Redystrybucja dochodów w starzejącym się społeczeństwie

Income Redistribution in the Aging Population Population aging causes that the question of distribution of the current flow of goods and services produced in the economic process becomes more and more important. The possibilities in this scope are determined by relations between the dynamics of the number of economically active population, the number of pensioners and the volume of national income. The dependencies – which result from this – are the subject of analysis done by use of the inter-generational income redistribution model (MMRD), which has been developed by the author of this paper. The presented model shows the essence of the problem of social inter-generational transfers which – in the country regarded as a common good – should be interpreted as liabilities of pensioners and their repayment should assure elder people a decent level of existence. The presentation of the model has been done for several EU Member States on the basis of national and the International Monetary Fund (IMF) data

Anticancer activity of a trans-platinum(II) complex of 3-aminoflavone to ovarian cancer cells

Objectives: Cisplatin is a classical anticancer drug used in the treatment of ovarian cancer. Unfortunately, the treatment is associated with numerous adverse effects. Studies concerning new platinum derivatives with less organ toxicity are conducted. The aim of this study was to analyse the effect of a new trans-platinum(II) complex of 3-aminoflavone on the viability and mortality of the cells from OVCAR 3 and CAOV 3 ovarian cancer cell lines and on the expression of the selected genes involved in the process of apoptosis. Material and methods: The viability of ovarian cancer cells and the cytotoxicity of a trans-platinum(II) complex of 3-amino­flavone: [trans-Pt(3-af )2Cl2), trans-bis-(3-aminoflavone) dichloridoplatinum(II)] and cisplatin were analysed using a spectrophotometric method with the use of MTT assay and LDH assay. BAX, BCL2, BIRC5 gene expression analysis on mRNA level was conducted with the use of Real-Time PCR method. Results: It was observed that parallel to an increase in the concentration of the new complex compound and cisplatin there is a decrease in viability and an increase in mortality of ovarian cancer cells. As a result of exposure to the studied compound and cisplatin, an increased BAX gene expression and decreased BCL2 and BIRC5 gene expression were observed in the studied ovarian cancer cell lines. Conclusion: Trans-Pt(3-af )2Cl2 exhibits anticancer activity towards OVCAR 3 and CAOV 3 ovarian cancer cell lines. The studied complex compound can be considered as a potential anticancer drug

White Schools, Diverse Populations: A Look at the North Star State

The purpose of this project is to understand the causes and address the challenges facing Latino youth in Minnesota in educational achievement.  Examination is addressed through reviewing previous works, completion of interviews and programatic exploration in order to address the barriers and provide potential solutions

White Schools, Diverse Populations: A Look at the North Star State

The purpose of this project is to understand the causes and address the challenges facing Latino youth in Minnesota in educational achievement.  Examination is addressed through reviewing previous works, completion of interviews and programatic exploration in order to address the barriers and provide potential solutions

Synthesis, Spectroscopy, Light Stability, Single-Crystal Analysis, and In Vitro Cytotoxic Activity on HepG2 Liver Cancer of Two Novel Silver(I) Complexes of Miconazole

Two novel silver(I) complexes of the biologically active ligand miconazole in the form of Ag(MCZ)2X (MCZ = 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole]; X = NO3 (1), ClO4 (2)) were synthesized and fully characterized. The complexes were obtained by reactions of Ag(I) salts with miconazole (MCZ). Silver(I) complexes were characterized by elemental analysis, 1H-NMR and infrared (IR) spectroscopy, electrospray ionization (ESI)-MS spectrometry, and X-ray-crystallography. This work also presents a cytotoxicity study of the silver(I) complexes of miconazole and appropriate silver(I) salts using Balb/c 3T3 and HepG2 cell lines. The cytotoxicity of the compounds was assessed based on four biochemical endpoints: lysosomal activity (neutral red uptake (NRU) assay), mitochondrial activity (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay), total protein content (TPC assay), and cellular membrane integrity (lactate dehydrogenase (LDH) assay). The cancer HepG2 cells were more sensitive to the complexes tested, and the most a ected endpoint was cellular membrane damage compared to Balb/c 3T3 fibroblasts. Moreover, study complexes inhibited the growth of cancer cells at submicromolecular concentrations (0.26–0.47 M) lower than that required for the anticancer agent, cisplatin, in MTT, NRU, and TPC assays. Both complexes were characterized by higher toxicity to human cancer cells (HepG2) than silver(I) salts and the free ligand. Combination of Ag(I) salts with miconazole is associated with the marked improvement of cytotoxic activities that can be considered as the significant point in the construction of a new generation of antineoplastic agents

Synthesis, spectroscopic analysis and assessment of the biological activity of new hydrazine and hydrazide derivatives of 3-formylchromone

The hydrazine and hydrazide derivatives of benzo-γ-pyrones with fluorine substituents remain an unexplored group of chemical compounds. This preliminary study reports the synthesis, structural assessment, initial microbiological screening and biological testing of the synthesized compounds on cell lines using the XTT-assay. A series of 10 novel hydrazine and hydrazide derivatives of 3-formylchromone were synthesized and their structures determined. Structural assessment consisted of elemental analysis, IR,1H-NMR,13C-NMR, MS and crystallographic studies. Antimicrobial activity was tested on standard strains representing different groups of microorganisms. The tested compounds were found to inhibit microbial growth. Concentrations of 0.01-1250 µmol/L were found to influence cell proliferation, demonstrating antiproliferative and stimulation of proliferation against two cell lines: the L929 cell line (mouse fibroblast cell line) and the EA.hy926 cell line (the human umbilical vein, somatic cell hybrid)

Primary production in the Southern Baltic in 1985 and 1986 compared with long-term mean seasonal variation

On the basis of long-term investigations, the course of seasonal variations of mean daily primary production and mean chlorophyll-a concentration in the Southern Baltic waters are presented. The mean annual primary production of the Gdańsk Deep, Bornholm Deep and the Gotland Deep amounted to 124.4 gC m-2, 88.8 gC m-2 and 107.2 gC m-2, respectively. The primary production of the Southern Baltic in 1986 was higher than in 1985, and higher than the long-term mean value. The mean annual production for the Southern Baltic in 1986 amounted to 130 gC m-2. On the basis of long-term observations of primary production and chlorophyll-a of the Southern Baltic, certain upward trends in phytoplankton production were observed

Co-culturing cell lines for efficient manufacture of multispecifics

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