Electrophysiological correlates of emotional source memory in high-trait-anxiety individuals

The interaction between recognition memory and emotion has become a research hotspot in recent years. Dual process theory posits that familiarity and recollection are two separate processes contributing to recognition memory, but further experimental evidence is needed. The present study explored the emotional context effects on successful and unsuccessful source retrieval amongst 15 high-trait-anxiety college students by using event-related potentials (ERPs) measurement. During study, a happy, fearful, or neutral face picture first was displayed, then a Chinese word was superimposed centrally on the picture and subjects were asked to remember the word and the corresponding type of picture. During the test participants were instructed to press one of four buttons to indicate whether the displayed word was an old or new word. And then, for the old word, indicate whether it had been shown with a fearful, happy, or neutral face during the study. ERPs were generally more positive for remembered words than for new words and the ERP difference was termed as an old/new effect. It was found that, for successful source retrieval (it meant both the item and the source were remembered accurately) between 500 and 700 ms (corresponding to a late positive component, LPC), there were significant old/new effects in all contexts. However, for unsuccessful source retrieval (it meant the correct recognition of old items matched with incorrect source attribution), there were no significant old/new effects in happy and neutral contexts, though significant old/new effects were observed in the fearful context. Between 700 and 1200 ms (corresponding to a late slow wave, LSW), there were significant old/new effects for successful source retrieval in happy and neutral contexts. However, in the fearful context, the old/new effects were reversed, ERPs were more negative for successful source retrieval compared to correct rejections. Moreover, there were significant emotion effects for successful source retrieval at this time window. Further analysis showed ERPs of old items were more negative in fearful context than in neutral context. The results showed that early unsuccessful fearful source retrieval processes (related to familiarity) were enhanced, but late successful fearful source retrieval processes during source retrieval monitoring (related to recollection) were weakened. This provided preliminary evidence for the dual processing theory

Problem gambling, gambling correlates and health seeking attitudes in a Chinese sample: An empirical evaluation.

There is an increasing consensus that problem gambling (PG) is a serious social issue among the Chinese, but little is known of the factors associated with PG among the Chinese using validated and improved PG measure-ments. This study examined the patterns of PG and the PG predictive ability of variables such as gam-bling-related cognitions, gambling urge, depression, anxiety, stress, and help-seeking attitudes among Chinese individuals living in Taiwan. The participants consisted of 801 Taiwanese Chinese student and community indi-viduals (Mean age = 25.36 years). The prevalence of PG (Problem Gambling Severity Index; PGSI) and patho-logical gambling (South Oaks Gambling Screen; SOGS) are higher in this Taiwanese Chinese sample as com-pared with past prevalence research. Significant differences were found between PGSI groups (i.e., non-PG, low-risk, moderate-risk, and PG) in socio-demographic variables. Erroneous gambling-related cognitions and overall negative psychological states significantly predicted PG. In addition, interaction effects of gender, mediation effects, and the predictive ability of help-seeking attitudes were discussed. The findings of this study have important implications in the understanding of PG among the Chinese. Gambling-related cognitions and negative psychological states are important factors that should be addressed in intervention programs

Treatment for anxiety disorders in Malaysia

This current study aims to systematically review the treatments for anxiety disorders in Malaysia. PsycINFO, MEDLINE databases, and 28 local journals were used to search published papers in this area. Eight articles were subjected to review after excluding 273 papers that did not meet the inclusion criteria. A total of 598 participants with various types of anxiety disorders were included in the review. Based on the findings, the combination of pharmacotherapy and psychotherapy provided better treatment outcomes if compared to psychotherapy or pharmacotherapy alone. The combination of selective serotonin reuptake inhibitors and cognitive behaviour therapy was considered as one of the most effective treatment to treat patients with anxiety disorders in Malaysia. This is in line with the clinical practice guidelines from the Ministry of Health Singapore and Canada. Even though there were some limitations in the methodology and reporting of the results, it can be concluded that efforts have been taken to conduct studies related to treatments for patients with anxiety disorders in Malaysia. Future studies are suggested to make conscious efforts to overcome these limitations

Victim sensitivity and altruistic behavior in school: mediating effects of teacher justice and teacher-student relationship

The current study aimed to explore how victim sensitivity influenced altruistic behaviors in school and to explore the mediating roles of teacher justice and teacher-student relationship. In 2018, we recruited 1,856 Chinese adolescents including 989 fourth graders (M = 10.35, SD = 0.56) and 867 eighth graders (M = 15.57, SD = 0.91), and the participation rate was 100%. Participations completed the self-report victim sensitivity scale, the teacher justice scale, the teacher-student relationship scale, and the altruistic behavior toward classmate scale. Structural equation modeling (SEM) indicated that victim sensitivity had a direct negative effect on altruistic behavior in school, but this relationship was mediated by teacher justice. There was also a mediated path between teacher justice and altruistic behavior by way of teacher-student relationship. These findings suggested possible mechanisms to explain the relationship between victim sensitivity and altruistic behavior and provided new directions for intervention

A systematic review on the validated measures used to assess anxiety in Malaysia

The current study aims to investigate the validated measures used to assess anxiety in Malaysia through a systematic review. The PsycINFO and MEDLINE databases, and 28 local journals were used to search for published papers in this particular area. Twenty articles met the inclusion criteria and reviewed. The results showed that majority of the studies have validated self-report inventories, rather than structured clinical interviews. The preferred measures validated were Depression Anxiety and Stress Scale, Hospital Anxiety and Depression Scale, and General Health Questionnaire-12 item. The psychometric properties of the validated measures were also reported in this review. In general, the measures have a wide range of reliability, validity, and factor structures. However, not all of the studies adhere to the standard procedures for adapting Western-based measure. The limitations of the studies under review were also being highlighted

Anxiety disorders in Malaysia from 2005 to 2015: a scoping review of their prevalence rates, associated factors, and predictors

Introduction: The current study aims to investigate the prevalence rates, associated factors, and predictors of anxiety disorders in Malaysia through a scoping review. Methods: PsyclNFO and MEDLINE databases and a total of 28 local journals were used to search for published papers in this particular area. In this case, 37 out of 105 articles managed to meet the inclusion criteria and were subjected to review. A total of 17,673 respondents, which comprised university students, the general community, and numerous types of clinical patients, were included in the review. Results: The results showed that the prevalence rate of anxiety disorders was in the range between 1% and 67.6% for the mentioned populations. Moreover, various types of associated factors were found to be related to anxiety such as being divorced, widowed, or single; having a lower than tertiary level of education; being unemployed or retired; and having a low socioeconomic status. Meanwhile, there were also several predictors of anxiety such as having to deal with negative life events; domestic violence; family history of mental illness; severe psychological problems; and chronic physical illness. Conclusion Generally, the prevalence of anxiety disorders is noticeable, and anxiety disorders may contribute to a decrease in the quality of life, an increase in social burden, reduced productivity, and increased utilization of health services. Therefore, awareness among community and health service providers regarding the prevalence rate of anxiety is believed to help in developing access to evidence-based psychological and pharmacological interventions

Psychometric properties of the Italian versions of the Gambling Urge Scale (GUS) and the Gambling Refusal Self-Efficacy Questionnaire (GRSEQ)

Gambling urges and gambling refusal self-efficacy beliefs play a major role in the development and maintenance of problem gambling. This study aimed to translate the Gambling Urge Scale (GUS) and the Gambling Refusal Self-Efficacy Questionnaire (GRSEQ) from English to Italian (GUS-I, GRSEQ-I) and to test their factor structure, internal consistency, construct validity, concurrent validity, and gender differences in 513 individuals from the Italian community. Factor structure and construct validity were tested through Confirmatory Factor Analysis, internal consistency through Cronbach’s alpha, concurrent validity through correlations with gambling-related cognitions (GRCS-I), probable pathological gambling (SOGS-I), and gambling functioning (GFA-R-I). Results confirmed that the 6 items of the GUS-I load highly on one dimension of Gambling Urge, and each of the 26 items of the GRSEQ-I load highly on their relevant sub-dimension, among the following: situations/thoughts, drugs, positive emotions, negative emotions. Both scales are internally consistent and show concurrent validity with gambling-related cognitions, probable pathological gambling, and gambling functioning. Males score higher than females at the GUS-I; females score higher than males at the GRSEQ-I. The findings from the present study suggest that the GUS-I and the GRSEQ-I are internally consistent and valid scales for the assessment of gambling urges and gambling refusal self-efficacy in Italian individuals from the community, with significant repercussions in terms of assessment, prevention, and intervention

Targeting poly(ADP-ribose) polymerase activity for cancer therapy

Poly(ADP-ribosyl)ation is a ubiquitous protein modification found in mammalian cells that modulates many cellular responses, including DNA repair. The poly(ADP-ribose) polymerase (PARP) family catalyze the formation and addition onto proteins of negatively charged ADP-ribose polymers synthesized from NAD+. The absence of PARP-1 and PARP-2, both of which are activated by DNA damage, results in hypersensitivity to ionizing radiation and alkylating agents. PARP inhibitors that compete with NAD+ at the enzyme’s activity site are effective chemo- and radiopotentiation agents and, in BRCA-deficient tumors, can be used as single-agent therapies acting through the principle of synthetic lethality. Through extensive drug-development programs, third-generation inhibitors have now entered clinical trials and are showing great promise. However, both PARP-1 and PARP-2 are not only involved in DNA repair but also in transcription regulation, chromatin modification, and cellular homeostasis. The impact on these processes of PARP inhibition on long-term therapeutic responses needs to be investigated

A Group Cognitive Behavioural Therapy Program for Depression

206 hlm., 26 c