3,658 research outputs found

    Exploring the Interdependence of Trust and Communication in the Teacher-Principal Relationship

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    This research explored teacher and principal perceptions of trust and communication in the teacher-principal relationship. Through in-depth interviews, research participants provided perceived characteristics needed for effective teachers, principals, and teacher-principal relationships, and pointed out characteristics detrimental to the effectiveness of the teacher-principal relationship. The research utilized past research in organizational communication, trust, and trust and communication within the teacher-principal relationship and other important components of effective teacher-principal relationships to provide a literary foundation for the study. The research identified perceptions of teachers and principals with respect to communication and trust in the teacher-principal relationship, and identified what priorities successful first-year principals need to cultivate for effective relationships with their faculty. Participants were comprised of teachers and principals from two elementary schools in southern Louisiana. Participants articulated their perspectives and shared experiences working with effective and ineffective principals. The experiences and perspectives of the research participants demonstrated the paralysis of functionality in the teacher-principal relationship caused by distrustful and non-communicative relationships. The research findings provide concrete evidence for the importance of establishing an effective teacher-principal relationship built on trust and communication. The eight participants shared the view that communication was a necessity for an effective teacher-principal relationship. Most of the participants also thought that trust needs to be present for successful teacher-principal relationships. The research findings revealed the participants had similar views of an effective teacher-principal relationship and the necessary characteristics of an effective principal and teacher

    Contribution of Piezo2 to endothelium-dependent pain.

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    BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced enhancement of hyperalgesia that is vascular endothelial cell dependent. We also evaluated its role in a preclinical model of a vascular endothelial cell dependent painful peripheral neuropathy.ResultsThe local administration of oligodeoxynucleotides antisense to Piezo2 mRNA, at the site of nociceptive testing in the rat's hind paw, but not intrathecally at the central terminal of the nociceptor, prevented innocuous stimulus-induced enhancement of hyperalgesia produced by endothelin-1 (100 ng). The mechanical hyperalgesia induced by oxaliplatin (2 mg/kg. i.v.), which was inhibited by impairing endothelial cell function, was similarly attenuated by local injection of the Piezo2 antisense. Polymerase chain reaction analysis demonstrated for the first time the presence of Piezo2 mRNA in endothelial cells.ConclusionsThese results support the hypothesis that Piezo2 is a mechano-transducer in the endothelial cell where it contributes to stimulus-dependent hyperalgesia, and a model of chemotherapy-induced painful peripheral neuropathy

    Distinct causal influences of parietal versus frontal areas on human visual cortex: evidence from concurrent TMS-fMRI

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    It has often been proposed that regions of the human parietal and/or frontal lobe may modulate activity in visual cortex, for example, during selective attention or saccade preparation. However, direct evidence for such causal claims is largely missing in human studies, and it remains unclear to what degree the putative roles of parietal and frontal regions in modulating visual cortex may differ. Here we used transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) concurrently, to show that stimulating right human intraparietal sulcus (IPS, at a site previously implicated in attention) elicits a pattern of activity changes in visual cortex that strongly depends on current visual context. Increased intensity of IPS TMS affected the blood oxygen level–dependent (BOLD) signal in V5/MT+ only when moving stimuli were present to drive this visual region, whereas TMS-elicited BOLD signal changes were observed in areas V1–V4 only during the absence of visual input. These influences of IPS TMS upon remote visual cortex differed significantly from corresponding effects of frontal (eye field) TMS, in terms of how they related to current visual input and their spatial topography for retinotopic areas V1–V4. Our results show directly that parietal and frontal regions can indeed have distinct patterns of causal influence upon functional activity in human visual cortex. Key words: attention, frontal cortex, functional magnetic resonance imaging, parietal cortex, top--down, transcranial magnetic stimulatio

    Tyrosine 263 in Cyanobacterial Phytochrome Cph1 Optimizes Photochemistry at the prelumi-R→lumi-R Step

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    We report a low-temperature fluorescence spectroscopy study of the PAS-GAF-PHY sensory module of Cph1 phytochrome, its Y263F mutant (both with known 3D structures) as well as Y263H and Y263S to connect their photochemical parameters with intramolecular interactions. None of the holoproteins showed photochemical activity at low temperature, and the activation barriers for the Pr→lumi-R photoreaction (2.5-3.1 kJ mol(-1)) and fluorescence quantum yields (0.29-0.42) were similar. The effect of the mutations on Pr→Pfr photoconversion efficiency (ΦPr→Pfr) was observed primarily at the prelumi-R S0 bifurcation point corresponding to the conical intersection of the energy surfaces at which the molecule relaxes to form lumi-R or Pr, lowering ΦPr→Pfr from 0.13 in the wild type to 0.05-0.07 in the mutants. We suggest that the Ea activation barrier in the Pr* S1 excited state might correspond to the D-ring (C19) carbonyl - H290 hydrogen bond or possibly to the hindrance caused by the C13(1) /C17(1) methyl groups of the C and D rings. The critical role of the tyrosine hydroxyl group can be at the prelumi-R bifurcation point to optimize the yield of the photoprocess and energy storage in the form of lumi-R for subsequent rearrangement processes culminating in Pfr formation

    2004-2005 Master Class - Jon Nakamatsu (Piano)

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    Piano Recital - Jon Nakamatsu (March 31, 2005) - Programhttps://spiral.lynn.edu/conservatory_masterclasses/1148/thumbnail.jp

    Individual Responses to an 8-Week Neuromuscular Training Intervention in Trained Pre-Pubescent Female Artistic Gymnasts

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    This study examined individual responses in leg stiffness, reactive strength index (RSI), movement proficiency (deep overhead squat and in-line lunge), and trunk muscular endurance (flexor and extensor tests) in young female gymnasts following an 8-week neuromuscular training intervention. Thirty-four pre-peak height velocity (PHV) female gymnasts were divided into either an experimental group (EXP n = 17) or control group (CON n = 17). The EXP replaced their normal gymnastics physical preparation with a neuromuscular training program, while the CON continued with their habitual gymnastics program. Chi square analysis showed that the EXP resulted in significantly more positive responders compared to CON for measures of leg stiffness (41% versus 12% responded positively), extensor muscular endurance, (76% versus 29%), and competency in the deep overhead squat, (76% versus 29%) and in-line lunge (left lead leg) (65% versus 18%). Conversely, the number of positive responders for RSI (53% versus 61%), the flexor endurance test (88% versus 53%), and the right in-line lunge (47% versus 35%) were not significantly different between groups. These findings suggest that most young gymnasts responded positively to neuromuscular training from the perspective of improving movement proficiency and trunk endurance; however, changes in leg stiffness and RSI were more variable and may require higher intensities to realise further adaptations

    Effect of Short-Term Failure Versus Nonfailure Training on Lower Body Muscular Endurance

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    This study compared failure versus nonfailure training with equated intensity and volume on lower body muscular endurance in trained men. Methods: Each subject performed one lower body workout per week for 6 weeks; the Failure group performed 3 sets of the squat, leg curl, and leg extension exercises to the point of voluntary exhaustion, while the Nonfailure group performed 4 sets for each of these exercises, but with a submaximal number of repetitions that did not allow failure to occur on any set. All subjects performed a pre- and postintervention muscular endurance test that involved 3 sets each for the squat, leg curl, and leg extension exercises. Blood lactate concentration (BL) was assessed before, and at 5 and 10 minutes following the test. Heart rate (HR) was assessed before the test, following the last set of each exercise, and for 10 minutes following the test. Results: Both groups demonstrated significant increases in total work (P \u3c .0001) for the postintervention test, with no significant differences between the groups (P = .882). When comparing the pre- and postintervention tests, BL and HR were not significantly different at any time point (P \u3e .05). Conclusions: These results indicate that when intensity and volume are equated, failure or nonfailure training results in similar gains in lower body muscular endurance. Therefore, when assessed over relatively short training cycles, the total volume of training might be more important versus whether sets are performed to failure for muscular endurance-related adaptations

    Effect of Short-Term Failure Versus Nonfailure Training on Lower Body Muscular Endurance

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    This study compared failure versus nonfailure training with equated intensity and volume on lower body muscular endurance in trained men. Methods: Each subject performed one lower body workout per week for 6 weeks; the Failure group performed 3 sets of the squat, leg curl, and leg extension exercises to the point of voluntary exhaustion, while the Nonfailure group performed 4 sets for each of these exercises, but with a submaximal number of repetitions that did not allow failure to occur on any set. All subjects performed a pre- and postintervention muscular endurance test that involved 3 sets each for the squat, leg curl, and leg extension exercises. Blood lactate concentration (BL) was assessed before, and at 5 and 10 minutes following the test. Heart rate (HR) was assessed before the test, following the last set of each exercise, and for 10 minutes following the test. Results: Both groups demonstrated significant increases in total work (P \u3c .0001) for the postintervention test, with no significant differences between the groups (P = .882). When comparing the pre- and postintervention tests, BL and HR were not significantly different at any time point (P \u3e .05). Conclusions: These results indicate that when intensity and volume are equated, failure or nonfailure training results in similar gains in lower body muscular endurance. Therefore, when assessed over relatively short training cycles, the total volume of training might be more important versus whether sets are performed to failure for muscular endurance-related adaptations
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