Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia

Objective: The authors systematically reviewed the literature on psychological approaches to treating the neuropsychiatric symptoms of dementia.Method: Reports of studies that examined effects of any therapy derived from a psychological approach that satisfied prespecified criteria were reviewed. Data were extracted, the quality of each study was rated, and an overall rating was given to each study by using the Oxford Centre for Evidence-Based Medicine criteria.Results: A total of 1,632 studies were identified, and 162 satisfied the inclusion criteria for the review. Specific types of psychoeducation for caregivers about managing neuropsychiatric symptoms were effective treatments whose benefits lasted for months, but other caregiver interventions were not. Behavioral management techniques that are centered on individual patients' behavior or on caregiver behavior had similar benefits, as did cognitive stimulation. Music therapy and Snoezelen, and possibly sensory stimulation, were useful during the treatment session but had no longer-term effects; interventions that changed the visual environment looked promising, but more research is needed.Conclusions: Only behavior management therapies, specific types of caregiver and residential care staff education, and possibly cognitive stimulation appear to have lasting effectiveness for the management of dementia-associated neuropsychiatric symptoms. Lack of evidence regarding other therapies is not evidence of lack of efficacy. Conclusions are limited because of the paucity of high-quality research ( only nine level-1 studies were identified). More high-quality investigation is needed

Effects of Non-Equilibrium Plasma on Eukaryotic Cells (Final Report: Grant FA9550-06-1-0004)

This document is our final report describing the research activities carried out under AFOSR Grant FA9550-06-1-0004. First, descriptions of our cold plasma generation systems are presented. Two systems, developed with past and present AFOSR support, are available in our laboratory. The first is a pulsed device capable of emitting a cold plasma plume in room air. The second is an air plasma generator the core of which is a dielectric barrier discharge excited by a high AC voltage. Following these brief descriptions we first present the effects of an atmospheric pressure air plasma on four different types of eukaryotic microalgae. Effects on the viability, motility, and morphology of the cells are presented and discussed. Second, we report on the results regarding the effect of plasma on a multi-cellular organism (planaria), to see if plasma alters in any way its growth after suffering a wound. Our preliminary conclusion is that plasma has no apparent negative effect on the cells regeneration process. We then report on our latest work regarding the characteristics of the plume generated by the Plasma Pencil. Finally, we report preliminary results on the effects of direct exposure of plasma to oral borne bacteria. This can lead to applications in dentistry

Estimation of Scottish pluvial flooding Expected Annual Damages using interpolation techniques

Flood modelling and mapping, underpinned by hydraulic modelling, are typically used to define flood hazard and allow a quantification of risk and associated Expected Annual Damages (EAD). At a regional or national scale, such modelling is often a lengthy process, which does not allow changes in risk resulting from new science such as revised rainfall frequency estimates or climate projections to be readily quantified by policy makers. A framework of interpolation and extrapolation methods has been developed in the R language via practical application to the city of Perth in central Scotland. These methods allow existing flood mapping, design rainfall estimates and property receptor datasets combined with revised design rainfall estimates to be used to rapidly assess the consequences of change in risk and EAD. The results are evaluated against detailed hydraulic modelling and are shown to provide a good approximation of changes in flood depth and EAD for properties previously modelled as at risk of flooding, particularly residential properties, with lower confidence for non-residential properties. In the Scottish context, the methods are considered to be robust for regional and national scale application and would allow policy makers with a means to rapidly determine the consequence of changes in design rainfall estimates without the immediate requirement to undertake complex hydraulic modelling

Currents, Waves and Turbulence Measurement: A view from multiple Industrial-Academic Projects in Tidal Stream Energy

This is the author accepted manuscript. The final version is available from IEEE via the DOI in this recordTidal Stream Energy is considered a regular, predictable and dense energy source with potential to make a significant contribution to our future energy needs. Development of the industry, from resource assessment to device design and operation, requires characterisation of the flow environment at a variety of spatial and temporal scales at tidal energy sites. Demand for flow characterisation arises from companies developing, installing and operating tidal turbine prototypes or small arrays in locations from Scotland to France to Canada. Flow characterisation for tidal stream applications relies on the measurement of water velocity at the relevant scales, yet given the non-uniformity of the flow field, no single instrument measures all the necessary data inputs required by the sector. This paper provides an overview of a variety of current, surface wave and turbulence metrics of industrial relevance to tidal stream and discusses methods employed to secure these datasets. The use of variants of acoustic current profilers is presented, which have been utilised and developed on previous and ongoing industrialacademic projects, including ReDAPT (ETI, UK), FloWTurb (EPSRC, UK) and RealTide (EC H2020, EU). These variants feature differing numbers of acoustic transducers and varying geometrical configurations with installations at both seabed locations and atop operating tidal stream energy converters. Ongoing development of advanced sensor configuration is discussed, aiming to achieve resilient, high resolution threedimensional measurement of mean and turbulent flow tailored for tidal energy applications. The paper gives practitioners and researchers an overview of tidal stream flow characterisation and practical lessons learnt.Engineering and Physical Sciences Research Council (EPSRC)European Union Horizon 202

The Ursinus Weekly, December 7, 1936

John Porambo, varsity center, is elected captain of 1937 gridmen by 21 lettermen • Articles by Groff and Yoh are Lantern prize winners • Xmas celebration is two nights • Ursinus rec center to open after Xmas • Y groups to present speaker on cooperative consumers plan • McClure, Sheeder, attend Association of Colleges meeting • Freshman gridders banquet in initial frosh grid fete • Bothell and Garber star in The Dark Tower; record crowd dances to Jan\u27s Tophatters • Dr. Meredith to address physical education group • Interfraternity council issues member list for new students • Students hear economist in talk on natural resources • Debating teams release schedules; women will meet Bucknell this Thursday; men to hold radio debate • Stevens new wrestling coach; good year expected; 27 candidates report for practice • Officials select all-dorm team; five frosh picked • Guest elected soccer captain, bear manager, by 11 lettermen • Costello and Heiges on conference team • Co-ed basketeers participate in new rules exhibition game • Snell\u27s belles end season with six wins, 3 losses • 15 basketballers report; 4 lettermen lead struggle • McAvoy\u27s bears end season in second place, F & M winners in conference; Captain Costello outstanding through season; twelve lettermen leave squadhttps://digitalcommons.ursinus.edu/weekly/1915/thumbnail.jp

Mapping topography and broad vegetation type to characterise the Boxford meadows SSSI (Unit 2)

Understanding the dynamic relationship between hydrology and ecology in a complex wetland setting should be considered integral to the sustainable management and conservation of wetland habitats and future water resource planning. Wetland hydrology can exhibit considerable spatial complexity as a result of sub surface and surface heterogeneity. The latter of which may be determined by the relationship between spatial topography variation and broad vegetation distribution. Any study to investigate such a relationship must be at a spatial resolution sufficient to identify patterns in surface topography and vegetation type. In this study state of the art survey technology was used to collect and record for subsequent mapping the topographic and vegetation characteristics of the Boxford lowland chalk groundwater dependent terrestrial ecosystem (GDTE). The resultant survey dataset successfully unveiled distinct patterns in topography and vegetation type. The analysis of the data in a Geographical Information System (GIS) desk confirmed for the first time the presence of paleo-channels and a braided fluvial system within the meadows. In addition the combined survey method gives some indication that the type of vegetation present appears to coincide with some of the more distinctive topographical features. The results demonstrate that combining the field survey campaign alongside desk based GIS analysis is an extremely useful and versatile tool and can provide valuable information to support the decision making process for both further scientific investigation and sustainable habitat management

4-H Poultry manual

The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311

LEUKEMIA-ASSOCIATED TRANSPLANTATION ANTIGENS RELATED TO MURINE LEUKEMIA VIRUS : THE X.1 SYSTEM: IMMUNE RESPONSE CONTROLLED BY A LOCUS LINKED TOH-2

Two BALB radiation leukemias are strongly rejected by hybrids of BALB with certain other mouse strains, although BALB mice themselves exhibit no detectable resistance whatever. Hybrids immunized with progressively increased inocula are resistant to 200 x 106 or more leukemia cells; their serum is cytotoxic for the leukemia cells in vitro and protects BALB mice against challenge with these BALB leukemias. The antigenic system thus identified has been named X.1. In (BALB x B6) hybrids the major determinant of resistance was shown to be a B6 gene in the K region of H-2. This is likely to be the Rgv-1 (Resistance to gross virus) locus of Lilly, which may thus be identified in this case as an Ir (Immune response) allele conferring ability to respond to X.1 antigen on MuLV and leukemia cells, and so responsible for production of X.1 antibody and the rejection of X.1+ leukemia cells by hybrid mice. Immunoelectron microscopy with X.1 antiserum (from immunized hybrids) shows labeling both on the cell surface and on virions produced by the leukemia cells. It is not known whether X.1 comprises only one or more than one antigen. Three radiation-induced BALB leukemias, one A strain radiation-induced leukemia, and 15/15 AKR primary spontaneous leukemias were typed X.1+ by the cytotoxicity test. Several other leukemias, including one induced by passage A Gross virus and one long-transplanted AKR ascites leukemia carried in (B6 x AKR)F1 hybrids, were X.1-. Normal mice of strains with a high incidence of leukemia and one other strain (129) express X.1 antigen, but evidently in amounts too small for certain detection in vitro; by the method of absorption in vivo, however, these strains could be typed X.1+ and other strains X.1-. We ascribe the X.1 antigen system tentatively to a sub-type of MuLV that is not passage A Gross virus and is probably not the dominant sub-type in strains with a high incidence of leukemia. After repeated passage in hybrids, one of the BALB leukemias became relatively resistant to rejection by the hybrid, partially lost its sensitivity to X.1 antiserum in vitro, and in electron micrographs was seen to produce fewer virions. The serum of untreated (BALB x B6) hybrids often contains cytotoxic antibody against leukemia cells, some of it probably anti-X.1. But another commonly occurring antibody, which is cytotoxic for C57BL leukemia EL4, appears to belong to another (undefined) system

Projecting impacts of climate change on habitat availability in a macrophyte dominated chalk river

Climate change will impact fluvial ecosystems through changes in the flow regime. Physical habitat is an established measure of a river's ecological status when assessing changes to flow. Yet, it requires extensive datasets, is site specific, and does not account for dynamic processes; shortcomings that the use of hydrological and hydraulic models may alleviate. Here, simulated flows along a 600 m reach of the River Lambourn, Boxford, UK, were extracted from the 1D MIKE 11 hydraulic component of an integrated MIKE SHE model of the Centre for Ecology & Hydrology River Lambourn Observatory. In-channel seasonal macrophyte growth and management through cutting alter water levels, represented in the hydraulic model by manipulating channel bed roughness (Manning's n). Assessment of climate change used outputs from the UK Climate Projections 2009 ensemble of global climate models for the 2080s. River discharge outputs were disaggregated to provide velocity and depth profiles across 41 cross sections along the reach. These were integrated with habitat suitability criteria for brown trout (Salmo trutta) to generate a measure of available physical habitat. The influence of macrophyte growth caused the habitat-discharge relationship to be unusable in evaluating the sensitivity of brown trout to flow changes. Instead, projected time series were used to show an overall reduction in habitat availability, more for adult than juvenile trout. Results highlighted the impact of weed cutting, and its potential role in mitigating both flood risk and the ecological impacts of climate change. The use of a hydraulic model to assess physical habitat availability has worldwide applicability