The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers.

G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on the surface of leukocytes. The EGF domains on the N-terminus add significant size to these receptors and they are considered to be among the largest members of the TM7 family. Although not all of their ligands or downstream targets have been identified, there is evidence implicating the EGF-TM7 family diverse processes such as cell adhesion, migration, inflammation, and autoimmune disease. Recent studies have identified expression of EGF-TM7 family members on human neoplasms including those of the thyroid, stomach, colon, and brain. Their presence on these tissues is not surprising given the ubiquity of GPCRs, but because their functional significance and pathways are not completely understood, they are of tremendous clinical and scientific interest. Current evidence suggests that expression of certain EGF-TM7 receptors is correlated with tumor grade, confers a more invasive phenotype, and increases the likelihood of metastatic disease. In this review, we will discuss the structure, function, and regulation of these receptors. We also describe the expression of these receptors in human cancers and explore their potential mechanistic significance

Charmonium-Nucleon Dissociation Cross Sections in the Quark Model

Charmonium dissociation cross sections due to flavor-exchange charmonium-baryon scattering are computed in the constituent quark model. We present results for inelastic $J/\psi N$ and $\eta_c N$ scattering amplitudes and cross sections into 46 final channels, including final states composed of various combinations of $D$, $D^*$, $\Sigma_c$, and $\Lambda_c$. These results are relevant to experimental searches for the deconfined phase of quark matter, and may be useful in identifying the contribution of initial $c\bar c$ production to the open-charm final states observed at RHIC through the characteristic flavor ratios of certain channels. These results are also of interest to possible charmonium-nucleon bound states.Comment: 10 pages, 5 eps figures, revte

Higher Derivative CP(N) Model and Quantization of the Induced Chern-Simons Term

We consider higher derivative CP(N) model in 2+1 dimensions with the Wess-Zumino-Witten term and the topological current density squared term. We quantize the theory by using the auxiliary gauge field formulation in the path integral method and prove that the extended model remains renormalizable in the large N limit. We find that the Maxwell-Chern-Simons theory is dynamically induced in the large N effective action at a nontrivial UV fixed point. The quantization of the Chern-Simons term is also discussed.Comment: 8 pages, no figure, a minor change in abstract, added Comments on the quantization of the Chern-Simons term whose coefficient is also corrected, and some references are added. Some typos are corrected. Added a new paragraph checking the equivalence between (3) and (5), and a related referenc

Energy levels of the soliton--heavy-meson bound states

We investigate the bound states of heavy mesons with finite masses to a classical soliton solution in the Skyrme model. For a given model Lagrangian we solve the equations of motion exactly so that the heavy vector mesons are treated on the same footing as the heavy pseudoscalar mesons. All the energy levels of higher grand spin states as well as the ground state are given over a wide range of the heavy meson masses. We also examine the validity of the approximations used in the literatures. The recoil effect of finite mass soliton is naively estimated.Comment: 24 pages, REVTeX v3.0, 6 figures are available upon request

Deformations of coisotropic submanifolds for fibrewise entire Poisson structures

We show that deformations of a coisotropic submanifold inside a fibrewise entire Poisson manifold are controlled by the $L_\infty$-algebra introduced by Oh-Park (for symplectic manifolds) and Cattaneo-Felder. In the symplectic case, we recover results previously obtained by Oh-Park. Moreover we consider the extended deformation problem and prove its obstructedness

Gravitationally Collapsing Shells in (2+1) Dimensions

We study gravitationally collapsing models of pressureless dust, fluids with pressure, and the generalized Chaplygin gas (GCG) shell in (2+1)-dimensional spacetimes. Various collapse scenarios are investigated under a variety of the background configurations such as anti-de Sitter(AdS) black hole, de Sitter (dS) space, flat and AdS space with a conical deficit. As with the case of a disk of dust, we find that the collapse of a dust shell coincides with the Oppenheimer-Snyder type collapse to a black hole provided the initial density is sufficiently large. We also find -- for all types of shell -- that collapse to a naked singularity is possible under a broad variety of initial conditions. For shells with pressure this singularity can occur for a finite radius of the shell. We also find that GCG shells exhibit diverse collapse scenarios, which can be easily demonstrated by an effective potential analysis.Comment: 27 pages, Latex, 11 figures, typos corrected, references added, minor amendments in introduction and conclusion introd

Coexistence of bulk and surface states probed by Shubnikov-de Haas oscillations in Bi2_2Se3_3 with high charge-carrier density

Topological insulators are ideally represented as having an insulating bulk with topologically protected, spin-textured surface states. However, it is increasingly becoming clear that these surface transport channels can be accompanied by a finite conducting bulk, as well as additional topologically trivial surface states. To investigate these parallel conduction transport channels, we studied Shubnikov-de Haas oscillations in Bi$_2$Se$_3$ thin films, in high magnetic fields up to 30 T so as to access channels with a lower mobility. We identify a clear Zeeman-split bulk contribution to the oscillations from a comparison between the charge-carrier densities extracted from the magnetoresistance and the oscillations. Furthermore, our analyses indicate the presence of a two-dimensional state and signatures of additional states the origin of which cannot be conclusively determined. Our findings underpin the necessity of theoretical studies on the origin of and the interplay between these parallel conduction channels for a careful analysis of the material's performance.Comment: Manuscript including supplemental materia

Immunocompetent murine models for the study of glioblastoma immunotherapy.

Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in clinical outcomes are modest, in no small part due to tumor-induced immunosuppressive mechanisms that promote immune escape and immuno-resistance. Immunotherapeutic strategies aimed at bolstering the immune response while neutralizing immunosuppression will play a critical role in improving treatment outcomes for glioblastoma patients. In vivo murine models of glioma provide an invaluable resource to achieving that end, and their use is an essential part of the preclinical workup for novel therapeutics that need to be tested in animal models prior to testing experimental therapies in patients. In this article, we review five contemporary immunocompetent mouse models, GL261 (C57BL/6), GL26 (C57BL/6) CT-2A (C57BL/6), SMA-560 (VM/Dk), and 4C8 (B6D2F1), each of which offer a suitable platform for testing novel immunotherapeutic approaches