Source Spectra and Site Response from S Waves of Intermediate-Depth Vrancea, Romania, Earthquakes

Seismograms from 55 intermediate-depth Vrancea earthquakes (M 4:0– 7:1) recorded at 43 stations of an accelerometric network in Romania are used to derive source spectra and site amplification functions from S waves in the frequency range 0.5–20 Hz with the generalized inversion technique (GIT) (Castro et al., 1990). Attenuation is taken into account using the nonparametric attenuation functions derived by Oth et al. (2008) from the same dataset, and the attenuation-corrected data are then split into source and site contributions. The source spectra follow the ω 2 model (Brune, 1970, 1971) with high corner frequencies and a related Brune stress drop of the order of 100 MPa. The site amplification functions are separately determined for both horizontal and vertical components. Contrary to widespread expectation, the vertical component shows significant amplification effects at high frequencies. The H=Z ratios determined from the GIT results compare well with H=V ratios computed directly from the S-wave window of the accelerograms (Lermo and Chávez-García, 1993). The basic assumption for the determination of site effects from H=V ratios is that the vertical component is not or only little affected by site effects. For Vrancea earthquakes, this assumption is incorrect; consequently, site effects should not be estimated from H=V ratios. The reason for this peculiar fact is the geometry of intermediate-depth seismicity that leads to almost vertical ray paths beneath the stations

Genioplasty with surgical guide using 3D-printing technology : a systematic review

The purpose of this systematic review is to evaluate the current state of the art of making genioplasties using 3D printing technology. A multi-database single-reviewer systematic review identified sixteen papers that fulfilled the selection criteria. There were mainly case series and case reports available (Level IV of the Oxford Evidence-based medicine scale); only two prospective study (Level III) evaluated this subject. These articles are analyzed in details and summarized in this review. The realization of genioplasties with surgical guide using 3D-printing technology could improve predictability and accuracy. It protects anatomical structures in the environment of the surgery, reducing by this way the morbidity and providing safer results. The type of printer and material used as well as the sterilization techniques should be further developed by the authors. The use of open-access software should also be further explored to allow the use of these new technologies by the largest number of surgeons. Finally, prospective multi-center studies with larger samples should be performed to definitively conclude the benefits of this new technology and allow for its routine use. This article is the first systematic review on this topic

Source processes and spectral ground motion models of intermediate depth Vrancea (Romania) earthquakes

For successful assessment and mitigation of earthquake hazards, it is necessary to be able to reliably predict the level of ground shaking which has to be expected from future large earthquakes. This prediction of ground motion can be done either by using empirical relations (derived from past earthquakes) between some ground motion parameter and the source and observer location, so-called attenuation relations, or by performing numerical simulations of future earthquakes based on models of the earthquake source and the propagation medium (i.e. the Earth). The capacity of the first option is at times rather limited, for instance if only very few large earthquakes occurred in the region of interest in instrumental times. Numerical simulations, on the other hand, cannot provide reliable results without a detailed description of the underlying source process and a thorough understanding of path and site effects. This thesis aims at a better understanding of the source process and the spectral characteristics of the intermediate-depth Vrancea (Romania) earthquakes...thesi

Structural Health Monitoring Using Wireless Technologies: An Ambient Vibration Test on the Adolphe Bridge, Luxembourg City

Major threats to bridges primarily consist of the aging of the structural elements, earthquake-induced shaking and standing waves generated by windstorms. The necessity of information on the state of health of structures in real-time, allowing for timely warnings in the case of damaging events, requires structural health monitoring (SHM) systems that allow the risks of these threats to be mitigated. Here we present the results of a short-duration experiment carried out with low-cost wireless instruments for monitoring the vibration characteristics and dynamic properties of a strategic civil infrastructure, the Adolphe Bridge in Luxembourg City. The Adolphe Bridge is a masonry arch construction dating from 1903 and will undergo major renovation works in the upcoming years. Our experiment shows that a network of these wireless sensing units is well suited to monitor the vibration characteristics of such a historical arch bridge and hence represents a low-cost and efficient solution for SHM

Synergistic and selective stimulation of gelatinase B production in macrophages by lipopolysaccharide, trans-retinoic acid and CGP 41251, a protein kinase C regulator

AbstractThe production of gelatinase B by macrophages is relevant in the immunological and migratory functions of macrophages. CGP 41251, an inhibitor of protein kinase C (PKC), was found to stimulate the expression of gelatinase B in macrophages, as shown by the study of two different monocytic/macrophagic cell lines, mouse RAW 264.7 and human THP-1 cells. When human monocytis and rat peritoneal macrophages were treated with CGP 41251, insignificant increases of 10 and 25% were obtained. This can possibly be due to the presence of contaminating cells in these two enriched populations, since the CGP 41251 treatment of non-macrophagic cell lines inhibited their PMA-induced gelatinase B production. Taken together, these results suggest that the stimulatory effect of CGP 41251 is specific to cells of the monocytic lineage. Using RAW 264.7 cells as a model, the effect of CGP 41251 is additive to that obtained using lipopolysaccharide (LPS) and phorbol 12-myristate 13-acetate (PMA), as revealed by gelatin zymography and Northern blot analysis. The stimulatory effect of CGP 41251 on gelatinase B production in RAW 264.7 was: (a) inhibited by calphostin C (as is the LPS-induced response), indicating a PKC-dependence; (b) inhibited by dexamethasone (as opposed to the LPS-induced response); and (c) enhanced by addition of trans-retinoic acid (RA). In fact, RA can induce gelatinase B production, either alone or in synergy with LPS and/or CGP 41251, since the combination of the three agents gives the highest gelatinase B response, at both the protein and the mRNA levels. This represents an important observation considering that RA is now being tested as an anti-cancer agent and proposed for prevention studies