THE ROLE OF CANDIDA ALBICANS ON THE DEVELOPMENT OF STOMATITIS IN PATIENTS WEARING DENTURES

Denture stomatitis is the most common inflammatory reaction that occurs in people who wear dentures. It is believed that in 60-65% of cases the cause of this inflammation is infections by yeasts from the genus Candida (C.), primarily Candida albicans infection. C.albicans is a part of the normal microflora of the respiratory and digestive tract. This yeast has the ability to adhere to the oral mucosa and to the base of the denture, as well as to form a biofilm. Its virulence is especially supported by the state of weakened resistance of the organism, when C.albicans expresses its pathological effect. This paper presents the pathogenesis of C. albicans-associated denture stomatitis, as well as the most common diagnostic and therapeutic procedures used to diagnose and successful therapy

Seven recommendations to make your invasive alien species data more useful

Science-based strategies to tackle biological invasions depend on recent, accurate, well-documented, standardized and openly accessible information on alien species. Currently and historically, biodiversity data are scattered in numerous disconnected data silos that lack interoperability. The situation is no different for alien species data, and this obstructs efficient retrieval, combination, and use of these kinds of information for research and policy-making. Standardization and interoperability are particularly important as many alien species related research and policy activities require pooling data. We describe seven ways that data on alien species can be made more accessible and useful, based on the results of a European Cooperation in Science and Technology (COST) workshop: (1) Create data management plans; (2) Increase interoperability of information sources; (3) Document data through metadata; (4) Format data using existing standards; (5) Adopt controlled vocabularies; (6) Increase data availability; and (7) Ensure long-term data preservation. We identify four properties specific and integral to alien species data (species status, introduction pathway, degree of establishment, and impact mechanism) that are either missing from existing data standards or lack a recommended controlled vocabulary. Improved access to accurate, real-time and historical data will repay the long-term investment in data management infrastructure, by providing more accurate, timely and realistic assessments and analyses. If we improve core biodiversity data standards by developing their relevance to alien species, it will allow the automation of common activities regarding data processing in support of environmental policy. Furthermore, we call for considerable effort to maintain, update, standardize, archive, and aggregate datasets, to ensure proper valorization of alien species data and information before they become obsolete or lost

Writing in War, Writing on War : The Dissolution of Yugoslavia in Literary Discourse

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Writing in War, Writing on War : The Dissolution of Yugoslavia in Literary Discourse

EThOS - Electronic Theses Online ServiceGBUnited Kingdo

The significance of second generation cardiac troponin I in early screening of hypoxic-ischemic encephalopathy after perinatal asphyxia

Introduction: In the last few years the use of cardiac troponin I and T, as diagnostic and prognostic factors of ischemic myocardial injury both in adult and neonatal medicine has been of great interest. Objective: The objective of our research was to investigate the significance of cardiac troponin I (cTnI) as an early indicator of the presence and severity of hypoxic-ischemic encephalopathy (HIE) in newborns. Methods: We analyzed 55 term newborns with HIE diagnosed based on clinical findings and ultrasonographic examination of the central nervous system. Serum concentration of cTnlultra was determined by immunoenzyme method during the first 24-48 hours after birth, and the obtained findings were compared with the values of identical parameter in 36 healthy term newborns. Results: During the first 24-48 hrs after birth, serum concentration of cTnl-ultra was significantly higher (p<0.0005) in term newborns with HIE (0.135±0.207 ug/l) and median (0.07,0.01-006 μg/1) in comparison to control group (0.0183±0.026 ug/l and median 0.01 (0.01-0.01 μg/l), with the cTnl-ultra level rising proportionally to the clinical HIE stages. The increase of cTnl-ultra of <0.12 μg/l indicated the development of significant cerebral damage with the sensitivity of 75% and specificity of 72.2%, while the cTnl-ultra level of <0.13 μg/l was a significant mortality predictor with sensitivity of 76.9% and specificity of 73.8%. Conclusion: The second generation cardiac troponin I assay highly correlates with clinical and ultrasonographic findings in neonates with HIE, so that it can be used as a significant diagnostic and prognostic indicator of this pathological condition

Difficulties in Preventing Repeated Genital Self-Mutilation

Self-mutilation is self-inflicted and intentional damage done to one’s body or one’s body parts without a conscious suicidal intention. The first case of genital self-mutilation was published in 1846, and the first scientific description of genital self-mutilation was written by Stroch in 1901. Since the first case has been described, there have been a relatively small number of described cases of genital self-mutilation in both genders; there have been an even smaller number of cases of repeated genital self-mutilation and only a few descriptions of repetitive forms of male genital self-mutilation in the literature. The aim of our study is to present difficulties in preventing repeated male genital self-mutilation of a patient with an intellectual disability who was diagnosed and treated for epilepsy and psychosis in early adult life and had a previous history of self-destructive behaviour during childhood. Previous literature does not contain many repeated cases of male genital self-mutilation. After evaluating the contribution of each individual factor in the aetiology of self-mutilation, we concluded that every individual factor is significant in the aetiology of self-mutilation; however, no single factor, as well as all the factors put together, is not enough for prevention of self-mutilation. Our conclusion is that all the presented factors in our research (intellectual disability, epilepsy, psychosis, self-destructive tendencies in childhood) have their place in the aetiology of male genital self-mutilation, but none of them are determining factors. This confirms that it is necessary to conduct further research in the field of aetiology of male genital self-mutilation, which would contribute towards more adequate prevention