Laser Shock Microforming of Thin Metal Sheets

Continuous and long-pulse lasers have been used for the forming of metal sheets in macroscopic mechanical applications. However, for the manufacturing of micro-electromechanical systems (MEMS), the applicability of such type of lasers is limited by the long-relaxation-time of the thermal fields responsible for the forming phenomena. As a consequence of such slow relaxation, the final sheet deformation state is attained only after a certain time, what makes the generated internal residual stress fields more dependent on ambient conditions and might make difficult the subsequent assembly process from the point of view of residual stresses due to adjustment. The use of ns laser pulses provides a suitable parameter matching for the laser forming of an important range of sheet components used in MEMS that, preserving the short interaction time scale required for the predominantly mechanic (shock) induction of deformation residual stresses, allows for the successful processing of components in a medium range of miniaturization, particularly important according to its frequent use in such systems. In the present paper, a discussion is presented on the physics of laser shock microforming and the influence of the different effects on the net bending angle. The experimental setup used for the experiments, sample fabrication and experimental results of influence of number of laser pulses on the net bending angle are also presented

Laser Shock Microformingof Thin Metal Sheets with ns Lasers

Continuous and long-pulse lasers have been used for the forming of metal sheets in macroscopic mechanical applications. However, for the manufacturing of micro-electromechanical systems (MEMS), the use of ns laser pulses provides a suitable parameter matching over an important range of sheet components that, preserving the short interaction time scale required for the predominantly mechanical (shock) induction of deformation residual stresses, allows for the successful processing of components in a medium range of miniaturization without appreciable thermal deformation.. In the present paper, the physics of laser shock microforming and the influence of the different experimental parameters on the net bending angle are presented

Model based optimization criteria for the generation of deep compressive residual stress fields in high elastic limit metallic alloys by ns-laser shock processing

Laser Shock Processing (LSP) is based on the application of a high intensity pulsed Laser beam (IN1 GW/cm2; τb50 ns) on a metallic target forcing a sudden vaporization of its surface into a high temperature and density plasma that immediately develops inducing a shock wave propagating into the material. The main acknowledged advantages of LSP consist on its capability of inducing a relatively deep compression residual stresses field into metallic alloy pieces allowing an improved mechanical behavior, explicitly, the life improvement of the treated specimens against wear, crack growth and stress corrosion cracking. Due to these specific advantages, Laser Shock Processing is considered as a competitive alternative technology to classical treatments for improving fatigue, corrosion cracking and wear resistance of metallic materials, and is being developed as a practical process amenable to production technology. In this paper, a model based systematization of process optimization criteria and a practical assessment on the real possibilities of the technique is presented along with practical results at laboratory scale on the application of LSP to characteristic high elastic limit metallic alloys, showing the induced residual stresses fields and the corresponding results on mechanical properties improvement induced by the treatment. The homogeneity of the residual stress fields distribution following the laser treatment spatial density will be specially analyzed

Retos y nuevas perspectivas en la revegetación de sistemas forestales

Entre los días 21 y 23 de noviembre de 2007 tuvo lugar la I Reunión del Grupo de Trabajo de Repoblaciones Forestales de la Sociedad Española de Ciencias Forestales (SECF) y el grupo de trabajo de Restauración Ecológica de la Asociación Española de Ecología Terrestre, y IV Reunión del Grupo de Trabajo de Repoblaciones Forestales de la SECF en las instalaciones del Rectorado de la Universidad de Alcalá. A la reunión asistieron 74 participantes, y se presentaron un total de 39 comunicaciones orales, 18 paneles y 8 ponencias invitadas. Además, se presentó el libro “Calidad de Planta Forestal para la Restauración en Ambientes Mediterráneos” y se organizaron dos mesas redondas, una sobre “Necesidades reales de investigación en calidad de planta y cultivo de planta forestal en vivero” (Tabla 1) y otra sobre “Necesidades reales de la investigación en reforestación” (Tabla 2, 3). Una densa agenda para alcanzar los principales objetivos de la reunión, la presentación de investigación de calidad en el ámbito de la revegetación de sistemas forestales, y el intercambio de experiencias e inquietudes entre los diversos colectivos implicados en la misma. Pero ¿qué imagen podemos extraer del estado actual de nuestros conocimientos en esta área a partir de las comunicaciones presentadas

Magnetothermal Conductivity of Highly Oriented Pyrolytic Graphite in the Quantum Limit

We report on the magnetic field (0T$\le B \le 9$T) dependence of the longitudinal thermal conductivity $\kappa(T,B)$ of highly oriented pyrolytic graphite in the temperature range 5 K $\le T\le$ 20 K for fields parallel to the $c-$axis. We show that $\kappa(T,B)$ shows large oscillations in the high-field region (B > 2 T) where clear signs of the Quantum-Hall effect are observed in the Hall resistance. With the measured longitudinal electrical resistivity we show that the Wiedemann-Franz law is violated in the high-field regime.Comment: 4 Figures, to be published in Physical Review B (2003

Analysis of induced surface modifications effects on the electrochemical behaviour of LSP-treated metallic alloys

The systematic evaluation of the electrochemical changes induced in relevant materials by LSP treatment has been envisaged. Analysis of cyclic polarization curves with clear identification of corrosion parameters (Ecorr, Icorr, Mcorr, Ep, Ip) has been succesfully performed for Al2024-T351 and AISI 316L steel. Electrochemical Impedance Spectroscopy (EIS) has been used in order to correlate the observed electrochemical behaviour (even at long timescales) with surface modifications induced by the LSP treatment, especially roughness and elemental chemical composition. A good physico-chemical process understanding has been gained in the case of Al2024-T351 and AISI 316L steel. Work has been initiated for other key materials with a more complex behaviour (i.e. Ti6Al4V).The development of a systematic assessment capability for the corrosion susceptibility modification effects of the LSP technique is under way

Breast cancer PAM50 signature: Correlation and concordance between RNA-Seq and digital multiplexed gene expression technologies in a triple negative breast cancer series

Background: Full RNA-Seq is a fundamental research tool for whole transcriptome analysis. However, it is too costly and time consuming to be used in routine clinical practice. We evaluated the transcript quantification agreement between RNA-Seq and a digital multiplexed gene expression platform, and the subtype call after running the PAM50 assay in a series of breast cancer patients classified as triple negative by IHC/FISH. The goal of this study is to analyze the concordance between both expression platforms overall, and for calling PAM50 triple negative breast cancer intrinsic subtypes in particular. Results: The analyses were performed in paraffin-embedded tissues from 96 patients recruited in a multicenter, prospective, non-randomized neoadjuvant triple negative breast cancer trial (NCT01560663). Pre-treatment core biopsies were obtained following clinical practice guidelines and conserved as FFPE for further RNA extraction. PAM50 was performed on both digital multiplexed gene expression and RNA-Seq platforms. Subtype assignment was based on the nearest centroid classification following this procedure for both platforms and it was concordant on 96% of the cases (N = 96). In four cases, digital multiplexed gene expression analysis and RNA-Seq were discordant. The Spearman correlation to each of the centroids and the risk of recurrence were above 0.89 in both platforms while the agreement on Proliferation Score reached up to 0.97. In addition, 82% of the individual PAM50 genes showed a correlation coefficient > 0.80. Conclusions: In our analysis, the subtype calling in most of the samples was concordant in both platforms and the potential discordances had reduced clinical implications in terms of prognosis. If speed and cost are the main driving forces then the preferred technique is the digital multiplexed platform, while if whole genome patterns and subtype are the driving forces, then RNA-Seq is the preferred method

Pathological response in a triple-negative breast cancer cohort treated with neoadjuvant carboplatin and docetaxel according to Lehmann's refined classification

Purpose: Triple-negative breast cancer (TNBC) requires the identification of reliable predictors of response to neoadjuvant chemotherapy (NACT). For this purpose, we aimed to evaluate the performance of the TNBCtype-4 classifier in a cohort of patients with TNBC treated with neoadjuvant carboplatin and docetaxel (TCb). Methods: Patients with TNBC were accrued in a nonrandomized trial of neoadjuvant carboplatin AUC 6 and docetaxel 75 mg/m2 for six cycles. Response was evaluated in terms of pathologic complete response (pCR, ypT0/is ypN0) and residual cancer burden by Symmans and colleagues. Lehmann's subtyping was performed using the TNBCtype online tool from RNAseq data, and germline sequencing of a panel of seven DNA damage repair genes was conducted. Results: Ninety-four out of the 121 patients enrolled in the trial had RNAseq available. The overall pCR rate was 44.7%. Lehmann subtype distribution was 34.0% BL1, 20.2% BL2, 23.4% M, 14.9% LAR, and 7.4% were classified as ERþ. Response to NACT with TCb was significantly associated with Lehmann subtype (P ¼ 0.027), even in multivariate analysis including tumor size and nodal involvement, with BL1 patients achieving the highest pCR rate (65.6%), followed by BL2 (47.4%), M (36.4%), and LAR (21.4%). BL1 was associated with a significant younger age at diagnosis and higher ki67 values. Among our 10 germline mutation carriers, 30% were BL1, 40% were BL2, and 30% were M. Conclusions: TNBCtype-4 is associated with significantly different pCR rates for the different subtypes, with BL1 and LAR displaying the best and worse responses to NACT, respectively