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Myocardial clearance of technetium-99m-teboroxime in reperfused injured canine myocardium
Background: Recent technical developments using solid-state technology have enabled rapid image acquisition with single photon emission computed tomography (SPECT) and have led to a renewed interest in technetium-99m-teboroxime (Tc-99m-teboroxime) as a myocardial imaging agent. Tc-99m-teboroxime has demonstrated high myocardial extraction, linear myocardial uptake relative to flow even at high flow rates, rapid uptake and clearance kinetics, and differential clearance in the setting of ischemia. However, the myocardial clearance kinetics of Tc-99m-teboroxime in a model of myocardial injury has not been previously reported. Thus, the purposes of this study were to use a canine model of ischemia-reperfusion to (1) compare Tc-99m-teboroxime clearance kinetics in normal and ischemic-reperfused myocardium and (2) assess the utility of Tc-99m-teboroxime clearance kinetics in determining the severity of injury following ischemia-reperfusion. Methods: Thirteen dogs underwent left circumflex coronary artery (LCx) occlusion for either 30 min (IR30, n = 6) or 120 min (IR120, n = 7), followed by reperfusion, and finally Tc-99m-teboroxime administration 120 min after reperfusion. Microsphere blood flows were determined at baseline, during occlusion, after reperfusion, and before euthanasia. Post-mortem, area at risk was determined using Evans blue dye, and viability was determined using triphenytetrazolium chloride (TTC) staining. The hearts were then subdivided into 24 pieces and Tc-99m activity was measured in a well counter. Results: TTC-determined infarct area as a percentage of total left ventricular myocardium was 1.1% ± 0.3% for the IR30 group and 7.5% ± 2.9% for the IR120 group (p < 0.05). During coronary occlusion, both the IR30 and IR120 groups demonstrated decreases in percent wall thickening in the ischemia-reperfusion zone (IRZ) as compared with the normal zone (NZ). In the IR30 group, percent wall thickening in the IRZ recovered during the reperfusion phase as compared with the NZ. In the IR120 group, percent wall thickening in the IRZ remained depressed during the reperfusion phase and through the end of the experiment as compared with the NZ. Final Tc-99m-teboroxime myocardial IRZ/NZ activity ratio was 0.94 ± 0.01 for the IR30 group, compared to 0.80 ± 0.01 for the IR120 group (p < 0.05). Conclusions: Tc-99m-teboroxime demonstrates moderate differential clearance in a model of severe injury with 120 min of ischemia-reperfusion, but only minimal differential clearance in a model of mild injury with 30 min of ischemia-reperfusion. Thus, Tc-99m-teboroxime clearance kinetics may be helpful in differentiating normal and minimally injured from severely injured myocardium
Higgs Boson Bounds in Three and Four Generation Scenarios
In light of recent experimental results, we present updated bounds on the
lightest Higgs boson mass in the Standard Model (SM) and in the Minimal
Supersymmetric extension of the Standard Model (MSSM). The vacuum stability
lower bound on the pure SM Higgs boson mass when the SM is taken to be valid up
to the Planck scale lies above the MSSM lightest Higgs boson mass upper bound
for a large amount of SUSY parameter space. If the lightest Higgs boson is
detected with a mass M_{H} < 134 GeV (150 GeV) for a top quark mass M_{top} =
172 GeV (179 GeV), it may indicate the existence of a fourth generation of
fermions. The region of inconsistency is removed and the MSSM is salvagable for
such values of M_{H} if one postulates the existence of a fourth generation of
leptons and quarks with isodoublet degenerate masses M_{L} and M_{Q} such that
60 GeV 170 GeV.Comment: 7 pages, 4 figures. To be published in Physical Review
Draft Nuclear Genome Sequence of the Liquid Hydrocarbon-Accumulating Green Microalga Botryococcus braunii Race B (Showa).
Botryococcus braunii has long been known as a prodigious producer of liquid hydrocarbon oils that can be converted into combustion engine fuels. This draft genome for the B race of B. braunii will allow researchers to unravel important hydrocarbon biosynthetic pathways and identify possible regulatory networks controlling this unusual metabolism
Not All Kinds of Revegetation Are Created Equal: Revegetation Type Influences Bird Assemblages in Threatened Australian Woodland Ecosystems
The value for biodiversity of large intact areas of native vegetation is well established. The biodiversity value of regrowth vegetation is also increasingly recognised worldwide. However, there can be different kinds of revegetation that have different origins. Are there differences in the richness and composition of biotic communities in different kinds of revegetation? The answer remains unknown or poorly known in many ecosystems. We examined the conservation value of different kinds of revegetation through a comparative study of birds in 193 sites surveyed over ten years in four growth types located in semi-cleared agricultural areas of south-eastern Australia. These growth types were resprout regrowth, seedling regrowth, plantings, and old growth
A Chandra X-ray Study of NGC 1068: II. The Luminous X-ray Source Population
We present an analysis of the compact X-ray source population in the
Seyfert~2 galaxy NGC 1068, imaged with Chandra. We find a total of 84 compact
sources, of which 66 are projected onto the galactic disk of NGC 1068. Spectra
of the brightest sources have been modeled with both multi-color disk blackbody
and power-law models. The power-law model provides the better description of
the spectrum for most of these sources. Five sources have 0.4-8 keV intrinsic
luminosities greater than 10^{39} erg/s, assuming that their emission is
isotropic and that they are associated with NGC 1068. We refer to these sources
as Intermediate Luminosity X-ray Objects (IXOs). If these five sources are
X-ray binaries accreting with luminosities that are both sub-Eddington and
isotropic, then the implied source masses are >7 solar masses, and so they are
inferred to be black holes. The brightest source has a much harder spectrum
(Gamma = 0.9\pm0.1) than that found in Galactic black hole candidates and other
IXOs. It also shows large-amplitude variability on both short-term and
long-term timescales. The ratio of the number of sources with luminosities
greater than 2.1 x 10^{38} erg/s in the 0.4-8 keV band to the rate of massive
star formation is the same, to within a factor of two, for NGC 1068, the
Antennae, NGC 5194 (the main galaxy in M51), and the Circinus galaxy. This
suggests that the rate of production of X-ray binaries per massive star is
approximately the same for galaxies with currently active star formation,
including ``starbursts''.Comment: 33 pages, 10 figures. To appear in The Astrophysical Journal, v591
n1, July 1, 2003 issu
Flavour Changing Neutral Higgs Boson Decays from Squark - Gluino Loops
We study the flavour changing neutral Higgs boson decays that can be induced
from genuine supersymmetric particles at the one-loop level and within the
context of the Minimal Supersymmetric Standard Model. We consider all the
possible flavour changing decay channels of the three neutral Higgs bosons into
second and third generation quarks, and focus on the Supersymmetric-QCD
corrections from squark-gluino loops which are expected to provide the dominant
contributions. We assume here the more general hypothesis for flavour mixing,
where there is misalignment between the quark and squark sectors, leading to a
flavour non-diagonal squark mass matrix. The form factors involved, and the
corresponding Higgs partial decay widths and branching ratios, are computed
both analytically and numerically, and their behaviour with the parameters of
the Minimal Supersymmetric Standard Model and with the squark mass mixing are
analyzed in full detail. The large rates found, are explained in terms of the
non-decoupling behaviour of these squark-gluino loop corrections in the
scenario with very large supersymmetric mass parameters. Our results show that
if these decays are seen in future colliders they could provide clear indirect
signals of supersymmetry.Comment: 32 Pages and 12 PostScript Level 2 Figures. Some references adde
Antigenic variation in <i>Trypanosoma brucei</i>: joining the DOTs
African trypanosomes, such as <i>Trypanosoma brucei</i>, are protistan parasites that cause sleeping sickness. Though first described more than a century ago, trypanosomes remain a blight on the health of the human population and on the economy of sub-Saharan Africa. <i>T. brucei</i> replicates in the bloodstream of infected mammals and traverses the blood-brain barrier to enter the central nervous system in the late, frequently fatal, stages of the disease. Because of its extracellular lifestyle, <i>T. brucei</i> is continuously exposed to antibody challenge. To circumvent this, the parasite uses antigenic variation of a surface protein named the variant surface glycoprotein (VSG). Around 107 VSG molecules are expressed on the parasite's cell surface, creating a dense coat that prevents adaptive immunity from detecting or accessing invariant antigens. However, antibodies against the expressed VSG are generated, and periodic switches to an immunologically distinct VSG coat are necessary for parasite survival. Such switches are pre-emptive of the immune response and contribute to the pattern of trypanosome growth seen in an infected host (Figure 1): parasite numbers increase, but then drop as VSG-specific antibodies are raised by the host. Cells that have switched to another VSG coat survive this killing and seed the outgrowth of a subsequent peak of parasites, which is again decimated by anti-VSG immune killing. As a survival strategy, antigenic variation succeeds by prolonging the time that the parasite
Electronic Structure and Valence Band Spectra of Bi4Ti3O12
The x-ray photoelectron valence band spectrum and x-ray emission valence-band
spectra (Ti K _beta_5, Ti L_alpha, O K_alpha) of Bi4Ti3O12 are presented
(analyzed in the common energy scale) and interpreted on the basis of a
band-structure calculation for an idealized I4/mmm structure of this material.Comment: 6 pages + 7 PostScript figures, RevTex3.0, to be published in
Phys.Rev.B52 (Oct.95). Figures also available via anonymous ftp at
ftp://ftp.physik.uni-osnabrueck.de/pub/apostnik/BiTiO
Running into New Territory in SUSY Parameter Space
The LEP-II bound on the light Higgs mass rules out the vast majority of
parameter space left to the Minimal Supersymmetric Standard Model (MSSM) with
weak-scale soft-masses. This suggests the importance of exploring extensions of
the MSSM with non-minimal Higgs physics. In this article, we explore a theory
with an additional singlet superfield and an extended gauge sector. The theory
has a number of novel features compared to both the MSSM and Next-to-MSSM,
including easily realizing a light CP-even Higgs mass consistent with LEP-II
limits, tan(beta) < 1, and a lightest Higgs which is charged. These features
are achieved while remaining consistent with perturbative unification and
without large stop-masses. Discovery modes at the Tevatron and LHC are
discussed.Comment: 15 pages, 5 figures; Typo in equation (4.5) corrected; submitted to
JHE
A Dynamic Knowledge Management Framework for the High Value Manufacturing Industry
Dynamic Knowledge Management (KM) is a combination of cultural and technological factors, including the cultural factors of people and their motivations, technological factors of content and infrastructure and, where these both come together, interface factors. In this paper a Dynamic KM framework is described in the context of employees being motivated to create profit for their company through product development in high value manufacturing. It is reported how the framework was discussed during a meeting of the collaborating company’s (BAE Systems) project stakeholders. Participants agreed the framework would have most benefit at the start of the product lifecycle before key decisions were made. The framework has been designed to support organisational learning and to reward employees that improve the position of the company in the market place
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