuje tudi vodonosnik Nabala- Rakvere, ki je lokalno pomemben vodni vir. Na tem območju se nahaja Tuhalski kras, ki je znan po občasno bruhajočem kraškem izviru Witch's Well (Čarovničin vodnjak). Tuhalski vodonosnik napaja reka Tuhala, bogata z huminskimi snovmi, prazni pa se skozi dve skupini izvirov. Da bi v prihodnje razvili ukrepe za trajnostno upravljanje vodonosnika, je bil namen te raziskave izboljšati razumevanje hidravličnega obnašanja in hidrodinamičnih lastnosti kraškega sistema. Od oktobra 2014 do decembra 2016 smo opravili obsežno terensko delo, ki je obsegalo spremljanje vodostajev in fizikalno-kemijskih parametrov v 23 površinskih in podzemnih točkah ter izvedbo štirih kvantitativnih sledilnih poskusov. Pridobljene podatke smo ovrednotili na podlagi krivulje odvisnosti vhodnih in izhodnih vodnih nivojev. Vzpostavili smo konceptualni model sistema. Rezultati kažejo na obstoj močne hidravlične povezave predvsem z dobro razvitimi kanali med območji napajanja in praznjenja kraškega sistema. Odvisno od hidroloških razmer se spreminjajo smeri in hitrosti toka podzemne vode, ki znašajo od ~225 do 800 m/h. Kapaciteta prepustnosti, ki jo uravnavajo določene mejne vrednosti, in posledične in terakcije s sosednjimi vodonosniki povzročajo neravnovesja med vhodnimi in izhodnimi pretočnimi vrednostmi kraškega sistema. Združevanje rezultatov sledilnih poskusov z analizo krivulje odvisnosti površinskih in podzemnih vodostajev nam je omogočilo, da smo določili mejne pretočne vrednosti izvira Witch's Well in druge ključne hidrološke dogodke. Hidravlični režim kraškega sistema smo razdelili na tri faze, od katerih ima vsaka določene mejne vrednosti in hidrodinamične lastnosti. Ključne besede: kraški sistem, plitvi karbonatni vodonosnik, monitoring, sledilni poskus, krivulja odvisnosti vodnih nivojev, prag, preliv.

Magnetism, spin texture and in-gap states: Atomic specialization at the surface of oxygen-deficient SrTiO3_3

Motivated by recent spin- and angular-resolved photoemission (SARPES) measurements performed on the two-dimensional electronic states confined near the (001) surface of SrTiO$_3$ in the presence of oxygen vacancies, we explore their spin structure by means of ab initio density functional theory (DFT) calculations of slabs. Relativistic nonmagnetic DFT calculations display Rashba-like spin winding with a splitting of a few meV and when surface magnetism on the Ti ions is in- cluded, bands become spin-split with an energy difference ~100 meV at the $\Gamma$ point, consistent with SARPES findings. While magnetism tends to suppress the effects of the relativistic Rashba interaction, signatures of it are still clearly visible in terms of complex spin textures. Furthermore, we observe an atomic specialization phenomenon, namely, two types of electronic contributions: one is from Ti atoms neighboring the oxygen vacancies that acquire rather large magnetic moments and mostly create in-gap states; another comes from the partly polarized t$_{2g}$ itinerant electrons of Ti atoms lying further away from the oxygen vacancy, which form the two-dimensional electron system and are responsible for the Rashba spin winding and the spin splitting at the Fermi surface.Comment: 6 pages, 4 figures, for Suppl. Mat. please contact first autho

Topology Optimization of Plastic Parts for Injection Molding

Topology optimization is broadly recognized as a design approach to generate high-performance conceptual designs suitable for freeform fabrication, e.g., additive manufacturing. When other fabrication methods are considered, topology optimization must integrate manufacturing constraints. The integration of constraints for extrusion and casting has been addressed in the past by a few researcher groups. In this work, extrusion and casting constraints are revisited and extended to include plastic injection. The proposed method relies on the use of intersection planes and the definition of a parting line within the planes. The resulting topologies can be injected in a two-plate mold without the use of inserts. The implementation and results of the proposed approach are demonstrated in classic three-dimensional problems that include a cantilevered beam with different load conditions

Neutrophil extracellular traps: from physiology to pathology.

At the frontline of the host defence response, neutrophil antimicrobial functions have adapted to combat infections and injuries of different origins and magnitude. The release of web-like DNA structures named neutrophil extracellular traps (NETs) constitutes an important mechanism by which neutrophils prevent pathogen dissemination or deal with microorganisms of a bigger size. At the same time, nuclear and granule proteins with microbicidal activity bind to these DNA structures promoting the elimination of entrapped pathogens. However, these toxic properties may produce unwanted effects in the host, when neutrophils uncontrollably release NETs upon persistent inflammation. As a consequence, NET accumulation can produce vessel occlusion, tissue damage, and prolonged inflammation associated with the progression and exacerbation of multiple pathologic conditions. This review outlines recent advances in understanding the mechanisms of NET release and functions in sterile disease. We also discuss mechanisms of physiological regulation and the importance of neutrophil heterogeneity in NET formation and composition.C.S.-R. receives funding from the Deutsche Forschungsgemeinschaft (SFB1123 TP A6). O.S. receives funding from the Deutsche Forschungsgemeinschaft (SFB914 TP B8, SFB1123 TP A6, TP B5, SFB1009 TP A13), the Vetenskapsra˚det (2017-01762), the Else-Kro¨ner-Fresenius Stiftung (2017_A13), the Swedish Heart–Lung Foundation (20190317), and the Leducq foundation (TNE-18CVD04). P.L. receives funding support from the National Heart, Lung, and Blood Institute (1R01HL134892), the American Heart Association (18CSA34080399), the RRM Charitable Fund, and the Simard Fund. V.P. receives core funding from the Francis Crick institute funded by UK Medical Research Council, Cancer Research UK and the Wellcome Trust (FC0010129, FC001134). I.V.A was funded by an EMBO LTF (ALTF 113-2019). A.H. is funded by Ministerio de Ciencia e Innovacion (RTI2018-095497-B-I00), La Caixa Foundation (HR17_00527), and the European Commision (FET-OPEN 861878).S

Qualitätssicherung in der Auftragsabwicklung : automatisierte Produktion von Nockenschaltern

Zunehmende Kundenanforderungen, einhergehend mit höherer Qualität und steigendem Kostendruck, zwingen zu einer effizienten Durchsetzung von Qualitätssicherungsmaßnahmen. Einfluß auf diese Entwicklung üben das Produktehaftungsgesetz und die Normung bezüglich der Einführung von Qualitätssicherungssystemen nach DIN ISO 9000 aus. Basierend auf einem Laboraufbau, gelang es zum Beispiel bei der automatisierten Produktion von Nockenschaltern, die gesamte Prozeßkette datentechnisch so zu integrieren, daß ein Großteil von Fehlern ausgeschlossen werden kann

Results of bone marrow examinations in patients with chronic immune thrombocytopenic purpura treated with eltrombopag

Background: Bone marrow (BM) reticulin fibers can be increased in conditions such as neoplasms and autoimmune diseases (Frisch Haematol [Budap] 1982; Aharon Lupus 1997) and can lead to a clinical situation similar to osteomyelofibrosis. In healthy individuals, grade 1 and 2 reticulin have been reported in 27–70% and 4–20% of BM biopsies, respectively (Hultdin Med Onc 2007; Beckman Arch Path Int Med 1990; Bauermeister Am J Clin Path 1971). The presence of grade 1/2 reticulin was reported in the BM of up to 67% of patients with immune thrombocytopenic purpura (ITP) (Mufti J Supp Onc 2007). Theoretically, prolonged stimulation of megakaryocytes with TPO-R agonists might increase the risk of myelofibrosis (MF). Increased reticulin and peripheral nucleated RBCs have been reported in chronic ITP patients treated with romiplostim (Bussel Blood 2009). Eltrombopag, an oral, small molecule, TPO-R agonist, is approved in the United States for the treatment of chronic ITP. Objective: To determine whether eltrombopag treatment is associated with an increase in BM reticulin. METHODS Reports of BM biopsies performed prior to eltrombopag treatment were reviewed. In eltrombopag studies, complete blood counts (CBC) including white blood cell (WBC) differentials were performed at each visit. If a WBC differential indicated the presence of immature or dysplastic cells in the RAISE, REPEAT, and EXTEND studies, then a peripheral blood smear was performed. If the presence of immature or dysplastic cells on the blood smear was not consistent with the chronic ITP diagnosis, then a BM biopsy was performed. Additionally, a BM biopsy could be performed at any time at the investigator\u27s discretion. In EXTEND, a BM biopsy was required after 1 year on treatment. Reticulin was quantified using the modified MF scale (Thiele Haematologica 2005). Results: Prestudy BM biopsies were available for 64/446 patients subsequently exposed to eltrombopag; 51 reports did not mention reticulin or fibrosis. Of the 13 remaining prestudy reports, 4 (31%) had increased reticulin. Ninety-one patients (5 patients RAISE; 86 patients EXTEND) had a BM biopsy following treatment initiation; none of the BM biopsies were prompted by an abnormal peripheral blood smear. In a 6-month placebo-controlled study (RAISE), 1 placebo-treated patient had an on-treatment BM examination that showed myelodysplastic syndrome, and 4 eltrombopag-treated patients (2 on-treatment and 2 posttreatment) had BM examinations. One patient treated with eltrombopag for 41 days had a posttreatment marrow examination that showed grade 2 (Bauermeister) reticulin. None of the 4 showed hematologically relevant BM alterations. In an open-label extension study (EXTEND), 86 patients treated for a median of 12 months (range: 1–18 months) at the time of the procedure had BM biopsies; 83 had mention of reticulin fibers in the report and were evaluable for this analysis. Five patients had MF grade 2 reticulin with no clinical signs or symptoms of BM dysfunction (eg, abnormal WBC differential or peripheral blood smear); 2 reported collagen. One patient had a biopsy 2 years prior to EXTEND (grade 1/3). After 15 months on study, a biopsy showed grade 2/3; this patient was withdrawn. Of note, while on treatment the patient was not considered a responder (platelets \u3c50,000/μL) but did have decreased bleeding. The second patient was 81 years old with a history of 3 cancers. A similar degree of reticulin was observed when comparing the biopsy taken 6 years prior to EXTEND and after 14 months on study, but collagen was noted on the second BM. A patient with MF grade 1 reticulin reported collagen, but did not experience any adverse event or significant change in CBC and is continuing on study with good platelet response. Conclusion: There was no evidence of clinically relevant BM abnormalities or clinical findings typically associated with MF in patients treated for up to 18 months with eltrombopag. Systematic longitudinal evaluation of BMs in EXTEND will provide meaningful data regarding incidence of fibrosis during long-term treatment

Evaluación de la eficacia de un abono orgánico en el cultivo de pimentón (Capsicum annuum L. ) en la granja del colegio integrado del carare (CICA) en el municipio de Cimitarra - Santander

Poultry manure is a widely used organic fertilizer due to its high content of nutrients such as nitrogen, phosphorus and potassium. It is produced from the decomposition and accumulation of poultry droppings, mainly hens, in combination with the material used to absorb moisture. Poultry manure is used to improve soil quality and structure, as well as to increase crop production. In the present work, the effect of poultry manure in combination with efficient microorganisms (EM) on the cultivation of paprika (Capsicum annuum L.) is evaluated. The farm of the Colegio Integrado del Carare has a problem of solid waste production from the feces of 600 laying hens, generating approximately 2 tons of solid waste per year. On the other hand, there are problems in the production of chicken manure because its preparation is not adequate and causes environmental problems. Therefore, the aim is to develop a biotechnological strategy to improve the production of poultry manure with the addition of efficient microorganisms (EM) and to use poultry manure as agricultural fertilizer to improve paprika production. The hypothesis is that the application of poultry manure with and without microorganisms will improve paprika crop growth, quality and production. The methodology used is the preparation of the poultry manure with EM, the establishment of the crop and the application of treatments. Treatments consist of grams of poultry manure/plant: absolute control (0 gr), treatment 1 (80 gr), treatment 2 (40 gr), treatment 3 (6 gr), and grams of poultry manure/plant + ME - absolute control 0 gr - treatment 1 (80 gr) - treatment 2 (80 gr + 10% ME) - treatment 3 (80 gr + 25% ME) - treatment 3 (80 gr + 50% ME). The statistical design is a completely randomized design with 6 replicates per treatment, and significant differences between treatments are evaluated by ANOVA and t-test. The impact we want to generate is to contribute to sustainable agricultural practices in the cultivation of paprika and the preservation of the environment through the proper preparation of poultry manure.La gallinaza es un abono orgánico ampliamente utilizado debido a su alto contenido de nutrientes como nitrógeno, fósforo y potasio. Se produce a partir de la descomposición y acumulación de los excrementos de aves de corral, principalmente gallinas, en combinación con el material utilizado para absorber la humedad. La gallinaza es utilizada para mejorar la calidad del suelo y su estructura, además para aumentar la producción de cultivos. En el presente trabajo, se evalúa el efecto de la gallinaza en combinación con microorganismos eficientes (EM) en el cultivo de pimentón (Capsicum annuum L.). En la granja del Colegio Integrado del Carare, se presenta un problema de producción de residuos sólidos procedentes de las heces de 600 gallinas ponedoras, generando aproximadamente 2 toneladas de residuos sólidos al año. Por otro lado, se tienen problemas en la producción de gallinaza debido a que su preparación no es adecuada y ocasiona problemas ambientales. Por lo anterior, se pretende desarrollar una estrategia biotecnológica para mejorar la producción de gallinaza con la adición de microorganismos eficientes (EM) y utilizar la gallinaza como abono agrícola para mejorar la producción de pimentón. La hipótesis consiste en que, si se aplica gallinaza con y sin microorganismos, se mejorará el crecimiento del cultivo de pimentón, calidad y producción. La metodología empleada es la preparación de la gallinaza con EM, el establecimiento del cultivo y la aplicación de tratamientos. Los tratamientos consisten en gramos de gallinaza/planta: control absoluto (0 gr), tratamiento 1 (80 gr), tratamiento 2 (40 gr), tratamiento 3 (6 gr), y gramos de gallinaza/planta + EM - control absoluto 0 gr - tratamiento 1 (80 gr) - tratamiento 2 (80 gr + 10% EM) - tratamiento 3 (80 gr + 25% EM) - tratamiento 3 (80 gr + 50% EM). El diseño estadístico es un diseño completamente al azar con 6 repeticiones por tratamiento, y se evalúan las diferencias significativas entre tratamientos por ANOVA y la prueba t. El impacto que queremos generar es contribuir a prácticas agrícolas sostenibles en el cultivo del pimentón y a la preservación del medio ambiente por medio de la adecuada preparación de la gallinaza

Association of sex and cardiovascular risk factors with atherosclerosis distribution pattern in lower extremity peripheral artery disease.

OBJECTIVE Atherosclerosis expression varies across not only coronary, cerebrovascular, and peripheral arteries but also within the peripheral vascular tree. The underlying pathomechanisms of distinct atherosclerosis phenotypes in lower extremity peripheral artery disease (PAD) is poorly understood. We investigated the association of cardiovascular risk factors (CVRFs) and atherosclerosis distribution in a targeted approach analyzing symptomatic patients with isolated anatomic phenotypes of PAD. METHODS In a cross-sectional analysis of consecutive patients undergoing first-time endovascular recanalization for symptomatic PAD, data of patients with isolated anatomic phenotypes of either proximal (iliac) or distal (infrageniculate) atherosclerosis segregation were extracted. We performed a multivariable logistic regression model with backward elimination to investigate the association of proximal and distal PAD with CVRFs. RESULTS Of the 637 patients (29% females) with endovascular recanalization, 351 (55%) had proximal and 286 (45%) had distal atherosclerosis. Female sex [odds ratio (OR) 0.33, 95% confidence interval (CI) 0.20-0.54, p = 0.01], active smoking (OR 0.16, 95% CI 0.09-0.28, p < 0.001), and former smoking (OR 0.33, 95% CI 0.20-0.57, p < 0.001) were associated with proximal disease. Diabetes mellitus (DM) (OR 3.25, 95% CI 1.93-5.46, p < 0.001), chronic kidney disease (CKD) (OR 1.18, 95% CI 1.08-1.28, p < 0.001), and older age (OR 1.31, 95% CI 1.06-1.61, p = 0.01) were associated with distal disease. CONCLUSION Female sex, particularly in the context of smoking, is associated with clinically relevant, proximal atherosclerosis expression. Our additional findings that distal atherosclerosis expression is associated with DM, CKD, and older age suggest that PAD has at least two distinct atherosclerotic phenotypes with sex-specific and individual susceptibility to atherogenic risk factors