Mapping Changes in Fractional Vegetation Cover on the Namib Gravel Plains with Satellite-Retrieved Land Surface Emissivity Data

Monitoring changes in vegetation cover over time is crucial for understanding the spatial distribution of rainfall, as well as the dynamics of plants and animals in the Namib desert. Traditional vegetation indices have limitations in capturing changes in vegetation cover within water-limited ecosystems like the Namib gravel plains. Spectral emissivity derived from thermal infrared remote sensing has recently emerged as a promising tool for distinguishing between bare ground and non-green vegetation in arid environments. This study investigates the potential of satellite-derived emissivities for mapping changes in fractional vegetation cover across the Namib gravel plains. Analyzing Moderate Resolution Imaging Spectroradiometer (MODIS) band 29 (λ = 8.55 µm) emissivity time series from 2001 to 2021, our findings demonstrate the ability of both Normalized Difference Vegetation Index (NDVI) and emissivity to detect sudden vegetation growth on the gravel plains. Emissivity additionally allows monitoring the extent of desiccated grass over several years after a rainfall event. Our results support a relationship between the change in fractional vegetation cover, the amount of rainfall and emissivity change magnitude. Information from NDVI and emissivity therefore provide complementary information for assessing vegetation in arid environments

Detection of Snow Pollution in the Chilean Andes Using DESIS Hyperspectral Data

This conference paper explored the possibility of using hyperspectral DESIS images to study snow pollution (particularly black carbon) at two test sites in the Chilean Andes

Breakthrough COVID-19 cases despite prophylaxis with 150 mg of tixagevimab and 150 mg of cilgavimab in kidney transplant recipients

The cilgavimab-tixagevimab combination retains a partial in vitro neutralizing activity against the current SARS-CoV-2 variants of concern (omicron BA.1, BA.1.1, and BA.2). Here, we examined whether preexposure prophylaxis with cilgavimab-tixagevimab can effectively protect kidney transplant recipients (KTRs) against the omicron variant. Of the 416 KTRs who received intramuscular prophylactic injections of 150 mg tixagevimab and 150 mg cilgavimab, 39 (9.4%) developed COVID-19. With the exception of one case, all patients were symptomatic. Hospitalization and admission to an intensive care unit were required for 14 (35.9%) and three patients (7.7%), respectively. Two KTRs died of COVID-19-related acute respiratory distress syndrome. SARS-CoV-2 sequencing was carried out in 15 cases (BA.1, n = 5; BA.1.1, n = 9; BA.2, n = 1). Viral neutralizing activity of the serum against the BA.1 variant was negative in the 12 tested patients, suggesting that this prophylactic strategy does not provide sufficient protection against this variant of concern. In summary, preexposure prophylaxis with cilgavimab-tixagevimab at the dose of 150 mg of each antibody does not adequately protect KTRs against omicron. Further clarification of the optimal dosing can assist in our understanding of how best to harness its protective potential

Loss of Hepatic Leucine-Rich Repeat-Containing G-Protein Coupled Receptors 4 and 5 Promotes Nonalcoholic Fatty Liver Disease

The roof plate-specific spondin-leucine-rich repeat-containing G-protein coupled receptor 4/5 (LGR4/5)-zinc and ring finger 3 (ZNRF3)/ring finger protein 43 (RNF43) module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation. However, its impact on nonalcoholic fatty liver disease (NAFLD) remains unclear. The current study investigated whether hepatic epithelial cell-specific loss of the Wnt/β-catenin modulator Lgr4/5 promoted NAFLD. The 3- and 6-month-old mice with hepatic epithelial cell-specific deletion of both receptors Lgr4/5 (Lgr4/5dLKO) were compared with control mice fed with normal diet (ND) or high-fat diet (HFD). Six-month-old HFD-fed Lgr4/5dLKO mice developed hepatic steatosis and fibrosis but the control mice did not. Serum cholesterol-high-density lipoprotein and total cholesterol levels in 3- and 6-month-old HFD-fed Lgr4/5dLKO mice were decreased compared with those in control mice. An ex vivo primary hepatocyte culture assay and a comprehensive bile acid (BA) characterization in liver, plasma, bile, and feces demonstrated that ND-fed Lgr4/5dLKO mice had impaired BA secretion, predisposing them to develop cholestatic characteristics. Lipidome and RNA-sequencing analyses demonstrated severe alterations in several lipid species and pathways controlling lipid metabolism in the livers of Lgr4/5dLKO mice. In conclusion, loss of hepatic Wnt/β-catenin activity by Lgr4/5 deletion led to loss of BA secretion, cholestatic features, altered lipid homeostasis, and deregulation of lipoprotein pathways. Both BA and intrinsic lipid alterations contributed to the onset of NAFLD