The increase of neuropathic symptoms in diabetic patients is related with osteopenia

Purpose To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN). Methods In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method. Results There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (- 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (- 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score <= - 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score. Conclusion The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia

Artık eyleyicili otonom hava-uzay araçlarının uçuş kontrolü

TÜBİTAK MAG01.06.2010Bu araştırmada artık eyleyicili, otonom, hava-uzay araçlarının kontrolü konusu işlenmiştir. Üç temel araç göz önüne alınmıştır: Model uçak temelli bir insansız hava aracı, yatar rotorlu insansız hava aracı, ve uydu. Uçak temelli insansız hava aracı için gerek klasik gerekse gürbüz kontrolcüler tanımlanmış ve kontrol dağıtım problemi incelenmiştir. Ayrıca oluşturulan kontrolcülerin denenebilmesi için bir platform tasarlanmış, bütünleştirilmiş, uçuş kontrol algoritmaları ile seyrüsefer algoritmaları geliştirilmiş ve uçuş testleri gerçekleştirilmiştir. Yatar rotorlu insansız uçak için ise yine kontrolcüler geliştirilmiş, özellikle dikine kalkıştan ileri uçuşa geçiş sırasındaki kontrol dağıtım problemi incelenmiştir. Bu çalışmada hal değişkeni bağımlı Ricatti denklemi temelli iki döngülü bir kontrolcü önerilmiştir. Kontrolcü iç döngüde hızları, dış döngüde ise açı konumları geri beslemektedir. Bu iki döngülü kontrol yöntemi ile sistemin her zaman kontrol edilebilirliği ve cebrik Ricatti denkleminin çözümünün bulunduğu gösterilmiştir. Uydu yönelim kontrol çalışmalarında ise artık eyleyiciler olarak tepki tekerlekleri, moment kontrol jiroskopları ve manyetik burucular göz önüne alınmıştır. Özgün olarak tepki tekerlekleri ve manyetik burucu yedekli sistemin sürülmesi, moment kontrol jiroskopu ile manyetik burucuların sürülmesi incelenmiştir. Ayrıca sınırlı dönme açılı moment kontrol jiroskoplarının gimbal ekseninde sınıra ulaşmadan ve tekilliğe düşmeden sürülmesi hususları incelenmiştir. Bu tip jiroskop kümelerinin momentum zarfları da çizilerek gösterilmiştir.In this study, the control of aerospace vehicles with redundant actuators is addressed. Three fundamental vehicles are considered: Model airplane based unmanned air vehicle (UAV), tilt-duct UAV and satellite. For the model airplane, both classical and robust control methods are addressed. To test the controllers, a platform is designed, integrated, flight control and navigation algorithms are developed, and flight tests are carried out. A novel controller is developed for the tilt-duct UAV, and the allocation problem especially during the transition phase from the vertical takeoff to forward flight is addressed. The novel controller uses two loop state dependent Ricatti equation control. In the inner loop, the rates, while in the outer loop, positions and attitudes are fed back. It is shown that in this two loop system, the system never becomes uncontrollable, and solution of algebraic Ricatti equation always exits. In satellite attitude control, on the other hand, reaction wheels, magnetic torque rods, and moment control gyroscopes are considered as redundant actuators sets. In particular, the employment of redundant set of reaction wheels and magnetic torque rods, control moment gyroscopes and magnetic torque rods are addressed. Also addressed is the use steering of control moment gyroscopes with limited gimbal angle travel, without saturating the gimbal rotation or getting trapped in the singularities. The momentum envelope for such clusters is also visualized

CD5 as a prognostic marker in patients with diffuse large B-cell lymphoma: a multicenter study

© 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL) and comprises a heterogeneous group of disease. While classification of B-cell lymphomas has been evolving to include clonality in a specific manner, morphology, and immunohistochemistry remain the backbone. We aimed to evaluate the value of CD5 expression on disease characteristics as well as prognosis in patients with DLBCL. Data of 131 patients with DLBCL with CD5 positivity and as a comparison arm, data of 129 patients with DLBCL without CD5 positivity were evaluated. Mean age was 59 and 55.7% of the patients were male. Overall survival was 29.8 months. Poor prognostic factors including (high-LDH levels, B symptoms, low ECOG score, high R-IPI and NCCN-IPI score) were observed to be significantly related with CD5 positivity. Mean survival in CD5 positive patients were 29.8 months, which is significantly shorter than the general DLBCL survival worldwide. CD5 expression shall be evaluated in all samples of DLBCL patients due to its possible effects on outcomes

Efficacy of Capecitabine and Temozolomide Regimen in Neuroendocrine Tumors: Data From the Turkish Oncology Group

INTRODUCTION: This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines of treatment in patients with metastatic neuroendocrine tumors (NETs). METHODS: We conducted a multicenter retrospective study analyzing the data of 308 patients with metastatic NETs treated with CAPTEM between 2010 and 2022 in 34 different hospitals across various regions of Turkey. RESULTS: The median follow-up time was 41.0 months (range: 1.7-212.1), and the median age was 53 years (range: 22-79). Our results across the entire patient cohort showed a median progression-free survival (PFS) of 10.6 months and a median overall survival (OS) of 60.4 months. First-line CAPTEM treatment appeared more effective, with a median PFS of 16.1 months and a median OS of 105.8 months (median PFS 16.1, 7.9, and 9.6 months in first-, second- and ≥third-line respectively, P = .01; with median OS values of 105.8, 47.2, and 24.1 months, respectively, P = .003) In terms of ORR, the first-line treatment again performed better, resulting in an ORR of 54.7% compared to 33.3% and 30.0% in the second and third or higher lines, respectively (P < .001). Grade 3-4 side effects occurred only in 22.5% of the patients, leading to a discontinuation rate of 9.5%. Despite the differences in outcomes based on treatment line, we did not observe a significant difference in terms of side effects between the first and subsequent lines of treatment. CONCLUSIONS AND RELEVANCE: The substantial superior outcomes in patients receiving first-line CAPTEM treatment highlight its potential as an effective treatment strategy for patients with metastatic NET