Chromosomes of the Laboratory Mouse

The chromosome number of 40 for the laboratory mouse was confirmed. A karyotype of mouse chromosomes was made. The chromosomes can be arranged into four groups based on size and shape

An Economic Analysis of Texas Shrimp Season Closures

Management of the Texas penaeid shrimp fishery is aimed at increasing revenue from brown shrimp, Penaeus aztecus, landings and decreasing the level of discards. Since 1960 Texas has closed its territorial sea for 45-60 days during peak migration of brown shrimp to the Gulf of Mexico. In 1981 the closure was extended to 200 miles to include the U.S. Exclusive Economic Zone. Simulation modeling is used in this paper to estimate the changes in landings, revenue, costs, and economic rent attributable to the Texas closure. Four additional analyses were conducted to estimate the effects of closing the Gulf 1- to 4-fathom zone for 45 and 60 days, with and without effort redirected to inshore waters. Distributional impacts are analyzed in terms of costs, revenues, and rents, by vessel class, shrimp species, vessel owner, and crew

A THREE DIMENSIONAL ANALYSIS OF THE WINDMILL SOFTBALL PITCH

The act of periorming the windmill softball pitch encompasses total body activity with activation of body parts through a link system. With the coordinated action of all body segments, ballistic energy is applied to the ball to result in the greatest produced velocity at the time of ball release. In attempt to improve periormance, coaches and educators must understand the motions about the joints involved. Therefore it was the purpose of this study to determine the joint motions and movement patterns of the kinetic chain in the ballistic skill of periorming the windmill pitch in attempt to improve athletic periormance as well as athletic instruction

A system for rapid creation and assessment of conceptual large vehicle designs using immersive virtual reality

Currently, new product concepts are often evaluated by developing detailed virtual part and assembly models with traditional computer aided design (CAD) tools followed by appropriate analyses (e.g., finite element analysis, computational fluid dynamics, etc.). The creation of these models and analyses are tremendously time consuming. If a number of different conceptual configurations have been determined, it may not be possible to model and analyze each of them due to the complexity of these evaluation processes. Thus, promising concepts might be eliminated based solely on insufficient time and resources for assessment. In addition, the virtual models and analyses performed are usually of much higher detail and accuracy than what is needed for such early assessment. By eliminating the time-consuming complexity of a CAD environment and incorporating qualitative assessment tools, engineers could spend more time evaluating concepts that may have been previously abandoned due to time constraints. To address these issues, the Advanced Systems Design Suite (ASDS), was created. The ASDS incorporates a PC user interface with an immersive virtual reality (VR) environment to ease the creation and assessment of conceptual design prototypes individually or collaboratively in an immersive VR environment. Assessment tools incorporate metamodeling approximations and immersive visualization to evaluate the feasibility of each concept. In this paper, the ASDS system and interface along with specifically designed immersive VR assessment tools such as state saving and dynamic viewpoint creation are presented for conceptual large vehicle design. A test case example of redesigning an airplane is presented to explore the feasibility of the proposed system

Biomarkers for Drug Development in Propionic and Methylmalonic Acidemias

There is an unmet need for the development and validation of biomarkers and surrogate endpoints for clinical trials in propionic acidemia (PA) and methylmalonic acidemia (MMA). This review examines the pathophysiology and clinical consequences of PA and MMA that could form the basis for potential biomarkers and surrogate endpoints. Changes in primary metabolites such as methylcitric acid (MCA), MCA:citric acid ratio, oxidation of 13C-propionate (exhaled 13CO2), and propionylcarnitine (C3) have demonstrated clinical relevance in patients with PA or MMA. Methylmalonic acid, another primary metabolite, is a potential biomarker, but only in patients with MMA. Other potential biomarkers in patients with either PA and MMA include secondary metabolites, such as ammonium, or the mitochondrial disease marker, fibroblast growth factor 21. Additional research is needed to validate these biomarkers as surrogate endpoints, and to determine whether other metabolites or markers of organ damage could also be useful biomarkers for clinical trials of investigational drug treatments in patients with PA or MMA. This review examines the evidence supporting a variety of possible biomarkers for drug development in propionic and methylmalonic acidemias

Cultural Resources Report for the Salt Creek Midstream, LLC Proposed Quito Draw Pipeline Project on University Lands, UT System Property in Ward County, Texas

Enercon Services, Inc. (ENERCON), in support of Salt Creek Midstream, LLC, conducted an intensive archeological survey for the proposed Quito Draw Pipeline Project. The proposed pipeline is approximately 19.3 miles (31.1 km) in length, located near Barstow and Pyote, Texas in Ward County. This report encompasses only the University Lands, UT System property segment of the proposed Quito Draw Pipeline Project which is approximately 11.8 miles (19.0km) in length. The University Lands, UT System property segment of the project area is depicted on the United States Geological Survey (USGS) Wink South, Tex. (1968), Soda Lake NE, Tex. (1968), and Soda Lake SE, Tex. (1968) 7.5 Minute Quadrangle maps. The construction corridor consists of a 50 foot (15m) wide permanent pipeline right-of-way (ROW) and a 50 foot (15m) wide temporary workspace corridor. The entire 50 foot (15m) wide ROW will be cleared of vegetation and the eight-inch gas pipeline will be installed in an open cut trench. The cultural resources survey corridor and area of potential effect (APE) was 100 foot (30m) wide for the entire 11.8 mile (19.0km) length of the pipeline segment through the University Lands, UT System property segment of the project, for a total of 143.03 acres (57.88 hectares). The survey of the University Lands, UT System, a political subdivision of the State of Texas, property, was completed under Texas Antiquities Permit No. 9011. The initial cultural resources field investigation on University Lands, UT System property was conducted October 7, 2018 to October 9, 2018 by Christopher Flowers and Gary D. Edington and consisted of an intensive pedestrian survey utilizing transects spaced no greater than 15m apart with shovel tests in areas which had the potential for buried cultural resources. The field investigation was conducted in accordance with the Texas Historical Commission (THC) Archeological Survey Standards for Texas. The entire project was supervised by Gary D. Edington, an ENERCON archeologist who meets the U.S. Secretary of the Interior’s Professional Qualification Standards for archeology as set forth in 36 CFR 61. The initial cultural resources investigation of the proposed Quito Draw Pipeline Project on University Lands, UT System property resulted in the observation of one isolated find (IF). IF#1 consists of a mottled pink and white tertiary chert flake. Ground Surface Visibility (GSV) at the location of IF#1 averaged around 65 percent. Five shovel tests were excavated in the vicinity of IF#1, all of which were negative for cultural resources. A pedestrian survey grid at 3-5m intervals at the location of IF#1 failed to identify any additional cultural materials and the location was noted as an isolated find. IF#1 lacks important information potential and is not recommended as eligible for the National Register of Historic Places (NRHP) or designation as a State Antiquities Landmark (SAL), and no further work is recommended at the location of IF#1. Prior to the initial survey, a site file check was conducted which resulted in the determination that no previously recorded sites are within the APE, or within 1-mile of the APE on University Lands, UT System property. Unfortunately, the Atlas was updated after the site file check was completed. A post facto site file check was conducted which resulted in the determination that seven previously recorded sites are recorded within 1-mile of the APE. Two of which, 41WR106 and 41WR107, are recorded within the APE and were partially impacted by the construction of the Quito Draw Pipeline on University Lands, UT System property. The field crew did not know 41WR106 and 41WR107 were recorded adjacent to the APE prior to fieldwork and these site locations were not observed during the initial survey. Prior to this Cultural Resources Report being presented to THC construction began on both the Quito Draw and Olifant 12-Inch pipelines. Thus, a post facto revisit of 41WR106 and 41WR107 was conducted on February 22, 2020 by J. Matthew Oliver and Gary D. Edington to assess the impact damage to both sites. Both sites, 41WR106 and 41WR107 were negatively impacted by the construction of the Quito Draw and Olifant 12-inch Pipelines on University Lands, UT System property. At site 41WR106 it appears that less than two percent of the previously recorded site area has been destroyed while at site 41WR107 it appears that approximately four percent of the site has been destroyed by the clearing of the Quito Draw and Olifant 12-inch pipelines. The cultural resources investigations did not result in finding any additional historic or prehistoric artifacts, features, cultural lenses, or sites over 50 years of age on University Lands, UT System property. Therefore, it is recommended that the project will have no effect on any additional historic property that may qualify for inclusion in the NRHP or determination as a SAL on University Lands, UT System property. No further cultural resources investigations are recommended for the Quito Draw Pipeline Project on University Lands, UT System property. If cultural material, including sites, features, or artifacts that are 50 years old or older are encountered within the ROW during maintenance activities of the Quito Draw and Olifant Pipelines on University Lands, UT System property, work in the area must cease and the THC (512-463- 5853) must be immediately be notified

Final Cultural Resources Report of the Salt Creek Midstream, LLC Proposed Olifant Eight Inch Pipeline Project on University Lands in Ward County, Texas

Enercon Services, Inc. (ENERCON), in support of Salt Creek Midstream, LLC, conducted an intensive archeological survey for the proposed Olifant Eight Inch Pipeline Project located near Pyote in Ward County, Texas. The proposed project consists of the construction of an approximately 800 foot (244 m) long eight inch steel pipeline on University Lands, extending from a tie-in at an existing well pad, trending generally south-southeast to a tie-in on the existing Quito Draw pipeline. The Olifant Eight Inch Pipeline Project area is mapped on the United States Geological Survey (USGS) Soda Lake NE, Texas (1967, photorevised 1981) 7.5 Minute Quadrangle map. The construction corridor consists of a 50 foot (15 m) wide permanent pipeline right-of-way (ROW) and a 50 foot (15 m) wide temporary workspace corridor. The cultural resources survey corridor and the area of potential effect (APE) was 100 feet (30 m) wide for the entire 800 foot (244 m) length of the proposed Olifant Eight Inch Pipeline Project, totaling 1.84 acres (.74 hectares). The proposed project is entirely on University Lands, a political subdivision of the State of Texas. The archeological survey was completed under Texas Antiquities Permit No. 9012. The cultural resources field investigation on University Lands was conducted on February 26, 2019 by ENERCON archeologist Gary Edington, who meets the U.S. Secretary of the Interior’s Professional Qualification Standards for archeology as set forth in 36 CFR 61, and consisted of an intensive pedestrian survey utilizing transects spaced no greater than 15 m apart, with shovel tests in areas which had the potential for buried cultural resources. The field investigation was conducted in accordance with the Texas Historical Commission (THC) Archeological Survey Standards for Texas. The entire project was supervised by Michael Margolis, an ENERCON archeologist who meets the U.S. Secretary of the Interior’s Professional Qualification Standards for archeology as set forth in 36 CFR 61. The cultural resources survey did not result in finding any historic or prehistoric artifacts, features, cultural lenses, or sites over 50 years of age on University Lands. Therefore, it is recommended that the project will have no effect on any historic property that may qualify for inclusion in the National Register of Historic Places (NRHP) on University Lands. No further cultural resources investigations are recommended prior to construction of the proposed Olifant Eight Inch Pipeline Project on University Lands. If cultural material, including sites, features, or artifacts that are 50 years old or older are encountered within the ROW during construction of this project, work in the area must cease and the THC must be immediately be notified