151 research outputs found
Velocity Distributions of Granular Gases with Drag and with Long-Range Interactions
We study velocity statistics of electrostatically driven granular gases. For
two different experiments: (i) non-magnetic particles in a viscous fluid and
(ii) magnetic particles in air, the velocity distribution is non-Maxwellian,
and its high-energy tail is exponential, P(v) ~ exp(-|v|). This behavior is
consistent with kinetic theory of driven dissipative particles. For particles
immersed in a fluid, viscous damping is responsible for the exponential tail,
while for magnetic particles, long-range interactions cause the exponential
tail. We conclude that velocity statistics of dissipative gases are sensitive
to the fluid environment and to the form of the particle interaction.Comment: 4 pages, 3 figure
Identification of miRNA signatures associated with radiation-induced late lung injury in mice.
Acute radiation exposure of the thorax can lead to late serious, and even life-threatening, pulmonary and cardiac damage. Sporadic in nature, late complications tend to be difficult to predict, which prompted this investigation into identifying non-invasive, tissue-specific biomarkers for the early detection of late radiation injury. Levels of circulating microRNA (miRNA) were measured in C3H and C57Bl/6 mice after whole thorax irradiation at doses yielding approximately 70% mortality in 120 or 180 days, respectively (LD70/120 or 180). Within the first two weeks after exposure, weight gain slowed compared to sham treated mice along with a temporary drop in white blood cell counts. 52% of C3H (33 of 64) and 72% of C57Bl/6 (46 of 64) irradiated mice died due to late radiation injury. Lung and heart damage, as assessed by computed tomography (CT) and histology at 150 (C3H mice) and 180 (C57Bl/6 mice) days, correlated well with the appearance of a local, miRNA signature in the lung and heart tissue of irradiated animals, consistent with inherent differences in the C3H and C57Bl/6 strains in their propensity for developing radiation-induced pneumonitis or fibrosis, respectively. Radiation-induced changes in the circulating miRNA profile were most prominent within the first 30 days after exposure and included miRNA known to regulate inflammation and fibrosis. Importantly, early changes in plasma miRNA expression predicted survival with reasonable accuracy (88-92%). The miRNA signature that predicted survival in C3H mice, including miR-34a-5p, -100-5p, and -150-5p, were associated with pro-inflammatory NF-κB-mediated signaling pathways, whereas the signature identified in C57Bl/6 mice (miR-34b-3p, -96-5p, and -802-5p) was associated with TGF-β/SMAD signaling. This study supports the hypothesis that plasma miRNA profiles could be used to identify individuals at high risk of organ-specific late radiation damage, with applications for radiation oncology clinical practice or in the context of a radiological incident
Опыт применения золадекса у больных эндометриозом и рецидивирующими гиперпластическими процессами эндометрия
ЭНДОМЕТРИОЗ /ЛЕК ТЕРЭНДОМЕТРИЯ ГИПЕРПЛАЗИЯ /ЛЕК ТЕРЗОЛАДЕК
Propagating front in an excited granular layer
A partial monolayer of ~ 20000 uniform spherical steel beads, vibrated
vertically on a flat plate, shows remarkable ordering transitions and
cooperative behavior just below 1g maximum acceleration. We study the stability
of a quiescent disordered or ``amorphous'' state formed when the acceleration
is switched off in the excited ``gaseous'' state. The transition from the
amorphous state back to the gaseous state upon increasing the plate's
acceleration is generally subcritical: An external perturbation applied to one
bead initiates a propagating front that produces a rapid transition. We measure
the front velocity as a function of the applied acceleration. This phenomenon
is explained by a model based on a single vibrated particle with multiple
attractors that is perturbed by collisions. A simulation shows that a
sufficiently high rate of interparticle collisions can prevent trapping in the
attractor corresponding to the nonmoving ground state.Comment: 16 pages, 9 figures, revised version, to appear in Phys. Rev. E, May
199
Knots and Random Walks in Vibrated Granular Chains
We study experimentally statistical properties of the opening times of knots
in vertically vibrated granular chains. Our measurements are in good
qualitative and quantitative agreement with a theoretical model involving three
random walks interacting via hard core exclusion in one spatial dimension. In
particular, the knot survival probability follows a universal scaling function
which is independent of the chain length, with a corresponding diffusive
characteristic time scale. Both the large-exit-time and the small-exit-time
tails of the distribution are suppressed exponentially, and the corresponding
decay coefficients are in excellent agreement with the theoretical values.Comment: 4 pages, 5 figure
Granular Collapse as a Percolation Transition
Inelastic collapse is found in a two-dimensional system of inelastic hard
disks confined between two walls which act as an energy source. As the
coefficient of restitution is lowered, there is a transition between a state
containing small collapsed clusters and a state dominated by a large collapsed
cluster. The transition is analogous to that of a percolation transition. At
the transition the number of clusters n_s of size s scales as with .Comment: 10 pages revtex, 5 figures, accepted by Phys Rev E many changes and
corrections from previous submissio
Clustering transitions in vibro-fluidized magnetized granular materials
We study the effects of long range interactions on the phases observed in
cohesive granular materials. At high vibration amplitudes, a gas of magnetized
particles is observed with velocity distributions similar to non-magnetized
particles. Below a transition temperature compact clusters are observed to form
and coexist with single particles. The cluster growth rate is consistent with a
classical nucleation process. However, the temperature of the particles in the
clusters is significantly lower than the surrounding gas, indicating a
breakdown of equipartition. If the system is quenched to low temperatures, a
meta-stable network of connected chains self-assemble due to the anisotropic
nature of magnetic interactions between particles.Comment: 4 pages, 5 figure
Coarsening of granular clusters: two types of scaling behaviors
We report on an experimental study of small cluster dynamics during the
coarsening process in driven granular submonolayers of 120mkm bronze particles.
The techniques of electrostatic and vertical mechanical vibration were employed
to excite the granular gas. We measure the scaling exponent for the evaporation
of small clusters during coarsening. It was found that the surface area of
small clusters S vs time t behaves as S ~ (t_0-t)^(2/3) for lower frequencies
and S ~ (t_0-t) for higher frequencies. We argue that the change in the scaling
exponent is related to the transition from three dimensional to two dimensional
character of motion in the granular gas.Comment: 4 pages,5 figures, submitted to Phys.Rev.
Shocks in supersonic sand
We measure time-averaged velocity, density, and temperature fields for steady
granular flow past a wedge and calculate a speed of granular pressure
disturbances (sound speed) equal to 10% of the flow speed. The flow is
supersonic, forming shocks nearly identical to those in a supersonic gas.
Molecular dynamics simulations of Newton's laws and Monte Carlo simulations of
the Boltzmann equation yield fields in quantitative agreement with experiment.
A numerical solution of Navier-Stokes-like equations agrees with a molecular
dynamics simulation for experimental conditions excluding wall friction.Comment: 4 pages, 5 figure
The dynamics of thin vibrated granular layers
We describe a series of experiments and computer simulations on vibrated
granular media in a geometry chosen to eliminate gravitationally induced
settling. The system consists of a collection of identical spherical particles
on a horizontal plate vibrating vertically, with or without a confining lid.
Previously reported results are reviewed, including the observation of
homogeneous, disordered liquid-like states, an instability to a `collapse' of
motionless spheres on a perfect hexagonal lattice, and a fluctuating,
hexagonally ordered state. In the presence of a confining lid we see a variety
of solid phases at high densities and relatively high vibration amplitudes,
several of which are reported for the first time in this article. The phase
behavior of the system is closely related to that observed in confined
hard-sphere colloidal suspensions in equilibrium, but with modifications due to
the effects of the forcing and dissipation. We also review measurements of
velocity distributions, which range from Maxwellian to strongly non-Maxwellian
depending on the experimental parameter values. We describe measurements of
spatial velocity correlations that show a clear dependence on the mechanism of
energy injection. We also report new measurements of the velocity
autocorrelation function in the granular layer and show that increased
inelasticity leads to enhanced particle self-diffusion.Comment: 11 pages, 7 figure
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