Source Area Weathering and Tectonic History Inferred from the Geochemistry of the Maastrichtian Sandstone from Patti Formation, Southern Bida Basin, North Central Nigeria

Sandstones sampled from Patti Formation, Southern Bida Basin, were studied geochemically using Inductively Coupled Plasma Atomic Emission Spectrophotometer (ICP-AES) and an Inductively Coupled Plasma Mass Spectrometry (ICP-MS) technique to evaluate their weathering and tectonic setting as well as to deduce the paleo-climatic conditions that existed during their deposition. Geochemically, SiO2 range from 73.9% to 86.2%, Al2O3 (6.7%~17.1%), Fe2O3 (1.1%~1.9%), K2O (0.1%~0.7%) while MgO, CaO, Na2O, P2O5, MnO and TiO2 were 80%) for indices like chemical index of alteration, chemical index of weathering, plagioclase index of alteration, mineralogical index of alteration and relatively lower values for weathering index of parker, recently used alpha indices (αAl E) of sodium (326.17αΑl Na80) indicates a steady-state of weathering under a warm/humid climate as confirmed by the SiO2 vs. Al2O3+ K2O + Na2O plot. High average SiO2 (75.41wt%) with K2O/Na2O ratio >1 (15.63), low Fe2O3 (1.27wt %), Al2O3 (15.82wt%) and TiO2 (0.46) suggest passive margin tectonic setting. This is supported by enriched ΣREE (209.64 ppm), ΣLREE (195.78), LREE/HREE (27.78) and negative Eu/Eu* (0.68), plots of log (K2O/Na2O) vs. SiO2 and SiO2/Al2O3 vs. K2O/Na2O. Major elements discriminant-function multi-dimensional diagram, DF1 (arcrift-col) vs. DF2 (arc-rift-col), for high-silica sediments revealed a continental rift tectonic setting. Thus, the Patti Formation sandstone underwent a high degree of weathering under a humid climatic condition within a continental rift tectonic setting

Institutional Communication and Administrative Effectiveness of Universities in Kwara State, Nigeria

The need for effective institutional communication in any social systems cannot be over-emphasized. Communication is crucial to the survival and effectiveness of any organization. It is on the basis of this background that this study examined institutional communication and administrative effectiveness of universities in Kwara State. The study adopted a correlational research design. The population of the study was 409 participants drawn from Principal Officers, Deans, Head of Departments, Directors of Units and Directorate of Information and Communication Units in all the universities. Thereafter, purposive sampling technique was used to select 272 participants for this study. Two instruments entitled “Institutional Communication Questionnaire” (ICQ) and “Administrative Effectiveness Questionnaire” (AEQ) were developed for data collection from the respondents. Validity and reliability of the instrument were ensured and a co-efficient value of Alpha 0.68 and 0.72 was obtained for ICQ and AEQ respectively. The finding of the study showed statistically that there was relationship between institutional communication and administrative effectiveness with calculated (r-value 0.647 < pvalue 0.000). The study recommends that university administrators should ensure that other institutional communication processes should be adequately and effectively employed to complement marketing communication; university administrators should improve on the use of institutional communication as a tool of sound decision-making and management communication channels should be encouraged and improved in the universities as a means of passing or transferring information

Assessment of Agroforestry Practices in Ago-Owu Forest Reserve, Ayedaade Local Government area, Osun State, South-western Nigeria

Agroforestry is a collective name for land use systems and practices in which woody perennials are integrated with food crop and forestry, either in a spatial mixture or in a temporal sequence and there are normally both ecological and economic interactions between woody and non woody components. This study investigated types of agroforestry practiced, the impact of agroforestry on the lives of people, assessed the impact of agroforestry on the environment, and identified possible problems associated with agroforestry system in Ago-owu Forest Reserve, Ayedaade Local Government area of Osun State, Nigeria by collecting samples from Mokore, Ajegunle and Alabameta villages using verified methods. Sampling intensity of 10% for population below 500, 5% sampling intensity for population between 500 and 1000 and 2.5% sampling intensity for the population above 1000. A total of eighty (80) questionnaires were administered, thirty copies of questionnaires were distributed both in Mokore and Ajegunle and twenty in Alabameta. The result was analysed using Descriptive Statistics such as frequency tables, percentages, bar chart and Chi square. The result showed that 47.5 % of the respondents are involved in Agri-silviculture. The benefits derived from agroforestry was also unfolded, they are medicinal (11.25%), Income generation (52.5%), production of food crop (33.75%) and non-timber forest products generation (2.5%). The impact of agroforestry to the environment includes Soil erosion control (48.75%), Soil stabilization (31.25%), and (Stable environment 20%)

Value relevance of financial statements and share price: a study of listed banks in Nigeria

This paper examined the effects of value relevance of financial statements on firms share price in Nigeria. In achieving the objectives of this research, the fact book from the Nigerian Stock Exchange Market and the audited financial statement of listed banks spanning the period 2010-2014 were used. Also, a total of 15 listed banks in the Nigerian stock exchange market were selected and analyzed for the study using the purposive sampling method. However, in analyzing the research hypotheses, the study adopted the use of both descriptive statistics and the use of Fixed Effects Panel data method of data analysis technique. Findings from the study showed that a significant positive relationship existed between earnings per share (EPS) and Last day share price (LDSP). The study recommends the need for banks in the country to improve on the quality of earnings reported, since it has a stronger ability to explaining share prices of firm

GENDER-RELATED ALTERATIONS IN FREE FATTY ACIDS AND OXIDATIVE STRESS IN HYPERTENSION CO-MORBIDLY OCCURRING WITH TYPE 2 DIABETES MELLITUS

Increase in plasma free fatty acids (FFAs) concentrations may cause cellular damage via the induction of oxidative stress. The aim of this present study was to investigate FFAs and oxidative stress in hypertension co-morbidly occurring with Type 2 Diabetes Mellitus (T2DM). Age and sex matched control subjects (n=150) and patients (n=470) [hypertensive nondiabetics (HND, n=179), normotensive diabetics (ND, n=132), hypertensive diabetics (HD, n=159)] presenting at the Medical Out-Patient Clinic of the State Hospital, Abeokuta, Nigeria were recruited. Fasting plasma glucose, creatinine, urea, FFAs, thiobarbituric acid reactive substances (TBARS) were determined spectrophotometrically. The presence of either or both diseases resulted in significant increase (p<0.05) in the plasma FFAs and oxidative stress marker-TBARS in different compartments (plasma, erythrocytes andlipoproteins) for both male and female patients when compared with their control counterparts. The increase in FFAs was more marked in comorbidity female when compared with other female patients. There was significant (p<0.05) difference in gender FFAs concentrations. In both controls and patients, FFAs in plasma are significantly (p<0.05) higher in male when compared with their female counterparts. This research revealed biochemical variations in hypertension co-morbidly occurring with T2DMcharacterised by gender-related elevation in FFAs and enhanced oxidative stress. Plasma FFAs might be a good biomarker predicting the occurrence and development of hypertension and/or T2DM. &nbsp

Evaluating a multi-component intervention to reduce and break up office workers' sitting with sit-stand desks using the APEASE criteria

Objective: Sedentary workplace interventions have had success in reducing excessive sitting time in office workers, but barriers to implementation and uptake remain. This study formally assessed a theory-derived, sit-stand desk intervention using the APEASE (Acceptability, Practicability, Effectiveness, Affordability, Side-effects, Equity) criteria. / Methods: Thirteen adults (eight female, mean age 38 ± 10 years) from the treatment arm of a sedentary behaviour intervention participated in semi-structured interviews. Thematic codes were inductively assigned to data items followed by deductive charting using the APEASE criteria. / Results: The intervention was highly acceptable, practicable, safe to deploy, and helped workers reduce workplace sitting time, though individual preferences and workload mediated engagement. Affordability of sit-stand desks and Equity of access were potential barriers to uptake. / Conclusions: Through the lens of the APEASE criteria, this theory-derived, multi-component sit-stand desk intervention showed acceptability, practicability and effectiveness in reducing and breaking up sedentary time at work with minimal side effects. Using this approach with further tailoring and personalisation may help workers achieve greater reductions in workplace sitting, though affordability and equity should be considered further

Esculentin-2CHa-Related Peptides Modulate Islet Cell Function and Improve Glucose Tolerance in Mice with Diet-Induced Obesity and Insulin Resistance

The frog skin host-defense peptide esculentin-2CHa (GFSSIFRGVA10KFASKGLGK D20LAKLGVDLVA30CKISKQC) displays antimicrobial, antitumor, and immunomodulatory properties. This study investigated the antidiabetic actions of the peptide and selected analogues. Esculentin-2CHa stimulated insulin secretion from rat BRIN-BD11 clonal pancreatic β-cells at concentrations greater than 0.3 nM without cytotoxicity by a mechanism involving membrane depolarization and increase of intracellular Ca2+. Insulinotropic activity was attenuated by activation of KATP channels, inhibition of voltage-dependent Ca2+ channels and chelation of extracellular Ca2+. The [L21K], [L24K], [D20K, D27K] and [C31S,C37S] analogues were more potent but less effective than esculentin-2CHa whereas the [L28K] and [C31K] analogues were both more potent and produced a significantly (P < 0.001) greater maximum response. Acute administration of [L28K]esculentin-2CHa (75 nmol/kg body weight) to high fat fed mice with obesity and insulin resistance enhanced glucose tolerance and insulin secretion. Twice-daily administration of this dose of [L28K]esculentin- 2CHa for 28 days had no significant effect on body weight, food intake, indirect calorimetry or body composition. However, mice exhibited decreased non-fasting plasma glucose (P < 0.05), increased non-fasting plasma insulin (P < 0.05) as well as improved glucose tolerance and insulin secretion (P < 0.01) following both oral and intraperitoneal glucose loads. Impaired responses of isolated islets from high fat fed mice to established insulin secretagogues were restored by [L28K]esculentin-2CHa treatment. Peptide treatment was accompanied by significantly lower plasma and pancreatic glucagon levels and normalization of α-cell mass. Circulating triglyceride concentrations were decreased but plasma cholesterol and LDL concentrations were not significantly affected. The data encourage further investigation of the potential of esculentin-2CHa related peptides for treatment of patients with type 2 diabetes

HISTOLOGICAL AND BIOCHEMICAL EFFECTS OF ARTEETHERTM ON THE LIVER OF WISTAR RATS

ArteetherTM is among the recent drugs that are used to combat choroquine-resistant malarial parasites. This study examined the effects of arteetherTM on enzyme biomarkers of the liver, serum protein concentrations, and liver morphology. Twenty (20) adult albino Wistar rats weighing 200 – 250 g were randomly divided into four groups (A, B, C and D) of five animals each, and used in this study. Group A rats were given intramuscular (i. m.) arteetherTM (3 mg/kg b. w.) daily for 3 days. Group B rats received i. m. arteetherTM (6 mg/kg b. w.) daily for 3 days. Group C rats were given i. m. arteetherTM (3 mg/kg b. w.) daily for 3 days. The same dose was repeated at two-weekly intervals for 4 further weeks, while group D rats which received normal saline (0.9 % w/ v, 3 ml/kg b.w.), served as controls. At the end of the experiment, the body weights of the animals were determined and recorded. Serum levels of alanine transaminase (ALT), aspartate transaminase (ASP), alkaline phosphatase (ALP), total protein (TP) and albumin were assayed, and histological studies were performed. Results obtained show no significant difference (