Fundamentals for the Dimensioning and Optimization of Prestressed Segmented Girders for Application in Bridge Crane Systems

Bridge cranes are widely used as discontinuous material handling systems in industrial environments. The so-called crane bridge plays a central role in the overall construction. With increasing span widths and load capacities, the dimensions of the crane bridge also increase. The core of this work is the design and optimization of a new type of bridge crane system, which consists of individual segments and is eccentrically pretensioned by a tensile member

Application of Segmented and Prestressed Supporting Structures in Bridge Crane Systems: Potentials and Challenges

In this paper, an alternative design approach to the construction of bridge crane systems is analyzed with respect to the potentials and challenges of use based on two possible construction methods. Compared to conventional crane bridges, which are manufactured as a single part, the innovation of the approach relates to designing the crane bridge in segments and assembling it from standardized individual components, which are small in dimension, to form a plug-in structure. These are then prestressed by means of a tensile member to establish the load-bearing capacity. The motivation of the alternative design concept arises from a challenging manufacturing and costly transportation of common crane bridges. Here, the different design approaches are first presented as to how a segmental crane bridge can be constructed and which function the involved components fulfill. In this context, the novel construction method also gives rise to new constraints that are not covered by the common design standards and are therefore discussed. The paper concludes with a comparative study to identify advantages and disadvantages of both concepts regarding defined criteria with the aim of determining design improvements and elaborates the potentials and challenges of the approach with respect to a future industrial implementation. Moreover, these findings additionally form the basis for further research work in this area

A Comprehensive Survey of Isocontouring Methods: Applications, Limitations and Perspectives

This paper provides a comprehensive overview of approaches to the determination of isocontours and isosurfaces from given data sets. Different algorithms are reported in the literature for this purpose, which originate from various application areas, such as computer graphics or medical imaging procedures. In all these applications, the challenge is to extract surfaces with a specific isovalue from a given characteristic, so called isosurfaces. These different application areas have given rise to solution approaches that all solve the problem of isocontouring in their own way. Based on the literature, the following four dominant methods can be identified: the marching cubes algorithms, the tessellation-based algorithms, the surface nets algorithms and the ray tracing algorithms. With regard to their application, it can be seen that the methods are mainly used in the fields of medical imaging, computer graphics and the visualization of simulation results. In our work, we provide a broad and compact overview of the common methods that are currently used in terms of isocontouring with respect to certain criteria and their individual limitations. In this context, we discuss the individual methods and identify possible future research directions in the field of isocontouring

Concept of Contamination Control Door for DEMO and Proof of Principle Design

During the maintenance period of a future fusion reactor power plant, called DEMOnstration Power Plant (DEMO), remotely handled casks are required to confine and handle DEMO in-vessel components during their transportation between the reactor and the active maintenance facility. In order to limit the dispersion of activated dust, a Contamination Control Door (CCD) is designed to be placed at an interface between separable containments (e.g., vacuum vessels and casks) to inhibit the release of contamination at the interface between them. The remotely operated CCD—technically, a double lidded door system—consists of two separable doors (the cask door and port door) and three different locking mechanisms: (i) between the cask door and cask, (ii) between the cask door and port door and (iii) between the port door and port. The locking mechanisms are selected and assessed according to different criteria, and the structure of the CCD is optimized using an Abaqus Topology Optimization Module. Due to the elastic properties of the CCD, deflections will occur during the lifting procedure, which may lead to malfunctions of the CCD. A test rig is developed to investigate the performance of high-risk components in the CCD in the case of deflections and also malpositioning. Misalignment can be induced along three axes and three angles intentionally to test the single components and items. The aim is to identify a possible range of operating in the case of misalignments. It is expected that the proposed CCD design should be able to operate appropriately in the case of ±3 mm translational misalignments and ±1° rotational misalignments

Skalierbarer modularer Brückenkranträger in Segmentbauweise

Die Herstellung und der Transport von Brückenkranen stellen aufgrund der großen Dimensionen eine zeit- und kostenintensive Herausforderung dar. In diesem Beitrag wird ein neuartiges Konzept für einen modular aufgebauten Brückenkranträger vorgestellt. Diese Kranbrücke besteht hierbei aus kleineren standardisierten Einzelbauteilen, die in Massenfertigung hergestellt, auf Europool-Paletten an den Einsatzort transportiert und dort zusammengebaut werden können. Die Verbindung der Einzelteile wird über Zuganker realisiert, die nur an den Enden mit der Kranbrücke verbunden werden und somit die gesamte Kranbrücke verspannen. Der Fokus dieses Beitrags liegt auf der Beschreibung der segmentierten Kranbrücke und des Funktionsprinzips. Weiterhin werden die ersten Untersuchungsergebnisse zu den statischen sowie dynamischen Eigenschaften des Trägers betrachtet

An overview and a roadmap for artificial intelligence in hematology and oncology

BACKGROUND Artificial intelligence (AI) is influencing our society on many levels and has broad implications for the future practice of hematology and oncology. However, for many medical professionals and researchers, it often remains unclear what AI can and cannot do, and what are promising areas for a sensible application of AI in hematology and oncology. Finally, the limits and perils of using AI in oncology are not obvious to many healthcare professionals. METHODS In this article, we provide an expert-based consensus statement by the joint Working Group on "Artificial Intelligence in Hematology and Oncology" by the German Society of Hematology and Oncology (DGHO), the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), and the Special Interest Group Digital Health of the German Informatics Society (GI). We provide a conceptual framework for AI in hematology and oncology. RESULTS First, we propose a technological definition, which we deliberately set in a narrow frame to mainly include the technical developments of the last ten years. Second, we present a taxonomy of clinically relevant AI systems, structured according to the type of clinical data they are used to analyze. Third, we show an overview of potential applications, including clinical, research, and educational environments with a focus on hematology and oncology. CONCLUSION Thus, this article provides a point of reference for hematologists and oncologists, and at the same time sets forth a framework for the further development and clinical deployment of AI in hematology and oncology in the future

An overview and a roadmap for artificial intelligence in hematology and oncology.

Artificial intelligence (AI) is influencing our society on many levels and has broad implications for the future practice of hematology and oncology. However, for many medical professionals and researchers, it often remains unclear what AI can and cannot do, and what are promising areas for a sensible application of AI in hematology and oncology. Finally, the limits and perils of using AI in oncology are not obvious to many healthcare professionals

Drug-perturbation-based stratification of blood cancer

As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongside genome, transcriptome, and DNA methylome analysis to understand determinants of drug response. We assembled a primary blood cancer cell encyclopedia data set that revealed disease-specific sensitivities for each cancer. Within chronic lymphocytic leukemia (CLL), responses to 62% of drugs were associated with 2 or more mutations, and linked the B cell receptor (BCR) pathway to trisomy 12, an important driver of CLL. Based on drug responses, the disease could be organized into phenotypic subgroups characterized by exploitable dependencies on BCR, mTOR, or MEK signaling and associated with mutations, gene expression, and DNA methylation. Fourteen percent of CLLs were driven by mTOR signaling in a non-BCR-dependent manner. Multivariate modeling revealed immunoglobulin heavy chain variable gene (IGHV) mutation status and trisomy 12 as the most important modulators of response to kinase inhibitors in CLL. Ex vivo drug responses were associated with outcome. This study overcomes the perception that most mutations do not influence drug response of cancer, and points to an updated approach to understanding tumor biology, with implications for biomarker discovery and cancer care.Peer reviewe

Fundamentals for the Dimensioning and Optimization of Prestressed Segmented Girders for Application in Bridge Crane Systems

Bridge cranes are widely used as discontinuous material handling systems in industrial environments. The so-called crane bridge plays a central role in the overall construction. With increasing span widths and load capacities, the dimensions of the crane bridge also increase. The core of this work is the design and optimization of a new type of bridge crane system, which consists of individual segments and is eccentrically pretensioned by a tensile member

Fundamentals for the Dimensioning and Optimization of Prestressed Segmented Girders for Application in Bridge Crane Systems

Bridge cranes are widely used as discontinuous material handling systems in industrial environments. The so-called crane bridge plays a central role in the overall construction. With increasing span widths and load capacities, the dimensions of the crane bridge also increase. The core of this work is the design and optimization of a new type of bridge crane system, which consists of individual segments and is eccentrically pretensioned by a tensile member