Meningococcal disease in North America: Updates from the Global Meningococcal Initiative

This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting, which explored meningococcal disease in North America. Invasive meningococcal disease (IMD) cases are documented through both passive and active surveillance networks. IMD appears to be decreasing in many areas, such as the Dominican Republic (2016: 18 cases; 2021: 2 cases) and Panama (2008: 1 case/100,000; 2021: <0.1 cases/100,000); however, there is notable regional and temporal variation. Outbreaks persist in at-risk subpopulations, such as people experiencing homelessness in the US and migrants in Mexico. The recent emergence of β-lactamase-positive and ciprofloxacin-resistant meningococci in the US is a major concern. While vaccination practices vary across North America, vaccine uptake remains relatively high. Monovalent and multivalent conjugate vaccines (which many countries in North America primarily use) can provide herd protection. However, there is no evidence that group B vaccines reduce meningococcal carriage. The coronavirus pandemic illustrates that following public health crises, enhanced surveillance of disease epidemiology and catch-up vaccine schedules is key. Whole genome sequencing is a key epidemiological tool for identifying IMD strain emergence and the evaluation of vaccine strain coverage. The Global Roadmap on Defeating Meningitis by 2030 remains a focus of the GMI.Medical writing support for the development of this manuscript, under the direction of the authors, was provided Matthew Gunther of Ashfield MedComms, an Inizio company. Medical writing support was funded by Sanofi Pasteur. All authors discussed and agreed to the objectives of this manuscript and con- tributed throughout its production. All authors read and approved the final manuscript.S

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

Reproducibility of fluorescent expression from engineered biological constructs in E. coli

We present results of the first large-scale interlaboratory study carried out in synthetic biology, as part of the 2014 and 2015 International Genetically Engineered Machine (iGEM) competitions. Participants at 88 institutions around the world measured fluorescence from three engineered constitutive constructs in E. coli. Few participants were able to measure absolute fluorescence, so data was analyzed in terms of ratios. Precision was strongly related to fluorescent strength, ranging from 1.54-fold standard deviation for the ratio between strong promoters to 5.75-fold for the ratio between the strongest and weakest promoter, and while host strain did not affect expression ratios, choice of instrument did. This result shows that high quantitative precision and reproducibility of results is possible, while at the same time indicating areas needing improved laboratory practices.Peer reviewe

Outcomes in Newly Diagnosed Atrial Fibrillation and History of Acute Coronary Syndromes: Insights from GARFIELD-AF

BACKGROUND: Many patients with atrial fibrillation have concomitant coronary artery disease with or without acute coronary syndromes and are in need of additional antithrombotic therapy. There are few data on the long-term clinical outcome of atrial fibrillation patients with a history of acute coronary syndrome. This is a 2-year study of atrial fibrillation patients with or without a history of acute coronary syndromes

Study of b−b-hadron decays to Λc+h−h′−\Lambda_c^+h^-h^{\prime -} final states

Decays of $\Xi_{b}^{-}$ and $\Omega_{b}^{-}$ baryons to $\Lambda_{c}^{+} h^- h^{\prime -}$ final states, with $h^- h^{\prime -}$ being $\pi^{-}\pi^{-}$, $K^{-}\pi^{-}$ and $K^{-}K^{-}$ meson pairs, are searched for using data collected with the LHCb detector. The data sample studied corresponds to an integrated luminosity of $8.7 \rm fb^{-1}$ of $pp$ collisions collected at centre-of-mass energies $\sqrt{s} = 7$, $8$ and $13 \rm TeV$. The products of the relative branching fractions and fragmentation fractions for each signal mode, relative to the $B^{-} \rightarrow \Lambda_{c}^{+} \bar{p} \pi^{-}$ mode, are measured, with $\Xi_{b}^{-} \rightarrow\Lambda_{c}^{+} K^{-} \pi^{-}$, $\Xi_{b}^{-} \rightarrow\Lambda_{c}^{+} K^{-} K^{-}$ and $\Omega_{b}^{-} \rightarrow\Lambda_{c}^{+} K^{-} K^{-}$ decays being observed at over $5\,\sigma$ significance. The $\Xi_{b}^{-} \rightarrow\Lambda_{c}^{+} K^{-} \pi^{-}$ mode is also used to measure the $\Xi_{b}^{-}$ production asymmetry, which is found to be consistent with zero. In addition, the $B^{-} \rightarrow \Lambda_{c}^{+} \bar{p} K^{-}$ decay is observed for the first time, and its branching fraction is measured relative to that of the $B^{-} \rightarrow \Lambda_{c}^{+} \bar{p} \pi^{-}$ mode.Decays of $\Xi_b^-$ and $\Omega_b^-$ baryons to $\Lambda_c^+ h^- h^{\prime -}$ final states, with $h^- h^{\prime -}$ being $\pi^-\pi^-$, $K^-\pi^-$ and $K^-K^-$ meson pairs, are searched for using data collected with the LHCb detector. The data sample studied corresponds to an integrated luminosity of $8.7\,\mathrm{fb}^{-1}$ of $pp$ collisions collected at centre-of-mass energies $\sqrt{s} = 7$, $8$ and $13\,\mathrm{Te\kern -0.1em V}$. The products of the relative branching fractions and fragmentation fractions for each signal mode, relative to the $B^- \to \Lambda_c^+ \overline{p} \pi^-$ mode, are measured, with $\Xi_{b}^- \to\Lambda_{c}^+ K^- \pi^-$, $\Xi_{b}^- \to\Lambda_{c}^+ K^- K^-$ and $\Omega_{b}^- \to\Lambda_{c}^+ K^- K^-$ decays being observed at over $5\,\sigma$ significance. The $\Xi_{b}^- \to\Lambda_{c}^+ K^- \pi^-$ mode is also used to measure the $\Xi_{b}^-$ production asymmetry, which is found to be consistent with zero. In addition, the $B^- \to \Lambda_{c}^+ \overline{p} K^-$ decay is observed for the first time, and its branching fraction is measured relative to that of the $B^- \to \Lambda_{c}^+ \overline{p} \pi^-$ mode

Tracking of charged particles with nanosecond lifetimes at LHCb

A method is presented to reconstruct charged particles with lifetimes between 10 ps and 10 ns, which considers a combination of their decay products and the partial tracks created by the initial charged particle. Using the $\Xi^-$ baryon as a benchmark, the method is demonstrated with simulated events and proton-proton collision data at $\sqrt{s}=13$ TeV, corresponding to an integrated luminosity of 2.0 fb${}^{-1}$ collected with the LHCb detector in 2018. Significant improvements in the angular resolution and the signal purity are obtained. The method is implemented as part of the LHCb Run 3 event trigger in a set of requirements to select detached hyperons. This is the first demonstration of the applicability of this approach at the LHC, and the first to show its scaling with instantaneous luminosity

Search for the Bs0→μ+μ−γB_s^0 \rightarrow \mu^+\mu^-\gamma decay

International audienceA search for the fully reconstructed $B_s^0 \rightarrow \mu^+\mu^-\gamma$ decay is performed at the LHCb experiment using proton-proton collisions at $\sqrt{s}=13$ TeV corresponding to an integrated luminosity of $5.4\,\mathrm{fb^{-1}}$. No significant signal is found and upper limits on the branching fraction in intervals of the dimuon mass are set \begin{align} {\cal B}(B_s^0 \rightarrow \mu^+\mu^-\gamma) < 4.2\times10^{-8},~&m(\mu\mu)\in[2m_\mu,~1.70]\,\mathrm{GeV/c^2} ,\nonumber {\cal B}(B_s^0 \rightarrow \mu^+\mu^-\gamma) < 7.7\times10^{-8},~&m(\mu\mu)\in[1.70,~2.88]\,\mathrm{GeV/c^2},\nonumber {\cal B}(B_s^0 \rightarrow \mu^+\mu^-\gamma) < 4.2\times10^{-8},~&m(\mu\mu)\in[3.92 ,~m_{B_s^0}]\,\mathrm{GeV/c^2},\nonumber \end{align} at 95% confidence level. Additionally, upper limits are set on the branching fraction in the $[2m_\mu,~1.70]\,\mathrm{GeV/c^2}$ dimuon mass region excluding the contribution from the intermediate $\phi(1020)$ meson, and in the region combining all dimuon-mass intervals

First observation of Λb0→Σc(∗)++D(∗)−K−\Lambda_{b}^{0} \rightarrow \Sigma_c^{(*)++} D^{(*)-} K^{-} decays

International audienceThe four decays, $\Lambda_{b}^{0} \rightarrow \Sigma_c^{(*)++} D^{(*)-} K^{-}$, are observed for the first time using proton-proton collision data collected with the LHCb detector at a centre-of-mass energy of $13\,\rm{TeV}$, corresponding to an integrated luminosity of $6\,\rm{fb}^{-1}$. By considering the $\Lambda_b^0 \rightarrow \Lambda_c^{+} \overline{D}^0 K^{-}$ decay as reference channel, the following branching fraction ratios are measured to be, $$\frac{\cal{B} (\Lambda_{b}^{0} \rightarrow \Sigma_{c}^{++} \rm{D}^{-} {K}^{-})}{\cal{B}(\Lambda_{b}^{0} \rightarrow \Lambda_c^{+} \rm \overline{D}^0 {K}^{-})} = {0.282}\pm{0.016}\pm{0.016}\pm{0.005}, \frac{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_{c}^{*++} \rm {D}^{-} {K}^{-})}{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_c^{++} \rm {D}^{-} {K}^{-})} = {0.460}\pm{0.052}\pm{0.028}, \frac{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_{c}^{++} \rm {D}^{*-} {K}^{-})}{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_c^{++} \rm {D}^{-} {K}^{-})} = {2.261}\pm{0.202}\pm{0.129}\pm{0.046}, \frac{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_{c}^{*++} \rm D^{*-} K^{-})}{\cal{B}(\Lambda_{b}^{0} \rightarrow \Sigma_c^{++} \rm D^{-} K^{-})} = {0.896}\pm{0.137}\pm{0.066}\pm{0.018},$$ where the first uncertainties are statistical, the second are systematic, and the third are due to uncertainties in the branching fractions of intermediate particle decays. These initial observations mark the beginning of pentaquark searches in these modes, with more data set to become available following the LHCb upgrade