56 research outputs found
Boeotian and Loyolan Art
In sorting through the mass of English-language poetry poured out by the printing-presses of the world, one\u27s problem is not so much to tell good from bad as to distinguish, out of the great press of the merely talented, that tiny handful of poets (probably not more than half a dozen in a generation) who have something major and distinctive to say. Among observers of Australian poetry suspicion has been hardening over the last five years that Les A. Murray may be such a one
Signaling Network Assessment of Mutations and Copy Number Variations Predicts Breast Cancer Subtype-specific Drug Targets
Individual cancer cells carry a bewildering number of distinct genomic
alterations i.e., copy number variations and mutations, making it a challenge
to uncover genomic-driven mechanisms governing tumorigenesis. Here we performed
exome-sequencing on several breast cancer cell lines which represent two
subtypes, luminal and basal. We integrated this sequencing data, and functional
RNAi screening data (i.e., for identifying genes which are essential for cell
proliferation and survival), onto a human signaling network. Two
subtype-specific networks were identified, which potentially represent
core-signaling mechanisms underlying tumorigenesis. Within both networks, we
found that genes were differentially affected in different cell lines; i.e., in
some cell lines a gene was identified through RNAi screening whereas in others
it was genomically altered. Interestingly, we found that highly connected
network genes could be used to correctly classify breast tumors into subtypes
based on genomic alterations. Further, the networks effectively predicted
subtype-specific drug targets, which were experimentally validated.Comment: 4 figs, more related papers at http://www.cancer-systemsbiology.org,
appears in Cell Reports, 201
AMTEC vapor-vapor series connected cells
An alkali metal thermoelectric converter (AMTEC) having a plurality of cells structurally connected in series to form a septum dividing a plenum into two chambers, and electrically connected in series, is provided with porous metal anodes and porous metal cathodes in the cells. The cells may be planar or annular, and in either case a metal alkali vapor at a high temperature is provided to the plenum through one chamber on one side of the wall and returned to a vapor boiler after condensation at a chamber on the other side of the wall in the plenum. If the cells are annular, a heating core may be placed along the axis of the stacked cells. This arrangement of series-connected cells allows efficient generation of power at high voltage and low current
Survivorship: cognitive function, version 1.2014.
Cognitive impairment is a common complaint among cancer survivors and may be a consequence of the tumors themselves or direct effects of cancer-related treatment (eg, chemotherapy, endocrine therapy, radiation). For some survivors, symptoms persist over the long term and, when more severe, can impact quality of life and function. This section of the NCCN Guidelines for Survivorship provides assessment, evaluation, and management recommendations for cognitive dysfunction in survivors. Nonpharmacologic interventions (eg, instruction in coping strategies; management of distress, pain, sleep disturbances, and fatigue; occupational therapy) are recommended, with pharmacologic interventions as a last line of therapy in survivors for whom other interventions have been insufficient
Survivorship: sleep disorders, version 1.2014.
Sleep disorders, including insomnia and excessive sleepiness, affect a significant proportion of patients with cancer and survivors, often in combination with fatigue, anxiety, and depression. Improvements in sleep lead to improvements in fatigue, mood, and quality of life. This section of the NCCN Guidelines for Survivorship provides screening, diagnosis, and management recommendations for sleep disorders in survivors. Management includes combinations of sleep hygiene education, physical activity, psychosocial interventions, and pharmacologic treatments
Diagnosis and management of selective fetal growth restriction in monochorionic twin pregnancies: A cross-sectional international survey.
ObjectiveTo identify current practices in the management of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies.DesignCross-sectional survey.SettingInternational.PopulationClinicians involved in the management of MCDA twin pregnancies with sFGR.MethodsA structured, self-administered survey.Main outcome measuresClinical practices and attitudes to diagnostic criteria and management strategies.ResultsOverall, 62.8% (113/180) of clinicians completed the survey; of which, 66.4% (75/113) of the respondents reported that they would use an estimated fetal weight (EFW) of 25% for the diagnosis of sFGR. For early-onset type I sFGR, 79.8% (75/94) of respondents expressed that expectant management would be their routine practice. On the other hand, for early-onset type II and type III sFGR, 19.3% (17/88) and 35.7% (30/84) of respondents would manage these pregnancies expectantly, whereas 71.6% (63/88) and 57.1% (48/84) would refer these pregnancies to a fetal intervention centre or would offer fetal intervention for type II and type III cases, respectively. Moreover, 39.0% (16/41) of the respondents would consider fetoscopic laser surgery (FLS) for early-onset type I sFGR, whereas 41.5% (17/41) would offer either FLS or selective feticide, and 12.2% (5/41) would exclusively offer selective feticide. For early-onset type II and type III sFGR cases, 25.9% (21/81) and 31.4% (22/70) would exclusively offer FLS, respectively, whereas 33.3% (27/81) and 32.9% (23/70) would exclusively offer selective feticide.ConclusionsThere is significant variation in clinician practices and attitudes towards the management of early-onset sFGR in MCDA twin pregnancies, especially for type II and type III cases, highlighting the need for high-level evidence to guide management
Vernacular and middle styles in Australian poetry
It is generally recognized that there is a move at present towards the ver· nacular style in poetry; and it seems obvious that this bears some relation to the increasing literary confidence and national assertiveness of the sixties and seventies, and to the upsurge in other Australian art·forms, most notably film and drama. Undoubtedly there has been a change not only in the writers but in public taste. Readership or audience that wants the home product and the local theme is one of the phenomena that connect the new drama, the new films, and much of the new poetry and the new short stories
Letter perfect
Stroke by stroke the language was slipping away from him. My dear nephew, he had written in his clear miniscule hand, I am sorry, though not, of course, surprised, to hear of your financial woes. And I am far from deaf to the eloquence of your arguments. (There was charity for you, he thought. His nephew on paper was like a cow on tiles.) I have long been aware that the economic climate in the dairying regions is nezther Invigorating nor, shall we say, sal- ... Damn! What was that word? Salub-? Solubr-? ... It was too vexing . ... neither invigorating nor healthy he concluded irritably
The Black Cabaret
Like every place on Earth it was packed. NEW UNSCRIPTED SHOW- THE WAY WE MIGHT HAVE BEEN ran the 3-D hoardings outside. The Black Cabaret was the latest thing: a place where people came, not to be lifted out of themselves, but to be lowered into a sort of communal sink of negative emotions. An inchoate prayer, .one of my men had called it. A gross slander on our parents, said another
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