Anatomie chirurgicale de la glande sublinguale

Because of its position, the sublingual gland is clinically important especially in the events of injuries and infections in the anterior part of the sublingual region.The morphology and relationships of this gland were studied by dissection methods applied on 80 fresh or formaldehyde fixed preparations of the mouth floor and of the tongue, which were partly (31 preparations) taken out together with the mandible.As for the shape of the gland, three main types were found: 1° the cuneiform type which was the most frequent (71 %), 2° the pyramidal type which was less frequent (16%) and the fusiform type (13%) which comprised the cases of a very elongated gland (up to 65 mm).The space in which the gland lied had four walls. Its internal wall consisted of the mylohyoid muscle and it comprised the hyoglossus muscle as well when the gland was very elongated. The inferior wall consisted of the mylohyoid muscle and sometimes it comprised also a narrow part of the superior surface of the geniohyoglossus muscle. An osseous depression on the internal side of the mandible represented the external wall of the sublingual gland space. The superior wall is clinically the most significant. It consists of the sublingual mucosa and a sublingual fold. This wall represents a main surgical access to the gland. In edentulous mandibles this mucous fold may be at the level of the upper mandibular border which may hinder the use of the lower dental prosthesis.La morphologie et les rapports de la glande sublinguale ont été étudiés par 80 dissections du plancher de la bouche et de la langue.Trois types différents de glandes ont été définis du point de vue forme: le type cunéiforme (71%), le type pyramidal (16%) et le type fusiforme (13%).La loge de la glande sublinguale possède quatre parois: deux (parois inférieure et interne) de nature musculaire, une (paroi externe) de nature osseuse et une (paroi supérieure) de nature muqueuse

Altérations athéroscléreuses de l’artère dentaire inférieure en corrélation avec celles de la bifurcation carotidienne et de l’aorte abdominale

50 corpses from adults aged 20 to 75 have been used in order to study the atherosclerotic lesions occurring in typical regions (bifurcation of the common carotid artery and the abdominal aorta) and their relationship to atherosclerotic changes in the inferior alveolar artery. Histological analysis revealed that atherosclerotic alterations of the inferior alveolar artery may appear sometimes earlier than it would be expected on the ground of age. Intima cell proliferation and thickening of elastic elements in the middle layer of the arterial wall, the first signs of atherosclerosis, were found already at the beginning of the third decade of life when the signs of this process in the typical regions were not yet evident. Atherosclerosis affects essentially the functional capacity of the inferior alveolar artery. The development of atherosclerosis in the wall of this artery favours an hypovascularization of the mandible, which must be of certain importance in every operative procedure in oral surgery, especially in those inducing a severe and long traumatism in bone and soft tissues, such as dental implantations.Cette étude, faite sur 50 cadavres (de 20 à 75 ans) concerne les altérations athéroscléreuses de l’artère dentaire inférieure et leurs rapports avec les altérations athéroscléreuses dans les territoires typiques (bifurcation carotidienne et aorte abdominale). L’examen histologique a fait apparaître que les altérations athéroscléreuses de l’artère dentaire inférieure peuvent être relativement plus évidentes et précoces que l’on ne s’y attendrait compte tenu de l’âge. Une prolifération cellulaire de l’intima et un épaississement de la lame élastique moyenne dans la paroi artérielle, premiers signes de l’athérosclérose, peuvent apparaître dès30 ans, alors que l’on ne trouve pas encore d’altérations de ce type dans les territoires typiques. L’athérosclérose a une influence cruciale sur la capacité fonctionnelle de l’artère dentaire inférieure puisque celle-ci chemine dans le canal osseux, qui empêche sa dilatation. Le développement de l’athérosclérose dans la paroi de cette artère favorise une hypovascularisation de la mandibule, ce qui a une importance certaine lors de toute intervention en chirurgie orale, surtout lorsqu’elle entraîne un traumatisme grave et prolongée de l’os et des parties molles, comme c’est le cas lors de l’insertion d’implants dentaires

Modeling Single Electron Transfer in Si:P Double Quantum Dots

Solid-state systems such as P donors in Si have considerable potential for realization of scalable quantum computation. Recent experimental work in this area has focused on implanted Si:P double quantum dots (DQDs) that represent a preliminary step towards the realization of single donor charge-based qubits. This paper focuses on the techniques involved in analyzing the charge transfer within such DQD devices and understanding the impact of fabrication parameters on this process. We show that misalignment between the buried dots and surface gates affects the charge transfer behavior and identify some of the challenges posed by reducing the size of the metallic dot to the few donor regime.Comment: 11 pages, 7 figures, submitted to Nanotechnolog

Violence, exclusion and the role of children and adolescents moral features in the sport domain: The save project

The prevention of violence and exclusion in the sport domain is one of the principal priorities of the European Union Programs. Sport Against Violence and Exclusion (SAVE) Project is an initiative co-founded by the Erasmus Plus Programme of the European Commission, whose aim is to train coach to recognize and manage violent and exclusion episodes in the sport situation. According to the psychological literature, one of the predictors of aggressiveness and antisocial tendencies is morality. In particular, for what concerns children, a less mature moral reasoning is associated to a greater tendency to aggress, while for adolescents, the moral atmosphere, in particular, the perception of the coach norms, seems to have the greatest influence on their behavior. For this reason, an in-depth training for coaches has been developed within SAVE Project. Furthermore, a scientific research involving seven countries has been conducted. The current Editorial Letter shows one year progress of SAVE Project . This and other initiatives, if supported by scientific community, could be an inspiration for broader policy reform

Influence of mechanochemical activation on the sintering of cordierite ceramics in the presence of Bi2O3 as a functional additive

Due to its outstanding electrical characteristics, such as the low temperature expansion coefficient, low dielectric constant and good mechanical properties, cordierite, 2MgO center dot 2Al(2)O(3)center dot 5SiO(2), is a very attractive high-temperature ceramic material. In order to accelerate the process of sintering, 2.50 mass% Bi2O3 has been added to the starting mixtures. Liquid phase sintering caused by the presence of bismuth-oxide lowers the temperature of cordierite formation. The mechanical activation of the starting mixtures (0-56 min in vibro-mill) additionally lowers sintering temperatures. The sintering process was performed at 1200, 1300, 1350 and 1400 degrees C, for 2 h. The particle size analysis (PSA) was employed in order to determine the changes in the particle size of the mechanically treated powders. The phase composition of the starting powders and sintered materials was analyzed by the X-ray diffraction method. Furthermore, scanning electron microscopy (SEM) was used in the analysis of the powder morphology. (C) 2011 Elsevier B.V. All rights reserved

FKBPL and SIRT-1 Are Downregulated by Diabetes in Pregnancy Impacting on Angiogenesis and Endothelial Function

Diabetes in pregnancy is associated with adverse pregnancy outcomes including preterm birth. Although the mechanisms leading to these pregnancy complications are still poorly understood, aberrant angiogenesis and endothelial dysfunction play a key role. FKBPL and SIRT-1 are critical regulators of angiogenesis, however, their roles in pregnancies affected by diabetes have not been examined before in detail. Hence, this study aimed to investigate the role of FKBPL and SIRT-1 in pre-gestational (type 1 diabetes mellitus, T1D) and gestational diabetes mellitus (GDM). Placental protein expression of important angiogenesis proteins, FKBPL, SIRT-1, PlGF and VEGF-R1, was determined from pregnant women with GDM or T1D, and in the first trimester trophoblast cells exposed to high glucose (25 mM) and varying oxygen concentrations [21%, 6.5%, 2.5% (ACH-3Ps)]. Endothelial cell function was assessed in high glucose conditions (30 mM) and following FKBPL overexpression. Placental FKBPL protein expression was downregulated in T1D (FKBPL; p<0.05) whereas PlGF/VEGF-R1 were upregulated (p<0.05); correlations adjusted for gestational age were also significant. In the presence of GDM, only SIRT-1 was significantly downregulated (p<0.05) even when adjusted for gestational age (r=-0.92, p=0.001). Both FKBPL and SIRT-1 protein expression was reduced in ACH-3P cells in high glucose conditions associated with 6.5%/2.5% oxygen concentrations compared to experimental normoxia (21%; p<0.05). FKBPL overexpression in endothelial cells (HUVECs) exacerbated reduction in tubule formation compared to empty vector control, in high glucose conditions (junctions; p<0.01, branches; p<0.05). In conclusion, FKBPL and/or SIRT-1 downregulation in response to diabetic pregnancies may have a key role in the development of vascular dysfunction and associated complications affected by impaired placental angiogenesis

Replica theory for learning curves for Gaussian processes on random graphs

Statistical physics approaches can be used to derive accurate predictions for the performance of inference methods learning from potentially noisy data, as quantified by the learning curve defined as the average error versus number of training examples. We analyse a challenging problem in the area of non-parametric inference where an effectively infinite number of parameters has to be learned, specifically Gaussian process regression. When the inputs are vertices on a random graph and the outputs noisy function values, we show that replica techniques can be used to obtain exact performance predictions in the limit of large graphs. The covariance of the Gaussian process prior is defined by a random walk kernel, the discrete analogue of squared exponential kernels on continuous spaces. Conventionally this kernel is normalised only globally, so that the prior variance can differ between vertices; as a more principled alternative we consider local normalisation, where the prior variance is uniform

Disorder Predictors Also Predict Backbone Dynamics for a Family of Disordered Proteins

Several algorithms have been developed that use amino acid sequences to predict whether or not a protein or a region of a protein is disordered. These algorithms make accurate predictions for disordered regions that are 30 amino acids or longer, but it is unclear whether the predictions can be directly related to the backbone dynamics of individual amino acid residues. The nuclear Overhauser effect between the amide nitrogen and hydrogen (NHNOE) provides an unambiguous measure of backbone dynamics at single residue resolution and is an excellent tool for characterizing the dynamic behavior of disordered proteins. In this report, we show that the NHNOE values for several members of a family of disordered proteins are highly correlated with the output from three popular algorithms used to predict disordered regions from amino acid sequence. This is the first test between an experimental measure of residue specific backbone dynamics and disorder predictions. The results suggest that some disorder predictors can accurately estimate the backbone dynamics of individual amino acids in a long disordered region