Investigar los métodos de gestión en educación con tomar el caso de un profesor en la etapa universitaria

The paper reveals the problem of the professional formation of a future teacher, training a teacher with a high intellectual level of self-awareness, being capable of conceptual thinking, creativity and being ready to independently managing one’s own professional activity, which will allow interacting more effectively with the learning environment, being an active subject of professional and pedagogical activity.El documento revela el problema de la formación profesional de un futuro maestro, capacitar a un maestro con un alto nivel intelectual de autoconciencia, ser capaz de pensamiento conceptual, creatividad y estar listo para gestionar de forma independiente la propia actividad profesional, lo que permitirá interactuar más efectivamente con el ambiente de aprendizaje, siendo un sujeto activo de actividad profesional y pedagógica

Investigating the Methods of Management in Education with Taking the Case of a Teacher at the Stage of University

The paper reveals the problem of the professional formation of a future teacher, training a teacher with a high intellectual level of self-awareness, being capable of conceptual thinking, creativity and being ready to independently managing one’s own professional activity, which will allow interacting more effectively with the learning environment, being an active subject of professional and pedagogical activity

Studying the effect of modifying additives on the hydration and hardening of cement composites for 3D printing

The development and application of multicomponent multifunctional additives for cement composites is an important research area since the use of such additives allows controlling both the rheological properties of fresh mixtures and the physical and mechanical properties of the hardened composite. In our study, we used several additives, including metakaolin and xanthan gum together with tetrapotassium pyrophosphate and a SiO2 based complex additive, to modify cementitious sand-based materials. We studied the peculiarities of the influence of these additives on the technological characteristics of mixtures (plasticity and shape retention) and the processes of setting, hydration, and hardening of the composite materials. The optimal values of plasticity, for stability, acceleration of hardening were demonstrated by sand-based systems modified with a complex nanosized additive and metakaolin. The hydration products in the such systems are mainly formed from low basic hydroxides. Metakaolin also results in the formation of ettringite. These systems demonstrate the optimal time of the beginning of setting and the maximum strength gain of the modified cementitious sand-based materials at 28 days. The optimal ratio of indicators of plasticity and shape retention of cement mixtures and the strength of composites based on them obtained by using the studied additives allows us to recommend using these additives in the innovative technologies for 3D-build printing

Study of the strength regulation factors for the adhesive bonding “cement matrix – reinforcing fiber” in composites for 3D-build printing

ABSTRACT: Introduction. As part of the solution for the problem of creating a new class of materials for building additive technologies, cement composites reinforced with high-strength fiber, this work presents the results of experimental studies of the strength of the adhesive bonding between cement matrices and reinforcing fibers with different chemical compositions, diameters, and tensile strength. Materials and methods. Rheological properties of cement systems were studied using shear and squeeze rheometry, the method of micromechanical testing for determining the strength of the adhesive bonding “cement matrix – reinforcing fiber” based on the pull-out test, which involves pulling out the fiber from the cement matrix layer; after the pull-out test for all the studied systems, the microstructure of the contact surface “cement matrix – reinforcing fiber” was assessed using a Thermo Scientific™ Phenom™ Desktop SEM scanning electron microscope; the compressive strength of hardened cement paste-samples was determined using an INSTRON Sates 1500HDS testing machine. Results and discussions. It was established that the combination of strength characteristics of matrices, fibers, and adhesive strength at their interface allowed securing the required strength characteristics of reinforced construction composites. In the “cement matrix – carbon fiber” systems, the value of adhesive strength was 9 – 11 MPa; in the “cement matrix – steel wire” systems, the value of adhesive strength was 3 – 4 MPa. Conclusions. Matrices with viscosity modifiers containing nano- and micro-sized particles of SiO2 (complex nano-sized additive and metakaolin) are reasonable options for combinations of the “cement matrix – reinforcing fiber” components. Carbon fiber and steel wire are recommended to be used as reinforcing fibers

Search for predictors of psoriatic arthritis in patients with psoriasis

Background. Psoriatic arthritis is a chronic inflammatory disease of the joints, spine and entheses that can occur in patients with psoriasis. The prevalence of psoriatic arthritis is 19.7%. In 70% of cases, psoriasis precedes the development of arthritis. It has been proven that a delay in the diagnosis of psoriatic arthritis even by 6 months is associated with a deterioration in long-term radiological and functional results, leading to disability. The problem of early diagnosis of joint damage can be solved by identifying predictors of the risk of developing psoriatic arthritis in patients with psoriasis. Aims. To determine possible predictors for the development of psoriatic arthritis in patients with psoriasis. Methods. The open, uncontrolled, prospective study enrolled 250 patients. The main group consisted of 190 patients diagnosed with plaque psoriasis. The control group consisted of 60 patients with psoriatic arthritis. In order to identify associations of clinical and genetic (HLA-B27 carriage) parameters with the development of psoriatic arthritis, we compared the frequency of occurrence of these parameters in patients with psoriatic arthritis and without. Results. Among 190 patients with plaque psoriasis 128 (67.4%) men, 62 (32.6%) women, aged 18 to 84 years (40.30 ± 15.56), the average duration of psoriasis was 10.09 ± 11.08 years (0–57). Among 60 patients with psoriatic arthritis 39 (65%) men, 21 (35%) women aged 18 to 86 years (44.43 ± 14.15), the average duration of psoriasis was 20.47 ± 13.22 years (2–57), the average duration of psoriatic arthritis was 7.97 ± 9.95 years (0–47). Сlinical predictors for the development of psoriatic arthritis in patients with psoriasis: nail psoriasis (OR = 2.244 [95% CI: 1.245–4.045]); severe psoriasis (PASI ≥ 20) (OR = 2.148 [95% CI: 1.161–3.975]); arterial hypertension (OR = 1.982 [95% CI: 1.031–3.812]); duration of psoriasis over 25 years (OR = 3.365 [95% CI: 1.676–6.756]), р 0,05. Conclusions. The joint consideration of informative predictors will allow us to develop an original multi-parameter mathematical model for calculating the risk of developing psoriatic arthritis in patients with psoriasis

The efficacy of the combination of eribulin and trastuzumab in advanced HER2-positive breast cancer: the results of Russian observational study

The article presents the experience of 19 Russian medical institutions on the use of eribulin in combination with trastuzumab in various treatment lines of metastatic HER2+ breast cancer in routine clinical practice. Aim. The main objective of this retrospective observational study was to evaluate the efficacy and tolerability of eribulin and trastuzumab combo in HER2+ breast cancer patients pretreated with anthracyclines and taxanes. The analysis included 60 patients who received at least 2 cycles of eribulin in combination with trastuzumab. 2 patients (3.3%) received treatment as the 1st line, as the 2nd 14 (23.3%), as the 3rd 16 (26.7%), and as the 4th and more 28 (46.7%). Materials and methods. Complete response was achieved in 2 (3.3%) patients, partial response in 9 (15%), stable disease in 33 (55%), stabilization for more than 6 months in 11 (18.3%), disease progression was detected in 16 (26.7%) patients. The objective response rate was 18.3% in the whole group, the clinical benefit rate 36.7%. Results. The objective response rate in the group of the luminal subtype (ER/PR+HER2+) was 26.9%, in HER2-overexpressed subtype (ER-PR-HER2+) 8.8% and 64.7%, respectively, disease progression was recorded 2.3 times more often 35.3% versus 15.5% in the luminal subtype group. The median progression-free survival in patients with HER2+ breast cancer was 4.95 months (95% confidence interval CI 3.048.29 months), in luminal subtype 6.38 months (95% CI 3.338.54 months), in non-luminal 4.44 months (95% CI 2.47.96 months); p=0.306. The treatment was well tolerated, the spectrum of adverse events corresponded to the eribulin toxicity profile. Conclusions. The uniqueness of this study lies in the fact that on a large clinical material from the standpoint of real clinical practice, a very promising treatment regimen that is not used routinely in a number of countries has been studied, its effectiveness and satisfactory tolerance have been confirmed

Investigating the Methods of Management in Education with Taking the Case of a Teacher at the Stage of University

The paper reveals the problem of the professional formation of a future teacher, training a teacher with a high intellectual level of self-awareness, being capable of conceptual thinking, creativity and being ready to independently managing one’s own professional activity, which will allow interacting more effectively with the learning environment, being an active subject of professional and pedagogical activity.El documento revela el problema de la formación profesional de un futuro maestro, capacitar a un maestro con un alto nivel intelectual de autoconciencia, ser capaz de pensamiento conceptual, creatividad y estar listo para gestionar de forma independiente la propia actividad profesional, lo que permitirá interactuar más efectivamente con el ambiente de aprendizaje, siendo un sujeto activo de actividad profesional y pedagógica

CRISPR-Cas Systems in Gut Microbiome of Children with Autism Spectrum Disorders

The human gut microbiome is associated with various diseases, including autism spectrum disorders (ASD). Variations of the taxonomical composition in the gut microbiome of children with ASD have been observed repeatedly. However, features and parameters of the microbiome CRISPR-Cas systems in ASD have not been investigated yet. Here, we demonstrate such an analysis in order to describe the overall changes in the microbiome CRISPR-Cas systems during ASD as well as to reveal their potential to be used in diagnostics and therapy. For the systems identification, we used a combination of the publicly available tools suited for completed genomes with subsequent filtrations. In the considered data, the microbiomes of children with ASD contained fewer arrays per Gb of assembly than the control group, but the arrays included more spacers on average. CRISPR arrays from the microbiomes of children with ASD differed from the control group neither in the fractions of spacers with protospacers from known genomes, nor in the sets of known bacteriophages providing protospacers. Almost all bacterial protospacers of the gut microbiome systems for both children with ASD and the healthy ones were located in prophage islands, leaving no room for the systems to participate in the interspecies competition

Round-the-World Voyage of the Threespine Stickleback (Gasterosteus aculeatus): Phylogeographic Data Covering the Entire Species Range

A total of 205 COI sequences and 310 cyt b sequences of the threespine stickleback (Gasterosteus aculeatus) from basins of all seas throughout the vast range of this species were analyzed. Median networks of haplotypes constructed in this study, combined with the results of reconstruction of paleogeographic conditions, led to the conclusion that the threespine stickleback emerged as a species in the Pacific Ocean basin and spread to Europe from the south, populating the system of water bodies that existed in the Oligocene. The main water body was the Paratethys Ocean (Sea), which existed 5–34 Mya. In the area of the modern North Sea, stickleback populations, part of which later migrated to the eastern and western coasts of North America, gave rise to the group of haplotypes that has the widest distribution in northern Europe. The stickleback populations belonging to the lineage that dispersed along the Arctic and western coasts of North America displaced the carriers of the haplotypes of the ancient phylogenetic lineage that inhabited the Pacific coast. The ancestors of G. wheatlandi dispersed from the Pacific to the Atlantic Ocean via the Arctic to meet G. aculeatus, which circled the globe from east to west

Round-the-World Voyage of the Threespine Stickleback (<i>Gasterosteus aculeatus</i>): Phylogeographic Data Covering the Entire Species Range

A total of 205 COI sequences and 310 cyt b sequences of the threespine stickleback (Gasterosteus aculeatus) from basins of all seas throughout the vast range of this species were analyzed. Median networks of haplotypes constructed in this study, combined with the results of reconstruction of paleogeographic conditions, led to the conclusion that the threespine stickleback emerged as a species in the Pacific Ocean basin and spread to Europe from the south, populating the system of water bodies that existed in the Oligocene. The main water body was the Paratethys Ocean (Sea), which existed 5–34 Mya. In the area of the modern North Sea, stickleback populations, part of which later migrated to the eastern and western coasts of North America, gave rise to the group of haplotypes that has the widest distribution in northern Europe. The stickleback populations belonging to the lineage that dispersed along the Arctic and western coasts of North America displaced the carriers of the haplotypes of the ancient phylogenetic lineage that inhabited the Pacific coast. The ancestors of G. wheatlandi dispersed from the Pacific to the Atlantic Ocean via the Arctic to meet G. aculeatus, which circled the globe from east to west