Towards a consensus on the circular economy

The growing importance of the concept of the circular economy as a way to attain sustainable development has encouraged scholars to propose different ways to understand it. Given the large number of studies done on the circular economy, their differing approaches and their multiple applications, this paper attempts to propose a consensus view of the basic notions of the circular economy framework and highlight its relationship with eco-innovation. To that end, this study carried out a systematic literature review that resulted in four main outputs: a knowledge map of the circular economy, an analysis of the main notions of the concept, principles, and determinants of a circular economy. Finally, this study brings to light some remarkable examples of eco-innovations developed for implementation in the circular econom

Crispr/cas9 editing for gaucher disease modelling

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid \u3b2-glucosidase gene (GBA1). Besides causing GD, GBA1 mutations constitute the main genetic risk factor for developing Parkinson\u2019s disease. The molecular basis of neurological manifestations in GD remain elusive. However, neuroinflammation has been proposed as a key player in this process. We exploited CRISPR/Cas9 technology to edit GBA1 in the human monocytic THP-1 cell line to develop an isogenic GD model of monocytes and in glioblastoma U87 cell lines to generate an isogenic GD model of glial cells. Both edited (GBA1 mutant) cell lines presented low levels of mutant acid \u3b2-glucosidase expression, less than 1% of residual activity and massive accumulation of substrate. Moreover, U87 GBA1 mutant cells showed that the mutant enzyme was retained in the ER and subjected to proteasomal degradation, triggering unfolded protein response (UPR). U87 GBA1 mutant cells displayed an increased production of interleukin-1\u3b2, both with and without inflammosome activation, \u3b1-syn accumulation and a higher rate of cell death in comparison with wild-type cells. In conclusion, we developed reliable, isogenic, and easy-to-handle cellular models of GD obtained from commercially accessible cells to be employed in GD pathophysiology studies and high-throughput drug screenings

Towards a consensus on the circular economy.

The growing importance of the concept of the circular economy as a way to attain sustainable devel- opment has encouraged scholars to propose different ways to understand it. Given the large number of studies done on the circular economy, their differing approaches and their multiple applications, this paper attempts to propose a consensus view of the basic notions of the circular economy framework and highlight its relationship with eco-innovation. To that end, this study carried out a systematic literature review that resulted in four main outputs: a knowledge map of the circular economy, an analysis of the main notions of the concept, principles, and determinants of a circular economy. Finally, this study brings to light some remarkable examples of eco-innovations developed for implementation in the circular economy

Beyond the Circular Economy Theory: Implementation Methodology for Industrial SMEs.

Purpose: The circular economy has multiple benefits and opportunities to achieve sustainability and a better future for the next generations. The purpose of this paper is to propose a methodology that guides step-by-step any industrial SMEs in the transition from the linear to a circular model. Small and medium enterprises (SMEs) have a crucial role in the sustainable development transition, considering that they represent most of the world's companies. Design/methodology/approach: To develop this methodology, two research techniques were used: a focus group and storyboarding. Findings: The resulting methodology, called Ecopyme, comprises five steps: 1) Firm identity, 2) Diagnosis, 3) Planning, 4) Get the ball rolling, and 5) Assessment and feedback. In addition, two key criteria that must be included in the whole process were identified: value creation in the firm through a circular economy and organization commitment from the top management to the staff. Research limitations/implications: The Ecopyme methodology has two limitations: It does not propose either implementation tools or involve consumers and actors at the meso (e.g., eco-industrial parks) and macro (e.g., cities, provinces, countries) levels. Practical implications: This study will help policymakers understand the SMEs' perspective and remove barriers that may hinder the paradigm shift. The methodology is also a useful tool for consultants and entrepreneurs to incorporate the circular economy (CE) principles into their business. Originality/value: In the CE literature, little attention has been paid to proposing a structured methodology to implement CE in SMEs. Thus, the study provides a step-by-step methodology that guides any industrial SMEs to transition from linear to circular. Also, it provides additional evidence concerning the importance of human commitment in changing firms' paradigm because people can encourage the adoption of responsible production practices if firms commit CEOs, sustainability managers, and staff

Evaluation of CSF neurotransmitters and folate in 25 patients with Rett disorder and effects of treatment

Background: Rett disorder (RD) is a progressive neurodevelopmental entity caused by mutations in the MECP2 gene. It has been postulated that there are alterations in the levels of certain neurotransmitters and folate in the pathogenesis of this disease. Here we re-evaluated this hypothesis. Patients and methods: We evaluated CSF folate, biogenic amines and pterines in 25 RD patients. Treatment with oral folinic acid was started in those cases with low folate. Patients were clinically evaluated and videotaped up to 6 months after therapy. Results: CSF folate was below the reference values in 32% of the patients. Six months after treatment no clinical improvement was observed. Three of the four patients with the R294X mutation had increased levels of a dopamine metabolite associated to a particular phenotype. Three patients had low levels of a serotonin metabolite. Two of them were treated with fluoxetine and one showed clinical improvement. No association was observed between CSF folate and these metabolites, after adjusting for the patients age and neopterin levels. Conclusion: Our results support that folinic acid supplementation has no significant effects on the course of the disease. We report discrete and novel neurotransmitter abnormalities that may contribute to the pathogenesis of RD highlighting the need for further studies on CSF neurotransmitters in clinically and genetically well characterized patients.Research in Rett syndrome is supported by FSE/FEDER and Fundação para a Ciência e Tecnologia (FCT, Portugal), Grant No. POCTI 41416/2001

Advancing circular economy performance indicators and their application in Spanish companies.

Current research on the circular economy (CE) reveals that, while the concept and its application have been extensively explored as shown in several case studies, the definition of tools and criteria measuring "circularity" of products, companies or regions are not well-defined. Therefore, indicators for measuring the different levels of a CE (micro, meso, and macro) should be a high priority for stakeholders (governments, companies, NGOs, civil society, etc.) in order to track progress on CE initiatives. However, the increasing interest on CE has caused a still open debate on the conceptualization of CE which hampers the creation of indicators based on a common conceptual framework. As a result, the absence of standard indicators to track progress on circularity is leading to contradiction and misunderstanding, which represents a challenge to the implementation of CE strategies. Thus, this study tries to address this gap by advancing a set of indicators adapted from existing indicators that guarantees simplicity and effectiveness, closely based on indicators proposed by government bodies. This research carried out an exploratory study to formulate the indicators requirements based on literature, refined through experts' opinion and then they were tested in Spanish companies located in the Basque Country region through an empirical work to assess this theory. A mix of research methods (e.g. semi-structured interviews and surveys) were used to seek applicability of CE indicators for organisations. The study showed that the proposed indicators currently used for assessing the CE at the macro level were applicable at the micro level based on companies' responses. This fact demonstrated that the indicators serve the purpose of being applicable to companies regardless of the type of economic activity they were in. Also, it shows that indicators used to monitor progress on CE at the macro level can be translated to the micro level. Consequently, it is recommended that the set of CE indicators focused on the methodology proposed in this study should be used across different industrial sectors in order to observe performance in companies to facilitate the transition to a CE model. (c) 2020 Elsevier Ltd. All rights reserved

Environmental Management Evolution Framework: Maturity Stages and Causal Loops.

Environmental management has become a fundamental concern for organizations, customers, and citizens, yet there are few environmental management metrics that guide toward environmental excellence. This research presents a detailed qualitative model of the evolution of environmental management of a firm through the definition of maturity stages and causal influences. The model provides a technique for assessing maturity stages as well as steps that can assist or negate their ecological advancement. The causal-based classification helps companies to understand the need for nontechnical elements in the process, such as top management commitment. This article also contributes to the literature on integrative multimethod research, as it brings together several approaches to environmental management

Challenges for ecolabeling growth: lessons from the EU Ecolabel in Spain

Purpose The European Ecolabel (EU Flower) has the mission to encourage cleaner production and influence consumers to promote Europe's transition to a circular economy. Nonetheless, little is known about EU Ecolabel evolution; it is not clear what the drivers that encourage its implementation are. Thus, this study aims to assess the growing acceptance of the EU Ecolabel in the European Union, and Spain more specifically, by examining product and service categories and geographical regions. Methods The methodological approach taken in this study is a mixed methodology based on the triangulation method by consulting the EU Ecolabel scheme database, EU Ecolabel delegates from some autonomous regions, and the academic literature. Also, a geographic analysis was run in the ArcGIS Software with data about the accumulation of licenses assigned in 2016. Results and discussion The analysis shows that most products in Spain that have been awarded the EU Ecolabel belong to the following categories: Do-It-Yourself Products (paint and varnish), Paper Products, Cleaning Up Products, and Electronic Equipment. At the same time, the study showed that this ecolabel faces significant obstacles in its diffusion, such as the competition with environmental labels launched previously in Europe and other regional labels. Conclusions The results of this study indicate the existence of five drivers that may encourage the implementation of EU Flower in a region: (1) public management, (2) communication strategy, (3) sustainable public procurement criteria, (4) local income per capita, and (5) international trade incentives. Finally, this study provides essential recommendations for policymakers to trigger ecolabeling practices such as the need to improve the understanding of the EU ecolabel impact in different levels of activity, which means countries, regions, industrial clusters, firms, and consumers. Also, this investigation identifies areas for further research, and it expresses the need to develop business case studies about ecolabeling with the objective to visualize this phenomenon as an eco-innovation process

An Overview of the Circular Economy among SMEs in the Basque Country: A Multiple Case Study.

Purpose: This research analyzes the maturity of environmental management as well as the degreeof to which the Circular Economy has been implemented in Basque SMEs.Design/methodology/approach:A total of 17 case studies were carried out in industrialSMEs companies in the Basque Country.Findings:The main results show that companies are limited to complying with the law and inmany cases are worried about the image of the company, although they are not committed toenvironmental issues. There is still a lot to do in SMEs, as they are the companies that face thebiggest challenges due to a lack of resources.Originality/value: Circular Economy aims to change a linear economy into promotingsustainability of the economy while also engaging in sustainable environmental protection. Thisresearch has focused on small and medium enterprises as they represent a 99% of companies inEurope and they are the ones that have the most difficulty reaching a stage of environmentalexcellence due to their limited resources

Evolución de la gestión ambiental a través de estados de madurez.

A primera vista, la gestión ambiental puede parecer diferente en cada empresa. Sin embargo, esta investigación ha demostrado que la evolución de la gestión ambiental es similar en todas las organizaciones; es decir, cada compañía pasa por análogos estados de madurez. A través de entrevistas y workshops con expertos en gestión ambiental, se ha definido esta evolución y se ha desarrollado una clasificación de estos estados de madurez: Cumplimiento de la Legislación, Formación, Sistematización, ECO2, Eco-Innovación y Empresa Líder en Gestión Ambiental. Esta clasificación ayuda a comprender con mayor precisión la evolución de la gestión del medio ambiente y la estructura que representa a esta evolución