Challenges and Opportunities in Cycling Safety in Nairobi City, Kenya

The road transport in Kenya is the most common means oftransport for people living in both urban and rural areas. The use of bicycles for transport dates back in the pre-colonial time and has been used as a mode of transport until 2008 when the use of motorcycles became a popular mode of travel in the rural and urban areas. However, the use of bicycle as a means of travel has declined consistently over the years until now and many have shifted to the use of car, public transport and most commonly motorcycles which are popularly known as 'boda boda' in Kenya. This modal shift can be attributed to a number of factors identified as challenges in the use of bicycles as a common mode of transport in comparison to other emerging modes of transport both in rural and urban areas. However, despite this modal shift, there are a substantial number of road users who would still prefer to use the bicycle mode amid prevalence in road traffic fatalities and injuries in Kenya. The government of Kenya has established initiatives to provide safe and inclusive transport system by investing in transport infrastructure that includes cycle tracks especially for roads located in the urban cities. This has been enabled by innovation in design, mixed traffic composition, change of legislation and road design standards especially in regards to non-motorized transport in Kenya. Cycling is still low in cities in Kenya despite this effort to improve geometric design of roads. This paper explores these challenges and opportunities in cycling in Kenya focusing on Nairobi city as a case study. [From: Introduction

A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers

<p>Abstract</p> <p>Background</p> <p>Previous investigations indicate that methotrexate, an old anticancer drug, could be used at low doses to treat malaria. A phase I evaluation was conducted to assess the safety and pharmacokinetic profile of this drug in healthy adult male Kenyan volunteers.</p> <p>Methods</p> <p>Twenty five healthy adult volunteers were recruited and admitted to receive a 5 mg dose of methotrexate/day/5 days. Pharmacokinetics blood sampling was carried out at 2, 4, 6, 12 and 24 hours following each dose. Nausea, vomiting, oral ulcers and other adverse events were solicited during follow up of 42 days.</p> <p>Results</p> <p>The mean age of participants was 23.9 ± 3.3 years. Adherence to protocol was 100%. No grade 3 solicited adverse events were observed. However, one case of transiently elevated liver enzymes, and one serious adverse event (not related to the product) were reported. The maximum concentration (C_max) was 160-200 nM and after 6 hours, the effective concentration (C_eff) was <150 nM.</p> <p>Conclusion</p> <p>Low-dose methotraxate had an acceptable safety profile. However, methotrexate blood levels did not reach the desirable C_effof 250-400-nM required to clear malaria infection <it>in vivo</it>. Further dose finding and safety studies are necessary to confirm suitability of this drug as an anti-malarial agent.</p

Endomyocardial Fibrosis: Still a Mystery after 60 Years

The pathologist Jack N. P. Davies identified endomyocardial fibrosis in Uganda in 1947. Since that time, reports of this restrictive cardiomyopathy have come from other parts of tropical Africa, South Asia, and South America. In Kampala, the disease accounts for 20% of heart disease patients referred for echocardiography. We conducted a systematic review of research on the epidemiology and etiology of endomyocardial fibrosis. We relied primarily on articles in the MEDLINE database with either “endomyocardial fibrosis” or “endomyocardial sclerosis” in the title. The volume of publications on endomyocardial fibrosis has declined since the 1980s. Despite several hypotheses regarding cause, no account of the etiology of this disease has yet fully explained its unique geographical distribution

Osteoperosis - from hormonal replacement therapy to bisphosphonates and beyond: a review

No Abstract. East African Medical Journal Vol. 84 (11) 2007: pp. 534-54

Challenges and Opportunities in Cycling Safety in Nairobi City, Kenya

The road transport in Kenya is the most common means oftransport for people living in both urban and rural areas. The use of bicycles for transport dates back in the pre-colonial time and has been used as a mode of transport until 2008 when the use of motorcycles became a popular mode of travel in the rural and urban areas. However, the use of bicycle as a means of travel has declined consistently over the years until now and many have shifted to the use of car, public transport and most commonly motorcycles which are popularly known as 'boda boda' in Kenya. This modal shift can be attributed to a number of factors identified as challenges in the use of bicycles as a common mode of transport in comparison to other emerging modes of transport both in rural and urban areas. However, despite this modal shift, there are a substantial number of road users who would still prefer to use the bicycle mode amid prevalence in road traffic fatalities and injuries in Kenya. The government of Kenya has established initiatives to provide safe and inclusive transport system by investing in transport infrastructure that includes cycle tracks especially for roads located in the urban cities. This has been enabled by innovation in design, mixed traffic composition, change of legislation and road design standards especially in regards to non-motorized transport in Kenya. Cycling is still low in cities in Kenya despite this effort to improve geometric design of roads. This paper explores these challenges and opportunities in cycling in Kenya focusing on Nairobi city as a case study. [From: Introduction

Challenges and Opportunities in Cycling Safety in Nairobi City, Kenya

The road transport in Kenya is the most common means oftransport for people living in both urban and rural areas. The use of bicycles for transport dates back in the pre-colonial time and has been used as a mode of transport until 2008 when the use of motorcycles became a popular mode of travel in the rural and urban areas. However, the use of bicycle as a means of travel has declined consistently over the years until now and many have shifted to the use of car, public transport and most commonly motorcycles which are popularly known as 'boda boda' in Kenya. This modal shift can be attributed to a number of factors identified as challenges in the use of bicycles as a common mode of transport in comparison to other emerging modes of transport both in rural and urban areas. However, despite this modal shift, there are a substantial number of road users who would still prefer to use the bicycle mode amid prevalence in road traffic fatalities and injuries in Kenya. The government of Kenya has established initiatives to provide safe and inclusive transport system by investing in transport infrastructure that includes cycle tracks especially for roads located in the urban cities. This has been enabled by innovation in design, mixed traffic composition, change of legislation and road design standards especially in regards to non-motorized transport in Kenya. Cycling is still low in cities in Kenya despite this effort to improve geometric design of roads. This paper explores these challenges and opportunities in cycling in Kenya focusing on Nairobi city as a case study. [From: Introduction

Rheumatic disorders in sub-Saharan Africa

Although multiple supernumerary teeth without any associated syndromes are rare, their occurrence can create a variety of clinical problems such as derangement of the occlusion, prevention of eruption of permanent teeth, damage to adjacent teeth, cystic degeneration and root resorption. Hence, clinical and radiographic evaluation of patients should always be thorough in order to detect their presence. Furthermore, because the clinical management of multiple supernumerary teeth pauses a great challenge to clinicians, timely, appropriate consultation and interdisciplinary approach to treatment is extremely important. We report two cases, a 14 year-old boy with eight and a 13-year-old girl with seven supernumerary teeth not associated with syndromes. In the boy, the teeth were bilaterally distributed in all quadrants in the premolar regions, and in the girl they were distributed bilaterally in the premolar regions in the mandible and bilaterally distal to the upper third molars. The clinical implications and management are discussed. (East African Medical Journal: 2002 79(4): 214-216