10 research outputs found
Cerium-Doped CuFe-Layered Catalyst for the Enhanced Oxidation of o‑Xylene and N,N‑Dimethylacetamide: Insights into the Effects of Temperature and Space Velocity
Comparison of the clinical features and hematopoietic stem cell transplantation outcomes of mediastinal malignant germ cell tumors with nonmediastinal extragonadal placements.
Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantation between mediastinal and nonmediastinal malignant EGCTs
Ursodeoxycholic acid treatment improves hepatocyte ultrastructure in rat liver fibrosis
AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers
Effectiveness of bendamustine in relapse or refractory lymphoma cases: A report from Turkey-The Turkish Oncology Group (TOG) study.
53rd Annual Clinical Meeting of the American-Society-of-Clinical-Oncology (ASCO) -- JUN 02-07, 2017 -- Chicago, ILWOS: 000411932200057…Amer Soc Clin Onco
Comparison of the clinical features and hematopoietic stem cell transplantation outcomes of mediastinal malignant germ cell tumors with nonmediastinal extragonadal placements
Objective: Even though the primary mediastinal extragonadal germ cell
tumors (EGCTs) are rare, they are noteworthy in the differential
diagnosis of mediastinal masses. In this study, we aimed to identify the
clinical features of mediastinal malignant GCTs and compare the results
of hematopoietic stem cell transplantation between mediastinal and
nonmediastinal malignant EGCTs.
Method: Data of the patients with EGCT who were treated and underwent
hematopoietic stem cell transplantation at our hospital between 1988 and
2015 were retrieved retrospectively. Results were compared between
mediastinal and nonmediastinal EGCTs.
Results: Data of 65 patients diagnosed with EGCT (37 {[}56.92\%] cases
with mediastinal EGCT and 28 {[}43.07\%] cases with nonmediastinal EGCT)
were assessed. The clinical stages, frequency of pretransplant status,
mean pretransplant time, and mean number of chemotherapy lines before
hematopoietic stem cell transplantation were not significantly different
between groups. Although the overall survival did not significantly
differ between groups, the 5-year survival was significantly higher in
mediastinal EGCTs (P= 0.02). Yolk sac tumor was significantly more
common in mediastinal EGCTs (P= 0.05). Mortality rates were higher in
seminomas and yolk sac tumors in all cases, higher in embryonal
carcinomas in mediastinal EGCT group and higher in yolk sac tumors in
nonmediastinal EGCT group. While choriocarcinomas had more aggressive
courses in mediastinal EGCTs, seminomas and yolk sac tumors had poorer
prognosis in nonmediastinal EGCTs. Short pretransplant time and
persistence of elevated posttransplant beta hCG and AFP levels were the
significant mortality risk factors both in mediastinal and
nonmediastinal EGCTs.
Conclusion: Mediastinal placement of EGCT was not a poor prognostic
factor; furthermore, the 5-year survival was significantly higher in
mediastinal EGCTs. According to our knowledge, this is the first study
that compares the clinical outcomes of hematopoietic stem cell
transplantation of mediastinal and nonmediastinal malignant EGCTs