473 research outputs found
Impact of Land Use Changes on Soil Quality of a Biosphere Reserve in Southwestern Nigeria
Many primary forests in the tropical regions of the world have been converted into degraded secondary or intensively used agricultural areas. Using the Spatial Analogue technique of studying ecosystem dynamics, soil impact of deforestation and conversion was evaluated by comparing soil properties under the natural forest, secondary regrowth of a logged-over forest, monoculture plantation of Cedrela odorata (Linn), and maize/cassava farm at 0 10, 10 20 and 20 30cm soil depths. % sand decreased with soil depth in all the land use types and was significantly different between the natural forest and each of the logged-over forest regrowth, monoculture plantation and farmland except at 0 10cm depth. % Clay increased with soil depth but did not vary significantly among land use types except at 20 30cm depth. Available phosphorus decreased gradually with soil depth in all land use types with the natural forest and farmland having the highest and lowest mean values respectively. Organic matter varied significantly between each of the natural forest, logged-over forest regrowth and monoculture plantation, with the farmland at the three soil depths. Total nitrogen was generally low in all land use types, though, the natural forest compared better than the others. Soil pH, calcium, magnesium, effective cation exchange capacity, and percentage base saturation decreased with soil depth in all land use types with the natural forest having higher mean values than the others. Indices of change computed for organic matter, total nitrogen, available phosphorus, calcium, magnesium, potassium, effective cation exchange capacity and percentage base saturation, showed that soil management in the introduced land use types, is tending away from sustainability. Inter-cropping with nutrient-regenerating agroforestry trees on the farmland and the use of low-impact logging techniques are suggested for soil conservation
Finite Temperature Aging Holography
We construct the gravity background which describes the dual field theory
with aging invariance. We choose the decay modes of the bulk scalar field in
the internal spectator direction to obtain the dissipative behavior of the
boundary correlation functions of the dual scalar fields. In particular, the
two-time correlation function at zero temperature has the characteristic
features of the aging system: power law decay, broken time translation and
dynamical scaling. We also construct the black hole backgrounds with asymptotic
aging invariance. We extensively study characteristic behavior of the finite
temperature two-point correlation function via analytic and numerical methods.Comment: 38 pages and 5 figures, expanded discussions on correlator, one
mistake is fixed, modified discussion on shear viscosity, to appear in JHE
A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells
MBD4 binds to methylated DNA and acts as a thymine DNA glycosylase in base excision repair. Deficiency of MBD4 in mice enhances mutation at CpG sites and alters apoptosis in response to DNA damage, but does not increase tumorigenesis in mismatch repair-deficient mice. However, in humans, frameshift mutation of MBD4, rather than deletion, is what occurs in up to 43% of microsatellite unstable colon cancers. There is no murine equivalent of this mutation. We now show that recombinant truncated MBD4 (MBD4tru) inhibits glycosylase activities of normal MBD4 or Uracil DNA glycosylase in cell-free assays as a dominant negative effect. Furthermore, overexpression of MBD4tru in Big Blue (lacI)-transfected, MSI human colorectal carcinoma cells doubled mutation frequency, indicating that the modest dominant negative effect on DNA repair can occur in living cells in short-term experiments. Intriguingly, the whole mutation spectrum was increased, not only at CpG sites, suggesting that truncated MBD4 has a more widespread effect on genomic stability. This demonstration of a dominant negative effect may be of significance in tumour progression and acquisition of drug resistance
Degenerate Rotating Black Holes, Chiral CFTs and Fermi Surfaces I - Analytic Results for Quasinormal Modes
In this work we discuss charged rotating black holes in
that degenerate to extremal black holes with zero entropy. These black holes
have scaling properties between charge and angular momentum similar to those of
Fermi surface operators in a subsector of SYM. We add a
massless uncharged scalar to the five dimensional supergravity theory, such
that it still forms a consistent truncation of the type IIB ten dimensional
supergravity and analyze its quasinormal modes. Separating the equation of
motion to a radial and angular part, we proceed to solve the radial equation
using the asymptotic matching expansion method applied to a Heun equation with
two nearby singularities. We use the continued fraction method for the angular
Heun equation and obtain numerical results for the quasinormal modes. In the
case of the supersymmetric black hole we present some analytic results for the
decay rates of the scalar perturbations. The spectrum of quasinormal modes
obtained is similar to that of a chiral 1+1 CFT, which is consistent with the
conjectured field-theoretic dual. In addition, some of the modes can be found
analytically.Comment: 41 pages, 1 figure, LaTeX; v2: typos corrected, references adde
Schr\"odinger Holography with and without Hyperscaling Violation
We study the properties of the Schr\"odinger-type non-relativistic holography
for general dynamical exponent z with and without hyperscaling violation
exponent \theta. The scalar correlation function has a more general form due to
general z as well as the presence of \theta, whose effects also modify the
scaling dimension of the scalar operator. We propose a prescription for minimal
surfaces of this "codimension 2 holography," and demonstrate the (d-1)
dimensional area law for the entanglement entropy from (d+3) dimensional
Schr\"odinger backgrounds. Surprisingly, the area law is violated for d+1 < z <
d+2, even without hyperscaling violation, which interpolates between the
logarithmic violation and extensive volume dependence of entanglement entropy.
Similar violations are also found in the presence of the hyperscaling
violation. Their dual field theories are expected to have novel phases for the
parameter range, including Fermi surface. We also analyze string theory
embeddings using non-relativistic branes.Comment: 62 pages and 6 figures, v2: several typos in section 5 corrected,
references added, v3: typos corrected, references added, published versio
Kerr/CFT, dipole theories and nonrelativistic CFTs
We study solutions of type IIB supergravity which are SL(2,R) x SU(2) x
U(1)^2 invariant deformations of AdS_3 x S^3 x K3 and take the form of products
of self-dual spacelike warped AdS_3 and a deformed three-sphere. One of these
backgrounds has been recently argued to be relevant for a derivation of
Kerr/CFT from string theory, whereas the remaining ones are holographic duals
of two-dimensional dipole theories and their S-duals. We show that each of
these backgrounds is holographically dual to a deformation of the DLCQ of the
D1-D5 CFT by a specific supersymmetric (1,2) operator, which we write down
explicitly in terms of twist operators at the free orbifold point. The
deforming operator is argued to be exactly marginal with respect to the
zero-dimensional nonrelativistic conformal (or Schroedinger) group - which is
simply SL(2,R)_L x U(1)_R. Moreover, in the supergravity limit of large N and
strong coupling, no other single-trace operators are turned on. We thus propose
that the field theory duals to the backgrounds of interest are nonrelativistic
CFTs defined by adding the single Schroedinger-invariant (1,2) operator
mentioned above to the original CFT action. Our analysis indicates that the
rotating extremal black holes we study are best thought of as finite
right-moving temperature (non-supersymmetric) states in the above-defined
supersymmetric nonrelativistic CFT and hints towards a more general connection
between Kerr/CFT and two-dimensional non-relativistic CFTs.Comment: 48+8 pages, 4 figures; minor corrections and references adde
Anomaly Equations and Intersection Theory
Six-dimensional supergravity theories with N=(1,0) supersymmetry must satisfy
anomaly equations. These equations come from demanding the cancellation of
gravitational, gauge and mixed anomalies. The anomaly equations have
implications for the geometrical data of Calabi-Yau threefolds, since F-theory
compactified on an elliptically fibered Calabi-Yau threefold with a section
generates a consistent six-dimensional N=(1,0) supergravity theory. In this
paper, we show that the anomaly equations can be summarized by three
intersection theory identities. In the process we also identify the geometric
counterpart of the anomaly coefficients---in particular, those of the abelian
gauge groups---that govern the low-energy dynamics of the theory. We discuss
the results in the context of investigating string universality in six
dimensions.Comment: 29 pages + appendices, 8 figures; v2: minor corrections, references
added; v3: minor corrections, reference adde
Oestradiol-17β plasma concentrations after intramuscular injection of oestradiol benzoate or oestradiol cypionate in llamas (Lama glama)
<p>Abstract</p> <p>Background</p> <p>Llamas (<it>Lama glama</it>) are induced ovulators and the process of ovulation depends on dominant follicular size. In addition, a close relationship between behavioural estrus and ovulation is not registered in llamas. Therefore, the exogenous control of follicular development with hormones aims to predict the optimal time to mate. Oestradiol-17β (E<sub>2</sub>) and its esters are currently used in domestic species, including camelids, in synchronization treatments. But, in llamas, there is no reports regarding the appropriate dosages to be used and most protocols have been designed by extrapolation from those recommended for other ruminants. The aim of the present study was to characterize plasma E<sub>2 </sub>concentrations in intact female llamas following a single intramuscular (i.m.) injection of two oestradiol esters: oestradiol benzoate (EB) and oestradiol cypionate (ECP).</p> <p>Methods</p> <p>Twelve non pregnant and non lactating sexually mature llamas were i.m. injected on day 0 with 2.5 mg of EB (EB group, n = 6) or ECP (ECP group, n = 6). Blood samples were collected immediately before injection, at 1, 6, 12, 24 h after treatment and then daily until day 14 post injection. Changes in hormone concentrations with time were analyzed in each group by analysis of variance (ANOVA) using a repeated measures (within-SS) design. Plasma E<sub>2 </sub>concentrations and area under the concentration-time curve (AUC) values were compared between groups by ANOVA. In all cases a Least-Significant Difference test (LSD) was used to determine differences between means. Hormonal and AUC data are expressed as mean ± S.E.M.</p> <p>Results</p> <p>Peak plasma E<sub>2 </sub>concentrations were achieved earlier and were higher in EB group than in ECP group. Thereafter, E<sub>2 </sub>returned to physiological concentrations earlier in EB group (day 5) than in ECP group (day 9). Although plasma E<sub>2 </sub>profiles differed over time among groups there were no differences between them on AUC values.</p> <p>Conclusions</p> <p>The i.m. injection of a single dose of both oestradiol esters resulted in plasma E<sub>2 </sub>concentrations exceeding physiological values for a variable period. Moreover, the plasma E<sub>2 </sub>profiles observed depended on the derivative of oestradiol administered. This basic information becomes relevant at defining treatment protocols including oestrogens in llamas.</p
Pediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccine
Background: Historically, Nigeria has experienced large bacterial meningitis outbreaks with high mortality in children.
Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae are major causes
of this invasive disease. In collaboration with the World Health Organization, we conducted longitudinal surveillance in sentinel
hospitals within Nigeria to establish the burden of pediatric bacterial meningitis (PBM).
Methods: From 2010 to 2016, cerebrospinal fluid was collected from children <5 years of age, admitted to 5 sentinel hospitals in
5 Nigerian states. Microbiological and latex agglutination techniques were performed to detect the presence of pneumococcus, meningococcus, and H. influenzae. Species-specific polymerase chain reaction and serotyping/grouping were conducted to determine
specific causative agents of PBM.
Results: A total of 5134 children with suspected meningitis were enrolled at the participating hospitals; of these 153 (2.9%) were
confirmed PBM cases. The mortality rate for those infected was 15.0% (23/153). The dominant pathogen was pneumococcus (46.4%:
71/153) followed by meningococcus (34.6%: 53/153) and H. influenzae (19.0%: 29/153). Nearly half the pneumococcal meningitis
cases successfully serotyped (46.4%: 13/28) were caused by serotypes that are included in the 10-valent pneumococcal conjugate vaccine. The most prevalent meningococcal and H. influenzae strains were serogroup W and serotype b, respectively.
Conclusions: Vaccine-type bacterial meningitis continues to be common among children <5 years in Nigeria. Challenges with
vaccine introduction and coverage may explain some of these finding. Continued surveillance is needed to determine the distribution of serotypes/groups of meningeal pathogens across Nigeria and help inform and sustain vaccination policies in the countr
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