Symmetry Classes of Spin and Orbital Ordered States in a t_{2g} Hubbard Model on a Two-dimensional Square Lattice

This paper presents symmetry classes of the Hartree-Fock (HF) solutions of spin and orbital ordered states in a t_{2g} Hubbard model on a two-dimensional square lattice. Using a group theoretical bifurcation theory of the Hartree Fock equation, we obtained many types of broken symmetry solutions which bifurcate from the normal state through one step transition in cases of commensurate ordering vectors Q_0=(0,0), Q_1=(\pi,\pi), Q_2=(\pi,0) and Q_3=(0,\pi). Each broken symmetry state is characterized by the presence of local order parameters(LOP) at each lattice site: quadrupole moment Q=(Q_2^2,Q_{12},Q_{23},Q_{31}), orbital angular momentum l=(l_1,l_2,l_3), spin density s=(s^1,s^2,s^3), spin quadrupole moment Q^{\lambda}=(Q_2^{2\lambda}, Q_{12}^{\lambda},Q_{23}^{\lambda},Q_{31}^{\lambda}) and spin orbital angular momentum l^{\lambda}=(l_1^{\lambda},l_2^{\lambda},l_3^{\lambda}) where \lambda=1,2,3. We performed numerical calculations for some parameter sets. Then we have found that many types of non-collinear magnetic orbital ordered states having LOP:Q^{\lambda} and l^{\lambda} can be the ground state for these parameter sets.Comment: 46 pages with 4 figure

On Local Symmetric Order Parameters of Vortex Lattice States

This paper gives a new refined definition of local symmetric order parameters (OPs)(s-wave, d-wave and p-wave order parameters) of vortex lattice states for singlet superconductivity. s-wave, d-wave and p-wave OPs at a site (m,n) are defined as A, B and E representations of the four fold rotation C_4 at the site (m,n) of nearest neighbor OPs etc. The new OPs have a well defined nature such that an OP(e.g. d-wave) at the site obtained under translation by a lattice vector (of the vortex lattice) from a site (m,n) is expressed by the corresponding OP (e.g. d-wave) at the site (m,n) times a phase factor. The winding numbers of s-wave and d-wave OPs are given.Comment: RevTeX v3.1, 5 pages with 3 figures, uses epsf.sty. to appear in Prog. Theor. Phys. Vol.101 No.3. (1999

p53: The Attractive Tumor Suppressor in the Cancer Research Field

p53 is one of the most studied tumor suppressors in the cancer research field. Of note, over 50% of human tumors carry loss of function mutations, and thus p53 has been considered to be a classical Knudson-type tumor suppressor. From the functional point of view, p53 is a nuclear transcription factor to transactivate a variety of its target genes implicated in the induction of cell cycle arrest, DNA repair, and apoptotic cell death. In response to cellular stresses such as DNA damage, p53 is activated and promotes cell cycle arrest followed by the replacement of DNA lesions and/or apoptotic cell death. Therefore, p53 is able to maintain the genomic integrity to prevent the accumulation of genetic alterations, and thus stands at a crossroad between cell survival and cell death. In this paper, we describe a variety of molecular mechanisms behind the regulation of p53

p73-Binding Partners and Their Functional Significance

p73 is one of the tumor-suppressor p53 family of nuclear transcription factor. As expected from the structural similarity between p53 and p73, p73 has a tumor-suppressive function. However, p73 was rarely mutated in human primary tumors. Under normal physiological conditions, p73 is kept at an extremely low level to allow cells normal growth. In response to a certain subset of DNA damages, p73 is induced dramatically and transactivates an overlapping set of p53-target genes implicated in the promotion of cell cycle arrest and/or apoptotic cell death. Cells undergo cell cycle arrest and/or apoptotic cell death depending on the type and strength of DNA damages. p73 is regulated largely through the posttranslational modifications such as phosphorylation and acetylation. These chemical modifications are tightly linked to direct protein-protein interactions. In the present paper, the authors describe the functional significance of the protein-protein interactions in the regulation of proapoptotic p73

Quick-drying, protective coating of papers with poly(methacrylate) latices containing alkali-hydrolysable emulsifiers

Surfaces of filter papers pretreated with sodium carbonate were coated with poly(methacrylate) latices containing alkali-hydrolysable or non-hydrolysable cationic emulsifiers by a simple drop-coating method and their surface properties were investigated. Determination of fixed amounts of polymers and observation of the paper surfaces suggest that glass transition temperature of the polymers and hydrolysability of the emulsifier are dominant factors for the coating. The latices of poly(2-ethylhexyl methacrylate) containing the hydrolysable emulsifier could coat the paper surface almost perfectly and smoothly, making it quick-drying and water repellent.ArticlePOLYMER BULLETIN. 67(7):1367-1377 (2011)journal articl

Preparation of surfactant-free vinyl polymers by conventional emulsion polymerization using hydrolysable emulsifiers

Emulsion polymerizations of several vinyl monomers, styrene, methyl methacrylate, butyl methacrylate, butyl acrylate, and vinyl acetate, in water using alkali-hydrolysable cationic surfactants with a betaine ester group (1-alkoxycarbonylmethyl)trimethylammonium chlorides, as emulsifiers were carried out and properties of the resulting latices and the polymers recovered by hydrolysis and salting out were investigated. There were little influences of the surfactants and monomers used here on the polymerizations, forming stable and monodisperse latices with a mean diameter of ca. 70 nm and giving a high molecular weight of polymers at high yields. All polymers were precipitated and recovered by adding a small amount of sodium hydroxide into the latex solutions contained little amount of ionic species. Solvent-cast films of the polymers were found to have surfaces as hydrophobic as those for the corresponding pure polymers prepared by bulk polymerization.ArticlePOLYMER BULLETIN. 67(8):1455-1462 (2011)journal articl

Alveolar soft part sarcoma: progress toward improvement in survival? A population-based study

Background Alveolar soft part sarcoma (ASPS) is a rare histological subtype of soft-tissue sarcoma, which remains refractory to conventional cytotoxic chemotherapy. We aimed to characterize ASPS and investigate whether the oncological outcome has improved over the past decade. Methods One hundred and twenty patients with newly diagnosed ASPS from 2006 to 2017, identified from the Bone and Soft-Tissue Tumor Registry in Japan, were analyzed retrospectively. Results The study cohort comprised 34 (28%) patients with localized ASPS and 86 (72%) with metastatic disease at presentation. The 5-year disease-specific survival (DSS) was 68% for all patients and 86% and 62% for localized and metastatic disease, respectively (p = 0.019). Metastasis at presentation was the only adverse prognostic factor for DSS (hazard ratio [HR]: 7.65; p = 0.048). Patients who were > 25 years (80%; p = 0.023), had deep-seated tumors (75%; p = 0.002), and tumors > 5 cm (5-10 cm, 81%; > 10 cm, 81%; p < 0.001) were more likely to have metastases at presentation. In patients with localized ASPS, adjuvant chemotherapy or radiotherapy did not affect survival, and 13 patients (45%) developed distant metastases in the lung (n = 12, 92%) and brain (n = 2, 15%). In patients with metastatic ASPS (lung, n = 85 [99%]; bone, n = 12 [14%]; and brain n = 9 [11%]), surgery for the primary or metastatic site did not affect survival. Prolonged survival was seen in patients who received pazopanib treatment (p = 0.045), but not in those who received doxorubicin-based cytotoxic chemotherapy. Overall, improved DSS for metastatic ASPS has been observed since 2012 (5-year DSS, from 58 to 65%) when pazopanib was approved for advanced diseases, although without a statistically significant difference (p = 0.117). Conclusion The national study confirmed a unique feature of ASPS with frequent metastasis to the lung and brain but an indolent clinical course. An overall trend toward prolonged survival after the introduction of targeted therapy encourages continuous efforts to develop novel therapeutic options for this therapeutically resistant soft-tissue sarcoma

Reconstruction With Ipsilateral Fibula Transfer With Pasteurized Bone After Excision of Bone Sarcoma of the Tibia

We report a technique of implantation of the ipsilateral vascularized fibula with pasteurized recycled bone after excision of tibia sarcoma in two cases. Plate and screws were used for osteosynthesis of the tibia or talus, vascularized fibula, and pasteurized bone. Microsurgery is not necessary for this reconstruction technique. Two patients who underwent this technique have obtained good functional results without tumor relapse 5 and 6 years after operation. The technique produced excellent results with regard to tibial reconstruction in these cases. We found it to be simple, speedy, safe, and a low cost technique by use of recycled bone

Reconstruction of Bone Defect Using the Bone Transport Technique for a Case of Osteosarcoma of the Femur

There are few reports on skeletal reconstruction using the bone transport technique to repair bone defects caused by resections of tumors associated with osteosarcoma. We attempted to reconstruct a 23 cm bone defect after resection of an osteosarcoma of the left femur, and succeeded in gaining 17 cm by bone transport. Five years after surgery, this patient remains alive without metastasis or local recurrence.</p