The use of genes for performance enhancement: doping or therapy?

Recent biotechnological advances have permitted the manipulation of genetic sequences to treat several diseases in a process called gene therapy. However, the advance of gene therapy has opened the door to the possibility of using genetic manipulation (GM) to enhance athletic performance. In such ‘gene doping’, exogenous genetic sequences are inserted into a specific tissue, altering cellular gene activity or leading to the expression of a protein product. The exogenous genes most likely to be utilized for gene doping include erythropoietin (EPO), vascular endothelial growth factor (VEGF), insulin-like growth factor type 1 (IGF-1), myostatin antagonists, and endorphin. However, many other genes could also be used, such as those involved in glucose metabolic pathways. Because gene doping would be very difficult to detect, it is inherently very attractive for those involved in sports who are prepared to cheat. Moreover, the field of gene therapy is constantly and rapidly progressing, and this is likely to generate many new possibilities for gene doping. Thus, as part of the general fight against all forms of doping, it will be necessary to develop and continually improve means of detecting exogenous gene sequences (or their products) in athletes. Nevertheless, some bioethicists have argued for a liberal approach to gene doping

Overcoming ambiguities in classical and quantum correlation measures

We identify ambiguities in the available frameworks for defining quantum, classical, and total correlations as measured by discordlike quantifiers. More specifically, we determine situations for which either classical or quantum correlations are not uniquely defined due to degeneracies arising from the optimization procedure over the state space. In order to remove such degeneracies, we introduce a general approach where correlations are independently defined, escaping therefore from a degenerate subspace. As an illustration, we analyze the trace-norm geometric quantum discord for two-qubit Bell-diagonal states.Comment: 5 pages, 2 figures. v2: Minor corrections. Published versio

Analytical results for long time behavior in anomalous diffusion

We investigate through a Generalized Langevin formalism the phenomenon of anomalous diffusion for asymptotic times, and we generalized the concept of the diffusion exponent. A method is proposed to obtain the diffusion coefficient analytically through the introduction of a time scaling factor $\lambda$. We obtain as well an exact expression for $\lambda$ for all kinds of diffusion. Moreover, we show that $\lambda$ is a universal parameter determined by the diffusion exponent. The results are then compared with numerical calculations and very good agreement is observed. The method is general and may be applied to many types of stochastic problem

PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance.

β-lactam antibiotics are excellent drugs for treatment of staphylococcal infections, due to their superior efficacy and safety compared to other drugs. Effectiveness of β-lactams is severely compromised due to resistance, which is widespread among clinical strains of Staphylococcus aureus. β-lactams inhibit bacterial cells by binding to penicillin binding proteins (PBPs), which perform the penultimate steps of bacterial cell wall synthesis. Among PBPs of S. aureus, PBP2a has received the most attention for the past several decades due to its preeminent role in conferring both high-level and broad-spectrum resistance to the entire class of β-lactam drugs. Studies on PBP2a have thus unraveled incredible details of its mechanism of action. We have recently identified that an uncanonical, low molecular weight PBP of S. aureus, PBP4, can also provide high-level and broad-spectrum resistance to the entire class of β-lactam drugs at a level similar to that of PBP2a. The role of PBP4 has typically been considered not so important for β-lactam resistance of S. aureus, and as a result its mode of action remains largely unknown. In this article, we review our current knowledge of PBP4 mediating β-lactam resistance in S. aureus

Photoassociative ionization of Na inside a storage ring

Motivated by recent interest in low dimensional arrays of atoms, we experimentally investigated the way cold collisional processes are affected by the geometry of the considered atomic sample. More specifically, we studied the case of photoassociative ionization (PAI) both in a storage ring where collision is more unidirectional in character and in a trap with clear undefinition of collision axis. First, creating a ring shaped trap (atomotron) we investigated two-color PAI dependence with intensity and polarization of a probing laser. The intensity dependence of the PAI rate was also measured in a magneto-optical trap presenting equivalent temperature and density conditions. Indeed, the results show that in the ring trap, the value of the PAI rate constant is much lower and does not show evidences of saturation, unlike in the case of the 3D-MOT. Cold atomic collisions in storage ring may represent new possibilities for study.Comment: 5 pages, 5 figures; Accepted by Optics Communicatio

Influência da época de plantio, da irrigação suplementar e tratos culturais sobre o rendimento do feijoeiro.

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